EKS-AIM-00455

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00455

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	424.8	9.1E-128	18	273	256

Status

Unreviewed

Ensembl Protein

ENSAMEP00000018480

UniProt Accession

D2HPF5;

Protein Name

Protein Synonyms/Alias

Gene Name

TBCK

Gene Synonyms/Alias

TBCK; PANDA_013655;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000017479	ENSAMEP00000018480	ENSAMET00000019223

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

893

Protein Sequence
(FASTA)

MFPLKDAEMG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTIIH PRLCQYVDIS 60

RGKHERLVVV AEHCERSLED LLRERKPVSY SKVLCIAFEV LQGLQYMNKH AIVHRALSPH 120

NILLDRKGHV KLAKFGLYHM TAHGDDVDFP IGYPSYLAPE VIAQGIFKTT DHVPCEKPLP 180

SGPKSDVWSL GIILFELCVG RKLFQSLDIS ERLKFLLTLD CVDDTIIVLA EEHGCLDIIK 240

DLPENVINLL QKCLTFHPSK RPTADELMQD KVFSEVSPLY TPFTKPASLF SSSLRCADLT 300

LPEDISQLCK DINSDYLAER SIEEVYYLWC LAGGDLEKEL VNKEIIRSKP PICTLPNFLF 360

EDGESFGQGR DRSSLLDDTT VTLSLCQLRN RLKDVGGEAF YPLLEDDQSN LPHSNSNNEL 420

SAAATLPLII RERDTEYQLN RIILFDRLLK AYPYKKNQIW KEARVDIPPL MRGLTWAALL 480

GVEGAIHAKY DAIDKDTPIP TDRQIEVDIP RCHQYDELLS SPEGHAKFRR VLKAWVVSHP 540

DLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM 600

IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV 660

AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESINL FCWTPKSATY RQHAQPPKPA 720

ADSSGVRSST PFFSTECPDP PKTDLSRESI PLNDLKSEVS PRISAEDLID LCELTVTGHF 780

KTPTKKTKSS KPKLLVVDIR NSEDFIRGHI SGSINIPFSA AFTAEGELTQ GPFTTVLQSF 840

KGKVIVIVGH VAKHTAEFAA HLVKMKYPRI CILDGGINKI KPTGLLTVPS PQI 893

Nucleotide Sequence
(FASTA)

