EKS-AIM-00249
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00249
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK456.74.3E-137192520329
StatusUnreviewed
Ensembl ProteinENSAMEP00000018904
UniProt AccessionG1MHR9;
Protein Name
Protein Synonyms/Alias
Gene NameHIPK2
Gene Synonyms/Alias HIPK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000017889ENSAMEP00000018904ENSAMET00000019661
OrganismAiluropoda melanoleuca
Functional Description
Protein Length1219
Protein Sequence
(FASTA)
MASHVQVFSP HTLQSSAFCS VKKLKVEPSS TWDMTGYGSH SKVYSQSKNI PPSQPATTTV 60
STSLPIPNPS LPYEQTIIFP GSTGHIVVTS ASSTSVTGQV LGGPHNLMRR STVSLLDTYQ 120
KCGLKRKSEE IENTSSVQII EEHPPMIQNN ASGATVATAT TSTATSKNSG SNSEGDYQLV 180
QHEVLCSMTN TYEVLEFLGR GTFGQVVKCW KRGTNEIVAI KILKNHPSYA RQGQIEVSIL 240
ARLSTESADD YNFVRAYECF QHKNHTCLVF EMLEQNLYDF LKQNKFSPLP LKYIRPVLQQ 300
VATALMKLKS LGLIHADLKP ENIMLVDPSR QPYRVKVIDF GSASHVSKAV CSTYLQSRYY 360
RAPEIILGLP FCEAIDMWSL GCVIAELFLG WPLYPGASEY DQIRYISQTQ GLPAEYLLSA 420
GTKTTRFFNR DTDSPYPLWR LKTPDDHEAE TGIKSKEARK YIFNCLDDMA QVNMTTDLEG 480
SDMLVEKADR REFIDLLKKM LTIDADKRIT PIETLNHPFV TMTHLLDFPH STQNSVKSCF 540
QNMEICKRRV NVYDTVNQSK TPFITHVAPS TSTNLTMTFN NQLNTVHNQV KPVLSAPTST 600
SATLSLANPE VSILNYQSAL YQPSAASMAA VAQRSMPLQT GTAQICARPD PFQQALIVCP 660
PGFQVGLQAS PSKHAGYSVR MENAVPIVTQ APGAQPLQIQ PGLLAQVSGR GIPNIIFTLN 720
ISKNSTPHPS SVPQGCVHGR PDLIETSSAL QQAWPSGTQQ ILLPPAWQQL TGVATHTSVQ 780
HATVIPETMA GTQQLADWRN THAHGSHYNP IMQQPALLTG HVTLPAAQPL NVGVAHVMRQ 840
QPTSTTSSRK SKQHQSSART RGLQIKKKKK YLLICSSVTC GWGDGASSTT RERQRQTIVI 900
PDTPSPTVSV ITISSDTDEE EEQKHAPTST VSKQRKNVIS CVTVHDSPYS DSSSNKPWQE 960
ETLSRTKGTF VSLLEPPARE RGDSPSSSAI LKTPKKSATG SCVDSSQGTG LNTCVTDSNV 1020
TSTSGHSSGS SSGAIAYRQQ RPGPHFQQQQ PLNLSQSLLS SSASPLPRPP PTFHPFLSYP 1080
LLTSLSVPPP SLLPPPPLPF SLPLLPPSPS PPRCPSPPHF SLFSSSPSSL PLLLTTTVAH 1140
LVASQGSARH TVQHTAYPAS IVHQVPVSMG PRVLPSPTIH PSQYPAQFAH QTYISASPAS 1200
AVYIGYPLSP AKVNQYPYI 1219
Nucleotide Sequence
(FASTA)
ATGGCCTCAC ATGTGCAAGT CTTCTCCCCT CACACCCTTC AATCAAGTGC CTTCTGTAGT 60
GTGAAGAAAC TGAAAGTAGA GCCGAGTTCC ACCTGGGACA TGACTGGGTA CGGCTCCCAC 120
AGCAAAGTGT ATAGCCAGAG CAAGAACATA CCACCTTCTC AGCCAGCCAC CACAACCGTC 180
AGCACCTCCT TGCCGATCCC AAACCCAAGC CTACCTTACG AGCAGACCAT CATCTTCCCA 240
GGAAGCACCG GGCACATTGT TGTAACATCA GCAAGTAGCA CTTCTGTCAC TGGGCAAGTC 300
CTCGGCGGAC CACATAACCT AATGCGTCGA AGCACTGTGA GCCTTCTTGA TACCTACCAA 360
AAATGCGGAC TCAAGCGTAA GAGTGAGGAG ATTGAGAACA CAAGCAGCGT GCAGATCATC 420
GAAGAGCACC CACCCATGAT TCAGAATAAT GCAAGTGGGG CCACTGTAGC CACTGCCACC 480
ACATCGACTG CCACCTCCAA AAACAGCGGC TCCAACAGCG AAGGGGATTA CCAGCTGGTC 540
