EKS-AIM-00305

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00305

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	316.8	1.2E-94	410	657	248

Status

Unreviewed

Ensembl Protein

ENSAMEP00000018164

UniProt Accession

D2GWB1;

Protein Name

Protein Synonyms/Alias

Putative uncharacterized protein;

Gene Name

PAK6

Gene Synonyms/Alias

PANDA_001080;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000017191	ENSAMEP00000018164	ENSAMET00000018903

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

680

Protein Sequence
(FASTA)

MFRKKKKKRP EISAPQNFQH RVHTSFDPKE GKFVGLPPQW QNILDTLRRP KPVVDPSRIT 60

RVQLQPMKTV VRGSSVPVDG YISGLLNDIQ KLSVISSNTL RGRSPTSRRR AQSLGLLGDE 120

HWAADPDMYL QSPQSERTDP HGLYLSCNGA TPAGRRQVPW PEPQSPRVLP NGLAAKAQSL 180

GPTEFQGTTQ RCLQLGACLQ SSPPGASPPA ATSRRGTKAA RHGSEEARPQ SCLVGLATGR 240

PGGEGSPSPK TQESSLKRRL FRSMFLSTPA TAPASSSKPG PPSQSKPNSS FRPPQKDPPP 300

SLVAKAQSLP SDQPMGTFSP LATSDTSSPQ KSLRTAPAAG PPPGRSSPAG SPRTRQAQIS 360

TSNLYLPQDP AVAKGALAGE DTGVVTHEQF KAALRMVVDQ GDPRMLLDSY VKIGEGSTGI 420

VCLAREKHSG RQVAVKMMDL RKQQRRELLF KVVIMRDYQH LNVVEMYKSF LVGEELWVLM 480

EFLQGGALTD IVSQVRLNEE QIATVCEAVL QALAYLHAQG VIHRDIKSDS ILLTLDGRVK 540

LSDFGFCAQI SKDVPKRKSL VGTPYWMAPE VISRSLYGTE VDIWSLGIMV IEMVDGEPPY 600

FSDSPVQAMK RLRDSPPPRL KNSHKVSPVL RDFLERMLVR DPQERATAQE LLDHPFLLQT 660

GLPECLAPLI QLYHKQTSTC 680

Nucleotide Sequence
(FASTA)

