EKS-AIM-00223

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00223

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	381.1	2.1E-114	57	309	253

Status

Unreviewed

Ensembl Protein

ENSAMEP00000019158

UniProt Accession

G1MIH3;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK2

Gene Synonyms/Alias

MARK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000018111	ENSAMEP00000019158	ENSAMET00000019921

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

784

Protein Sequence
(FASTA)

YLSDGISEGR QSPCSDPVIH LQPTLGHLDP KPSSKSNMLR GRNSAASADE QPHIGNYRLL 60

KTIGKGNFAK VKLARHILTG KEVAVKIIDK TQLNSSSLQK LFREVRIMKV LNHPNIVVKL 120

FEVIETEKTL YLVMEYASGG EVFDYLVAHG RMKEKEARAK FRQIVSAVQY CHQKFIVHRD 180

LKAENLLLDA DMNIKIADFG FSNEFTFGNK LDTFCGSPPY AAPELFQGKK YDGPEVDVWS 240

LGVILYTLVS GSLPFDGQNL KELRERVLRG KYRIPFYMST DCENLLKKFL ILNPSKRGTL 300

EQIMKDRWMN VGHEDDELKP YVEPLPDYKD PRRTELMVSM GYTREEIQDS LVGQRYNEVM 360

ATYLLLGYKS SELEGDTITL KPRPSADLTN SSAPSPSHKV QRSVSANPKQ RRFSDQAAGP 420

AIPTSNSYSK KTQSNNAENK RPEEDRESGR KASSTAKVPA SPLPGLERKK TTPTPSTNSV 480

LSTSTNRSRN SPLLERASLG QASIQNGKDS LTMPGSRAST ASASAAVSAA RPRQHQKSMS 540

ASMHPNKATG LPPTDSNCEV PRPSTAPQRV PVASPSAHNI SSSGGAPDRT NFPRGVSSRS 600

TFHAGQLRQV RDQQNLPYGV TPASPSGNSQ GRRGASGSIF SKFTSKFVRR NLNEPESKDR 660

VETLRPHVVG GGGNDKDKEE FREAKPRSLR FTWSMKTTSS MEPNEMMREI RKVLDANSCQ 720

SELHEKYMLL CMHGTPGHEN FVQWEMEVCK LPRLSLNGVR FKRISGTSMA FKNIASKIAN 780

ELKL 784

Nucleotide Sequence
(FASTA)

