EKS-AIM-00251

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00251

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	445.6	1.0E-133	159	479	321

Status

Unreviewed

Ensembl Protein

ENSAMEP00000019263

UniProt Accession

G1MIS8;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK1A

Gene Synonyms/Alias

DYRK1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000018223	ENSAMEP00000019263	ENSAMET00000020029

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

763

Protein Sequence
(FASTA)

LLVGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMPHSHQY SDRRQPNISD QQVSALSYSD 60

PIQQPLTNQV MPDIVMLQRR MPQTFRDPAT APLRKLSVDL IKTYKHINEV YYAKKKRRHQ 120

QGQGDDSSHK KERKVYNDGY DDDNYDYIVK NGEKWMDRYE IDSLIGKGSF GQVVKAYDRV 180

EQEWVAIKII KNKKAFLNQA QIEVRLLELM NKHDTEMKYY IVHLKRHFMF RNHLCLVFEM 240

LSYNLYDLLR NTNFRGVSLN LTRKFAQQMC TALLFLATPE LSIIHCDLKP ENILLCNPKR 300

SAIKIVDFGS SCQLGQRIYQ YIQSRFYRSP EVLLGMPYDL AIDMWSLGCI LVEMHTGEPL 360

FSGANEVDQM NKIVEVLSIP PAHILDQAPK ARKFFEKLPD GTWNLKKTKD GKREYKPPGT 420

RKLHNILGVE TGGPGGRRAG ESGHTVADYL KFKDLILRML DYDPKTRIQP YYALQHSFFK 480

KTADEGTNTS NSVSTSPAME QSQSSGTTSS TSSSSGGSSG TSNSGRARSD PTHQHRHSGG 540

HFTAAVQAMD CETHSPQVRQ QFPAPLGWSG TEAPTQVTVE THPVQETTFH VAPQQNALHH 600

HHGNSSHHHH HHHHHHHHHG QQALGNRTRP RVYNSPTNSS STQDSMEVGH SHHSMTSLSS 660

STTSSSTSSS STGNQGNQAY QNRPVAANTL DFGQNGAMDV NLTVYSNPRQ ETGIAGHPTY 720

QFSANTGPTH YMTEGHLTMR QGADREESPM TGVCVQQSSV ASS 763

Nucleotide Sequence
(FASTA)

