EKS-AIM-00196

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00196

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	464.5	9.7E-140	13	297	285

Status

Unreviewed

Ensembl Protein

ENSAMEP00000017786

UniProt Accession

G1MEK8;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL5

Gene Synonyms/Alias

CDKL5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000016835	ENSAMEP00000017786	ENSAMET00000018510
ENSAMEG00000016835	ENSAMEP00000017779	ENSAMET00000018503

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

904

Protein Sequence
(FASTA)

MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKETHEIVA IKKFKDSEEN EEVKETTLRE 60

LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL EEMPNGVPPE KVKSYIYQLI 120

KAIHWCHKND IVHRDIKPEN LLISHNDVLK LCDFGFARNL SEGNNANYTE YVATRWYRSP 180

ELLLGAPYGK SVDMWSVGCI LGELSDGQPL FPGESEIDQL FTIQKVLGPL PSEQMKLFYS 240

NPRFHGLRFP AVNHPQTLER RYLGILNSVL LDLMKNLLKL DPADRYLTEQ CLNHPTFQTQ 300

RLLDRSPSRS AKRKPYHVES STLSNRNQAS KSAALQSHHR SNSKDIQNLG VGLPRADEGL 360

PANESFLNGN LAGATLSPMH TKTYQASSQP GPTSKDLTNN NIPHLLSPKE AKSKTEFDFN 420

IDPKPSEGPG TKYLKSSTRS QQNRHSFMES SQSKAGTLQP TEKQSRHSYI DTIPQSSRSP 480

SYRTKAKSHG ALSDSKSVSN LSEARAQITE SNTSRYFPSS CLDLNSPTSP TPTRHSDTRT 540

LLSPSGRNNR SEGTLDSRRT TTRHSKTMEE LKLPEHMDSS HSHSLSAPHE SFSYGLGYTS 600

PFSSQQRPHR HSMYVTRDKV RAKGLDGSLS VGQGMAARAN SLQLLSPQPG EQLPPEMTVA 660

RSSVKESSRE GTSSFHSRQK SEGGAYHDPH SDDGTAPKEN RHLYNDPVPR RVGSFYRVPS 720

PRPDNSFHEN NVSTRVSSLP SESSSGTNHS KRQPAFDPWK SPENISHSEQ LKEKEKQGFF 780

RSMKKKKKKS QTVPNSDGPD LLTLQKAIHS ASTPSSRPKE WRPEKISDLQ TQSQPLKSLR 840

KLLHLSSASN HPASSDPRFQ PLTTQQAKNS FSEIRIHPLS QASGGSSNIR QEPTPKGRPA 900

LQLP 904

Nucleotide Sequence
(FASTA)

