EPS-AIM-00027

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-AIM-00027

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	229.3	6.9E-68	93	349	257

Status

Unreviewed

Ensembl Protein

ENSAMEP00000018540

UniProt Accession

G1MGQ6;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1L

Gene Synonyms/Alias

PPM1L;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000017554	ENSAMEP00000018540	ENSAMET00000019285

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

360

Protein Sequence
(FASTA)

MIEDTMTLLS LLGRIMRYFL LRPETLFLLC ISLALWSYFF HTDEVKTIVK SSRDAVKMVK 60

GKVAEIMQND RLGGLDVLEA EFSKTWEFKS HNVAVYSIQG RRDHMEDRFE VLTDLANKTH 120

PSIFGIFDGH GGETAAEYVK SRLPEALKQH LQDYEKDKEN SVLSYQTILE QQILSIDREM 180

LEKLTVSYDE AGTTCLIALL SDKDLTVANV GDSRGVLCDK DGNAIPLSHD HKPYQLKERK 240

RIKRAGGFIS FNGSWRVQGI LAMSRSLGDY PLKNLNVVIP DPDILTFDLD KLQPEFMILA 300

SDGLWDAFSN EEAVRFIKER LDEPHFGAKS IVLQSFYRGC PDNITVMVVK FRNSSKTEEQ 360

Nucleotide Sequence
(FASTA)

ATGATAGAGG ATACAATGAC TTTGCTGTCT CTGCTGGGTC GCATCATGCG CTACTTCTTG 60

CTGAGACCCG AGACACTCTT CCTGCTGTGC ATCAGCTTGG CACTGTGGAG TTACTTCTTC 120

CACACGGACG AGGTGAAGAC CATCGTCAAG TCCAGCCGGG ACGCCGTGAA GATGGTGAAG 180

GGCAAGGTGG CCGAGATCAT GCAGAACGAT CGGCTCGGCG GGCTCGACGT CCTGGAGGCC 240

GAGTTTTCCA AGACCTGGGA GTTTAAGAGC CACAACGTGG CTGTGTATTC CATCCAGGGC 300

CGGAGAGACC ACATGGAGGA CCGATTTGAA GTTCTTACGG ACCTAGCCAA CAAGACGCAC 360

CCGTCCATCT TCGGGATCTT TGACGGACAC GGTGGCGAGA CTGCAGCTGA GTATGTAAAA 420

TCGAGACTCC CAGAGGCCCT TAAACAGCAT CTTCAGGACT ACGAGAAGGA CAAAGAAAAT 480

AGTGTTCTGT CTTACCAGAC CATCCTTGAA CAGCAGATTC TGTCTATTGA CCGAGAAATG 540

CTAGAAAAAT TGACTGTATC CTATGACGAA GCAGGTACGA CGTGTCTGAT TGCTCTGCTC 600

TCAGATAAGG ACCTCACCGT GGCCAATGTG GGTGACTCGA GAGGGGTCCT GTGTGACAAG 660

GACGGAAACG CCATTCCTCT GTCTCATGAT CACAAGCCTT ACCAACTGAA GGAGAGAAAG 720

AGGATAAAGA GAGCTGGTGG ATTTATCAGT TTCAATGGCT CCTGGAGGGT CCAGGGAATC 780

CTAGCCATGT CTCGGTCCCT GGGGGATTAT CCGCTGAAAA ATCTCAATGT GGTCATCCCA 840

GACCCAGATA TCCTGACCTT TGACCTGGAC AAGCTCCAGC CCGAGTTCAT GATCTTGGCA 900

TCAGATGGCC TCTGGGATGC TTTCAGCAAT GAAGAAGCCG TTCGATTCAT CAAGGAGCGC 960

TTGGATGAAC CTCACTTTGG GGCTAAGAGC ATAGTTTTAC AGTCATTTTA CAGAGGCTGT 1020

CCTGACAATA TAACGGTCAT GGTGGTGAAG TTCAGGAATA GCAGCAAAAC AGAAGAGCAG 1080

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheila  62

         v v+s++grr++med++++ +++++++      ++fg++DGhgg+++a++++++l e+l+

Q: 93    VAVYSIQGRRDHMEDRFEVLTDLANKTHP----SIFGIFDGHGGETAAEYVKSRLPEALK  148

         6789***************9999998665....69*************************

S: 63    eele....sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdskly  118

         + l+    ++e++    +++l++  ls+d+e+  le+ + + d+ G+t+++al++d++l+

Q: 149   QHLQdyekDKENSVLSYQTILEQQILSIDREM--LEKLTVSYDEAGTTCLIALLSDKDLT  206

         ****654333333344459*************..999999********************

S: 119   vanvGdSravLcr.ngkavelssdHkpsredEleRieeaggsvilkdga.RvlGvLavsR  176

         vanvGdSr vLc+ +g+a++ls dHkp + +E++Ri++agg +  + g  Rv+G La+sR

Q: 207   VANVGDSRGVLCDkDGNAIPLSHDHKPYQLKERKRIKRAGGFISFN-GSwRVQGILAMSR  265

         *************566************************999977.667**********

S: 177   alGdlylk..pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdvlekke  233

         +lGd+ lk   +v+p+P++  ++l++ +  f+iLasDGlwd +sneeav++++++l+

Q: 266   SLGDYPLKnlNVVIPDPDILTFDLDKLQPeFMILASDGLWDAFSNEEAVRFIKERLD---  322

         ********8889************765544***************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

         ++   ak++v ++  rg+ dn++++vv

Q: 323   EPHFGAKSIVLQSFYRGCPDNITVMVV  349

         999********************9997

Domain Sequence
(FASTA)

VAVYSIQGRR DHMEDRFEVL TDLANKTHPS IFGIFDGHGG ETAAEYVKSR LPEALKQHLQ 60

DYEKDKENSV LSYQTILEQQ ILSIDREMLE KLTVSYDEAG TTCLIALLSD KDLTVANVGD 120

SRGVLCDKDG NAIPLSHDHK PYQLKERKRI KRAGGFISFN GSWRVQGILA MSRSLGDYPL 180

KNLNVVIPDP DILTFDLDKL QPEFMILASD GLWDAFSNEE AVRFIKERLD EPHFGAKSIV 240

LQSFYRGCPD NITVMVV 257

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0000165	; P:MAPK cascade
GO:0006470	; P:protein dephosphorylation
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

aml:100472797

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013