EKS-AIM-00352

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00352

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	320.2	1.0E-95	175	412	238

Status

Unreviewed

Ensembl Protein

ENSAMEP00000017773

UniProt Accession

G1MEJ5;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K13

Gene Synonyms/Alias

MAP3K13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000016822	ENSAMEP00000017773	ENSAMET00000018497

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

973

Protein Sequence
(FASTA)

HTHGTMANPQ EHLSCSSSPH LPLSESRTFN GLQDELTSGG GHPSPKLLKD QQEKGVLQTE 60

LTESMNSPIT TTVLTSVSED SRDQFENSVL QLREQDESEM AVSQGNSNTM DGESTSGTED 120

IKIQFSRSGS SSGGFLEGLF GCLRPVWNII GKAYSTDYKL QQQDTWEVPF EEISELQWLG 180

SGAQGAVFLG KFRAEEVAIK KVREQNETDI KHLRKLKHPN IIAFKGVCTQ APCYCIIMEY 240

CAHGQLYEVL RAGRKITPRL LVDWSTGIAS GMNYLHLHKI IHRDLKSPNV LVTHTDAVKI 300

SDFGTSKELS DKSTKMSFAG TVAWMAPEVI RNEPVSEKVD IWSFGVVLWE LLTGEIPYKD 360

VDSSAIIWGV GSNSLHLPVP STCPDGFKIL MKQTWQSKPR NRPSFRQTLM HLDIASADVL 420

ATPQETYFKS QAEWREEVKK HFEKIKSEGT CIHRLDEELI RRRREELRHA LDIREHYERK 480

LERANNLYME LSAIMLQLEM REKELIKREQ AVEKKYPGTY KRHPVRPIIH PNAMEKLMKR 540

KGAPHKSGMQ TKRPDLLRSE GIPSMEVAPA ASPLSGSPKT STSSSKSRYR SKPRHRRGNS 600

RGSHSDFAGI LKNQPAQENP PHPTYLHDAQ PQYPSPHHHH PLQQQYQQTP PATSQSHHPR 660

LNMHGQDIAT CANNLRYFGP AAALRSPLSN HAQRQMPGSS PDLISTAMAA DCWRSSEPDQ 720

GPAGPWGCCQ ADPYDPCLQC RPEQCGSLDI PSAEPVGRSP DLFKSPAHNP LSEDAQGSEK 780

MEENEFKGRR SASSLGIPHH ITPPMLPRNT RPLQKSGDDS SEEEEGEVDS EVEFPRRQSS 840

RPHRCISSCQ SYSTFSSENF SVSDGEEGNT SDHSNSPDEL ADKLEDRLAE KLDDLLSQTP 900

EIPIEISSHS DGLSDKECAV RRVKTQMSLG KLCAEERGYE NPMQFEESDC DSSDGECSDA 960

TVRTNKHYSS ATW 973

Nucleotide Sequence
(FASTA)