ATGAAGATTC CTAACATTGG TAATGTGATG AATAAATTTG AGATCCTTGG GGTTGTAGGT 60

GAAGGAGCCT ATGGAGTTGT ACTTAAATGC AGACACAAGG AAACACATGA AATTGTGGCA 120

ATCAAGAAAT TCAAGGACAG TGAAGAAAAT GAAGAAGTCA AGGAAACGAC TTTACGAGAG 180

CTTAAAATGC TTCGTACTCT CAAGCAGGAA AACATCGTGG AGCTGAAGGA AGCCTTTCGT 240

CGGAGGGGGA AATTGTACTT GGTGTTTGAG TATGTTGAAA AAAATATGCT TGAATTGCTG 300

GAAGAAATGC CAAATGGAGT TCCACCTGAA AAAGTTAAAA GTTACATCTA TCAGTTAATC 360

AAAGCTATTC ACTGGTGCCA TAAGAATGAT ATTGTCCATA GAGATATAAA GCCAGAAAAT 420

CTCTTAATCA GCCACAATGA TGTTTTGAAA CTCTGTGATT TTGGTTTTGC TCGGAATTTA 480

TCAGAAGGCA ATAATGCTAA TTATACAGAA TATGTGGCCA CCAGGTGGTA TCGGTCCCCA 540

GAACTCTTAC TTGGAGCTCC TTATGGAAAG TCCGTTGATA TGTGGTCAGT GGGCTGTATT 600

CTTGGGGAGC TTAGCGATGG ACAGCCTTTA TTTCCTGGAG AAAGCGAGAT TGACCAACTT 660

TTTACTATTC AGAAGGTGCT AGGACCACTT CCATCTGAAC AGATGAAGCT CTTCTACAGT 720

AATCCTCGAT TCCATGGGCT CCGGTTTCCA GCTGTTAACC ATCCTCAGAC ATTGGAGAGA 780

AGATACCTTG GAATTCTAAA TAGCGTCTTA CTTGACTTAA TGAAGAATTT ACTGAAGCTG 840

GACCCAGCTG ACAGATACTT GACAGAACAG TGTTTGAATC ACCCTACATT TCAAACCCAG 900

AGACTTTTGG ATCGCTCCCC TTCAAGGTCA GCAAAAAGAA AACCTTACCA CGTGGAAAGC 960

AGCACTTTGT CTAATAGAAA CCAAGCCAGC AAAAGTGCTG CTTTGCAGTC TCACCACAGA 1020

TCCAACAGCA AGGACATCCA GAACCTAGGT GTGGGTCTGC CCCGGGCTGA CGAAGGTCTT 1080

CCTGCCAATG AAAGCTTCCT AAACGGAAAT CTTGCTGGAG CTACTCTTAG TCCCATGCAC 1140

ACCAAAACCT ACCAAGCAAG CAGCCAACCT GGACCTACCA GCAAAGATCT TACCAACAAT 1200

AACATACCAC ATCTTCTCAG CCCAAAAGAA GCCAAGTCAA AGACAGAGTT TGATTTTAAT 1260

ATTGACCCTA AGCCTTCAGA AGGCCCGGGC ACAAAGTACC TCAAGTCAAG CACCAGATCT 1320

CAGCAGAACC GGCACTCATT TATGGAAAGC TCTCAGAGCA AAGCCGGGAC ACTGCAGCCC 1380

ACTGAAAAGC AGAGTCGGCA TAGCTACATT GACACTATTC CCCAGTCCTC TAGGAGTCCC 1440

TCCTATAGGA CCAAGGCCAA AAGCCATGGG GCGTTGAGTG ACTCCAAGTC TGTGAGCAAC 1500

CTTTCTGAAG CCAGGGCCCA AATTACAGAG TCCAATACCA GTAGGTACTT CCCATCCAGC 1560

TGCTTGGACT TGAACTCTCC CACCAGCCCA ACCCCCACCA GGCACAGTGA CACGAGAACT 1620

TTGCTCAGCC CCTCGGGGAG AAATAATCGA AGCGAGGGCA CTCTTGACTC ACGCCGAACC 1680

ACAACCAGGC ATTCTAAAAC GATGGAGGAG TTGAAGCTGC CCGAGCACAT GGACAGCAGC 1740

CATTCCCATT CTCTGTCTGC ACCTCATGAA TCCTTTTCTT ATGGGCTGGG CTATACTAGC 1800

CCCTTCTCTT CCCAGCAGCG TCCGCATAGG CATTCCATGT ACGTGACCCG GGACAAAGTG 1860

AGAGCCAAAG GCTTGGATGG AAGCTTGAGC GTAGGGCAAG GAATGGCGGC CAGGGCCAAC 1920

AGCCTGCAGC TCTTGTCACC TCAGCCTGGA GAACAGCTCC CTCCAGAGAT GACTGTGGCT 1980

CGATCTTCCG TTAAAGAATC TTCCAGAGAA GGCACCTCTT CATTCCACTC AAGGCAGAAG 2040

TCTGAGGGTG GAGCATATCA TGACCCCCAC TCTGATGATG GCACTGCCCC CAAAGAAAAT 2100

AGACACCTGT ACAATGACCC TGTTCCGAGG AGAGTTGGCA GTTTCTACCG AGTGCCATCT 2160

CCTCGTCCAG ACAATTCTTT CCATGAAAAT AATGTATCAA CCAGAGTTTC TTCCCTACCA 2220

TCAGAGAGCA GTTCTGGAAC CAACCACTCA AAAAGACAGC CAGCATTCGA TCCATGGAAA 2280

AGTCCTGAAA ACATTAGTCA TTCCGAACAA CTCAAGGAAA AGGAGAAACA AGGTTTTTTC 2340

AGGTCAATGA AAAAGAAAAA GAAGAAATCT CAAACAGTGC CTAATTCTGA CGGCCCTGAT 2400

CTACTGACAT TACAGAAAGC CATTCACTCT GCTAGCACCC CGAGCAGCAG ACCAAAGGAA 2460

TGGCGTCCTG AGAAGATCTC TGATCTACAG ACCCAAAGCC AGCCGTTAAA ATCACTGCGC 2520

AAGCTGTTAC ATCTTTCTTC AGCCTCAAAT CACCCGGCTT CCTCAGACCC CCGCTTCCAG 2580

CCCTTAACAA CTCAACAAGC CAAAAATTCC TTCTCAGAAA TTCGGATCCA TCCTCTGAGC 2640

CAGGCCTCTG GCGGGAGCAG TAACATCCGG CAGGAGCCCA CACCAAAGGG CAGACCAGCC 2700

CTCCAGCTGC CA 2712

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         +e lg+vGeG+yGvvlkcr+k+t++ivaikkf++se+++evk+++lre+k+l++lk+en+

Q: 13    FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI  72

         799*********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         v+l+e+frr+ klylvfeyv+k++l+ le++pnGv+ e+vk+++yq++kai++chkn+i+

Q: 73    VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIV  132

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarlla.apgdvytdyvatrwyrapellvgdtkyGks  179

         hrdikpen+lis+++v+klcdfGfar+l+ +++++yt+yvatrwyr+pell+g + yGks

Q: 133   HRDIKPENLLISHNDVLKLCDFGFARNLSeGNNANYTEYVATRWYRSPELLLG-APYGKS  191

         ****************************98999********************.9*****

S: 180   vdvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpe  239

         vd+w++Gc+l el++G+plfpg+s++dql++i+k+lG+l ++++k+f++n++f+G+++p+

Q: 192   VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPA  251

         ************************************************************

S: 240   vedleslekkyp.klnevlldllkkclkldpaerlsceellkheyf  284

         v+++++le++y   ln+vlldl+k++lkldpa+r+++e++l+h++f

Q: 252   VNHPQTLERRYLgILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF  297

         ***********9899****************************998

Domain Sequence
(FASTA)

FEILGVVGEG AYGVVLKCRH KETHEIVAIK KFKDSEENEE VKETTLRELK MLRTLKQENI 60

VELKEAFRRR GKLYLVFEYV EKNMLELLEE MPNGVPPEKV KSYIYQLIKA IHWCHKNDIV 120

HRDIKPENLL ISHNDVLKLC DFGFARNLSE GNNANYTEYV ATRWYRSPEL LLGAPYGKSV 180

DMWSVGCILG ELSDGQPLFP GESEIDQLFT IQKVLGPLPS EQMKLFYSNP RFHGLRFPAV 240

NHPQTLERRY LGILNSVLLD LMKNLLKLDP ADRYLTEQCL NHPTF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013