EKS-AIM-00214

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00214

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	433.2	3.3E-130	72	333	262

Status

Unreviewed

Ensembl Protein

ENSAMEP00000018501

UniProt Accession

G1MGL7;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPKAPK2

Gene Synonyms/Alias

MAPKAPK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000017497	ENSAMEP00000018501	ENSAMET00000019244

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

408

Protein Sequence
(FASTA)

LLFTNQDFSA PVPCPSPPSP SRQPRPSTLR VPAPAQPHPP AQPPPQPPQQ FPQFHVKSSL 60

QIKKNAIIDD YKVTTQVLGL GINGKVLQIF NKRTQEKFAL KMLQDCPKAR REVELHWRAS 120

QCPHIVRIVD VYENLYAGRK CLLIVMECLD GGELFSRIQD RGDQAFTERE ASEIMKSIGE 180

AIQYLHSINI AHRDVKPENL LYTSKRPNAI LKLTDFGFAK ETTSHNSLTT PCYTPYYVAP 240

EVLGPEKYDK SCDMWSLGVI MYILLCGYPP FYSNHGLAIS PGMKSRIRMG QYEFPNPEWS 300

EVSEEVKMLI RNLLKTEPTQ RMTITEFMNH PWIMQSTKVP QTPLHTSRVL KEDKERWEDV 360

KEEMTSALAT MRVDYEQIKI KKIEDASNPL LLKRRKKARA LEAAALAH 408

Nucleotide Sequence
(FASTA)

CTTCTATTTA CGAACCAGGA TTTCTCAGCC CCCGTTCCCT GTCCTTCACC CCCCAGCCCC 60

AGCCGGCAGC CCCGGCCCTC CACACTCCGG GTGCCAGCCC CGGCCCAGCC TCACCCCCCG 120

GCCCAGCCGC CGCCGCAGCC CCCGCAGCAG TTTCCCCAGT TCCATGTCAA GTCGAGCCTG 180

CAGATCAAGA AGAACGCCAT CATCGACGAC TACAAGGTCA CCACCCAGGT CCTGGGACTG 240

GGCATCAACG GGAAAGTTTT GCAGATCTTC AATAAGAGGA CCCAGGAGAA ATTCGCCCTA 300

AAAATGCTTC AGGATTGCCC CAAGGCCCGC CGGGAGGTGG AGCTGCACTG GCGGGCCTCG 360

CAGTGCCCCC ACATCGTGCG GATTGTGGAT GTATACGAGA ACTTGTATGC GGGCAGGAAG 420

TGCCTGCTAA TCGTCATGGA GTGTTTGGAT GGTGGAGAAC TCTTTAGCCG AATCCAGGAC 480

CGAGGAGACC AAGCGTTCAC AGAAAGAGAA GCATCAGAAA TCATGAAGAG CATTGGGGAG 540

GCCATCCAGT ATTTGCACTC AATCAACATT GCTCATCGGG ATGTCAAGCC TGAAAATCTC 600

CTATACACCT CCAAAAGGCC CAACGCCATC CTGAAACTCA CAGATTTTGG CTTTGCCAAG 660

GAAACCACCA GCCACAACTC TTTGACCACT CCTTGTTATA CGCCGTACTA TGTGGCTCCA 720

GAAGTGCTGG GTCCCGAGAA GTATGACAAG TCCTGTGACA TGTGGTCCTT GGGTGTCATC 780

ATGTACATCC TGCTGTGTGG GTATCCCCCC TTCTATTCCA ATCACGGTCT TGCCATCTCT 840

CCGGGCATGA AGAGTCGCAT CCGAATGGGC CAGTATGAGT TCCCCAACCC AGAATGGTCA 900

GAAGTATCGG AGGAAGTAAA GATGCTCATC CGGAACCTGC TGAAAACAGA GCCCACTCAG 960

AGAATGACCA TCACGGAGTT TATGAACCAC CCCTGGATCA TGCAATCAAC AAAGGTCCCT 1020

CAAACCCCAC TGCACACCAG CCGGGTCCTG AAGGAGGACA AGGAGCGGTG GGAGGACGTC 1080

AAGGAGGAGA TGACCAGTGC CTTGGCCACA ATGCGTGTCG ACTATGAACA GATCAAGATA 1140

AAGAAGATTG AAGATGCATC CAATCCTCTC CTTCTGAAGA GGCGGAAGAA AGCTCGGGCC 1200

CTGGAGGCCG CGGCCCTTGC TCACTGA 1227

Domain Profile

S: 1     klteevlGeGisgkvlecvkkktgekyalkilkdrkkvrrevelhvqasghknivelidv  60

         k+t++vlG Gi+gkvl++++k+t+ek+alk+l+d++k+rrevelh++as++++iv+++dv

Q: 72    KVTTQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDV  131

         5799********************************************************

S: 61    fensfedekrlllvlekleGGellsriqer..kaftekeasevvkdiasalkflhsknia  118

         +en ++++k+ll+v+e+l+GGel+sriq+r  +afte+ease++k+i++a+++lhs nia

Q: 132   YENLYAGRKCLLIVMECLDGGELFSRIQDRgdQAFTEREASEIMKSIGEAIQYLHSINIA  191

         *******************************9****************************

S: 119   hrDlkpenlLyeskeknapvklcDfglaketeeeeelktpcltaeyvaPevleaekeeal  178

         hrD+kpenlLy+sk+ na++kl+Dfg+aket+++++l+tpc+t++yvaPevl++ek

Q: 192   HRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEK----  247

         ********************************************************....

S: 179   lydksCDlWslGvilyillcGypPfyskkgraiskklkeriqegkyefPeeeWsevseea  238

          ydksCD+WslGvi+yillcGypPfys++g ais+++k+ri++g+yefP++eWsevsee+

Q: 248   -YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKSRIRMGQYEFPNPEWSEVSEEV  306

         .***********************************************************

S: 239   kdlirklLkrdpkerltieevlnhpwv  265

         k+lir+lLk++p++r+ti+e++nhpw+

Q: 307   KMLIRNLLKTEPTQRMTITEFMNHPWI  333

         **************************8

Domain Sequence
(FASTA)

KVTTQVLGLG INGKVLQIFN KRTQEKFALK MLQDCPKARR EVELHWRASQ CPHIVRIVDV 60

YENLYAGRKC LLIVMECLDG GELFSRIQDR GDQAFTEREA SEIMKSIGEA IQYLHSINIA 120

HRDVKPENLL YTSKRPNAIL KLTDFGFAKE TTSHNSLTTP CYTPYYVAPE VLGPEKYDKS 180

CDMWSLGVIM YILLCGYPPF YSNHGLAISP GMKSRIRMGQ YEFPNPEWSE VSEEVKMLIR 240

NLLKTEPTQR MTITEFMNHP WI 262

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0070935	; P:3'-UTR-mediated mRNA stabilization
GO:0035924	; P:cellular response to vascular endothelial growth factor stimulus
GO:0031572	; P:G2/M transition DNA damage checkpoint
GO:0006954	; P:inflammatory response
GO:0048839	; P:inner ear development
GO:0044351	; P:macropinocytosis
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0032675	; P:regulation of interleukin-6 production
GO:0032680	; P:regulation of tumor necrosis factor production
GO:0032496	; P:response to lipopolysaccharide
GO:0002224	; P:toll-like receptor signaling pathway
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013