CACACTCATG GCACCATGGC CAACCCTCAG GAGCACCTGA GCTGCTCCTC TTCCCCACAC 60

TTACCCTTGA GTGAAAGCAG AACCTTCAAC GGACTACAAG ATGAACTCAC GTCTGGGGGG 120

GGCCACCCTT CACCCAAGCT CCTTAAGGAC CAGCAGGAAA AGGGGGTGCT ACAAACAGAG 180

CTAACTGAGA GCATGAACAG CCCCATCACC ACAACAGTGT TGACAAGCGT GAGTGAGGAT 240

TCCAGGGACC AATTTGAGAA CAGTGTTCTT CAGCTAAGGG AACAAGATGA ATCAGAGATG 300

GCCGTGTCTC AGGGGAACAG CAACACCATG GATGGAGAGA GCACAAGTGG AACTGAAGAC 360

ATCAAGATTC AGTTCAGCAG GTCGGGCAGC AGCAGTGGTG GGTTTCTGGA AGGACTCTTT 420

GGATGCTTAA GGCCTGTATG GAATATCATT GGGAAGGCAT ATTCCACTGA TTACAAATTG 480

CAGCAGCAAG ATACTTGGGA AGTGCCATTT GAGGAGATCT CAGAGCTGCA GTGGCTGGGT 540

AGTGGAGCCC AAGGAGCTGT CTTCTTGGGC AAGTTCCGAG CGGAGGAGGT GGCCATCAAG 600

AAAGTGAGAG AACAGAATGA GACGGATATC AAGCATTTGA GGAAGTTGAA GCACCCTAAC 660

ATCATCGCGT TCAAGGGTGT TTGTACTCAG GCCCCCTGTT ACTGCATCAT CATGGAATAC 720

TGTGCTCACG GACAACTCTA CGAGGTTTTG CGAGCTGGCA GGAAGATCAC ACCTCGATTG 780

CTGGTGGACT GGTCCACGGG AATTGCAAGT GGAATGAATT ATTTGCACCT CCATAAAATT 840

ATTCATCGTG ATCTCAAATC ACCTAATGTT TTGGTGACTC ACACAGATGC GGTAAAGATT 900

TCAGATTTTG GCACATCTAA GGAGCTCAGT GACAAAAGTA CCAAGATGTC CTTCGCCGGC 960

ACCGTTGCCT GGATGGCCCC AGAGGTGATA CGCAATGAAC CTGTCTCTGA AAAAGTCGAT 1020

ATATGGTCTT TCGGAGTGGT GCTTTGGGAG CTGCTGACAG GAGAGATTCC TTACAAAGAT 1080

GTAGACTCTT CAGCCATAAT TTGGGGTGTT GGAAGCAATA GCCTACACCT TCCAGTTCCT 1140

TCCACTTGCC CTGATGGATT CAAAATCCTT ATGAAACAGA CATGGCAGAG TAAACCTCGC 1200

AACCGGCCTT CTTTCCGGCA GACGCTCATG CATTTAGACA TTGCCTCCGC AGACGTTCTT 1260

GCCACCCCAC AAGAAACCTA CTTCAAGTCT CAGGCTGAAT GGAGAGAAGA GGTGAAAAAA 1320

CACTTTGAGA AGATCAAAAG TGAGGGAACT TGTATACACC GATTAGATGA AGAACTGATT 1380

CGGAGGCGCA GAGAAGAGCT CAGGCATGCT CTGGATATCC GTGAACACTA TGAGAGAAAA 1440

CTTGAGCGGG CTAATAATTT ATACATGGAA CTGAGTGCCA TCATGCTGCA GCTAGAAATG 1500

CGGGAGAAGG AGCTCATTAA ACGTGAGCAA GCAGTGGAAA AGAAGTATCC TGGAACCTAC 1560

AAACGACACC CCGTCCGTCC AATAATCCAC CCCAACGCCA TGGAGAAACT CATGAAGAGG 1620

AAAGGCGCAC CTCATAAATC TGGGATGCAG ACCAAACGGC CAGATCTGTT GAGATCCGAA 1680

GGTATCCCCA GTATGGAGGT GGCTCCCGCT GCGTCCCCTT TGTCCGGAAG TCCCAAAACG 1740

TCCACCTCAA GCAGCAAGAG CCGGTATCGG AGCAAACCAC GCCACCGCCG AGGGAATAGC 1800

AGAGGCAGCC ATAGTGACTT TGCCGGGATC TTGAAAAACC AGCCAGCCCA GGAAAATCCA 1860

CCCCATCCCA CTTATCTACA CGACGCTCAG CCCCAGTACC CTTCTCCCCA TCACCACCAT 1920

CCTCTGCAGC AGCAGTACCA GCAAACCCCT CCTGCCACGT CTCAGAGTCA CCATCCCAGG 1980

CTCAATATGC ACGGACAGGA CATTGCAACG TGCGCCAACA ACCTGCGGTA TTTTGGCCCT 2040

GCAGCAGCCC TGCGGAGCCC ACTCAGCAAC CATGCTCAGA GACAGATGCC TGGCTCCAGC 2100

CCTGACCTCA TCTCCACGGC CATGGCAGCA GACTGCTGGA GAAGCTCTGA GCCGGACCAG 2160

GGCCCGGCTG GCCCGTGGGG CTGTTGTCAG GCTGACCCTT ATGACCCCTG CCTCCAGTGC 2220

AGGCCAGAAC AGTGTGGGTC CTTAGACATA CCCTCTGCTG AGCCGGTGGG TAGGAGTCCC 2280

