EKS-AIM-00141
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00141
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR525.72.0E-158476752277
StatusUnreviewed
Ensembl ProteinENSAMEP00000019241
UniProt AccessionG1MIQ6;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR4
Gene Synonyms/Alias FGFR4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000018201ENSAMEP00000019241ENSAMET00000020007
OrganismAiluropoda melanoleuca
Functional Description
Protein Length809
Protein Sequence
(FASTA)
VSRDACALPV QHVLQTQAAP SAGAVGLTDL CPWPTEPCLA PSPEQQEQEL TVALGQPVRL 60
CCGRAERGGH WYKEGSRLPP AGRVRGWRSR LEIASFLPED AGCYLCLARG SMLVLHNVTL 120
VVDVPDIDSS TSSNGNEDPK AHGGPLNGHI YPQQAPYWTH PQRMEKKLHA VPAGNTVKFR 180
CPAAGNPTPT IRWLKDGQDF HGEHRIGGIR LRHQHWSLVM ESVVPSDRGT YTCLVENSMG 240
SLRYSYLLDV LERSPHRPIL QAGLPANTTA VAGSDVELLC KVYSDAQPHI QWLKHIVING 300
SSFRADGFPY VQVLKTADIN SSEVEVLYLR NVSAEDAGEY TCLAGNSIGL SYQSAWLTVL 360
PEEDLTWTAA APEARYTDII LYVSGSLALV VLLLLAGLYR GQVLISQHPR QPTTVQKLSR 420
FPLARQFSLE SGSSAKSSSS LVRGVRLSSS GPPLLAGLVS LDLPLDPLWE FPRDRLVLGK 480
PLGEGCFGQV VRAEAFGMDP ARPDQASTVA VKMLKDNASD KDLADLVSEM EVMKLIGRHK 540
NIINLLGVCT QEGPLYVIVE CAAKGNLREF LRARRPPGPD LSPDGPRSSE GPLSFPALVS 600
CAYQVARGMQ YLESRKCIHR DLAARNVLVT EDNAMKIADF GLARGIHHID YYKKTSNGRL 660
PVKWMAPEAL FDRVYTHQSD VWSFGILLWE IFTLGGSPYP GIPVEELFSL LREGHRMDRP 720
PNCPPELYGL MRECWHAAPS QRPTFKQLVE ALDKVLLAVS EEYLDLRLTF GPYSPAGGDA 780
SSCSSNDSVF CHDPLPLGPS SFSFPGAET 809
Nucleotide Sequence
(FASTA)
GTGTCCAGGG ATGCTTGTGC CCTGCCTGTG CAGCATGTTC TCCAGACACA GGCGGCTCCC 60
TCAGCTGGGG CTGTGGGGCT CACTGACCTC TGCCCTTGGC CCACAGAGCC CTGCCTGGCC 120
CCCAGCCCGG AGCAGCAAGA GCAGGAGCTG ACCGTGGCCC TCGGGCAGCC CGTGCGGCTA 180
TGCTGTGGGC GGGCTGAGCG TGGTGGCCAC TGGTACAAGG AGGGCAGTCG CCTACCACCT 240
GCTGGCCGGG TACGAGGCTG GAGGAGCCGC TTGGAGATCG CCAGCTTCCT ACCGGAGGAC 300
GCCGGCTGCT ACCTCTGCCT GGCACGAGGC TCCATGCTTG TCCTGCACAA TGTTACCTTG 360
GTTGTGGATG TCCCTGACAT AGACTCCTCG ACCTCCAGCA ATGGTAATGA GGACCCTAAG 420
GCCCATGGGG GCCCCTTGAA CGGGCATATT TACCCCCAGC AAGCTCCCTA CTGGACACAC 480
CCTCAGCGCA TGGAGAAGAA ACTGCACGCA GTGCCTGCTG GGAACACGGT CAAGTTCCGC 540
TGTCCAGCTG CAGGCAACCC CACACCCACC ATCCGCTGGC TCAAGGACGG ACAGGACTTC 600
CACGGGGAGC ATCGCATCGG AGGCATTCGG CTGCGCCACC AGCACTGGAG CCTGGTGATG 660
GAAAGCGTGG TGCCCTCGGA CCGTGGCACA TACACTTGCC TCGTGGAGAA CTCGATGGGC 720