CTTCTTGTAG GAGGAGAGAC TTCAGCATGC AAACCTTCAT CTGTTCGGCT TGCACCGTCA 60

TTTTCATTCC ATGCTGCTGG CCTTCAGATG GCTGGACAGA TGCCCCATTC ACATCAGTAC 120

AGTGACCGTC GCCAGCCAAA CATAAGTGAC CAACAGGTTT CTGCCTTATC TTATTCTGAC 180

CCGATTCAGC AACCTCTAAC TAACCAGGTG ATGCCTGATA TTGTCATGTT ACAGAGGCGG 240

ATGCCCCAAA CCTTCCGTGA TCCAGCAACT GCTCCCCTGA GAAAACTTTC TGTTGACTTG 300

ATCAAAACAT ATAAGCATAT TAATGAGGTT TACTATGCAA AAAAGAAGCG AAGACACCAA 360

CAGGGCCAGG GAGACGATTC TAGTCATAAG AAGGAGCGGA AGGTTTATAA TGATGGTTAT 420

GATGATGATA ACTATGATTA TATTGTAAAA AACGGAGAGA AGTGGATGGA TCGTTACGAA 480

ATTGACTCCT TGATTGGCAA AGGTTCCTTT GGACAGGTTG TAAAGGCATA TGATCGTGTG 540

GAGCAAGAAT GGGTTGCCAT TAAAATAATA AAGAACAAGA AGGCTTTTCT GAATCAAGCC 600

CAAATAGAAG TGCGACTTCT TGAGCTCATG AACAAACATG ACACTGAAAT GAAATACTAC 660

ATAGTGCATT TGAAACGCCA CTTTATGTTT CGAAACCATC TCTGTTTAGT TTTTGAAATG 720

CTGTCGTACA ACCTCTATGA CTTGTTGAGG AACACCAATT TTCGAGGTGT CTCTTTGAAC 780

CTAACACGAA AGTTTGCACA GCAGATGTGC ACTGCACTGC TTTTCCTCGC GACTCCAGAA 840

CTTAGTATCA TTCACTGTGA CCTAAAACCT GAGAATATCC TTCTTTGTAA CCCCAAACGC 900

AGTGCAATCA AGATCGTTGA CTTTGGCAGT TCCTGTCAAT TGGGGCAGAG GATATACCAG 960

TATATTCAGA GTCGCTTTTA TCGGTCTCCA GAGGTGCTAC TGGGAATGCC TTACGACCTT 1020

GCTATTGACA TGTGGTCCCT TGGGTGTATT TTGGTTGAAA TGCACACTGG AGAACCTCTG 1080

TTCAGTGGAG CCAATGAGGT AGATCAGATG AATAAAATAG TGGAAGTTCT GAGTATTCCA 1140

CCTGCTCATA TTCTTGACCA AGCACCAAAA GCAAGAAAGT TCTTTGAGAA GTTGCCAGAT 1200

GGCACTTGGA ACTTAAAGAA GACCAAAGAT GGAAAACGGG AGTATAAACC ACCAGGAACC 1260

CGTAAACTTC ATAATATTCT CGGAGTAGAA ACAGGAGGAC CTGGTGGGCG TCGTGCTGGG 1320

GAATCGGGTC ATACTGTAGC TGACTACTTG AAGTTCAAAG ACCTCATTTT AAGGATGCTT 1380

GATTATGACC CCAAAACTCG AATTCAACCT TACTATGCCC TGCAGCACAG TTTTTTCAAG 1440

AAAACAGCTG ACGAAGGCAC TAACACAAGT AATAGTGTGT CTACCAGCCC CGCGATGGAG 1500

CAGTCCCAGT CTTCGGGCAC CACCTCCAGT ACGTCTTCAA GCTCAGGTGG ATCGTCGGGG 1560

ACGAGCAACA GCGGGAGAGC CAGGTCAGAC CCGACGCACC AGCACCGGCA CAGCGGCGGG 1620

CACTTCACAG CTGCAGTCCA GGCCATGGAC TGTGAGACCC ACAGTCCCCA GGTGCGTCAG 1680

CAATTTCCTG CTCCCCTTGG TTGGTCAGGC ACTGAAGCTC CTACACAGGT CACTGTGGAA 1740

ACTCATCCCG TTCAAGAAAC AACCTTTCAT GTAGCCCCTC AGCAGAATGC ATTGCATCAT 1800

CACCATGGAA ACAGTTCCCA TCACCATCAC CACCACCATC ACCACCACCA CCACCATGGA 1860

CAACAAGCCT TGGGTAACCG GACCAGGCCA AGGGTCTACA ATTCTCCAAC GAATAGCTCC 1920

TCTACCCAGG ATTCTATGGA GGTTGGCCAT AGTCACCACT CCATGACATC CCTGTCTTCC 1980

TCAACTACTT CCTCCTCTAC ATCTTCCTCC TCGACTGGTA ATCAAGGCAA TCAGGCCTAC 2040

CAGAATCGCC CAGTGGCTGC TAATACCTTG GACTTTGGAC AGAATGGAGC TATGGACGTT 2100

AATTTAACCG TCTACTCCAA TCCCCGCCAA GAGACTGGCA TAGCTGGACA TCCAACATAC 2160

CAATTTTCTG CTAATACAGG TCCTACACAT TACATGACTG AAGGACATCT GACAATGAGG 2220

CAAGGGGCTG ATAGAGAAGA GTCCCCCATG ACAGGAGTTT GTGTGCAACA GAGTTCTGTA 2280

GCTAGCTCGT GA 2292

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         ye++++igkGsfgqVvka+d+ ++e+vaikiiknkk+f++qaq+Ev++Le +nk+d+e+k

Q: 159   YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK  218

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119

         y++v+l+++f+frnhlclvfe+ls+nLy+ll++++f+g+sl+l+rk+aqq+++aL +L+

Q: 219   YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAt  278

         **********************************************************99

S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++

Q: 279   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMP  337

         99*************************************.********************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238

         yd aiDmWSlGc+l+E++tG+pLf+G+nevdq+++ivevl +pp+++l++a ka+kff+k

Q: 338   YDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLSIPPAHILDQAPKARKFFEK  397

         ************************************************************

S: 239   keapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.f  288

           + ++ lk++          ++rk +++l+v++ +     p+ +++ge+ ++++d+l f

Q: 398   LPDGTWNLKKTkdgkreykpPGTRKLHNILGVETGG-----PGGRRAGESGHTVADYLkF  452

         ********9997777777777777777777777776.....99*****************

S: 289   kdllkrmleldpakRitpkealkhpfv  315

         kdl+ rml++dp++Ri+p++al+h+f+

Q: 453   KDLILRMLDYDPKTRIQPYYALQHSFF  479

         **************************7

Domain Sequence
(FASTA)

YEIDSLIGKG SFGQVVKAYD RVEQEWVAIK IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK 60

YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS LNLTRKFAQQ MCTALLFLAT 120

PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY 180

DLAIDMWSLG CILVEMHTGE PLFSGANEVD QMNKIVEVLS IPPAHILDQA PKARKFFEKL 240

PDGTWNLKKT KDGKREYKPP GTRKLHNILG VETGGPGGRR AGESGHTVAD YLKFKDLILR 300

MLDYDPKTRI QPYYALQHSF F 321

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0030529	; C:ribonucleoprotein complex
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0043518	; P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0090312	; P:positive regulation of protein deacetylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013