EPS-AIM-00075

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-AIM-00075

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/PTEN	144.1	6.2E-42	358	514	157

Status

Unreviewed

Ensembl Protein

ENSAMEP00000017732

UniProt Accession

G1MEF4;

Protein Name

Protein Synonyms/Alias

Gene Name

GAK

Gene Synonyms/Alias

GAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000016761	ENSAMEP00000017732	ENSAMET00000018454

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

1258

Protein Sequence
(FASTA)

GGFAFVYEAQ DLGSGREYAL KRLLSNEEEK NRAIIQEVCF MKKLSGHPNI VQFCSAASIG 60

KEESDTGQAE FLLLTELCKG QLVEFLKKIE SRGPLSCDTV LKIFYQTCRA VQHMHRQKPP 120

IIHRDLKVEN LLLSNQGTIK LCDFGSATTI SHYPDYSWSA QRRALVEEEI TRNTTPMYRT 180

PEIVDLYSNF PIGEKQDRLA LGCILYLLCF RQHPFEDGAK LRIVNGKFSI PPNDTRYSVF 240

HDLIRATLKV NPEERLSITE LVNQLQEIAA ARNVNPKSPI TELLEQNGGY GNAVPSRGPP 300

PPGGSSSGGY SGGLALAEYD QPYGGLLDIL RGGTERLFTN IKDTSSKVIQ SVANYAKGDL 360

DISYITSRIA VMSFPAEGVE SAIKNNIEDV RLFLDSKHPG HYAVYNLSPR TYRSSKFHNR 420

VSECGWAARR APNLRSLYSV CKNMHSWLRQ DHKNVCVVHC VDGRAASAVA VCSFLCFCRL 480

FSTAEAAVYM FSMKRCPPGI WPSHKRYIEY MCDMVAEEPI TPHSKPILVK AVAMTPVPLF 540

SKQRNGCRPF CEVYVGDERV TTTSQEYDKM RDFKIEDGKA VIPLGITVQG DVLIIIYHAR 600

STLGGRLQAK VASMKMFQVQ FHTGFVPRNA TTVKFAKYDL DACDIQEKYP DLFQVNLEVE 660

VEPRDRPSRE APPWESTSMR GLNPKILFSS REEQQDILSK FGKPELPRQP GSTAQYDAEA 720

GSLDAEPTES DSPQSSSTDP SHFLHTLDWH EEKDTGTGPG QFAKESVSAP AKDAGGSEPS 780

DEEAATLSAE SRDAADEDTP GPATRAQERE LGFDAATPAT PQEPTLQEDS VDLLGLNSEA 840

GLAPPMQACG AAPSTADLLS RLLGAPDPAP EVPPGDLLGG EAPLLFSSPA PSLSAQSPPR 900

EGPAAVADPF DPLLLPSGPD TQPCSKPDLF GEFLNSESPA AAPASFPSAH SAPPPACSTD 960

FLHLGDLPAE PGKMTASSSH PDLLGGWEAW AEAPAPVPAA EGPFFSPGGQ PAAPGPPASW 1020

TKSQSLDPFA DLGDLSTGLQ GSSAGFAPGG FGPKTAPPPT GGSSWQQTSR PLAQGTPRAP 1080

QAKPPPKACA QPRPNYAANV SVIGSREERG VRAPSFGQKP RVSESDFEDL LSDQGFSSKA 1140

DRKGPRTMAE MRRQEQARDA DPLKLKLLEW TEGKERNIRA LLSTLHTVLW DGESRWTPVG 1200

MADLVTPGQV KKHYRRAVLV VHPDKAAGQP YEQYAKMIFM ELNDAWAEFE SQGSRPLF 1258

Nucleotide Sequence
(FASTA)