AGCCTCCGCT ATAGCTATCT GCTGGACGTG CTGGAGCGGT CCCCGCACCG GCCCATCCTG 780
CAGGCGGGGC TCCCGGCCAA CACAACAGCT GTGGCAGGCA GCGATGTGGA GCTGCTGTGT 840
AAGGTGTACA GCGACGCCCA GCCCCACATC CAGTGGCTGA AGCACATCGT CATCAACGGC 900
AGCAGTTTCA GGGCCGACGG CTTCCCCTAC GTGCAAGTCC TGAAGACAGC AGACATCAAT 960
AGCTCAGAGG TGGAGGTCCT GTACCTTCGG AACGTGTCAG CTGAGGATGC GGGCGAATAC 1020
ACCTGCCTGG CGGGCAACTC CATTGGCCTC TCCTACCAGT CCGCCTGGCT CACAGTGCTG 1080
CCAGAGGAGG ACCTCACATG GACAGCAGCA GCGCCTGAGG CCAGGTACAC GGACATCATT 1140
CTGTACGTGT CCGGCTCTCT GGCTTTGGTT GTCCTCCTGC TGCTAGCTGG GCTGTACCGA 1200
GGGCAGGTTC TCATCAGCCA GCACCCCAGG CAGCCCACCA CTGTGCAGAA GTTGTCCCGC 1260
TTCCCTCTGG CCCGACAGTT CTCACTGGAG TCTGGTTCTT CGGCCAAGTC AAGCTCCTCC 1320
TTGGTGCGGG GTGTCCGTCT GTCCTCCAGT GGCCCTCCCT TGCTCGCTGG CCTTGTGAGT 1380
CTAGACCTAC CTCTCGACCC ACTGTGGGAG TTCCCCCGGG ACAGGCTGGT GCTCGGGAAG 1440
CCGCTGGGTG AGGGCTGCTT CGGGCAGGTG GTGCGTGCGG AGGCCTTTGG CATGGACCCC 1500
GCCCGGCCTG ACCAAGCCAG CACCGTGGCT GTCAAGATGC TCAAGGACAA TGCCTCCGAC 1560
AAGGACTTGG CAGACCTGGT CTCTGAGATG GAGGTGATGA AGCTGATTGG CCGACACAAG 1620
AACATTATCA ATCTGCTGGG CGTCTGTACT CAGGAAGGGC CCCTGTATGT GATTGTGGAG 1680
TGTGCCGCCA AGGGAAACCT GCGGGAGTTC CTGCGGGCCC GGCGGCCCCC AGGCCCTGAC 1740
CTCAGCCCTG ACGGGCCGAG GAGCAGTGAG GGGCCGCTTT CCTTCCCTGC CCTGGTGTCC 1800
TGCGCCTACC AGGTGGCCCG AGGCATGCAG TATCTAGAGT CGAGGAAGTG CATCCACCGG 1860
GACCTGGCTG CCCGAAACGT ACTGGTGACA GAGGACAATG CGATGAAGAT CGCCGACTTC 1920
GGGCTGGCCC GCGGCATCCA CCACATTGAC TACTACAAGA AAACCAGCAA TGGCCGCCTG 1980
CCTGTCAAGT GGATGGCACC TGAGGCCTTA TTTGACCGAG TCTACACACA TCAGAGTGAC 2040
GTGTGGTCGT TCGGGATCCT GCTGTGGGAG ATCTTCACCC TCGGGGGCTC CCCGTACCCC 2100
GGCATCCCCG TGGAGGAGCT ATTCTCACTG CTGCGGGAGG GGCATCGGAT GGACCGGCCC 2160
CCGAACTGCC CCCCAGAGCT GTACGGGCTG ATGCGGGAGT GCTGGCACGC AGCACCCTCT 2220
CAGAGGCCTA CGTTCAAGCA GCTGGTGGAG GCACTGGACA AGGTCCTGCT GGCCGTCTCC 2280
GAGGAGTACC TAGACCTCCG CCTGACCTTC GGACCCTACT CCCCTGCCGG CGGGGACGCC 2340
AGCAGCTGCT CCTCCAATGA CTCTGTCTTC TGCCACGACC CCCTGCCCCT GGGGCCCAGC 2400
TCCTTCTCCT TCCCGGGGGC GGAGACATGA 2430
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         lvlgk+lGeG+fGqvv+aea+g+d  ++++++tvavkmlk++a+dkdladlvsemev+kl
Q: 476   LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKL  535
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iG+hkniinllG+ctqeGplyvive+aakGnlreflrarrp+g + s d +++se  l++
