EKS-AIM-00410

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00410

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	488.7	4.4E-147	76	344	269

Status

Unreviewed

Ensembl Protein

ENSAMEP00000019239

UniProt Accession

G1MIQ4;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPB

Gene Synonyms/Alias

CDC42BPB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000018199	ENSAMEP00000019239	ENSAMET00000020005

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

1715

Protein Sequence
(FASTA)

MSAKVRLKKL EQLLLDGPWR NESALSVETL LDVLVCLYTE CSHSALRRDK YVAEFLEWAK 60

PFTQLVKEMQ LHREDFEIIK VIGRGAFGEV AVVKMKNTER IYAMKILNKW EMLKRAETAC 120

FREERDVLVN GDCQWITTLH YAFQDENYLY LVMDYYVGGD LLTLLSKFED KLPEDMARFY 180

IGEMVLAIDS IHQLHYVHSN RDIKPDNVLL DVNGHIRLAD FGSCLKMNDD GTVQSSVAVG 240

TPDYISPEIL QAMEDGMGKY GPECDWWSLG VCMYEMLYGE TPFYAESLVE TYGKIMNHEE 300

RFQFPSHVTD VSEEAKDLIQ RLICSRERRL GQNGIEDFKK HAFFEGLNWE NIRNLEAPYI 360

PDVSSPSDTS NFDVDDDMLR NIEILPPGSH TGFSGLHLPF IGFTFTTESC FSDRGSLKSI 420

MQSSTLTKDE GVQRDLENSL QVEAYERRIR RLEQEKLELS RKLQESTQTV QSLHGSARAL 480

GGAARDKEIK KLNEEIERLK NKIADSNRLE RQLEDTVTLR QEHEDSTHRL KGLEKQYRVV 540

RQEKEDFHKQ LVEASERLKS QARELKDAHQ QRKLALQEFS ELNERMAELR SQKQKVSRQL 600

RDKEEEAEVA MQKIDSMRQE MRKSEKFRKE LEARLEDAIA EASRERKLRE HSENFSKQVE 660

SELEALKMKQ GGRGPGATLE HQQEISKIKS ELEKKVLFYE EELVRREASH VLEVKNVKKE 720

VHDSESHQLA LQKEVLMLKD KLEKSKRERH TEMEEAVGTV RDKYERERAL LLEENKKLTA 780

ENERLCSFVD KLTAQNRQLE DELQDLAAKK ESVAHWEAQI AEIIQWVSDE KDARGYLQAL 840

ASKMTEELET LRSSSLGSRA LDPLWKVRRS QKLDMSARLE LQSALEAEIR AKQLVQEELR 900

KVKDTNLSFE SKLKDSEAKN RELLEEMEIL KKRMEEKFRA DTGLKLADFQ DSIFEYFNTA 960

PLAHDLTFRI GSAGEQETQA PKPEVSPSVS LAASTEQQED MARAMQRPPT VPLPTTQPLA 1020

LAGPKPKAHQ FSIKSFSSPT QCSHCTSLMV GLIRQGYACE VCSFACHVSC KESAPQVCPI 1080

PPEQSKRPLG VDVQRGIGTA YKGYVKVPKP TGVKKGWQRA YAVVCDCKLF LYDLPEGKST 1140

QPGVVASQVL DLRDEEFSVS SVLASDVIHA SRRDIPCIFR VTASLLGTPS KTSSLLILTE 1200

NENEKRKWVG ILEGLQSILH KNRLRNQVVH VPQEAYDSTL PLIKAVLSAA VLDGDRIVVG 1260

LEEGLYVIEV TRDVIVRVAD YKKVYQIELA PKEKVAVLLC GRNHHVHLCP WSAFDGAESN 1320

VDIKLPETKG CQLIATATLK KSSSTCLFAA VKRLVLCYEV QRTRPFHRKV NEIVAPGTVQ 1380

WMAVLKDKLC VGYPSGFSLL SPQGDGQALT LVNPNDPSLT FLSQQSFDAL CAVELKSEEY 1440

LLCFSHMGLY VDPQGRRSRM QELMWPAAPV ACSCSPSHVT VYSEYGVDVF DVRTMEWVQT 1500

IGLRRVRPGA GRGGLLPAPG GRAARSHRVV PVPAGTALNV PDTSDNSKKQ MLRTRSKRRF 1560

VFKVPEEERL QSLREMLRDP ELRSKMISNP TNFNHVAHMG PGDGMQVLMD LPLSAVPPSQ 1620

EERPGPAPPG LSRQPPPRNK PYISWPSSGG SEPGVAVPLR SMSDPDQDFD KEPDSDSTKH 1680

STPSNSSNPS GPPSPNSPHR SQLPLEGLEQ PAYDA 1715

Nucleotide Sequence
(FASTA)

