EKS-AIM-00231

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00231

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	318.5	2.9E-95	3	237	235

Status

Unreviewed

Ensembl Protein

ENSAMEP00000018231

UniProt Accession

D2HX61;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKAA2

Gene Synonyms/Alias

PRKAA2; PANDA_017181;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000017253	ENSAMEP00000018231	ENSAMET00000018970

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

521

Protein Sequence
(FASTA)

VGEHQLTGHK VAVKILNRQK IRSLDVVGKI KREIQNLKLF RHPHIIKLYQ VISTPTDFFM 60

VMEYVSGGEL FDYICKHGRV EEVEARRLFQ QILSAVDYCH RHMVVHRDLK PENVLLDAHM 120

NAKIADFGLS NMMSDGEFLR TSCGSPNYAA PEVISGRLYA GPEVDIWSCG VILYALLCGT 180

LPFDDEHVPT LFKKIRGGVF YIPEYLNRSV ATLLMHMLQV DPLKRATIKD IREHEWFKQD 240

LPSYLFPEDP SYDANVIDDE AVKEVCEKFE CTESEVMNSL YSGDPQDQLA VAYHLIIDNR 300

RIMNQASEFY LASSPPTGSF MDDSTMHIPP GLKPHPERMP PLIADSPKAR CPLDALNTTK 360

PKSLAVKKAK WHLGIRSQSK PYDIMAEVYR AMKQLDFEWK VVNAYHLRVR RKNPVTGNYV 420

KMSLQLYLVD NRSYLLDFKS IDDEVVEQRS GSSTPQRSCS AAGLHRPRSS FDSVTAESHS 480

LSGSLTGSLT GSTLSSVPPR LGSHTMDFFE MCASLITTLA R 521

Nucleotide Sequence
(FASTA)

