EKS-AIM-00297

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00297

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	336.1	1.5E-100	34	292	259

Status

Unreviewed

Ensembl Protein

ENSAMEP00000019000

UniProt Accession

D2GXY5;

Protein Name

Protein Synonyms/Alias

Gene Name

SLK

Gene Synonyms/Alias

SLK; PANDA_001804;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000017981	ENSAMEP00000019000	ENSAMET00000019761

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

1242

Protein Sequence
(FASTA)

MSFFNFRKIF KLGSEKKKKQ YEHVKRDLNP EEFWEIIGEL GDGAFGKVYK AQNKETNVLA 60

AAKVIDTKSE EELEDYMVEI DILASCDHPN IVKLLDAFYY ENNLWILIEF CAGGAVDAVM 120

LELERPLTES QIQVVCKQTL EALNYLHDNK IIHRDLKAGN ILFTLDGDIK LADFGVSAKN 180

TRTIQRRDSF IGTPYWMAPE VVMCETSKDR PYDYKADVWS LGITLIEMAE IEPPHHELNP 240

MRVLLKIAKS EPPTLAQPSK WSSNFKDFLK KCLEKNVDSR WTTSQLLQHP FVTVDSNKPI 300

RELIAEAKAE VTEEVEDGKE EDDDEETENS LPIPASKRAS SDLSIASSEE DKLSQNACIL 360

ESVSEKTERN ASEDKFNSKV LNEKLATDEP EKAAEGINEH INDVHLEAMA EFHNRTTVIE 420

ESGREEKRPK LENLPDTEDQ EIVDINSVSE GKENNIMITL KTDIEQNLTP EEERDQEKQQ 480

IFESKIMKSE EIKDTAIQTM DSVSQETGEK EADIQPVESE VVLTKEDTQE KLGKDDKILE 540

DVISNTSNLI GTNEEGDVAQ KGVENNAEDA QSNDGKEMVG IDQKLVSKPT EGPEAGGTEE 600

VPIKDVVETN KIDQKSVEDR DEEQLINSLE NIVKTNEESG TNQSEEITES GSTEEREIIR 660

EVTHTDQQGL GSETRDAQEA TAQIDTEQKA IPCEMPIKTE PQVTPSSQPS EPQPIPIPSI 720

NINSEDAENK GEIGALSKTE TMLLPESENQ KENDTDSGTG STADNSSIDL NLSISSFLSK 780

TKDSGSISLQ ETRRQKKTLK KTRKFVVDGV EVSVTTSKIV TDSDSKTEEL RFLRRQELRE 840

LRFLQKEEQR AQQQLNSKLQ QQREQIFRRF EQEMMSKKRQ YDQEIENLEK QQKQTIERLE 900

QEHTNRLRDE AKRIKGEQEK ELSKFQNMLK NRKKEVINEV EKAPKELRKE LMKRRKEELA 960

QSQHAQEQEF VQKQQQELDG SLKKIIQQQK AELANIEREC LNNKQQLMRA REAAIWELEE 1020

RHLQEKHQLL KQQLKDQYFM QRHQLLKRHE KETEQMQRYN QRLIEELKNR QTQERARLPK 1080

IQRSEAKTRM AMFKKSLRIN STATPDQDRD KIKQFAAQEE KRQKNERMAQ HQKHENQMRD 1140

LQLQCEANVR ELHQLQNEKC HLLVEHETQK LKELDEEHSQ ELKEWREKLR PRKKTLEEEF 1200

ARKLQEQEVF FKMTGESECL NPSTQSRISK FYPIPSLHST GS 1242

Nucleotide Sequence
(FASTA)