ATGTCTGCCA AGGTGCGGCT CAAGAAGCTG GAGCAGCTGC TCCTGGACGG GCCCTGGCGC 60

AACGAGAGCG CCCTGAGCGT GGAGACGCTG CTCGACGTGC TCGTCTGCCT GTACACCGAG 120

TGCAGCCACT CGGCCCTGCG GCGCGACAAG TATGTGGCCG AGTTCCTCGA GTGGGCCAAA 180

CCATTTACAC AACTGGTGAA GGAGATGCAA CTTCATCGAG AAGACTTCGA AATAATTAAA 240

GTGATCGGAA GAGGGGCTTT TGGAGAGGTT GCTGTTGTCA AAATGAAGAA CACTGAACGG 300

ATCTATGCCA TGAAAATCCT CAACAAGTGG GAAATGCTTA AAAGAGCAGA GACTGCTTGT 360

TTCCGAGAAG AACGTGATGT GCTGGTGAAC GGGGACTGCC AGTGGATCAC GACGCTGCAC 420

TACGCCTTTC AGGACGAGAA CTACCTGTAC TTAGTCATGG ATTACTATGT GGGAGGTGAT 480

TTACTGACCC TGCTCAGTAA ATTTGAAGAC AAGCTTCCAG AAGATATGGC AAGATTCTAC 540

ATTGGTGAAA TGGTGTTGGC CATCGATTCC ATCCATCAGC TTCACTATGT GCACAGTAAC 600

AGAGACATTA AACCTGACAA TGTCCTTTTG GACGTGAATG GTCATATTCG CCTGGCTGAC 660

TTTGGATCAT GCTTGAAGAT GAATGACGAT GGAACTGTCC AGTCCTCTGT GGCCGTGGGC 720

ACTCCTGACT ACATCTCACC TGAGATCCTG CAGGCGATGG AGGACGGCAT GGGCAAGTAC 780

GGCCCTGAGT GTGACTGGTG GTCGCTGGGT GTCTGCATGT ACGAGATGCT GTACGGAGAA 840

ACGCCCTTCT ATGCAGAGTC ACTCGTGGAG ACCTATGGAA AGATCATGAA CCACGAAGAG 900

CGATTTCAGT TTCCGTCCCA TGTCACCGAC GTGTCTGAAG AAGCCAAAGA CCTCATTCAG 960

AGACTCATCT GCAGCAGAGA GCGCCGGCTG GGACAGAACG GGATAGAGGA CTTCAAAAAG 1020

CACGCGTTCT TTGAAGGTCT GAATTGGGAA AACATACGGA ACCTGGAAGC ACCTTATATT 1080

CCTGATGTGA GCAGCCCTTC TGACACCTCC AACTTTGATG TGGATGACGA CATGCTAAGA 1140

AATATTGAAA TATTACCTCC TGGTTCTCAT ACAGGCTTCT CTGGGCTACA TTTGCCATTC 1200

ATCGGTTTTA CTTTCACAAC GGAAAGCTGC TTTTCCGACC GAGGCTCTCT GAAGAGCATA 1260

ATGCAGTCCA GCACCTTGAC CAAAGACGAG GGTGTGCAGC GGGACCTGGA GAACAGCCTG 1320

CAGGTGGAAG CCTATGAGCG GCGGATCCGG AGGCTGGAGC AGGAGAAGCT GGAGCTGAGC 1380

CGGAAGCTGC AGGAGTCCAC CCAGACCGTG CAGTCGCTGC ACGGCTCTGC CCGCGCCCTG 1440

GGTGGCGCGG CCCGGGACAA AGAAATCAAA AAGCTCAATG AGGAGATCGA GCGTCTGAAG 1500

AATAAAATAG CAGATTCAAA CAGGCTTGAG CGGCAGCTGG AGGACACGGT GACGCTTCGC 1560

CAAGAACACG AGGACTCCAC ACATCGGCTG AAAGGCCTGG AAAAGCAGTA CCGTGTGGTG 1620

CGGCAGGAGA AGGAGGATTT TCACAAGCAA TTGGTTGAAG CTTCAGAGCG ATTGAAATCC 1680