GTTGGAGAAC ATCAATTGAC AGGCCATAAA GTGGCAGTTA AAATCTTAAA TAGACAGAAG 60

ATTCGCAGTT TAGATGTTGT TGGAAAAATA AAACGAGAAA TTCAAAACCT AAAACTCTTT 120

CGTCATCCTC ATATAATCAA ACTATACCAG GTGATCAGCA CTCCAACAGA TTTTTTTATG 180

GTGATGGAAT ATGTGTCTGG TGGTGAATTA TTTGACTACA TCTGTAAACA TGGACGGGTT 240

GAAGAGGTGG AAGCAAGGCG GCTCTTTCAG CAGATTCTGT CAGCTGTGGA TTACTGTCAT 300

AGGCATATGG TGGTTCATCG AGACCTGAAA CCAGAGAATG TGCTGTTGGA TGCTCACATG 360

AATGCCAAGA TAGCTGATTT TGGATTGTCT AATATGATGT CAGATGGTGA ATTTCTGCGA 420

ACCAGTTGTG GATCTCCAAA TTATGCAGCA CCTGAAGTCA TCTCAGGCAG ATTGTATGCA 480

GGTCCTGAAG TTGATATCTG GAGCTGTGGT GTTATTTTGT ATGCCCTTCT TTGTGGCACC 540

CTCCCATTTG ATGATGAGCA TGTACCTACG TTATTTAAGA AGATCCGAGG GGGTGTTTTT 600

TATATCCCAG AATATCTCAA TCGTTCTGTT GCCACTCTCT TGATGCATAT GCTGCAGGTT 660

GACCCCCTGA AACGAGCAAC CATCAAAGAT ATAAGAGAGC ATGAATGGTT TAAACAAGAT 720

TTGCCCAGTT ACTTATTTCC TGAAGACCCC TCCTATGATG CTAACGTCAT TGATGATGAG 780

GCTGTGAAAG AAGTGTGTGA AAAATTTGAG TGTACAGAAT CAGAAGTAAT GAACAGTTTA 840

TATAGTGGTG ACCCTCAAGA CCAGCTTGCA GTGGCTTATC ATCTTATCAT TGACAATCGG 900

AGAATAATGA ACCAAGCCAG TGAGTTCTAC CTCGCCTCTA GTCCCCCAAC AGGTTCTTTT 960

ATGGATGATA GTACCATGCA TATTCCCCCA GGCCTGAAAC CTCATCCAGA ACGGATGCCA 1020

CCTCTTATAG CAGACAGCCC TAAAGCGAGA TGTCCATTGG ATGCACTGAA CACAACTAAG 1080

CCCAAATCTT TAGCTGTGAA AAAAGCCAAG TGGCATCTTG GAATCAGAAG TCAAAGCAAA 1140

CCGTATGACA TTATGGCTGA GGTCTACCGA GCTATGAAGC AGCTGGATTT TGAATGGAAG 1200

GTAGTGAATG CATACCATCT TCGTGTAAGA AGGAAAAATC CAGTGACTGG CAATTATGTG 1260

AAAATGAGCT TACAACTTTA CCTGGTTGAC AACAGAAGCT ATCTTTTGGA CTTTAAAAGC 1320

ATTGATGATG AGGTGGTGGA GCAGAGGTCT GGTTCTTCAA CACCTCAGCG TTCCTGTTCT 1380

GCTGCTGGCT TACATAGACC AAGATCAAGT TTTGATTCTG TAACTGCAGA GAGCCATTCA 1440

CTTTCTGGCT CTCTCACTGG CTCTTTGACC GGAAGCACAT TGTCTTCAGT TCCACCCCGC 1500

CTAGGCAGTC ACACCATGGA TTTTTTTGAA ATGTGTGCCA GTCTGATCAC TACCTTAGCC 1560

CGTTGA 1566

Domain Profile

S: 19    khketkekvavKiikkkkl.seeslekikrEieilkklkhpniikllevietkkklylvl  77

         +h++t++kvavKi++++k+ s + + kikrEi+ lk ++hp+iikl++vi+t +++++v+

Q: 3     EHQLTGHKVAVKILNRQKIrSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVM  62

         799***************96667788**********************************

S: 78    eyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgivHrDlKpeNllldkkeni  137

         ey+sggeLfdyi ++gr++e ear+lf+q++sav+Y+h++ +vHrDlKpeN+lld+++n

Q: 63    EYVSGGELFDYICKHGRVEEVEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNA  122

         ************************************************************

S: 138   kiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvDvWslGvvLyalvtgklP  197

         kiaDFGl+n++++g+ l+t+cGsp+YaaPe+++g+ Y gp+vD+Ws+Gv+Lyal++g+lP

Q: 123   KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLP  182

         ************************************************************

S: 198   fdeenlkellekilkgkleipkklskelesLlrklLvvdpekRatieeilkhewl  252

         fd+e++ +l++ki  g + ip++l++++++Ll ++L+vdp kRati++i++hew+

Q: 183   FDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF  237

         ******************************************************7

Domain Sequence
(FASTA)

EHQLTGHKVA VKILNRQKIR SLDVVGKIKR EIQNLKLFRH PHIIKLYQVI STPTDFFMVM 60

EYVSGGELFD YICKHGRVEE VEARRLFQQI LSAVDYCHRH MVVHRDLKPE NVLLDAHMNA 120

KIADFGLSNM MSDGEFLRTS CGSPNYAAPE VISGRLYAGP EVDIWSCGVI LYALLCGTLP 180

FDDEHVPTLF KKIRGGVFYI PEYLNRSVAT LLMHMLQVDP LKRATIKDIR EHEWF 235

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0004679	; F:AMP-activated protein kinase activity
GO:0005524	; F:ATP binding
GO:0003682	; F:chromatin binding
GO:0035174	; F:histone serine kinase activity
GO:0042149	; P:cellular response to glucose starvation
GO:0042593	; P:glucose homeostasis
GO:0008610	; P:lipid biosynthetic process
GO:0043066	; P:negative regulation of apoptotic process
GO:0032007	; P:negative regulation of TOR signaling cascade
GO:0010508	; P:positive regulation of autophagy
GO:0042752	; P:regulation of circadian rhythm

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013