GACCTTTTCA AGTCACCAGC ACATAATCCC CTCTCGGAAG ATGCCCAAGG TTCTGAGAAA 2340

ATGGAAGAAA ATGAATTCAA AGGCCGTAGG TCTGCGTCAT CCCTTGGCAT TCCTCATCAC 2400

ATCACCCCCC CAATGCTACC TCGAAACACA AGGCCCCTGC AAAAGAGTGG CGATGACTCC 2460

TCAGAAGAGG AAGAAGGAGA AGTAGATAGT GAAGTTGAAT TTCCACGAAG ACAGAGTTCT 2520

AGGCCCCATC GCTGTATCAG CAGCTGCCAG TCGTATTCAA CTTTTAGCTC TGAGAATTTC 2580

TCTGTGTCTG ACGGAGAGGA GGGAAATACC AGTGACCACT CCAACAGTCC TGATGAGTTA 2640

GCGGATAAAC TTGAAGACCG CCTGGCGGAG AAGCTAGACG ACCTGCTGTC CCAGACGCCA 2700

GAGATCCCCA TTGAGATATC CTCGCATTCG GATGGGCTCT CTGACAAGGA GTGCGCTGTG 2760

CGCCGCGTGA AGACGCAGAT GTCTCTGGGC AAGCTGTGTG CAGAGGAACG TGGCTATGAG 2820

AATCCTATGC AGTTTGAAGA ATCGGACTGT GACTCTTCTG ACGGAGAGTG TTCTGATGCC 2880

ACAGTTAGGA CCAATAAACA CTACAGCTCT GCTACTTGGT AA 2922

Domain Profile

S: 3     leeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiell  62

         + +++gsga+g+v+ +k+r++eva+Kk+re++e+         ++k+l+kl+hpnii+++

Q: 175   ELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNET---------DIKHLRKLKHPNIIAFK  225

         6789**************************9999.........*****************

S: 63    GvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkki  122

         Gvc++ p+++++mey+++g+L++vl++   r+i+++ lv+w++ iA+Gm+YLh +   ki

Q: 226   GVCTQAPCYCIIMEYCAHGQLYEVLRA--GRKITPRLLVDWSTGIASGMNYLHLH---KI  280

         ***************************..99************************...9*

S: 123   ihrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseks  181

         ihrdLks+nvL+ ++++ +ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+

Q: 281   IHRDLKSPNVLV-THTDAVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKV  339

         ************.999***************99***************************

S: 182   DvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedp  241

         D+wS+gvvLWellt+e+Pykd+++ ai+++v++++l+lp+ps+cp+ +k Lmk++w+++p

Q: 340   DIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKP  399

         ************************************************************

S: 242   ekRpsfseivksl  254

         ++Rpsf++ +++l

Q: 400   RNRPSFRQTLMHL  412

         *******998775

Domain Sequence
(FASTA)

ELQWLGSGAQ GAVFLGKFRA EEVAIKKVRE QNETDIKHLR KLKHPNIIAF KGVCTQAPCY 60

CIIMEYCAHG QLYEVLRAGR KITPRLLVDW STGIASGMNY LHLHKIIHRD LKSPNVLVTH 120

TDAVKISDFG TSKELSDKST KMSFAGTVAW MAPEVIRNEP VSEKVDIWSF GVVLWELLTG 180

EIPYKDVDSS AIIWGVGSNS LHLPVPSTCP DGFKILMKQT WQSKPRNRPS FRQTLMHL 238

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008385	; C:IkappaB kinase complex
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0007254	; P:JNK cascade
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017419	; MAP3K12_MAP3K13.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013