CAGGCCAGAG AACTCAAAGA TGCCCACCAG CAGCGAAAGC TGGCCTTGCA GGAGTTCTCG 1740

GAGCTCAACG AGCGCATGGC AGAGCTCCGC TCCCAGAAGC AGAAGGTGTC CCGGCAGCTC 1800

CGCGACAAAG AGGAGGAGGC GGAGGTGGCC ATGCAGAAGA TCGACTCCAT GCGGCAGGAA 1860

ATGCGCAAGT CTGAGAAGTT CAGGAAAGAG CTGGAAGCTC GGCTGGAGGA TGCCATTGCT 1920

GAGGCCTCCA GGGAGCGCAA GCTTCGTGAA CACAGCGAGA ACTTCTCCAA GCAAGTGGAA 1980

AGTGAGCTTG AGGCCCTGAA GATGAAGCAA GGAGGCCGGG GACCGGGGGC CACCTTAGAA 2040

CATCAGCAGG AGATTTCCAA AATCAAATCT GAGCTTGAGA AGAAAGTCCT GTTTTATGAA 2100

GAGGAATTGG TCAGGCGTGA GGCCTCCCAT GTGCTGGAAG TCAAAAACGT GAAGAAGGAG 2160

GTGCACGATT CGGAGAGCCA CCAGCTGGCC CTGCAAAAAG AAGTTCTTAT GTTAAAAGAC 2220

AAATTGGAGA AGTCAAAGCG AGAGCGGCAC ACAGAAATGG AGGAGGCGGT AGGCACAGTA 2280

AGAGATAAGT ATGAGCGCGA GAGAGCCTTG CTGCTGGAGG AGAACAAGAA GCTCACGGCT 2340

GAGAACGAGA GGCTTTGTTC CTTTGTGGAT AAACTCACAG CTCAAAATAG ACAGCTGGAG 2400

GATGAGCTGC AGGACCTGGC AGCCAAGAAG GAGTCGGTTG CCCACTGGGA AGCTCAGATT 2460

GCAGAGATCA TTCAGTGGGT CAGCGACGAG AAAGATGCCC GAGGTTATCT TCAGGCCCTT 2520

GCTTCGAAGA TGACCGAAGA GCTTGAGACT CTGAGGAGCT CCAGTCTGGG GTCAAGAGCA 2580

CTGGATCCCC TTTGGAAAGT TCGCCGGAGT CAGAAGCTAG ACATGTCCGC ACGGCTAGAA 2640

CTGCAGTCTG CTCTTGAGGC AGAGATCCGG GCCAAACAGC TTGTTCAAGA GGAGCTGAGG 2700

AAAGTCAAAG ACACGAATCT CTCCTTTGAA AGTAAACTAA AGGATTCCGA AGCCAAAAAT 2760

AGAGAATTAT TAGAAGAAAT GGAAATTTTG AAGAAAAGGA TGGAAGAAAA ATTTAGAGCA 2820

GATACTGGAC TCAAACTTGC AGATTTTCAG GATTCTATTT TTGAGTATTT CAACACTGCA 2880

CCTCTTGCAC ACGATCTGAC GTTTCGAATC GGCTCAGCTG GGGAGCAAGA AACACAGGCT 2940

CCGAAGCCAG AGGTGTCCCC ATCGGTTTCT TTGGCCGCAA GCACAGAACA GCAGGAAGAC 3000

ATGGCTCGGG CCATGCAGAG GCCACCCACT GTGCCGCTGC CCACCACGCA GCCCCTCGCT 3060

CTGGCCGGAC CAAAGCCAAA AGCTCACCAG TTCAGCATCA AGTCCTTCTC CAGCCCAACA 3120

CAGTGCAGCC ACTGCACATC CCTGATGGTG GGGCTGATCC GGCAGGGCTA CGCCTGCGAG 3180

GTGTGCTCGT TTGCTTGCCA TGTGTCCTGC AAAGAGAGCG CTCCCCAGGT GTGCCCCATC 3240

CCTCCTGAGC AGTCCAAGCG GCCTCTGGGC GTGGACGTGC AGAGGGGCAT AGGAACAGCT 3300

TACAAGGGCT ACGTCAAGGT CCCGAAGCCC ACTGGGGTGA AGAAAGGATG GCAGCGGGCT 3360

