EKS-AIM-00274

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00274

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	313.9	7.3E-94	767	1030	264

Status

Unreviewed

Ensembl Protein

ENSAMEP00000018192

UniProt Accession

G1MFR2;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1B

Gene Synonyms/Alias

BUB1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000017203	ENSAMEP00000018188	ENSAMET00000018927
ENSAMEG00000017203	ENSAMEP00000018192	ENSAMET00000018931

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

1064

Protein Sequence
(FASTA)

MAAMKKEGGA LSEAMSLEGD EWELSKENVQ PLRQGRIMST LQGALAQQES ASNATLQQQK 60

RAFESEIRFY TGNDPLDVWD RWVFLFNKGT GNLTGYINWT EQNYPQGGKE SNMSTLLERA 120

VEALQGEKRY YNDPRFLSLW LKLGHLCNEP LDMYSYLHSQ GIGVSLAQFY ISWAEEYEAR 180

ENFKKADKIF QEGIQQKAEP LDRLQSQHRQ FQARVSRQTV LALEKEEEEE VFGSSEPQRS 240

TLAELKSKGK KTARAPISRV GGALKAPNQN RGLQNPVPQQ MQSNSRITVF DENADEASRA 300

ELSKPTVQPW IAPPVSRAKE NELQAGPWNT GRPLEYRPRG GIASVTTVPS LLPSFTPYVE 360

ETAQQPVMTP CKIEPSINHI LSTRKPGKEE GDPLQRVQSH QQESQEKKEK MMYCKEKIYA 420

GVGEFSFEEI RAEVFRKKLK EQREAELLTS AEKRAEMQKQ IEEMEKKLKE IQTTQRERTG 480

DQQEEKMTTK ETAELQIALE SQEIPGMALS NSVCPVNSCA RETSLAENIW QEPHSKGPSI 540

PFSIFDEFLL SEKKNTSRPA DPPRVLSQRR PFAILKTSES INSNEDVSPD VCDEFTGIEP 600

LSEDAIITGF RNVTICPNPE DTCDFARAAR FVSTPFHEIV SLKDLPSDPE RLLQEEDLDM 660

KLSEDQQTAC GTIYNPTLSI KKLSPIIEDS REATHSSGFS GSSASVTSSS SIKCLQIPEK 720

LELTNETADN PTQSPWCPQY RRQLLKSLME LRASAEFFIE DRPMPKLEIE KEIELGNEDY 780

CIKQEYLICE DYKLFWVTPG NSAELTIIKV SSQPVPWDFY INLKLKERLN EEYDHLCSCY 840

QYQDGCIVWH QYINCFTLQD LLQHSELITH EIIVLVIYNL LTIVEKLHRA EIVHGDLSPR 900

SLILRNRIHD PYDYNKNDQA LKIVDFSYSV DLRVQPDVFI LSGFRTVQIL EGQKILANCS 960

SPYQVDLFGI ADLAHLLLFK EHLQVFWDGS LWKLSQNISE LKDGELWNKF FVRILNASDE 1020

STVSVLRELG AAMSGVFDTT FQNHLNKALW KVGQLISPGA LLFQ 1064

Nucleotide Sequence
(FASTA)