Q: 536   IGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSF  595
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
           lvs+ayqvarGm+yl+s+kcihrdlaarnvlvtedn +kiadfGlar++h+idyykkt
Q: 596   PALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNAMKIADFGLARGIHHIDYYKKT  655
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         +nGrlpvkwmapealfdrvyt+qsdvwsfG+llwei+tlGgspypgi+veelf+ll+eGh
Q: 656   SNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH  715
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm++p +c+ ely lmrecwha++s+rptfkqlve+l
Q: 716   RMDRPPNCPPELYGLMRECWHAAPSQRPTFKQLVEAL  752
         **********************************986
Domain Sequence
(FASTA)
LVLGKPLGEG CFGQVVRAEA FGMDPARPDQ ASTVAVKMLK DNASDKDLAD LVSEMEVMKL 60
IGRHKNIINL LGVCTQEGPL YVIVECAAKG NLREFLRARR PPGPDLSPDG PRSSEGPLSF 120
PALVSCAYQV ARGMQYLESR KCIHRDLAAR NVLVTEDNAM KIADFGLARG IHHIDYYKKT 180
SNGRLPVKWM APEALFDRVY THQSDVWSFG ILLWEIFTLG GSPYPGIPVE ELFSLLREGH 240
RMDRPPNCPP ELYGLMRECW HAAPSQRPTF KQLVEAL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>
EKS-ANC-00141
EKS-BOT-00149
EKS-CAF-00157
EKS-CAP-00150
EKS-EQC-00148
EKS-FEC-00139
EKS-GAA-00174
EKS-ICT-00143
EKS-LOA-00148
EKS-MOD-00149
EKS-MUM-00154
EKS-MUP-00154
EKS-MYL-00158
EKS-ORC-00140
EKS-PAT-00140
EKS-RAN-00148
EKS-SAH-00144
EKS-SUS-00130
EKS-TAG-00178
EKS-XET-00138
Gene Ontology
GO:0005911; C:cell-cell junction
GO:0005783; C:endoplasmic reticulum
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008201; F:heparin binding
GO:0061144; P:alveolar secondary septum development
GO:0016477; P:cell migration
GO:0042593; P:glucose homeostasis
GO:0001759; P:organ induction
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0055062; P:phosphate ion homeostasis
GO:0008284; P:positive regulation of cell proliferation
GO:2000573; P:positive regulation of DNA biosynthetic process
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048554; P:positive regulation of metalloenzyme activity
GO:0045862; P:positive regulation of proteolysis
GO:0046777; P:protein autophosphorylation
GO:0070857; P:regulation of bile acid biosynthetic process
GO:2000188; P:regulation of cholesterol homeostasis
GO:0010715; P:regulation of extracellular matrix disassembly
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013