CAGCATGAGG TGCTGTGCTC CATGACCAAC ACTTACGAAG TCTTAGAGTT CCTGGGCCGA 600
GGGACGTTTG GGCAAGTGGT CAAGTGCTGG AAGCGGGGCA CCAATGAAAT CGTGGCCATC 660
AAAATCCTGA AGAACCACCC GTCGTATGCC CGGCAGGGTC AGATCGAGGT GAGCATCCTG 720
GCCCGCCTGA GCACGGAGAG CGCCGACGAC TACAACTTTG TCCGTGCCTA CGAGTGCTTC 780
CAGCACAAGA ACCACACGTG CTTGGTGTTT GAGATGTTGG AGCAGAACCT CTATGACTTT 840
CTGAAGCAGA ACAAGTTTAG CCCCCTGCCC CTCAAATACA TTCGCCCCGT CCTCCAGCAG 900
GTCGCCACAG CCCTGATGAA ACTGAAAAGC CTAGGTCTCA TCCATGCTGA CCTCAAACCA 960
GAAAACATCA TGCTGGTAGA TCCTTCCAGA CAACCATACA GAGTAAAGGT CATCGACTTC 1020
GGTTCGGCCA GTCACGTGTC CAAGGCTGTG TGTTCCACCT ACTTGCAGTC CAGATACTAC 1080
AGGGCCCCTG AGATCATCCT TGGTTTACCA TTTTGCGAAG CAATTGATAT GTGGTCCCTG 1140
GGCTGTGTCA TTGCGGAGCT GTTCCTGGGC TGGCCGCTCT ATCCAGGAGC TTCCGAGTAT 1200
GATCAGATTC GGTATATTTC ACAAACACAG GGTTTGCCAG CTGAATATTT ATTAAGTGCA 1260
GGGACAAAGA CAACGAGGTT TTTCAACCGT GACACAGACT CACCGTATCC TTTGTGGAGG 1320
CTGAAGACAC CAGATGACCA TGAAGCAGAG ACGGGGATTA AGTCGAAAGA AGCAAGAAAG 1380
TACATTTTCA ACTGTTTAGA TGACATGGCC CAGGTGAACA TGACAACAGA TTTGGAAGGG 1440
AGTGACATGT TGGTGGAGAA GGCAGACCGG CGGGAGTTCA TTGACCTGTT AAAGAAGATG 1500
CTGACCATAG ATGCCGATAA GAGAATCACT CCAATTGAAA CCCTGAACCA CCCCTTTGTC 1560
ACCATGACAC ACCTGCTCGA TTTTCCCCAC AGCACACAGA ACAGCGTCAA GTCATGTTTC 1620
CAGAACATGG AGATTTGCAA GCGTCGGGTC AATGTGTATG ACACGGTGAA CCAGAGCAAA 1680
ACCCCTTTCA TCACGCATGT GGCTCCCAGC ACATCCACCA ACCTGACCAT GACCTTCAAC 1740
AACCAGCTGA ACACTGTCCA CAACCAGGTA AAACCTGTCC TTTCTGCTCC CACCTCCACC 1800
AGCGCCACTC TTTCCTTAGC CAATCCCGAG GTCTCCATAC TAAACTACCA ATCTGCACTC 1860
TACCAGCCCT CAGCGGCATC GATGGCCGCA GTGGCCCAGC GGAGCATGCC CCTGCAGACG 1920
GGAACAGCCC AGATCTGCGC CCGGCCCGAC CCCTTCCAGC AAGCTCTCAT CGTGTGTCCG 1980
CCCGGCTTCC AAGTAGGGTT GCAGGCCTCG CCCTCTAAGC ACGCTGGCTA TTCCGTGCGA 2040
ATGGAGAATG CCGTGCCCAT CGTCACTCAA GCCCCGGGAG CACAGCCTCT TCAGATCCAA 2100
CCAGGTCTGC TCGCCCAGGT ATCAGGCAGA GGCATTCCAA ACATTATCTT TACTTTAAAC 2160
ATATCCAAAA ACAGCACCCC ACATCCTTCA AGCGTGCCCC AAGGATGTGT GCACGGGAGG 2220
CCAGACCTAA TTGAAACGTC CTCTGCTCTA CAGCAGGCCT GGCCAAGTGG GACCCAGCAA 2280
ATCCTGCTTC CGCCGGCATG GCAGCAGCTG ACCGGAGTGG CCACCCACAC GTCTGTGCAG 2340
CACGCGACTG TGATTCCCGA GACCATGGCA GGCACCCAGC AGCTGGCCGA CTGGAGGAAC 2400
ACCCACGCTC ACGGCAGCCA TTACAATCCC ATCATGCAGC AGCCTGCGCT ATTGACTGGT 2460
CATGTGACCC TTCCAGCAGC CCAGCCCTTG AATGTGGGTG TAGCCCACGT GATGCGGCAG 2520
CAGCCAACCA GCACCACCTC CTCCCGGAAG AGTAAGCAGC ACCAGTCCTC TGCGAGGACA 2580
AGAGGTCTCC AAATTAAAAA AAAAAAAAAG TATTTGCTAA TTTGCTCCTC CGTCACGTGC 2640
GGGTGGGGCG ACGGGGCCTC CAGCACCACC AGGGAGCGGC AGCGGCAGAC GATTGTCATT 2700
CCCGACACCC CCAGCCCCAC GGTCAGCGTC ATCACCATCA GCAGCGACAC GGACGAGGAG 2760
