EPS-AIM-00046

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-AIM-00046

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP7	563.8	8.9E-170	124	455	332

Status

Unreviewed

Ensembl Protein

ENSAMEP00000017763

UniProt Accession

G1MEI5;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPEF1

Gene Synonyms/Alias

PPEF1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000016806	ENSAMEP00000017763	ENSAMET00000018487

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

654

Protein Sequence
(FASTA)

ACHCSSFFIS HGSAALKAAL IIQNWYRGYS ARLKARQRYA LTIFQSIEYA DEQGQLQLSK 60

FFSFMLENYT HIHEKDPESQ EDISLRTECT LQDCKDRQEY VSCIDVPDSY NGPRLQFPLT 120

FTDIDILLEA FKQQQILHAH YVLEVLFETK KVLKQMPNFT HVKTSPSKEI TICGDLHGKL 180

DDLFLIFYKN GLPSGSNSYI FNGDFVDRGK HSMEILMILF VSFLVYPNDL HLNRGNHEDF 240

MMNLRYGFTK EILHKYKMHG KKILQILEDV YTWLPIGTII DNEILIIHGG ISESTDLNLL 300

HRIERNKMKS VLMPPIPLDE DHDTDLKTKV GATIIPREVK TNGSLSEQLT KHEWEQVINI 360

LWSDPRGKRG CYPNKSRGGG CYFGPDITSK VLNKYQLKML IRSHECKPEG YEICHGGKVV 420

TVFSASNYYE EGSNRGAYIK LCCDMTPRFF QYQVTRTTCS RPLYQRVNAI ESSAIRILKE 480

RMISRKTALI RAFQLQDHSK SGKLSMAQWA FSMENILGLD LPWRSLSSHL VTTDKNGNIN 540

YMSSFQDIHI QKPVKEAQST LIETLYRYRS DLQIIFNVID TDHSGLISME EFRAMWKLFS 600

SHYSIPIDDF QVDELAERMD LNKDGSIDFN EFLKAFYVVH KLDKTIKPVI LNLG 654

Nucleotide Sequence
(FASTA)