GGAGGGTTTG CGTTTGTGTA CGAAGCCCAA GACCTGGGGA GCGGCAGAGA GTACGCCTTG 60

AAGAGATTAT TGTCTAATGA AGAGGAAAAG AACAGAGCCA TCATTCAGGA AGTTTGTTTC 120

ATGAAAAAAC TTTCTGGCCA CCCCAATATT GTCCAGTTTT GTTCTGCAGC GTCCATAGGG 180

AAAGAGGAGT CAGACACTGG GCAGGCTGAG TTCCTGCTGC TCACCGAGCT CTGCAAAGGG 240

CAGCTGGTGG AATTTTTAAA GAAAATTGAA TCTAGAGGTC CGCTCTCGTG CGATACTGTT 300

CTGAAGATAT TCTATCAGAC GTGCAGAGCG GTGCAGCACA TGCACAGACA AAAGCCGCCC 360

ATCATCCATA GAGACCTCAA GGTGGAAAAC TTGTTGCTCA GTAACCAGGG GACCATCAAG 420

CTGTGTGACT TTGGCAGTGC CACGACCATA TCGCATTACC CTGACTACAG CTGGAGCGCC 480

CAGCGGCGGG CCCTCGTAGA AGAAGAGATC ACCAGGAACA CCACACCCAT GTACAGGACG 540

CCAGAAATCG TGGACTTGTA CTCGAACTTC CCGATCGGCG AGAAGCAGGA CAGGCTGGCC 600

CTGGGCTGCA TCTTGTATCT GCTGTGCTTC CGGCAGCATC CTTTTGAAGA CGGAGCAAAA 660

CTTCGAATAG TCAACGGGAA GTTTTCGATC CCCCCTAATG ATACCCGGTA TTCCGTGTTC 720

CACGACCTCA TCCGTGCCAC GCTGAAGGTC AACCCCGAGG AGCGGCTGTC CATCACAGAA 780

CTGGTCAACC AGCTGCAGGA GATCGCAGCC GCCAGGAACG TGAACCCCAA GTCTCCCATC 840

ACTGAGCTCC TGGAGCAGAA TGGAGGCTAT GGGAACGCTG TCCCATCCCG AGGGCCACCC 900

CCTCCTGGGG GCTCCAGCAG TGGTGGCTAC AGTGGAGGCC TGGCACTTGC TGAGTACGAC 960

CAGCCCTACG GCGGGCTCCT GGACATCCTG CGGGGGGGCA CTGAGCGCCT CTTCACAAAC 1020

ATCAAGGACA CCTCCTCCAA GGTCATCCAG TCCGTTGCCA ATTATGCAAA GGGAGATTTG 1080

GACATCTCTT ACATCACATC CAGAATTGCT GTGATGTCAT TCCCAGCAGA AGGCGTGGAG 1140

TCGGCTATCA AGAATAACAT AGAAGACGTG CGGTTGTTTC TGGACTCCAA GCACCCGGGA 1200

CACTATGCGG TCTACAACCT GTCCCCGAGA ACGTACCGGT CCTCCAAGTT TCATAACCGG 1260

GTCTCCGAGT GCGGCTGGGC GGCCAGGCGG GCCCCAAACC TTCGCAGCCT GTACAGCGTT 1320

TGCAAGAACA TGCATTCATG GCTCCGGCAA GACCACAAGA ACGTCTGTGT GGTGCACTGC 1380

GTGGACGGGA GAGCCGCGTC CGCTGTAGCC GTCTGCTCCT TCCTGTGCTT CTGCCGGCTC 1440

TTCAGCACCG CGGAGGCCGC CGTGTACATG TTCAGTATGA AGCGCTGCCC GCCGGGCATC 1500

TGGCCGTCCC ACAAAAGGTA CATCGAGTAC ATGTGTGACA TGGTGGCGGA GGAGCCCATC 1560

ACGCCCCACA GCAAGCCGAT CCTGGTGAAA GCCGTGGCCA TGACGCCCGT GCCGCTGTTC 1620

AGCAAGCAGA GGAACGGCTG CAGGCCCTTC TGCGAGGTCT ACGTGGGGGA CGAGCGGGTG 1680

ACCACCACAT CTCAGGAGTA TGACAAGATG AGGGATTTCA AAATCGAGGA CGGCAAAGCA 1740

GTCATTCCCT TGGGCATAAC TGTGCAAGGG GACGTGCTTA TTATAATCTA CCACGCCAGG 1800

TCCACTCTGG GAGGAAGACT GCAGGCCAAG GTGGCGTCCA TGAAGATGTT CCAGGTCCAG 1860

TTCCACACGG GCTTTGTGCC TCGGAATGCA ACTACTGTGA AATTTGCAAA GTATGACCTG 1920

GATGCCTGTG ACATTCAGGA GAAATACCCG GATTTATTCC AAGTGAACCT GGAGGTGGAG 1980

GTGGAGCCCA GAGACAGGCC CAGCCGGGAG GCCCCACCCT GGGAGAGCAC CAGCATGAGG 2040

GGGCTGAACC CCAAAATCCT GTTTTCCAGC CGGGAGGAGC AGCAAGACAT TCTGTCTAAA 2100

TTTGGGAAGC CAGAGCTCCC CAGGCAGCCC GGCTCCACCG CTCAGTACGA CGCTGAGGCA 2160

GGGTCTCTGG ATGCTGAGCC CACGGAGTCT GATTCACCGC AGAGCAGCAG CACGGACCCC 2220

AGCCACTTCC TCCACACGCT GGATTGGCAT GAGGAGAAAG ACACGGGGAC GGGCCCAGGT 2280

CAGTTTGCCA AGGAGAGTGT GTCAGCCCCA GCCAAGGACG CAGGTGGGAG TGAGCCTTCT 2340

GATGAGGAAG CAGCGACACT GTCAGCTGAG AGCAGAGACG CGGCTGACGA GGACACGCCC 2400

GGCCCGGCAA CGAGGGCGCA AGAGCGAGAG CTGGGTTTTG ATGCGGCCAC GCCAGCCACA 2460