ATGTTTCCCC TGAAGGATGC TGAAATGGGT GCCTTTACCT TCTTTGCCTC GGCTCTGCCA 60

CATGATGTTT GTGGAAGCAA TGGGCTTCCT CTCACACCAA ATTCCATCAA AATTTTAGGG 120

CGATTTCAAA TCCTTAAGAC CATCATCCAT CCCAGACTTT GCCAGTATGT GGATATTTCT 180

AGGGGAAAGC ATGAAAGACT GGTGGTGGTA GCTGAACACT GTGAACGGAG TCTAGAAGAC 240

TTGCTGCGAG AGAGGAAACC CGTGAGCTAT TCAAAAGTTC TGTGCATTGC GTTTGAAGTA 300

CTTCAAGGTT TGCAGTACAT GAACAAACAT GCTATAGTGC ACCGAGCACT GTCTCCTCAT 360

AATATTCTTT TGGACCGAAA GGGACATGTT AAATTGGCTA AATTTGGACT TTATCACATG 420

ACAGCTCATG GTGATGATGT TGATTTCCCA ATTGGATATC CATCATACTT GGCACCCGAG 480

GTAATTGCAC AAGGAATTTT CAAAACCACC GATCATGTGC CATGTGAAAA ACCATTGCCG 540

TCTGGCCCCA AATCAGATGT GTGGTCTCTC GGAATCATTT TATTTGAGCT TTGTGTGGGA 600

AGAAAATTAT TTCAGAGCTT GGATATTTCT GAAAGACTAA AATTTTTGCT TACATTAGAT 660

TGCGTAGATG ACACAATAAT AGTTCTGGCT GAAGAGCATG GTTGCCTGGA CATTATAAAG 720

GACCTTCCCG AAAATGTGAT AAATCTTTTG CAGAAGTGTC TCACCTTCCA CCCTTCCAAG 780

AGGCCAACCG CAGATGAATT AATGCAGGAC AAGGTATTTA GTGAAGTGTC ACCTTTATAT 840

ACTCCCTTTA CCAAACCTGC CAGCCTGTTT TCGTCTTCTT TGAGATGTGC TGATTTGACT 900

CTGCCTGAGG ATATCAGTCA ACTGTGTAAA GATATAAACA GTGATTACCT GGCAGAAAGA 960

TCTATTGAAG AAGTATATTA CCTTTGGTGT TTAGCTGGAG GTGACTTGGA GAAAGAGCTT 1020

GTCAACAAGG AAATCATTCG ATCCAAACCA CCTATCTGCA CACTCCCAAA CTTTCTCTTT 1080

GAAGATGGTG AAAGCTTTGG ACAAGGTCGA GATAGAAGCT CACTATTAGA TGACACCACT 1140

GTGACATTGT CATTATGCCA GCTAAGAAAT AGATTAAAAG ATGTTGGTGG AGAAGCATTT 1200

TACCCACTAC TTGAAGATGA CCAGTCCAAT TTACCTCATT CAAACAGCAA TAATGAGTTG 1260

TCTGCAGCTG CCACTCTCCC TTTAATCATC CGAGAGAGGG ACACAGAGTA CCAGCTAAAC 1320

AGAATCATTC TCTTTGACAG GCTGCTAAAG GCTTATCCAT ATAAAAAAAA TCAAATCTGG 1380

AAAGAAGCAA GAGTTGACAT TCCTCCTCTT ATGAGAGGTT TAACCTGGGC TGCCCTTCTG 1440

GGAGTTGAGG GGGCTATTCA TGCCAAGTAT GATGCAATTG ATAAAGATAC TCCAATTCCT 1500

ACAGATAGAC AAATAGAAGT GGATATTCCT CGGTGCCATC AGTATGATGA ACTGTTATCA 1560

TCACCAGAAG GTCATGCAAA ATTTCGGCGT GTATTAAAAG CCTGGGTCGT GTCTCATCCT 1620

GATCTTGTGT ATTGGCAAGG TCTTGATTCA CTTTGTGCTC CATTCCTATA TTTAAATTTC 1680

AATAATGAAG CCTTGGCTTA TGCATGTATG TCTGCTTTTA TCCCCAAATA CCTGTATAAC 1740

TTCTTCTTGA AAGACAACTC ACATGTAATA CAAGAGTATC TGACCGTATT CTCACAGATG 1800

ATTGCATTCC ATGATCCAGA GCTGAGCAAT CATCTCAATG AGATTGGATT TATCCCAGAT 1860

CTCTATGCCA TCCCTTGGTT TCTCACCATG TTTACTCATG TATTTCCACT GCACAAAATT 1920

TTCCACCTCT GGGATACCTT ACTCCTTGGG AATTCCTCTT TCCCATTCTG TATTGGAGTA 1980

GCAATTCTCC AGCAGCTACG GGACCGGCTT TTGGCTAATG GCTTTAATGA GTGCATTCTT 2040

CTCTTCTCTG ATTTACCAGA AATTGACATC GAACGCTGTG TGCGAGAATC AATCAACCTG 2100

TTTTGTTGGA CTCCTAAAAG TGCTACTTAC AGACAGCATG CTCAACCTCC AAAGCCAGCT 2160

GCTGATAGCA GTGGAGTCAG AAGTTCGACG CCTTTTTTCT CCACTGAGTG CCCAGATCCT 2220

CCAAAAACAG ATTTGTCAAG AGAATCTATC CCATTAAATG ACCTAAAGTC AGAAGTATCA 2280

CCCCGGATTT CAGCAGAGGA CCTGATTGAT TTGTGTGAAC TCACAGTGAC AGGCCATTTC 2340

AAAACACCCA CCAAGAAGAC AAAGTCCAGT AAACCAAAGC TCCTGGTAGT TGACATCCGG 2400

AATAGTGAAG ATTTTATTCG GGGTCATATT TCAGGCAGCA TCAACATTCC ATTCAGTGCT 2460

GCCTTCACGG CAGAAGGGGA ACTTACCCAG GGCCCTTTCA CTACTGTGCT CCAGAGCTTC 2520

AAAGGGAAGG TCATTGTCAT CGTGGGGCAT GTGGCAAAGC ACACAGCAGA GTTTGCAGCT 2580

CATCTTGTGA AGATGAAATA TCCAAGAATC TGCATTCTAG ATGGTGGCAT TAATAAGATC 2640

AAGCCAACAG GCCTCCTCAC TGTCCCGTCT CCTCAAATAT GA 2682

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk++ h+rLcqY+disrgkher++vvaeh+e+s

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKTIIHPRLCQYVDISRGKHERLVVVAEHCERS  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         LeDll+erkpvs s+vl+ia+evl+gl+y+nkh ivhral+p++illdrkg+ vkLak+G

Q: 78    LEDLLRERKPVSYSKVLCIAFEVLQGLQYMNKHAIVHRALSPHNILLDRKGH-VKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+ta+G+dvdfpigy+sylaPe+i+q+          +k+l++++ksDvWsLg+il+e

Q: 137   LYHMTAHGDDVDFPIGYPSYLAPEVIAQGifkttdhvpCEKPLPSGPKSDVWSLGIILFE  196

         *************************************99*********************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l++g+kLf++ld+serlk+ll+l++vd+t+i+laee++cldiik+l+e++++ll+kCLt+

Q: 197   LCVGRKLFQSLDISERLKFLLTLDCVDDTIIVLAEEHGCLDIIKDLPENVINLLQKCLTF  256

         ************************************************************

S: 232   lpskRpspdellkekvf  248

         +pskRp+ del+++kvf

Q: 257   HPSKRPTADELMQDKVF  273

         ***************98

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKT IIHPRLCQYV DISRGKHERL VVVAEHCERS 60

LEDLLRERKP VSYSKVLCIA FEVLQGLQYM NKHAIVHRAL SPHNILLDRK GHVKLAKFGL 120

YHMTAHGDDV DFPIGYPSYL APEVIAQGIF KTTDHVPCEK PLPSGPKSDV WSLGIILFEL 180

CVGRKLFQSL DISERLKFLL TLDCVDDTII VLAEEHGCLD IIKDLPENVI NLLQKCLTFH 240

PSKRPTADEL MQDKVF 256

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

aml:100469361

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013