EKS-AIM-00265

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00265

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	407.9	2.3E-122	186	473	288

Status

Unreviewed

Ensembl Protein

ENSAMEP00000018708

UniProt Accession

G1MH74;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2B

Gene Synonyms/Alias

ACVR2B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000017697	ENSAMEP00000018708	ENSAMET00000019457

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

508

Protein Sequence
(FASTA)

RGGLWTAQPF SHLPGTGSGR GEAETRECIY YNANWELERT NQSGLERCEG EQDKRLHCYA 60

SWDRGRQGPL QTAWSSGKLC ASRQECVATE ENPQVYFCCC EGNFCNERFT HLPEAGGPEV 120

TYEPPPTAPT LLTVLAYSLL PIGGLSLIVL LAFWMYRHRK PPYGHVDIHE DPGPPPPSPL 180

VGLKPLQLLE IKARGRFGCV WKAQLMNDFV AVKIFPLQDK QSWQSEREIF STPGMKHENL 240

LQFIAAEKRG SNLEVELWLI TAFHDKGSLT DYLKGNIITW NELCHVAETM SRGLSYLHED 300

VPWCRGEGHK PSIAHRDFKS KNVLLKSDLT AVLADFGLAV RFEPGKPPGD THGQVGTRRY 360

MAPEVLEGAI NFQRDAFLRI DMYAMGLVLW ELVSRCKAAD GPVDEYMLPF EEEIGQHPSL 420

EELQEVVVHK KMRPAIKDHW LKHPGLAQLC VTIEECWDHD AEARLSAGCV EERVSLIRRS 480

VNGTTSDCLV SLVTSVTNVD LPPKESSI 508

Nucleotide Sequence
(FASTA)