CCGCAGGAGC CCACGCTGCA GGAGGACAGT GTCGACCTCC TGGGGCTGAA CTCCGAGGCG 2520

GGGCTGGCAC CCCCCATGCA GGCCTGCGGG GCAGCCCCCA GTACTGCCGA CCTGCTCAGC 2580

CGCCTCCTGG GGGCCCCCGA CCCAGCTCCA GAGGTCCCCC CAGGTGATCT GCTGGGCGGA 2640

GAGGCCCCCT TGCTCTTCTC AAGCCCGGCC CCTTCCTTGA GCGCGCAGAG CCCACCCCGC 2700

GAAGGGCCGG CTGCAGTTGC CGACCCGTTT GACCCTCTCC TGCTGCCATC TGGTCCAGAC 2760

ACCCAGCCCT GCTCCAAGCC CGACCTCTTT GGTGAATTTC TTAATTCCGA GTCTCCTGCC 2820

GCCGCCCCTG CATCCTTCCC CTCCGCCCAC AGCGCCCCAC CCCCAGCCTG CAGCACCGAC 2880

TTCCTGCACC TGGGGGATCT ACCGGCAGAG CCTGGCAAGA TGACGGCCTC AAGCAGCCAC 2940

CCGGATCTGC TGGGGGGGTG GGAGGCCTGG GCTGAGGCGC CGGCCCCCGT ACCTGCTGCA 3000

GAAGGTCCCT TCTTCTCTCC AGGAGGCCAG CCTGCCGCCC CCGGCCCCCC AGCCAGCTGG 3060

ACCAAGTCTC AGAGCCTGGA CCCATTTGCA GACCTCGGTG ACCTCAGTAC TGGCCTCCAA 3120

GGCTCGTCGG CTGGATTTGC TCCTGGGGGT TTCGGCCCCA AAACAGCCCC CCCTCCCACG 3180

GGCGGCAGCT CCTGGCAGCA GACAAGTCGG CCCCTGGCCC AGGGCACCCC CCGTGCCCCC 3240

CAGGCCAAGC CACCCCCAAA AGCCTGTGCA CAGCCGAGGC CTAACTATGC CGCCAATGTG 3300

AGTGTGATCG GCAGCCGAGA GGAGAGGGGG GTCCGCGCCC CCAGCTTCGG TCAGAAGCCA 3360

AGAGTGTCCG AGAGCGACTT TGAGGACCTA CTGTCTGACC AGGGCTTCTC CTCCAAGGCC 3420

GATAGGAAGG GGCCCAGGAC CATGGCCGAG ATGCGGAGGC AGGAGCAGGC AAGGGACGCA 3480

GACCCGCTCA AGCTGAAGCT CCTGGAGTGG ACCGAGGGCA AGGAGAGGAA CATCCGTGCG 3540

CTGCTGTCCA CCCTGCACAC CGTGCTGTGG GACGGCGAGA GCCGCTGGAC GCCCGTGGGC 3600

ATGGCCGACC TGGTGACCCC AGGGCAGGTG AAGAAACATT ACCGCCGTGC TGTGCTGGTG 3660

GTCCACCCAG ACAAGGCCGC AGGGCAGCCC TACGAGCAGT ACGCCAAGAT GATCTTCATG 3720

GAGCTGAATG ACGCGTGGGC TGAGTTCGAG AGCCAGGGCT CCCGGCCCCT CTTCTGA 3777

Domain Profile

S: 8     fdldltyvteriiavsfPaeareevyrnnlrevvrlldskhrnkyklynlcserrydltk  67

          dld+ y+t ri  +sfPae+ e+  +nn+++v  +ldskh ++y +ynl s r y  +k

Q: 358   GDLDISYITSRIAVMSFPAEGVESAIKNNIEDVRLFLDSKHPGHYAVYNL-SPRTYRSSK  416

         59************************************************.*********

S: 68    lnakvaefgiedlnaPaleklvsickeldeWlseddenvvvlhckggkgrlGvivcayll  127

         ++++v+e g+   +aP+l  l s+ck+++ Wl +d++nv v+hc  g+    v vc++l

Q: 417   FHNRVSECGWAARRAPNLRSLYSVCKNMHSWLRQDHKNVCVVHCVDGRAASAVAVCSFLC  476

         ************************************************************

S: 128   aseisakadealdtfgerrtredkvagvkqPsqrryvsyfsql  170

         + + +++a+ a+++f+++r           Ps +ry++y + +

Q: 477   FCRLFSTAEAAVYMFSMKRCPPG-----IWPSHKRYIEYMCDM  514

         ******************97654.....59*********9876

Domain Sequence
(FASTA)

GDLDISYITS RIAVMSFPAE GVESAIKNNI EDVRLFLDSK HPGHYAVYNL SPRTYRSSKF 60

HNRVSECGWA ARRAPNLRSL YSVCKNMHSW LRQDHKNVCV VHCVDGRAAS AVAVCSFLCF 120

CRLFSTAEAA VYMFSMKRCP PGIWPSHKRY IEYMCDM 157

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR001623	; DnaJ_N.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00226	; DnaJ; 1.
PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

SM00271

; DnaJ; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS50076	; DNAJ_2; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013