ATGTTCCGAA AGAAAAAGAA GAAACGCCCT GAGATCTCAG CCCCACAGAA CTTCCAGCAC 60

CGCGTCCACA CCTCCTTTGA CCCCAAAGAA GGCAAGTTTG TGGGCCTCCC ACCACAATGG 120

CAGAACATCC TGGACACACT GCGGAGACCC AAGCCCGTGG TGGACCCTTC TCGCATTACT 180

CGGGTGCAGC TCCAGCCCAT GAAGACCGTG GTGCGGGGCA GCTCGGTGCC CGTGGATGGC 240

TACATCTCAG GGCTGCTCAA TGACATCCAG AAGTTGTCGG TCATCAGCTC CAACACCCTT 300

CGTGGCCGCA GCCCCACCAG CCGGCGGCGG GCACAGTCCC TGGGGCTCCT GGGGGATGAG 360

CACTGGGCCG CGGACCCAGA CATGTACCTG CAGAGCCCCC AGTCTGAGCG CACTGACCCC 420

CACGGCCTCT ACCTCAGCTG CAATGGGGCC ACACCAGCAG GCCGCAGGCA GGTGCCATGG 480

CCAGAGCCAC AGAGCCCAAG GGTCCTCCCC AATGGGCTGG CCGCCAAGGC ACAGTCACTA 540

GGCCCCACGG AGTTCCAGGG CACCACGCAG CGCTGCCTGC AGCTGGGTGC CTGCCTGCAG 600

AGCTCCCCAC CCGGCGCCTC ACCCCCCGCA GCCACCAGTA GGCGCGGGAC CAAGGCTGCC 660

AGGCACGGTT CCGAGGAGGC CCGGCCGCAG TCCTGCCTGG TGGGCTTGGC GACAGGCAGG 720

CCGGGCGGGG AGGGCAGCCC CAGCCCTAAG ACCCAGGAAA GCAGCCTTAA GCGCAGGCTC 780

TTCCGAAGCA TGTTCCTGTC TACTCCTGCC ACGGCCCCTG CAAGCAGCAG CAAGCCGGGC 840

CCTCCCTCCC AGAGCAAGCC TAATTCCTCT TTCCGGCCAC CACAGAAAGA CCCCCCACCA 900

AGCCTGGTGG CCAAGGCCCA GTCCTTGCCC TCGGACCAGC CCATGGGGAC CTTCAGCCCT 960

CTGGCCACCT CAGATACCAG CAGCCCCCAG AAGTCCCTCC GCACGGCCCC CGCTGCCGGC 1020

CCACCCCCAG GCCGGTCTTC CCCTGCGGGC TCCCCACGCA CTAGGCAAGC CCAGATCAGC 1080

ACCAGCAACC TGTACCTGCC CCAGGACCCC GCGGTGGCCA AGGGTGCCCT GGCTGGCGAA 1140

GACACAGGTG TTGTGACACA TGAGCAGTTC AAGGCTGCAC TCAGGATGGT GGTGGACCAG 1200

GGTGACCCCC GGATGCTGCT GGACAGCTAC GTGAAGATCG GCGAGGGCTC CACGGGCATC 1260

GTCTGCCTGG CCCGGGAGAA GCACTCAGGC CGCCAGGTGG CCGTCAAGAT GATGGACCTC 1320

AGGAAGCAGC AGCGCAGGGA GCTGCTCTTT AAGGTGGTGA TCATGCGAGA CTACCAGCAC 1380

CTCAACGTGG TGGAGATGTA TAAGAGCTTC CTGGTGGGCG AGGAGCTGTG GGTGCTTATG 1440

GAGTTCCTGC AGGGCGGGGC GCTCACGGAC ATTGTCTCCC AAGTCAGGCT GAACGAGGAG 1500

CAGATCGCCA CTGTGTGCGA GGCCGTACTG CAGGCCCTGG CTTACCTGCA CGCCCAGGGT 1560

GTCATCCACC GGGACATCAA GAGTGACTCC ATCCTCCTGA CTCTCGATGG CAGGGTGAAA 1620

CTCTCGGACT TTGGATTCTG TGCTCAGATC AGCAAAGACG TCCCTAAGAG GAAGTCCCTG 1680

GTAGGAACCC CCTACTGGAT GGCTCCTGAA GTGATCTCCA GGTCTCTGTA TGGGACTGAG 1740

GTGGATATCT GGTCCCTGGG CATCATGGTG ATTGAGATGG TGGACGGGGA GCCACCCTAC 1800

TTCAGTGACT CCCCGGTGCA GGCCATGAAG AGGCTCCGGG ACAGCCCCCC ACCCAGGCTG 1860

AAAAACTCTC ACAAGGTCTC CCCAGTGCTT CGAGACTTCC TGGAACGGAT GCTGGTGCGG 1920

GACCCCCAGG AGAGAGCCAC GGCTCAGGAG CTCCTGGACC ACCCTTTCCT GCTGCAGACG 1980

GGGCTGCCCG AGTGCCTGGC GCCCCTGATC CAGCTCTACC ACAAGCAGAC CTCCACCTGC 2040

TGA 2043

Domain Profile

S: 4     leeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyle  63

         + +ig+G++g v+larek++g++va+k+++l+kq++ e+l+k + ++++++h n+ve+++

Q: 410   YVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFK-VVIMRDYQHLNVVEMYK  468

         679******************************888877776.789**************

S: 64    sflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrd  123

         sfl+ eelw++me+l+gG+l+d+v+   + +l+Eeqia++++ vl+aL+ylH+++viHrd

Q: 469   SFLVGEELWVLMEFLQGGALTDIVS---QVRLNEEQIATVCEAVLQALAYLHAQGVIHRD  525

         *************************...99******************************

S: 124   ikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDi  183

         ik+++iLlt +g+VkLsdfg++aq++k++ krk++vgtpywmAPEvi+  ++ Y +++Di

Q: 526   IKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVIS--RSLYGTEVDI  583

         ************************************************..9*********

S: 184   wslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpe  243

         wslGI++ie+++gepP+++ +p++a+ +  +++pp+lk+++k+s+ +++f+e++l ++p+

Q: 584   WSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPRLKNSHKVSPVLRDFLERMLVRDPQ  643

         ************************************************************

S: 244   kRpsasellkhkFl  257

         +R++a+ell+h+Fl

Q: 644   ERATAQELLDHPFL  657

         *************7

Domain Sequence
(FASTA)

YVKIGEGSTG IVCLAREKHS GRQVAVKMMD LRKQQRRELL FKVVIMRDYQ HLNVVEMYKS 60

FLVGEELWVL MEFLQGGALT DIVSQVRLNE EQIATVCEAV LQALAYLHAQ GVIHRDIKSD 120

SILLTLDGRV KLSDFGFCAQ ISKDVPKRKS LVGTPYWMAP EVISRSLYGT EVDIWSLGIM 180

VIEMVDGEPP YFSDSPVQAM KRLRDSPPPR LKNSHKVSPV LRDFLERMLV RDPQERATAQ 240

ELLDHPFL 248

Keyword

ATP-binding; Kinase; Nucleotide-binding; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013