ATGGCGGCGA TGAAGAAGGA AGGGGGTGCT CTGAGTGAAG CCATGTCCTT GGAGGGAGAT 60

GAGTGGGAGC TGAGTAAAGA AAATGTCCAA CCACTAAGGC AGGGGAGGAT CATGTCCACA 120

CTTCAGGGAG CATTGGCTCA GCAAGAATCT GCCTCTAACG CTACTCTTCA GCAACAGAAA 180

CGGGCATTTG AATCTGAAAT TCGATTTTAC ACTGGAAATG ACCCTCTGGA TGTTTGGGAT 240

AGGTGGGTCT TTTTATTTAA CAAGGGCACT GGAAACTTAA CAGGGTATAT TAACTGGACA 300

GAGCAGAACT ATCCTCAGGG GGGGAAAGAG AGTAATATGT CGACATTATT AGAAAGAGCT 360

GTTGAAGCAC TACAAGGAGA AAAACGATAC TATAATGATC CCCGATTTCT TAGTCTCTGG 420

CTTAAATTGG GGCATTTATG CAATGAACCT TTGGATATGT ACAGTTATTT ACACAGCCAA 480

GGGATCGGTG TTTCACTTGC TCAATTCTAT ATCTCATGGG CTGAAGAATA TGAAGCTAGA 540

GAAAACTTTA AGAAAGCAGA TAAGATATTT CAGGAGGGGA TTCAACAGAA GGCCGAACCA 600

CTGGACCGAC TGCAGTCACA GCACCGACAA TTCCAAGCTC GGGTGTCTCG GCAAACTGTG 660

TTGGCACTTG AGAAAGAAGA GGAGGAGGAA GTTTTTGGAT CTTCTGAACC ACAACGAAGC 720

ACACTGGCTG AACTAAAAAG CAAAGGGAAG AAGACAGCAA GAGCTCCAAT CAGCCGTGTA 780

GGAGGTGCTC TTAAGGCTCC AAACCAGAAC AGAGGACTCC AAAATCCAGT TCCTCAACAG 840

ATGCAAAGTA ATTCCAGAAT TACTGTTTTT GATGAAAATG CTGATGAGGC TTCTAGAGCA 900

GAGTTGTCTA AGCCTACAGT TCAGCCATGG ATAGCACCCC CTGTGTCCAG GGCCAAAGAG 960

AACGAGCTGC AGGCAGGCCC TTGGAACACA GGCAGGCCTT TGGAATACAG GCCTCGTGGT 1020

GGTATAGCTT CTGTGACCAC TGTACCCTCT CTGCTTCCCA GTTTTACTCC ATATGTTGAA 1080

GAAACTGCAC AACAGCCAGT TATGACACCA TGTAAAATTG AACCTAGTAT AAACCACATT 1140

CTAAGCACAA GAAAGCCTGG AAAGGAAGAA GGAGATCCCC TGCAAAGAGT TCAAAGCCAT 1200

CAGCAAGAGT CCCAGGAGAA GAAAGAGAAG ATGATGTATT GTAAGGAGAA GATTTATGCA 1260

GGGGTTGGGG AGTTCTCCTT TGAAGAGATC CGGGCTGAAG TTTTCCGGAA GAAATTAAAA 1320

GAGCAAAGAG AAGCTGAGCT ACTGACCAGT GCAGAGAAAA GAGCAGAAAT GCAGAAACAG 1380

ATTGAAGAGA TGGAGAAGAA GCTCAAAGAA ATTCAAACTA CTCAGCGAGA AAGAACGGGT 1440

GATCAGCAAG AAGAGAAGAT GACTACAAAG GAGACAGCTG AACTGCAAAT TGCTTTGGAG 1500

TCTCAGGAAA TACCAGGAAT GGCTCTATCC AATTCTGTTT GTCCAGTAAA CTCTTGTGCC 1560

AGGGAGACTT CACTTGCAGA AAACATTTGG CAAGAACCTC ATTCTAAAGG TCCCAGTATA 1620

CCTTTCTCCA TTTTTGATGA GTTTCTTCTT TCAGAAAAAA AAAATACCAG TCGTCCTGCC 1680

GATCCCCCAC GGGTTTTATC CCAACGAAGA CCCTTTGCAA TTCTCAAAAC TTCAGAAAGC 1740

ATCAACTCAA ATGAGGATGT GTCTCCAGAT GTTTGTGATG AATTTACAGG AATTGAGCCC 1800

TTGAGTGAGG ATGCTATTAT CACAGGTTTC AGGAATGTAA CTATCTGTCC TAACCCAGAA 1860

GACACTTGTG ACTTCGCCAG AGCAGCTCGC TTTGTATCCA CGCCTTTTCA TGAGATAGTG 1920

TCCTTGAAGG ATCTCCCTTC TGATCCTGAG AGGCTGCTGC AGGAGGAGGA TCTAGACATG 1980

AAGCTCTCTG AGGACCAGCA GACTGCTTGT GGCACCATCT ACAACCCGAC TCTCAGCATC 2040

AAGAAGCTCA GCCCAATTAT CGAAGACAGC CGTGAAGCCA CACACTCCTC TGGGTTCTCT 2100

GGGTCTTCTG CCTCAGTTAC AAGTTCCTCC TCCATCAAAT GTCTTCAGAT TCCTGAGAAA 2160

CTGGAGCTTA CTAATGAGAC TGCAGACAAC CCTACTCAGT CACCCTGGTG TCCACAGTAT 2220

CGCAGACAAC TACTAAAATC TCTGATGGAG CTGAGGGCCT CTGCAGAGTT TTTTATAGAA 2280

GATAGACCGA TGCCTAAGTT GGAAATAGAA AAGGAGATTG AACTGGGTAA TGAGGATTAT 2340

TGCATAAAAC AAGAATACCT AATATGTGAA GATTACAAGT TATTCTGGGT GACACCAGGA 2400

AACTCTGCAG AATTAACCAT AATAAAGGTA TCGTCTCAAC CTGTCCCATG GGACTTTTAT 2460