GAGGAACAGA AGCATGCCCC CACCAGCACT GTCTCCAAGC AGAGAAAAAA CGTCATCAGC 2820
TGTGTCACGG TCCACGACTC TCCCTACTCC GACTCCTCCA GCAACAAACC TTGGCAGGAA 2880
GAAACACTCT CTAGAACCAA AGGAACCTTT GTGTCCCTGT TGGAGCCGCC TGCAAGGGAA 2940
AGAGGAGATA GTCCTTCCTC ATCTGCGATC TTAAAAACTC CAAAAAAATC TGCTACGGGC 3000
AGTTGTGTTG ACAGTAGCCA GGGGACAGGG CTCAATACCT GTGTTACCGA TAGCAACGTG 3060
ACCTCCACCA GCGGTCACTC TTCAGGGAGC TCGTCTGGAG CCATCGCCTA CCGGCAGCAG 3120
CGGCCAGGAC CGCATTTCCA GCAGCAGCAG CCTCTCAATC TCAGCCAGTC CCTCCTCTCC 3180
TCCTCCGCCT CCCCACTGCC CCGTCCTCCC CCCACCTTCC ACCCTTTCCT CTCTTACCCC 3240
CTTCTCACTT CTCTCTCTGT CCCTCCTCCC TCCCTACTTC CCCCTCCTCC CCTTCCCTTC 3300
TCCCTCCCAC TTCTTCCTCC TTCCCCCTCC CCTCCTCGCT GCCCTTCCCC TCCTCACTTC 3360
TCTCTCTTCT CCTCCTCTCC CTCCTCCCTC CCACTTCTCC TCACAACAAC AGTGGCCCAC 3420
CTGGTGGCCT CCCAAGGCTC GGCACGTCAC ACCGTGCAGC ACACTGCCTA CCCGGCCAGC 3480
ATCGTCCACC AGGTCCCCGT GAGCATGGGC CCCCGGGTCC TGCCCTCGCC CACCATCCAC 3540
CCGAGTCAGT ATCCAGCCCA GTTTGCCCAC CAGACCTACA TCAGCGCCTC TCCAGCCTCC 3600
GCTGTCTACA TTGGATACCC ACTGAGCCCC GCCAAGGTCA ACCAGTACCC TTACATATAA 3660
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         yevle++g+G+fgqVvk++++ t+eivaiki+kn++++arq+q+Ev+iL++l++ +++++
Q: 192   YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLST-ESADD  250
         9****************************************************9.999**
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120
         yn+vr++e+f+++nh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aL++Lk+
Q: 251   YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS  310
         ************************************************************
S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178
         l++iHaDlKPeNi+lv+++r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+
Q: 311   LGLIHADLKPENIMLVDPSRQPyrVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP  370
         *********************999************************************
S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236
         ++eaiDmWSlGcv+aElf+G+pL+pG++e+dq+++i++++glp+e+ll++++k+++ff  
Q: 371   FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFnr  430
         **********************************************************88
S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286
          t++ +p ++lkt          ks++++k+++n+ +++++++++++ e +++l ek+d+
Q: 431   dTDSPYPLWRLKTPddheaetgiKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADR  490
         87889999999999********************************************99
S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315
         + f+dllk+ml++d++kRitp e+l+hpfv