TATTTGAGCG ATGGGATATC TGAGGGCAGA CAGTCGCCTT GCTCAGACCC TGTCATTCAC 60

CTGCAGCCCA CCCTGGGACA CCTCGACCCC AAGCCCAGCA GTAAGTCCAA CATGCTGCGG 120

GGCCGCAACT CAGCCGCCTC TGCTGACGAG CAGCCCCACA TCGGCAACTA CCGACTCCTT 180

AAGACCATCG GCAAGGGCAA CTTCGCCAAG GTGAAGCTGG CTCGGCACAT CCTGACTGGG 240

AAAGAGGTAG CTGTGAAGAT CATTGACAAG ACCCAACTGA ACTCCTCCAG CCTCCAGAAA 300

CTGTTCCGCG AAGTAAGAAT AATGAAGGTT TTGAATCATC CCAACATAGT AGTTAAGTTA 360

TTTGAAGTGA TCGAGACTGA GAAAACTCTA TACCTTGTCA TGGAGTATGC CAGTGGAGGA 420

GAGGTGTTTG ACTACCTGGT GGCTCATGGC AGGATGAAAG AAAAAGAGGC TCGAGCCAAA 480

TTCCGCCAGA TAGTGTCTGC TGTGCAGTAC TGCCACCAGA AGTTTATTGT GCATAGAGAC 540

TTAAAGGCAG AAAACTTGCT CTTGGATGCT GATATGAACA TCAAGATTGC AGACTTTGGC 600

TTCAGCAACG AATTCACCTT TGGGAACAAG CTGGATACCT TCTGTGGCAG TCCCCCGTAT 660

GCTGCCCCAG AGCTCTTCCA GGGCAAAAAA TACGATGGAC CCGAGGTAGA TGTGTGGAGC 720

CTGGGAGTTA TCCTGTATAC ACTGGTCAGT GGATCCCTGC CTTTTGATGG ACAGAACCTC 780

AAGGAGCTAC GGGAGCGGGT ACTGAGGGGA AAATACCGCA TTCCGTTCTA CATGTCCACG 840

GACTGTGAAA ACCTGCTTAA GAAATTTCTC ATTCTCAACC CCAGCAAGAG AGGCACTTTA 900

GAGCAAATCA TGAAAGATCG ATGGATGAAT GTGGGTCACG AAGATGATGA ATTAAAGCCT 960

TATGTGGAGC CACTCCCTGA CTACAAGGAC CCCCGGCGGA CAGAATTGAT GGTGTCCATG 1020

GGTTACACAC GGGAAGAGAT CCAGGACTCA CTGGTGGGCC AGAGGTACAA CGAGGTGATG 1080

GCCACCTATC TGCTCCTGGG CTACAAGAGC TCTGAGTTGG AGGGCGACAC CATCACCTTG 1140

AAGCCCCGGC CTTCAGCTGA TCTGACCAAT AGCAGTGCCC CTTCCCCCTC CCACAAGGTA 1200

CAGCGTAGTG TCTCGGCCAA CCCCAAGCAG CGGCGCTTCA GTGACCAGGC AGCTGGTCCT 1260

GCCATTCCCA CATCTAATTC CTACTCTAAG AAGACGCAGA GTAACAACGC AGAGAATAAG 1320

CGGCCTGAGG AAGACCGGGA GTCAGGGCGG AAGGCCAGCA GCACAGCCAA AGTGCCTGCC 1380

AGCCCCCTGC CTGGCCTGGA GAGGAAGAAG ACCACCCCTA CCCCCTCCAC GAACAGCGTC 1440

CTCTCCACCA GCACAAATCG AAGCAGGAAT TCCCCACTTT TGGAGAGGGC CAGCCTTGGC 1500

CAGGCCTCCA TCCAGAACGG CAAAGACAGC CTAACCATGC CAGGGTCCCG GGCCTCCACG 1560

GCTTCTGCTT CCGCCGCGGT CTCTGCGGCC CGGCCCCGCC AGCACCAGAA ATCCATGTCG 1620

GCCTCCATGC ACCCCAACAA GGCCACTGGG CTGCCCCCCA CGGACAGTAA CTGTGAGGTG 1680

CCGCGGCCCA GCACAGCCCC CCAGCGTGTC CCTGTCGCCT CCCCCTCCGC CCACAACATC 1740

AGCAGCAGCG GTGGAGCCCC AGACCGAACT AATTTCCCCC GGGGTGTGTC CAGTCGAAGC 1800

ACCTTCCACG CTGGACAGCT CCGGCAGGTG CGGGACCAGC AGAATTTGCC CTACGGTGTG 1860

ACCCCAGCCT CTCCCTCTGG CAACAGCCAG GGCCGGCGGG GGGCCTCGGG GAGCATCTTC 1920

AGCAAATTCA CTTCCAAGTT TGTACGCAGG AACCTGAATG AACCTGAAAG CAAAGACCGA 1980

GTGGAGACGC TCAGACCTCA CGTGGTGGGC GGCGGAGGCA ACGACAAAGA CAAGGAGGAG 2040

TTTCGGGAGG CCAAGCCGCG CTCTCTGCGC TTCACGTGGA GCATGAAGAC CACCAGCTCC 2100

ATGGAGCCCA ACGAGATGAT GCGGGAGATC CGCAAGGTGC TGGACGCGAA CAGCTGTCAG 2160

AGCGAGCTGC ACGAGAAGTA CATGCTGCTG TGCATGCACG GCACGCCGGG CCACGAGAAC 2220

TTCGTGCAGT GGGAGATGGA GGTGTGCAAA CTGCCGCGGC TGTCTCTCAA CGGTGTCCGA 2280

TTTAAGCGGA TATCGGGCAC CTCCATGGCC TTCAAAAACA TTGCCTCCAA AATAGCCAAC 2340

GAGCTCAAGC TTTAA 2355

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++vavKii+k++l+++sl+k++rE++i+k l+hpni

Q: 57    YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI  116

         99*********************************************************8

S: 61    .ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgi  119

          +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k i

Q: 117   vVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI  176

         369*********************************************************

S: 120   vHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkv  179

         vHrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+v

Q: 177   VHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV  236

         ************************************************************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         DvWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+k+L  +p+k

Q: 237   DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK  296

         ************************************************************

S: 240   Ratieeilkhewl  252

         R t+e+i+k++w+

Q: 297   RGTLEQIMKDRWM  309

         ************8

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH ILTGKEVAVK IIDKTQLNSS SLQKLFREVR IMKVLNHPNI 60

VVKLFEVIET EKTLYLVMEY ASGGEVFDYL VAHGRMKEKE ARAKFRQIVS AVQYCHQKFI 120

VHRDLKAENL LLDADMNIKI ADFGFSNEFT FGNKLDTFCG SPPYAAPELF QGKKYDGPEV 180

DVWSLGVILY TLVSGSLPFD GQNLKELRER VLRGKYRIPF YMSTDCENLL KKFLILNPSK 240

RGTLEQIMKD RWM 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0045180	; C:basal cortex
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030010	; P:establishment of cell polarity
GO:0045197	; P:establishment or maintenance of epithelial cell apical/basal polarity
GO:0007243	; P:intracellular protein kinase cascade
GO:0010976	; P:positive regulation of neuron projection development
GO:0050770	; P:regulation of axonogenesis
GO:0006979	; P:response to oxidative stress

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013