EKS-AIM-00156
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00156
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb431.51.1E-129401660260
StatusUnreviewed
Ensembl ProteinENSAMEP00000018946
UniProt AccessionG1MHW1;
Protein Name
Protein Synonyms/Alias
Gene NameRPS6KA4
Gene Synonyms/Alias RPS6KA4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000017931ENSAMEP00000018946ENSAMET00000019707
OrganismAiluropoda melanoleuca
Functional Description
Protein Length715
Protein Sequence
(FASTA)
VPTANLTGHE EKVSVENFEL LKVLGTGAYG KVFLVRKAVG HDAGKLYAMK VLRKAALVQR 60
AKTQEHTRTE RSVLELVRQA PFLVTLHYAF QTDAKLHLIL DYVSGGEMFT HLYQRQHFKE 120
AEVRVYGGEI VLALEHLHKL GIIYRDLKLE NVLLDSEGHI VLTDFGLSKE FLTEEKERTF 180
SFCGTIEYMA PEIIRSKSGH GKAVDWWSLG ILLFELLTGA SPFTLEGERN TQAEVSRRIL 240
KCSPPFPPRI GPVAQDLLRR LLCKDPKKRL GAGPQGAQEV KNHPFFQGLD WAALAARKIP 300
APFRPQIRSE LDVGNFAEEF TRLEPVYSPP GSPPPGDPRI FQGYSFVAPS ILFDHNNAVM 360
MTDVLEASGA GDRPGRAAVA RSAMMQDSPF FQQYELDLRE PALGQGSFSV CRRCRQRQSG 420
QEFAVKILSR RLEANTQREV AALRLCQSHP NVVKLHDVHH DQLHTYLVLE LLRGGELLEH 480
IRKKRHFSES EASQILRSLV SAVSFMHEEA GVVHRDLKPE NILYADDTPG APVKIIDFGF 540
ARLRPQSPAG PMQTPCFTLQ YAAPELLAQQ GYDESCDLWS LGVILYMMLS GQVPFQGVSG 600
QGGQSQAAEI MCKIREGRFS LDGEAWQGVS EEAKELVRGL LTVDPAKRLK LEGLRSSSWL 660
QDGSARSSPP LRTPDVLESS GPAVRSGLNA TFMAFNRGKR EGFFLKSVEN APLAK 715
Nucleotide Sequence
(FASTA)
GTGCCCACAG CCAACCTGAC CGGGCACGAG GAGAAGGTGA GCGTCGAGAA CTTCGAGCTG 60
CTCAAGGTGC TGGGCACGGG AGCCTACGGG AAGGTGTTCC TGGTGCGGAA GGCAGTCGGG 120
CACGATGCCG GGAAGCTGTA TGCCATGAAA GTGCTGCGCA AGGCGGCGCT GGTGCAGCGT 180
GCCAAGACGC AGGAGCACAC GCGCACCGAG CGCTCCGTGC TGGAACTCGT GCGCCAGGCC 240
CCCTTCCTGG TTACGCTGCA CTACGCCTTC CAGACGGATG CCAAGCTGCA CCTCATCCTG 300
GATTATGTGA GTGGAGGCGA GATGTTCACC CACCTCTACC AGCGCCAGCA CTTCAAAGAG 360
GCTGAGGTGC GCGTGTACGG GGGCGAGATC GTGCTGGCCC TGGAGCACCT GCACAAGCTG 420
GGTATCATCT ACCGCGATTT GAAGCTGGAG AACGTGCTGC TGGACTCCGA GGGCCACATC 480
GTCCTCACCG ACTTCGGGCT TAGCAAGGAG TTCCTGACGG AGGAGAAAGA ACGAACCTTC 540
TCCTTCTGTG GCACTATCGA GTACATGGCC CCCGAAATTA TCCGCAGCAA GTCGGGACAT 600
GGCAAGGCTG TGGACTGGTG GAGCCTGGGT ATCCTGCTCT TTGAGCTGCT GACCGGGGCC 660
TCGCCCTTCA CCCTGGAGGG CGAGAGGAAC ACTCAGGCAG AGGTGTCCCG ACGGATCCTG 720
AAGTGCTCCC CTCCCTTCCC CCCCCGGATC GGGCCCGTGG CACAGGACCT GCTGCGGCGG 780
CTACTTTGCA AGGACCCCAA AAAGCGGCTG GGCGCGGGGC CCCAGGGGGC GCAGGAAGTC 840
AAGAACCACC CCTTCTTCCA GGGTCTAGAT TGGGCTGCTC TGGCTGCCAG GAAAATTCCA 900
GCCCCATTCC GACCCCAGAT CCGCTCGGAG CTGGATGTGG GCAACTTTGC AGAGGAATTT 960
ACTCGGCTGG AGCCTGTCTA CTCGCCCCCT GGCAGCCCCC CGCCTGGGGA CCCTCGCATC 1020
TTCCAGGGAT ACTCCTTCGT GGCGCCCTCC ATCCTGTTCG ACCATAACAA CGCGGTAATG 1080
ATGACCGATG TCCTGGAAGC GTCCGGCGCT GGAGACCGGC CCGGCCGGGC AGCCGTGGCC 1140
AGGAGCGCCA TGATGCAGGA CTCGCCCTTC TTCCAGCAGT ATGAGCTGGA CCTGCGGGAG 1200
CCCGCGCTGG GCCAGGGCAG CTTCTCCGTG TGTCGCCGCT GTCGCCAGCG CCAGAGCGGC 1260
CAGGAGTTCG CGGTTAAGAT CCTCAGCCGC AGGCTGGAGG CGAACACACA GCGAGAAGTG 1320
GCCGCCCTGC GGCTTTGCCA GTCACACCCA AACGTGGTGA AGTTACACGA TGTGCATCAC 1380
GACCAGCTGC ACACGTACCT GGTTCTGGAG CTGCTGCGGG GCGGGGAGCT GCTGGAACAC 1440
ATCCGCAAGA AGCGGCACTT CAGCGAGTCC GAAGCGAGCC AGATCCTGCG CAGCCTCGTG 1500
