EPS-AIM-00124

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-AIM-00124

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PPP_Unique	432.2	9.1E-130	37	336	300

Status

Unreviewed

Ensembl Protein

ENSAMEP00000017848

UniProt Accession

G1MER9;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP3CB

Gene Synonyms/Alias

PPP3CB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000016865	ENSAMEP00000017848	ENSAMET00000018573

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

522

Protein Sequence
(FASTA)

PRSLESAPPP PPQSAVHAGL SPKIAAVPFP PTHRLTSEEV FDMDGIPRVD VLKNHLVKEG 60

RVDEEIALRI INEGAAILRR EKTMIEVEAP ITVCGDIHGQ FFDLMKLFEV GGSPANTRYL 120

FLGDYVDRGY FSIECVLYLW VLKILYPSTL FLLRGNHECR HLTEYFTFKQ ECKIKYSERV 180

YEACMEAFDS LPLAALLNQQ FLCVHGGLSP EIHTLDDIRR LDRFKEPPAF GPMCDLLWSD 240

PSEDFGNEKS QEHFSHNTVR GCSYFYNYPA VCEFLQNNNL LSIIRAHEAQ DAGYRMYRKS 300

QTTGFPSLIT IFSAPNYLDV YNNKAAVLKY ENNVMNIRQF NCSPHPYWLP NFMDVFTWSL 360

PFVGEKVTEM LVNVLSICSD DELMTEGEDQ FDVGSAAARK EIIRNKIRAI GKMARVFSVL 420

REESESVLTL KGLTPTGMLP SGVLAGGRQT LQSATVEAIE AEKAIRGFSP PHRICSFEEA 480

KGLDRINERM PPRKDAVQQD GFNSLNTAHA TENHGTGNHS AQ 522

Nucleotide Sequence
(FASTA)