TACGCAGTAG TCTGTGACTG CAAGCTGTTT CTGTATGACC TGCCCGAAGG AAAATCCACC 3420

CAGCCTGGTG TTGTCGCCAG CCAGGTCCTG GACCTCAGAG ATGAGGAGTT CTCAGTGAGC 3480

TCAGTCCTGG CCTCAGACGT CATACATGCT TCCCGCCGAG ACATCCCGTG TATCTTCAGG 3540

GTGACAGCCT CTCTCTTAGG GACACCTTCT AAGACCAGCT CACTGCTCAT TCTGACAGAA 3600

AATGAGAACG AAAAGAGGAA GTGGGTTGGT ATTCTAGAAG GACTGCAGTC AATCCTCCAC 3660

AAGAACCGCT TGAGGAACCA GGTCGTGCAT GTCCCGCAGG AGGCCTACGA CAGCACTCTG 3720

CCTCTCATCA AGGCCGTCCT GAGCGCCGCC GTCCTGGATG GAGATAGGAT CGTGGTTGGC 3780

CTGGAAGAAG GGCTCTATGT CATAGAGGTG ACCCGCGATG TGATCGTCCG TGTTGCCGAC 3840

TACAAGAAAG TCTACCAGAT CGAGCTTGCT CCCAAAGAGA AAGTCGCTGT CCTCCTCTGC 3900

GGCCGGAATC ACCACGTCCA TCTCTGTCCG TGGTCTGCCT TCGATGGGGC AGAAAGTAAT 3960

GTCGACATCA AGCTCCCAGA AACAAAAGGC TGCCAGCTCA TAGCGACCGC AACACTGAAG 4020

AAGAGCTCCT CCACCTGCCT GTTTGCGGCT GTGAAACGGC TGGTCCTTTG CTATGAGGTC 4080

CAGAGAACTA GGCCTTTCCA CAGGAAGGTC AATGAAATTG TGGCCCCTGG CACTGTGCAG 4140

TGGATGGCCG TGCTCAAGGA CAAGCTCTGT GTTGGCTACC CTTCTGGGTT CTCTCTGCTG 4200

AGCCCCCAGG GGGACGGGCA GGCTCTAACC CTGGTAAATC CCAATGACCC CTCGCTTACG 4260

TTCCTCTCAC AGCAGTCTTT TGATGCCCTT TGTGCTGTGG AGCTCAAAAG CGAGGAGTAC 4320

CTGCTTTGCT TCAGCCACAT GGGACTGTAC GTGGACCCAC AAGGTCGGAG GTCACGCATG 4380

CAGGAGCTCA TGTGGCCTGC GGCGCCTGTT GCCTGTAGTT GCAGCCCGTC CCACGTCACG 4440

GTGTACAGCG AGTACGGCGT GGACGTGTTC GACGTGCGCA CCATGGAATG GGTTCAGACC 4500

ATCGGCCTGC GCAGGGTAAG GCCCGGGGCG GGGCGGGGCG GCCTCCTGCC GGCCCCCGGC 4560

GGGAGGGCCG CCCGGAGCCA CAGGGTCGTC CCTGTTCCCG CAGGGACAGC CCTCAACGTG 4620

CCCGACACCT CCGATAACAG CAAGAAGCAG ATGCTCCGGA CCAGGAGCAA GAGGCGCTTT 4680

GTCTTCAAAG TGCCCGAGGA GGAGAGGCTG CAGTCCCTCA GAGAGATGCT CAGAGACCCA 4740

GAACTGAGAT CCAAAATGAT ATCCAACCCG ACCAACTTCA ACCACGTGGC CCACATGGGC 4800

CCGGGTGATG GAATGCAGGT GCTCATGGAC TTGCCTCTGA GCGCCGTGCC CCCCTCCCAG 4860

GAGGAAAGGC CTGGCCCTGC TCCCCCCGGC CTGTCCCGGC AGCCTCCCCC CAGGAACAAG 4920

CCCTACATCT CGTGGCCCTC ATCAGGTGGG TCAGAGCCCG GAGTGGCTGT GCCTCTTAGG 4980

AGTATGTCCG ACCCCGACCA GGACTTCGAC AAAGAGCCTG ACTCCGATTC GACCAAACAC 5040