Q: 491   ReFIDLLKKMLTIDADKRITPIETLNHPFV  520
         99***************************7
Domain Sequence
(FASTA)
YEVLEFLGRG TFGQVVKCWK RGTNEIVAIK ILKNHPSYAR QGQIEVSILA RLSTESADDY 60
NFVRAYECFQ HKNHTCLVFE MLEQNLYDFL KQNKFSPLPL KYIRPVLQQV ATALMKLKSL 120
GLIHADLKPE NIMLVDPSRQ PYRVKVIDFG SASHVSKAVC STYLQSRYYR APEIILGLPF 180
CEAIDMWSLG CVIAELFLGW PLYPGASEYD QIRYISQTQG LPAEYLLSAG TKTTRFFNRD 240
TDSPYPLWRL KTPDDHEAET GIKSKEARKY IFNCLDDMAQ VNMTTDLEGS DMLVEKADRR 300
EFIDLLKKML TIDADKRITP IETLNHPFV 329
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Saccharomyces cerevisiae"; ?>
EKS-ANC-00256
EKS-BOT-00267
EKS-CAJ-00273
EKS-CAF-00274
EKS-CAP-00302
EKS-CII-00160
EKS-DAR-00602
EKS-DRM-00137
EKS-EQC-00259
EKS-FEC-00253
EKS-GAG-00224
EKS-GAA-00331
EKS-GOG-00267
EKS-HOS-00273
EKS-ICT-00252
EKS-LAC-00284
EKS-MAM-00269
EKS-MEG-00212
EKS-MOD-00264
EKS-MUM-00298
EKS-MUP-00264
EKS-MYL-00269
EKS-ORN-00344
EKS-ORC-00252
EKS-ORL-00320
EKS-OTG-00273
EKS-PAT-00252
EKS-PES-00237
EKS-PEM-00141
EKS-POA-00263
EKS-RAN-00282
EKS-SAH-00251
EKS-SUS-00240
EKS-TAG-00282
EKS-TAR-00340
EKS-TEN-00334
EKS-TUT-00032
EKS-SAC-00053
Gene Ontology
GO:0005813; C:centrosome
GO:0031965; C:nuclear membrane
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0001105; F:RNA polymerase II transcription coactivator activity
GO:0003714; F:transcription corepressor activity
GO:0046790; F:virion binding
GO:0007628; P:adult walking behavior
GO:0009952; P:anterior/posterior pattern specification
GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0048596; P:embryonic camera-type eye morphogenesis
GO:0060059; P:embryonic retina morphogenesis in camera-type eye
GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0061072; P:iris morphogenesis
GO:0060235; P:lens induction in camera-type eye
GO:0030514; P:negative regulation of BMP signaling pathway
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0030182; P:neuron differentiation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0045766; P:positive regulation of angiogenesis
GO:0008284; P:positive regulation of cell proliferation
GO:0043388; P:positive regulation of DNA binding
GO:0046330; P:positive regulation of JNK cascade
GO:0032092; P:positive regulation of protein binding
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:0010842; P:retina layer formation
GO:0060395; P:SMAD protein signal transduction
GO:0007224; P:smoothened signaling pathway
GO:0007179; P:transforming growth factor beta receptor signaling pathway
GO:0050882; P:voluntary musculoskeletal movement
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013