CGTGGGGGTT TATGGACTGC TCAGCCCTTC TCTCACCTCC CGGGCACAGG TTCCGGGCGC 60

GGGGAGGCTG AGACTCGGGA GTGCATTTAC TACAACGCCA ACTGGGAGCT GGAGCGCACC 120

AACCAGAGCG GCCTGGAGCG CTGCGAGGGT GAGCAGGACA AGCGGCTGCA CTGCTATGCC 180

TCCTGGGATA GAGGGAGACA AGGGCCTCTC CAGACAGCTT GGTCAAGTGG GAAACTGTGT 240

GCCTCCAGGC AGGAGTGTGT GGCCACCGAG GAGAACCCCC AGGTGTACTT CTGCTGCTGT 300

GAAGGCAACT TCTGCAACGA GCGCTTCACC CACTTGCCAG AGGCCGGGGG CCCGGAAGTC 360

ACGTACGAGC CACCCCCGAC AGCCCCCACC CTTCTCACGG TGCTGGCCTA CTCGCTGCTG 420

CCCATTGGGG GCCTCTCCCT CATCGTCCTG CTGGCCTTCT GGATGTACCG GCATCGCAAG 480

CCTCCCTACG GCCACGTGGA CATCCACGAG GACCCCGGAC CTCCACCGCC ATCCCCTCTG 540

GTGGGCCTGA AGCCTCTGCA GCTGCTGGAG ATCAAGGCTC GGGGGCGCTT TGGCTGTGTC 600

TGGAAGGCGC AGCTCATGAA TGACTTTGTG GCTGTCAAGA TCTTCCCACT CCAGGACAAG 660

CAGTCATGGC AGAGTGAACG GGAGATCTTC AGCACGCCTG GCATGAAGCA TGAGAACCTG 720

CTGCAGTTCA TTGCCGCTGA GAAGCGAGGC TCCAACCTTG AGGTGGAGCT GTGGCTCATC 780

ACGGCCTTCC ATGACAAGGG CTCGCTCACG GATTATCTCA AGGGGAACAT CATCACATGG 840

AATGAACTGT GTCACGTGGC AGAGACAATG TCAAGAGGCC TCTCGTACCT TCACGAGGAT 900

GTACCCTGGT GCCGTGGTGA GGGCCACAAG CCGTCTATTG CCCACAGGGA CTTCAAAAGC 960

AAGAATGTAT TGCTCAAGAG TGACCTCACA GCCGTGCTGG CTGACTTTGG TCTGGCTGTT 1020

AGGTTTGAGC CAGGGAAACC TCCGGGGGAC ACTCACGGGC AGGTGGGCAC GCGGCGGTAC 1080

ATGGCCCCTG AGGTGCTTGA GGGAGCCATC AACTTCCAGA GGGATGCCTT CCTGCGCATT 1140

GACATGTATG CCATGGGGCT GGTGCTGTGG GAGCTTGTGT CCCGCTGCAA GGCTGCAGAT 1200

GGCCCTGTGG ATGAGTACAT GCTGCCCTTT GAGGAGGAGA TCGGCCAGCA CCCGTCGTTG 1260

GAGGAGCTGC AGGAAGTGGT CGTGCACAAG AAGATGCGGC CTGCCATTAA GGATCACTGG 1320

CTGAAACACC CGGGCCTGGC CCAGCTCTGC GTGACCATCG AGGAATGCTG GGACCATGAT 1380

GCAGAGGCTC GCCTGTCTGC AGGCTGTGTG GAGGAGCGGG TGTCCCTGAT CCGGAGGTCG 1440

GTCAACGGCA CTACCTCGGA CTGTCTTGTC TCCCTGGTGA CCTCCGTCAC CAATGTGGAC 1500

CTGCCCCCTA AGGAGTCGAG CATCTAA 1527

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l+++ vAvKif+ +d++sw++E+ei++t+ ++hen+lqfia

Q: 186   LQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIA  245

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++++el+l+t++h+kgsL+dyLk ++++++el+++a+++++Gl++LHe++++++

Q: 246   AEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCR  305

         ************************************************************

S: 121   g.kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

         g  +Kp+iaHRD+kskN+l+k+dlt+++aD+GLa+++e  k   d  ++ qvGt+RYmaP

Q: 306   GeGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAP  363

         *99***************************************888..79***********

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         Evle+a+n+++ +af r+D+Y++gLvlWE++sRc+++d+ v+ey+lpfee++g++Pslee

Q: 364   EVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEE  422

         **********9.9***********************************************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         ++evvv+kk+rP i+++w k++ l++l+ ++eecWd+d+eaRl+a +v++r

Q: 423   LQEVVVHKKMRPAIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEER  473

         ************************************************998

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL MNDFVAVKIF PLQDKQSWQS EREIFSTPGM KHENLLQFIA 60

AEKRGSNLEV ELWLITAFHD KGSLTDYLKG NIITWNELCH VAETMSRGLS YLHEDVPWCR 120

GEGHKPSIAH RDFKSKNVLL KSDLTAVLAD FGLAVRFEPG KPPGDTHGQV GTRRYMAPEV 180

LEGAINFQRD AFLRIDMYAM GLVLWELVSR CKAADGPVDE YMLPFEEEIG QHPSLEELQE 240

VVVHKKMRPA IKDHWLKHPG LAQLCVTIEE CWDHDAEARL SAGCVEER 288

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005737	; C:cytoplasm
GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004712	; F:protein serine/threonine/tyrosine kinase activity
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0032147	; P:activation of protein kinase activity
GO:0009952	; P:anterior/posterior pattern specification
GO:0060840	; P:artery development
GO:0001974	; P:blood vessel remodeling
GO:0030509	; P:BMP signaling pathway
GO:0007368	; P:determination of left/right symmetry
GO:0048617	; P:embryonic foregut morphogenesis
GO:0001702	; P:gastrulation with mouth forming second
GO:0007507	; P:heart development
GO:0030073	; P:insulin secretion
GO:0001822	; P:kidney development
GO:0030324	; P:lung development
GO:0001946	; P:lymphangiogenesis
GO:0060836	; P:lymphatic endothelial cell differentiation
GO:0007498	; P:mesoderm development
GO:0042475	; P:odontogenesis of dentin-containing tooth
GO:0035265	; P:organ growth
GO:0060021	; P:palate development
GO:0031016	; P:pancreas development
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0009791	; P:post-embryonic development
GO:0009749	; P:response to glucose stimulus
GO:0061298	; P:retina vasculature development in camera-type eye
GO:0023014	; P:signal transduction by phosphorylation
GO:0048705	; P:skeletal system morphogenesis
GO:0060841	; P:venous blood vessel development

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013