ATGTCCTTCT TCAATTTCCG TAAGATCTTC AAGTTGGGGA GCGAGAAGAA GAAGAAGCAA 60

TACGAGCATG TGAAGAGGGA TCTGAACCCC GAGGAGTTTT GGGAAATTAT AGGAGAATTG 120

GGGGACGGAG CCTTTGGGAA AGTGTACAAG GCCCAGAATA AAGAGACCAA TGTTTTAGCT 180

GCTGCAAAGG TGATTGACAC GAAATCTGAA GAAGAACTTG AAGATTACAT GGTTGAGATT 240

GATATATTAG CGTCTTGTGA TCACCCAAAT ATAGTCAAAC TTCTGGATGC CTTCTATTAT 300

GAGAACAATC TTTGGATCCT CATTGAATTT TGTGCAGGTG GAGCAGTGGA TGCTGTGATG 360

CTTGAACTTG AGAGACCATT AACTGAGTCC CAAATACAAG TAGTTTGTAA ACAGACTCTA 420

GAGGCCTTGA ACTACTTGCA TGATAATAAA ATCATCCACC GAGATCTAAA GGCTGGCAAC 480

ATTCTTTTTA CCTTAGATGG AGATATTAAG TTGGCGGATT TCGGAGTATC AGCTAAAAAC 540

ACAAGGACAA TTCAAAGAAG AGATTCCTTT ATTGGCACAC CATATTGGAT GGCTCCTGAA 600

GTAGTCATGT GTGAAACATC TAAGGACAGA CCCTATGACT ACAAAGCTGA TGTTTGGTCC 660

CTGGGTATCA CTTTAATAGA AATGGCTGAG ATAGAACCAC CTCATCATGA ATTAAATCCA 720

ATGCGAGTGC TGCTAAAAAT AGCAAAATCA GAGCCCCCTA CATTAGCACA GCCATCAAAA 780

TGGTCTTCAA ATTTTAAGGA CTTTCTAAAA AAATGCTTGG AAAAGAATGT GGATTCCAGG 840

TGGACTACAT CTCAGCTACT GCAACATCCC TTTGTTACGG TTGATTCCAA CAAACCAATT 900

CGGGAGCTGA TTGCAGAGGC AAAGGCTGAA GTAACAGAAG AAGTTGAAGA TGGCAAAGAG 960

GAAGATGATG ATGAGGAAAC AGAAAATTCT TTGCCAATAC CCGCAAGTAA GCGTGCCTCA 1020

TCTGACCTCA GTATTGCCAG CTCTGAGGAA GATAAACTTT CACAAAATGC TTGTATTTTG 1080

GAATCTGTCT CAGAAAAAAC AGAACGTAAT GCTTCTGAAG ATAAATTTAA CAGCAAAGTT 1140

CTTAATGAAA AACTCGCCAC TGATGAACCT GAAAAAGCTG CAGAGGGTAT TAATGAACAT 1200

ATTAATGATG TTCACTTAGA AGCTATGGCT GAATTTCATA ATAGAACAAC AGTAATCGAG 1260

GAAAGTGGGA GAGAAGAGAA GAGACCCAAG CTTGAAAATT TGCCTGACAC AGAAGACCAA 1320

GAAATAGTGG ACATTAATTC AGTCAGTGAA GGAAAAGAGA ATAACATAAT GATAACTTTA 1380

AAAACAGATA TTGAACAGAA TCTGACACCT GAGGAAGAAA GGGATCAGGA AAAGCAACAG 1440

ATATTTGAAA GTAAGATTAT GAAATCTGAA GAAATTAAAG ATACTGCTAT TCAAACAATG 1500

GATTCAGTTT CTCAAGAGAC TGGAGAAAAA GAGGCAGACA TTCAGCCAGT TGAAAGTGAA 1560

GTTGTGCTTA CAAAGGAAGA CACCCAAGAG AAATTGGGAA AAGATGACAA AATTCTAGAA 1620

GATGTGATCA GCAATACAAG CAATTTGATA GGAACAAATG AGGAAGGAGA TGTTGCTCAA 1680

AAGGGAGTTG AAAACAATGC TGAGGATGCT CAGAGTAATG ATGGGAAAGA AATGGTTGGA 1740

ATAGACCAGA AATTAGTAAG TAAGCCCACA GAGGGTCCTG AGGCTGGTGG TACTGAGGAA 1800

GTTCCTATTA AAGACGTAGT GGAAACTAAT AAGATAGATC AGAAATCTGT GGAAGATAGA 1860

GATGAGGAAC AATTAATCAA CAGTTTAGAG AACATAGTGA AGACCAATGA GGAATCTGGG 1920

ACAAATCAAA GTGAGGAAAT TACTGAGTCC GGTAGCACTG AAGAAAGAGA GATCATACGT 1980

GAGGTAACTC ATACTGACCA GCAAGGTTTA GGAAGTGAAA CTCGGGATGC TCAGGAAGCC 2040

ACTGCTCAGA TAGATACAGA GCAAAAAGCA ATTCCATGTG AGATGCCGAT TAAAACAGAA 2100

CCTCAGGTGA CTCCCTCTTC ACAGCCTAGT GAACCTCAGC CTATTCCAAT ACCCAGTATT 2160

AATATCAACT CTGAAGATGC AGAAAATAAA GGAGAAATAG GTGCTTTATC AAAAACTGAA 2220

ACCATGCTGC TTCCAGAATC CGAGAATCAA AAGGAAAATG ATACTGATTC AGGCACTGGT 2280

TCCACTGCTG ATAATAGCAG CATTGACTTG AATTTATCCA TCTCTAGCTT CCTAAGCAAA 2340

ACTAAAGACA GTGGATCAAT ATCTTTGCAA GAAACAAGAA GACAAAAGAA AACATTGAAG 2400

AAAACACGCA AATTTGTTGT TGATGGTGTA GAAGTGAGTG TAACAACGTC AAAGATAGTT 2460

ACAGATAGTG ATTCCAAAAC TGAAGAGCTG AGGTTTCTTA GACGTCAGGA ACTTCGGGAG 2520

TTAAGATTCC TTCAAAAAGA AGAGCAAAGA GCCCAACAAC AGCTCAATAG CAAGCTGCAA 2580

CAACAGCGAG AACAAATTTT CCGGCGTTTT GAGCAAGAAA TGATGAGCAA AAAGCGACAA 2640