ATCAACCTCA AGTTAAAGGA ACGTTTAAAT GAGGAGTATG ACCATTTGTG CAGCTGTTAC 2520

CAGTACCAAG ACGGTTGTAT TGTTTGGCAC CAATATATAA ACTGCTTCAC CCTTCAGGAT 2580

CTTCTTCAAC ACAGTGAACT TATTACCCAT GAAATAATAG TGTTGGTTAT TTATAACCTT 2640

TTGACAATAG TGGAGAAATT ACACAGAGCA GAAATAGTCC ATGGTGACTT GAGTCCAAGG 2700

AGTCTGATTC TTAGAAACAG AATCCACGAT CCCTATGATT ATAATAAGAA CGATCAAGCT 2760

TTGAAGATAG TGGACTTTTC CTACAGTGTC GACCTTAGGG TGCAGCCTGA TGTTTTTATC 2820

CTCAGCGGCT TTCGGACTGT ACAAATCCTG GAAGGACAAA AGATCCTGGC TAACTGTTCT 2880

TCTCCCTACC AGGTAGATCT GTTTGGTATA GCAGATTTAG CACATTTACT GTTGTTCAAG 2940

GAACACCTAC AGGTCTTCTG GGATGGGTCC CTCTGGAAAC TTAGCCAAAA TATTTCTGAG 3000

CTAAAAGATG GTGAACTGTG GAATAAATTC TTTGTACGGA TTCTGAATGC CAGTGATGAG 3060

TCCACAGTGT CTGTTTTGAG GGAACTTGGA GCAGCAATGA GTGGGGTGTT TGACACCACC 3120

TTTCAAAATC ACCTGAACAA AGCTTTGTGG AAGGTAGGGC AGTTAATCAG TCCTGGGGCT 3180

TTGCTCTTTC AA 3192

Domain Profile

S: 1     leiekeigeGayakvykaeh....dsk........sgelvalKvekpansWefYIclqlk  48

         leiekei+ G++++++k+e+    d+k        s+el+++Kv++++++W+fYI+l+lk

Q: 767   LEIEKEIELGNEDYCIKQEYliceDYKlfwvtpgnSAELTIIKVSSQPVPWDFYINLKLK  826

         68******************999988899999999*************************

S: 49    eRlkeeellksiieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvll  108

         eRl+ee     +++++s++++qd+++++++y++++tl+dl+++++ +t     +e++vl+

Q: 827   ERLNEE-----YDHLCSCYQYQDGCIVWHQYINCFTLQDLLQHSELIT-----HEIIVLV  876

         ****99.....*************************************.....*******

S: 109   ivqllkiveklHeveIiHgDlkPdnfllgnrimdkadkdkeekglkliDfgrsiDmkllp  168

         i++ll+iveklH++eI+HgDl+P++++l+nri+d++d +k++++lk++Df++s+D++++p

Q: 877   IYNLLTIVEKLHRAEIVHGDLSPRSLILRNRIHDPYDYNKNDQALKIVDFSYSVDLRVQP  936

         ************************************************************

S: 169   dgtkfkgkaktdafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkq  228

         d++ ++g+++++++e++++la++s++YqvDlfg+a+++h+llf+++l+v+++g+ wkl+q

Q: 937   DVFILSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSLWKLSQ  996

         ************************************************************

S: 229   kikrllkkelwekiferlLNisdastlpsleelv  262

         +i++l++ elw+k+f+r+LN+sd+st+++l el

Q: 997   NISELKDGELWNKFFVRILNASDESTVSVLRELG  1030

         ******************************9985

Domain Sequence
(FASTA)

LEIEKEIELG NEDYCIKQEY LICEDYKLFW VTPGNSAELT IIKVSSQPVP WDFYINLKLK 60

ERLNEEYDHL CSCYQYQDGC IVWHQYINCF TLQDLLQHSE LITHEIIVLV IYNLLTIVEK 120

LHRAEIVHGD LSPRSLILRN RIHDPYDYNK NDQALKIVDF SYSVDLRVQP DVFILSGFRT 180

VQILEGQKIL ANCSSPYQVD LFGIADLAHL LLFKEHLQVF WDGSLWKLSQ NISELKDGEL 240

WNKFFVRILN ASDESTVSVL RELG 264

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0000940	; C:condensed chromosome outer kinetochore
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0007091	; P:mitotic metaphase/anaphase transition
GO:0034501	; P:protein localization to kinetochore

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489

; BUB1_N; 1.

Prints

Created Date

20-Feb-2013