GCTTGTCACT GTAGTAGCTT TTTCATATCC CACGGGTCTG CAGCGCTGAA AGCTGCATTG 60

ATCATCCAGA ACTGGTACCG AGGTTACAGT GCTCGGCTGA AGGCCAGACA ACGCTATGCC 120

CTCACCATCT TCCAGTCCAT CGAATATGCT GATGAACAAG GCCAATTGCA GCTATCCAAG 180

TTCTTTTCCT TCATGTTGGA AAACTATACA CATATACACG AGAAAGACCC AGAGAGTCAG 240

GAAGATATAT CTCTAAGAAC GGAATGCACC CTCCAGGACT GCAAGGATAG ACAGGAGTAT 300

GTCTCATGCA TAGACGTCCC AGACTCCTAT AATGGTCCTC GGCTGCAATT TCCTCTCACT 360

TTTACTGATA TTGATATACT TCTTGAGGCC TTCAAGCAAC AACAGATACT TCATGCTCAT 420

TACGTCTTAG AGGTGCTCTT TGAAACCAAG AAAGTCCTGA AGCAAATGCC GAACTTCACT 480

CACGTAAAAA CTTCTCCCTC CAAAGAGATA ACAATCTGTG GTGATTTGCA TGGGAAACTG 540

GATGATCTTT TTTTGATCTT CTATAAGAAT GGTCTCCCCT CAGGGAGCAA CTCATATATT 600

TTTAATGGTG ATTTTGTAGA TCGAGGAAAA CATTCCATGG AGATCCTAAT GATCCTGTTT 660

GTGAGTTTTC TTGTCTACCC CAATGACCTG CACTTGAACA GAGGGAACCA TGAAGATTTT 720

ATGATGAATC TGAGGTATGG CTTCACAAAA GAAATTTTGC ATAAATATAA GATGCATGGA 780

AAGAAAATCT TACAAATCTT AGAAGACGTC TATACCTGGC TCCCAATTGG TACAATCATT 840

GACAATGAAA TCCTGATCAT ACATGGTGGG ATATCAGAGT CCACAGACTT GAATTTGCTC 900

CACCGTATAG AACGAAACAA AATGAAGTCT GTGCTGATGC CACCAATTCC CTTAGATGAA 960

GACCATGATA CTGACTTGAA AACTAAAGTA GGTGCGACTA TTATACCTCG GGAAGTCAAA 1020

ACAAATGGAT CCCTTTCTGA ACAGTTAACA AAGCACGAAT GGGAACAGGT TATCAATATT 1080

CTGTGGAGTG ATCCCAGAGG CAAAAGAGGC TGTTACCCAA ACAAAAGTCG AGGAGGGGGC 1140

TGCTATTTTG GACCAGATAT TACCTCCAAG GTTCTTAATA AATACCAGTT GAAGATGCTC 1200

ATTAGATCTC ATGAATGTAA GCCTGAAGGG TATGAAATCT GCCACGGTGG GAAGGTTGTT 1260

ACTGTATTTT CTGCTTCTAA TTATTATGAA GAAGGCAGCA ATCGAGGAGC TTACATCAAA 1320

CTATGTTGTG ATATGACCCC TCGATTTTTC CAGTACCAAG TAACTAGGAC AACGTGCTCA 1380

AGGCCTCTTT ACCAAAGGGT GAATGCTATT GAGAGTAGTG CCATCAGGAT ATTGAAAGAG 1440

AGAATGATTT CAAGAAAAAC TGCCCTCATT CGTGCTTTCC AACTTCAAGA CCACAGTAAA 1500

TCAGGAAAAC TTTCTATGGC CCAGTGGGCT TTTTCCATGG AGAACATTTT GGGGCTGGAC 1560

TTACCATGGA GATCCCTGAG TTCACATCTG GTAACCACAG ACAAAAATGG AAATATTAAC 1620

TACATGTCCA GCTTCCAGGA CATCCACATT CAGAAACCTG TGAAAGAGGC TCAGTCTACT 1680

CTAATTGAAA CTCTGTACAG ATACCGCTCT GACCTGCAAA TCATCTTCAA TGTCATTGAC 1740

ACTGATCACT CAGGCCTGAT TTCCATGGAA GAATTTCGTG CCATGTGGAA ACTCTTCAGT 1800

AGTCACTACA GCATTCCTAT CGATGATTTT CAAGTTGATG AACTCGCTGA AAGAATGGAC 1860

TTAAACAAAG ATGGAAGCAT TGACTTTAAT GAATTTCTAA AGGCTTTCTA TGTAGTGCAT 1920

AAATTGGATA AGACTATAAA ACCAGTAATT CTCAATCTTG GA 1962

Domain Profile

S: 1     idlllevfkkkrilhakyvlevlfeakkvlkqlpnishvstavskevtvvGdlhGklddl  60

         id+lle+fk+++ilha+yvlevlfe+kkvlkq+pn++hv+t++ske+t++GdlhGklddl

Q: 124   IDILLEAFKQQQILHAHYVLEVLFETKKVLKQMPNFTHVKTSPSKEITICGDLHGKLDDL  183

         89**********************************************************

S: 61    llvlkknGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkvmn  120

         +l+++knGlPs +n+y+fnGdfvdrGk+++e+l++l ++flv+Pn+++lnrGnhed++mn

Q: 184   FLIFYKNGLPSGSNSYIFNGDFVDRGKHSMEILMILFVSFLVYPNDLHLNRGNHEDFMMN  243

         ************************************************************

S: 121   aryGfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllksv  180

         +ryGf+ke+l+kyk +gk+il+ile+vy+wlP+g+i+d+++l++hGG+sest+l+ll+++

Q: 244   LRYGFTKEILHKYKMHGKKILQILEDVYTWLPIGTIIDNEILIIHGGISESTDLNLLHRI  303

         ************************************************************

S: 181   erkkrksvllpPeessrd..............lgrldtdgepreslteteweqiidilws  226

         er+k+ksvl+pP + + d                 ++t+g+ +e+lt++eweq+i+ilws

Q: 304   ERNKMKSVLMPPIPLDEDhdtdlktkvgatiiPREVKTNGSLSEQLTKHEWEQVINILWS  363

         *************9999899*******99998788*************************

S: 227   dPratnGlvPntlrGaGvyfGPdvtedflkkyelklvirsheckpegyeilhdgkvvtif  286

         dPr++ G++Pn+ rG+G+yfGPd+t+++l+ky+lk++irsheckpegyei+h gkvvt+f

Q: 364   DPRGKRGCYPNKSRGGGCYFGPDITSKVLNKYQLKMLIRSHECKPEGYEICHGGKVVTVF  423

         ************************************************************

S: 287   sasnyyeegsnkgayiklnsqltprfvqyiva  318

         sasnyyeegsn+gayikl+ ++tprf+qy+v+

Q: 424   SASNYYEEGSNRGAYIKLCCDMTPRFFQYQVT  455

         ******************************98

Domain Sequence
(FASTA)

IDILLEAFKQ QQILHAHYVL EVLFETKKVL KQMPNFTHVK TSPSKEITIC GDLHGKLDDL 60

FLIFYKNGLP SGSNSYIFNG DFVDRGKHSM EILMILFVSF LVYPNDLHLN RGNHEDFMMN 120

LRYGFTKEIL HKYKMHGKKI LQILEDVYTW LPIGTIIDNE ILIIHGGISE STDLNLLHRI 180

ERNKMKSVLM PPIPLDEDHD TDLKTKVGAT IIPREVKTNG SLSEQLTKHE WEQVINILWS 240

DPRGKRGCYP NKSRGGGCYF GPDITSKVLN KYQLKMLIRS HECKPEGYEI CHGGKVVTVF 300

SASNYYEEGS NRGAYIKLCC DMTPRFFQYQ VT 332

Keyword

Calcium; Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005509	; F:calcium ion binding
GO:0005506	; F:iron ion binding
GO:0030145	; F:manganese ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0050906	; P:detection of stimulus involved in sensory perception

KEGG

InterPros

IPR011992	; EF-hand-like_dom.
IPR018247	; EF_Hand_1_Ca_BS.
IPR018249	; EF_HAND_2.
IPR002048	; EF_hand_Ca-bd.
IPR000048	; IQ_motif_EF-hand-BS.
IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR012008	; Ser/Thr-Pase_EF-hand_contain.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.

SMARTs

SM00054	; EFh; 2.
SM00015	; IQ; 1.
SM00156	; PP2Ac; 1.

Prosites

PS00018	; EF_HAND_1; 2.
PS50222	; EF_HAND_2; 3.
PS50096	; IQ; 1.
PS00125	; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013