TCGACTCCAT CAAACAGCTC CAACCCCAGC GGCCCCCCCA GCCCCAACTC ACCGCACAGG 5100

AGCCAGCTCC CCCTTGAAGG CCTGGAGCAA CCAGCCTACG ACGCCTGA 5148

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         fei+kviGrGafgevavv++k+te++yamkil+k+e+lkrae+a+freerdvlv++d++w

Q: 76    FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQW  135

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqde+ylylvm+y+vGGdlltllsk+edklpe++arfy+ e+vla+ds+h+l+

Q: 136   ITTLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLH  195

         ************************************************************

S: 121   yvh..rdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkalee  178

         yvh  rdikpdn+lld++Ghi+ladfGsclk+n+dgtv+ssvavGtpdyispe+l+a+e+

Q: 196   YVHsnRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMED  255

         ***999******************************************************

S: 179   gkgeygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseea  237

         g+g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nh+e+++fp+++ +vseea

Q: 256   GMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVtDVSEEA  315

         ****************************************************99******

S: 238   kdlikklltsreerlgregiedlkkhpff  266

         kdli++l++sre+rlg++gied+kkh+ff

Q: 316   KDLIQRLICSRERRLGQNGIEDFKKHAFF  344

         ****************************9

Domain Sequence
(FASTA)

FEIIKVIGRG AFGEVAVVKM KNTERIYAMK ILNKWEMLKR AETACFREER DVLVNGDCQW 60

ITTLHYAFQD ENYLYLVMDY YVGGDLLTLL SKFEDKLPED MARFYIGEMV LAIDSIHQLH 120

YVHSNRDIKP DNVLLDVNGH IRLADFGSCL KMNDDGTVQS SVAVGTPDYI SPEILQAMED 180

GMGKYGPECD WWSLGVCMYE MLYGETPFYA ESLVETYGKI MNHEERFQFP SHVTDVSEEA 240

KDLIQRLICS RERRLGQNGI EDFKKHAFF 269

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0042641	; C:actomyosin
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0031032	; P:actomyosin structure organization
GO:0016477	; P:cell migration
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013