CCCAGGTCCC TAGAGTCTGC CCCGCCCCCG CCCCCGCAAA GCGCGGTGCA TGCCGGTCTT 60

AGCCCAAAAA TTGCAGCTGT ACCTTTCCCC CCGACACATC GCTTGACATC TGAAGAAGTA 120

TTTGATATGG ATGGGATACC CAGGGTTGAT GTTCTGAAGA ACCACTTAGT AAAAGAAGGT 180

CGGGTAGATG AAGAAATTGC ACTTAGAATT ATCAATGAGG GTGCTGCCAT CCTTCGGAGA 240

GAGAAAACCA TGATAGAAGT AGAGGCTCCA ATTACAGTGT GTGGTGACAT CCATGGCCAA 300

TTTTTTGATC TGATGAAACT TTTTGAAGTA GGAGGATCAC CTGCTAATAC ACGATACCTT 360

TTTCTTGGTG ATTATGTGGA CAGAGGTTAT TTTAGTATAG AGTGTGTCTT ATATTTATGG 420

GTCCTGAAGA TTCTGTACCC AAGCACATTA TTTCTTCTGA GAGGCAATCA TGAATGCAGA 480

CACCTTACTG AATATTTTAC CTTTAAGCAG GAATGTAAAA TTAAATACTC AGAAAGAGTC 540

TATGAAGCTT GTATGGAAGC TTTTGATAGT CTGCCTCTTG CTGCACTTTT AAATCAACAA 600

TTTCTTTGTG TTCATGGTGG ACTTTCACCA GAAATACACA CACTGGATGA TATTAGGAGA 660

TTAGATAGAT TCAAAGAGCC ACCTGCATTT GGACCAATGT GTGACTTGCT ATGGTCCGAT 720

CCTTCTGAAG ATTTTGGAAA TGAAAAATCA CAGGAACATT TTAGTCACAA TACAGTTCGA 780

GGATGTTCTT ATTTTTATAA CTATCCAGCA GTGTGTGAAT TTTTGCAAAA CAATAATTTG 840

TTATCGATTA TTAGAGCTCA TGAAGCTCAA GATGCAGGCT ATAGAATGTA CAGAAAAAGT 900

CAAACTACAG GGTTCCCTTC ATTAATAACA ATTTTTTCGG CACCTAATTA CTTAGATGTC 960

TACAATAATA AAGCTGCTGT ATTAAAGTAT GAAAATAATG TGATGAATAT TCGACAGTTT 1020

AACTGTTCTC CACATCCTTA CTGGTTGCCC AATTTTATGG ATGTCTTCAC ATGGTCTTTA 1080

CCATTTGTTG GAGAAAAAGT GACAGAAATG TTGGTAAATG TTCTGAGTAT TTGCTCTGAT 1140

GATGAACTGA TGACTGAAGG TGAAGACCAG TTTGATGTAG GTTCAGCTGC AGCCCGGAAA 1200

GAAATCATAA GAAACAAAAT TCGAGCAATT GGCAAGATGG CACGGGTCTT CTCTGTTCTC 1260

AGGGAGGAGA GTGAAAGCGT GCTGACACTC AAGGGCCTGA CTCCCACAGG GATGTTGCCT 1320

AGTGGAGTGT TGGCTGGAGG ACGGCAGACC CTGCAAAGTG CCACAGTTGA GGCTATTGAG 1380

GCTGAAAAAG CAATACGAGG ATTCTCTCCA CCACATAGAA TCTGCAGTTT TGAAGAGGCA 1440

AAGGGTTTGG ATAGGATCAA TGAGAGAATG CCACCCCGGA AAGATGCTGT ACAGCAAGAT 1500

GGTTTCAATT CTCTGAACAC CGCACATGCC ACTGAGAACC ACGGGACTGG CAACCATAGT 1560

GCCCAG 1566

Domain Profile

S: 2     kkevfdidlllevfkekkhlkleaklveevllevkkvlkkllnlekvslevskpvtvcGD  61

         ++evfd+d++++v++ k+hl++e++++ee++l+++++++++l++ek+++ev++p+tvcGD

Q: 37    SEEVFDMDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGD  96

         789*********************************************************

S: 62    iHGqfedllklfevgGlpsetkylflGDyvDRGkfsievlllLlalklkypeklfllrGN  121

         iHGqf+dl+klfevgG+p++t+ylflGDyvDRG+fsie++l+L++lk+ yp++lfllrGN

Q: 97    IHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGN  156

         ************************************************************

S: 122   HEsrslnevygFkdEvkrkykarvyealtevfdlLplaallnekilcvHGGlspelktld  181

         HE+r+l+e+++Fk+E+k+ky++rvyea++e+fd Lplaalln+++lcvHGGlspe++tld

Q: 157   HECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLD  216

         ************************************************************

S: 182   dirkieRnkevPdegplcDlLWsDP......dksqeglvent.RGvsvlfgkdvvkkfle  234

         dir+++R+ke+P+ gp+cDlLWsDP      +ksqe++++nt RG+s+++++ +v++fl+

Q: 217   DIRRLDRFKEPPAFGPMCDLLWSDPsedfgnEKSQEHFSHNTvRGCSYFYNYPAVCEFLQ  276

         ************************************************************

S: 235   knnlkliiRaHevkdegyellrdskv......vtifsasnyyeegsnkgayiklasstlp  288

         +nnl +iiRaHe++d+gy+++r+s++      +tifsa+ny +  +nk+a +k +++ ++

Q: 277   NNNLLSIIRAHEAQDAGYRMYRKSQTtgfpslITIFSAPNYLDVYNNKAAVLKYENNVMN  336

         ************************97333333689******************9998775

Domain Sequence
(FASTA)

SEEVFDMDGI PRVDVLKNHL VKEGRVDEEI ALRIINEGAA ILRREKTMIE VEAPITVCGD 60

IHGQFFDLMK LFEVGGSPAN TRYLFLGDYV DRGYFSIECV LYLWVLKILY PSTLFLLRGN 120

HECRHLTEYF TFKQECKIKY SERVYEACME AFDSLPLAAL LNQQFLCVHG GLSPEIHTLD 180

DIRRLDRFKE PPAFGPMCDL LWSDPSEDFG NEKSQEHFSH NTVRGCSYFY NYPAVCEFLQ 240

NNNLLSIIRA HEAQDAGYRM YRKSQTTGFP SLITIFSAPN YLDVYNNKAA VLKYENNVMN 300

Keyword

Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005955	; C:calcineurin complex
GO:0005886	; C:plasma membrane
GO:0005509	; F:calcium ion binding
GO:0005516	; F:calmodulin binding
GO:0033192	; F:calmodulin-dependent protein phosphatase activity
GO:0008144	; F:drug binding
GO:0030346	; F:protein phosphatase 2B binding
GO:0017156	; P:calcium ion-dependent exocytosis
GO:0035690	; P:cellular response to drug
GO:0007507	; P:heart development
GO:0001915	; P:negative regulation of T cell mediated cytotoxicity
GO:0035774	; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0006470	; P:protein dephosphorylation
GO:0006468	; P:protein phosphorylation
GO:0010468	; P:regulation of gene expression
GO:0034097	; P:response to cytokine stimulus
GO:0035176	; P:social behavior
GO:0030217	; P:T cell differentiation
GO:0043029	; P:T cell homeostasis

KEGG

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125

; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013