TATGATCAAG AAATTGAGAA TCTAGAAAAA CAGCAGAAAC AGACGATCGA ACGTCTAGAA 2700

CAAGAACACA CAAATCGCTT ACGAGATGAG GCCAAACGCA TTAAAGGAGA ACAAGAGAAA 2760

GAGTTGTCCA AATTTCAGAA TATGTTAAAG AACCGAAAGA AGGAGGTTAT AAATGAAGTG 2820

GAGAAAGCAC CCAAAGAGCT GAGAAAAGAG CTCATGAAAC GCAGGAAAGA GGAGCTTGCG 2880

CAAAGCCAGC ATGCTCAGGA ACAGGAATTT GTTCAGAAGC AACAACAAGA ATTAGATGGC 2940

TCTCTGAAAA AGATCATCCA GCAGCAGAAG GCAGAGCTAG CCAATATTGA AAGAGAGTGC 3000

CTGAATAACA AACAGCAACT CATGAGAGCT CGAGAAGCTG CAATTTGGGA ACTTGAAGAA 3060

CGACACTTAC AAGAAAAACA CCAGCTGCTC AAACAGCAAC TTAAAGATCA GTATTTCATG 3120

CAAAGACATC AGCTACTTAA GCGCCATGAG AAGGAAACAG AACAAATGCA GCGTTACAAT 3180

CAACGACTTA TTGAGGAATT AAAAAACAGA CAGACTCAAG AAAGAGCAAG ACTGCCTAAG 3240

ATCCAGCGCA GTGAAGCCAA GACTCGAATG GCCATGTTTA AGAAAAGCTT GAGAATTAAC 3300

TCAACGGCCA CACCAGATCA GGACCGTGAC AAAATTAAGC AGTTTGCTGC TCAAGAAGAA 3360

AAGAGGCAGA AAAATGAGAG AATGGCTCAG CATCAAAAAC ACGAAAATCA GATGCGGGAT 3420

CTTCAATTGC AGTGTGAAGC CAACGTCCGA GAGCTGCATC AGCTGCAGAA TGAAAAATGC 3480

CACCTATTGG TTGAACACGA GACTCAGAAA CTGAAGGAGT TAGATGAGGA ACACAGCCAA 3540

GAATTAAAGG AGTGGAGAGA GAAATTGAGA CCCAGGAAAA AGACACTGGA AGAAGAGTTT 3600

GCCAGGAAAC TGCAGGAACA GGAGGTGTTC TTTAAAATGA CTGGGGAGTC TGAGTGCCTT 3660

AACCCATCAA CACAGAGCCG GATTTCCAAG TTCTATCCTA TTCCTAGCTT GCATTCCACT 3720

GGGTCGTAA 3729

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +e++ e+g+Ga+gkvy+a++k+t+ l+a k+i+++++e+le+++ ei +l +++hpniv+

Q: 34    WEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVK  93

         78999*******************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +l++f++e++lw+++e++agG+++ ++  el+++l+E+qi+++++++l+aL+ylH++k+i

Q: 94    LLDAFYYENNLWILIEFCAGGAVDAVML-ELERPLTESQIQVVCKQTLEALNYLHDNKII  152

         **************************99.9******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe...ekgY  177

         Hrd+ka+niL+t +g++kL+dfgv+a+ ++t ++r++++gtpywmAPEv+ +e   ++ Y

Q: 153   HRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCEtskDRPY  212

         ****************************************************9998999*

S: 178   dekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekc  237

         d+kaD+wslGIt+ie+ae epP+++l+p+++llki+k+epp+l +++k+s++fk+f++kc

Q: 213   DYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSKWSSNFKDFLKKC  272

         ************************************************************

S: 238   lqknpekRpsasellkhkFl  257

         l+kn+++R+++s+ll+h+F+

Q: 273   LEKNVDSRWTTSQLLQHPFV  292

         *******************7

Domain Sequence
(FASTA)

WEIIGELGDG AFGKVYKAQN KETNVLAAAK VIDTKSEEEL EDYMVEIDIL ASCDHPNIVK 60

LLDAFYYENN LWILIEFCAG GAVDAVMLEL ERPLTESQIQ VVCKQTLEAL NYLHDNKIIH 120

RDLKAGNILF TLDGDIKLAD FGVSAKNTRT IQRRDSFIGT PYWMAPEVVM CETSKDRPYD 180

YKADVWSLGI TLIEMAEIEP PHHELNPMRV LLKIAKSEPP TLAQPSKWSS NFKDFLKKCL 240

EKNVDSRWTT SQLLQHPFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

aml:100480047

;

InterPros

IPR011009	; Kinase-like_dom.
IPR022165	; PKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001943	; UVR_dom.

Pfam

PF00069	; Pkinase; 1.
PF12474	; PKK; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50151	; UVR; 1.

Prints

Created Date

20-Feb-2013