TCGGCCGTGA GCTTCATGCA CGAGGAGGCG GGCGTGGTGC ATCGCGACCT CAAGCCCGAG 1560
AACATTCTGT ACGCCGATGA CACGCCCGGA GCCCCCGTGA AGATCATCGA CTTTGGGTTC 1620
GCGCGGCTGC GCCCGCAGAG CCCCGCGGGG CCCATGCAGA CGCCCTGCTT CACGCTGCAG 1680
TACGCAGCTC CCGAGCTGTT GGCGCAGCAG GGCTACGACG AGTCCTGCGA CCTCTGGAGC 1740
CTCGGCGTCA TTCTGTACAT GATGCTGTCG GGGCAGGTCC CCTTCCAGGG CGTCTCAGGC 1800
CAGGGCGGGC AGAGCCAGGC AGCAGAGATC ATGTGCAAGA TCCGCGAGGG GCGCTTCTCT 1860
CTCGACGGGG AGGCCTGGCA GGGCGTGTCT GAAGAAGCTA AGGAGCTGGT CCGAGGGCTC 1920
CTGACGGTGG ACCCCGCCAA GCGGCTGAAG CTCGAGGGGC TGCGGAGCAG CTCGTGGCTG 1980
CAGGACGGCA GCGCCCGCTC CTCGCCCCCA CTCCGGACGC CTGACGTGCT GGAGTCCTCG 2040
GGGCCGGCTG TGCGCTCGGG GCTCAACGCC ACCTTCATGG CCTTCAACCG GGGCAAGCGC 2100
GAGGGCTTCT TCCTGAAGAG CGTGGAGAAC GCGCCGCTCG CCAAG 2145
Domain Profile
S: 5     edlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdvyd  63
           lG+Gs+svc+rc++++++qefavki++++ +++t++e+++l+++++hpn+v+l+dv++
Q: 401   PALGQGSFSVCRRCRQRQSGQEFAVKILSRRlEANTQREVAALRLCQSHPNVVKLHDVHH  460
         579*********************************************************
S: 64    dgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheq.Gvvhrdlkpe  122
         d++++ylvlell+GGell++i+kk++fse+eas+ilr+lv+av+++he+ Gvvhrdlkpe
Q: 461   DQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEaGVVHRDLKPE  520
         ***********************************************999**********
S: 123   nilyvdesdnaesikiidfGfaklkraeng.llktpcytlnfvapevlkrqGydeacdlw  181
         nily+d++++a+ +kiidfGfa+l+++++  +++tpc+tl+++ape+l++qGyde+cdlw
Q: 521   NILYADDTPGAP-VKIIDFGFARLRPQSPAgPMQTPCFTLQYAAPELLAQQGYDESCDLW  579
         ************.*************99755*****************************
S: 182   slGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvsk  237
         slGv+ly+ml+G+vpf    ++g++++a+ei++ki+eG+fsl+Geaw++vseeak+lv++
Q: 580   SLGVILYMMLSGQVPFqgvsGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRG  639
         ****************999999**************************************
S: 238   lltvdpakrlkleqllkhswl  258
         lltvdpakrlkle+l+++swl
Q: 640   LLTVDPAKRLKLEGLRSSSWL  660
         ********************7
Domain Sequence
(FASTA)
PALGQGSFSV CRRCRQRQSG QEFAVKILSR RLEANTQREV AALRLCQSHP NVVKLHDVHH 60
DQLHTYLVLE LLRGGELLEH IRKKRHFSES EASQILRSLV SAVSFMHEEA GVVHRDLKPE 120
NILYADDTPG APVKIIDFGF ARLRPQSPAG PMQTPCFTLQ YAAPELLAQQ GYDESCDLWS 180
LGVILYMMLS GQVPFQGVSG QGGQSQAAEI MCKIREGRFS LDGEAWQGVS EEAKELVRGL 240
LTVDPAKRLK LEGLRSSSWL 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00159
EKS-BOT-00164
EKS-CAE-00125
EKS-CAJ-00168
EKS-CAF-00171
EKS-CAP-00163
EKS-CII-00093
EKS-CIS-00194
EKS-DAR-00453
EKS-DIO-00087
EKS-DRM-00077
EKS-EQC-00155
EKS-FEC-00154
EKS-GAG-00140
EKS-GAA-00194
EKS-GOG-00163
EKS-HOS-00170
EKS-ICT-00159
EKS-LAC-00165
EKS-LOA-00163
EKS-MAM-00162
EKS-MAE-00060
EKS-MEG-00130
EKS-MOD-00162
EKS-MUM-00169
EKS-MUP-00168
EKS-MYL-00173
EKS-NOL-00157
EKS-ORN-00204
EKS-ORA-00141
EKS-ORC-00151
EKS-ORL-00189
EKS-OTG-00168
EKS-PAT-00154
EKS-PES-00145
EKS-PEM-00087
EKS-POA-00160
EKS-RAN-00161
EKS-SAH-00158
EKS-SUS-00141
EKS-TAG-00191
EKS-TAR-00211
EKS-TEN-00204
EKS-XET-00152
EKS-XIM-00199
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013