EKS-AIM-00373
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00373
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR610.78.6E-184593950358
StatusUnreviewed
Ensembl ProteinENSAMEP00000019410
UniProt AccessionG1MJ75;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRA
Gene Synonyms/Alias PDGFRA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000018351ENSAMEP00000019410ENSAMET00000020179
OrganismAiluropoda melanoleuca
Functional Description
Protein Length1089
Protein Sequence
(FASTA)
MRTSLLGFLI LGCLLTGPSR IFCQLSLPSI LPNENEKVVQ LNSSFSLRCF GESEVSWQYP 60
MSEEENPNVE IRNEENNSGL FVAVLEVVNA SAAHTGLYTC YYNHTQTEET DVEGRRIYIY 120
VPDPDVAFVP LGMTDYLVIV ENDDSAIIPC RTTDPKTPVT LRSNDRVVHA SYDSRQGFNG 180
TFSVGPYICE ATVRGKKFQT IPFNIYSLKA TSELDLEMEA LKTVYKSGET IVVTCAVFNN 240
EVVDLQWTYP GEVKGKGITM LEEIKVPSIK LVYTLRVPEA TVKDSGDYEC AARQATKEVK 300
EMKKVTISVY EKGFIEIKPN FSPLEAVDLH EVKHFVVDVQ AYPPPRISWL KDNLTLIENL 360
TEITTDIEKI QEIRYRSKLK LIRAKEEDSG HYTIVVQNED DVKSYTFELL TQVPSSILDL 420
VDDHHGSTGG QTVRCTAEGT PLPDIEWMIC KDIKKCNNET SWVILASNIS NIITEVHPRD 480
RNTVEGRVTF TRVEETIAVR CLAKNLLGAQ SRELKLVAPT LRSELTVAAA VLVLLVIVII 540
SLIVLVVIWK QKPRYEIRWR VIESISPDGH EYIYVDPMQL PYDSRWEFPR DGLVLGRILG 600
SGAFGKVVEG TAYGLSRSQP VMKVAVKMLK PTARSSEKQA LMSELKIMTH LGPHLNIVNL 660
LGACTKSGPI YIITEYCFYG DLVNYLHKNR DSFLSRHPEK PKKELDIFGL NPADDSTRSY 720
VILSFENNGD YMDMKQADAT QYVPMLERKE AAKYSDVQRS LYDRPASSKK KSVLDSEVKN 780
LLSDDNSEGL TLLDLLSFTY QVARGMEFLA SKNCVHRDLA ARNVLLAQGK IVKICDFGLA 840
RDIMHDSNYV SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS LGGTPYPGMM 900
VDSTFYNKIK SGYRMAKPDH ATSEVYEIMV KCWHSEPEKR PSFYHLSEIV ENLLPGQYKK 960
SYEKIHLDFL KSDHPAVARM RVDSDNAYIG VTYKNEEDKL KDWEGSLDEQ RLSADSGYII 1020
PLPDIDPVPE EEDLGKRNRH SSQTSEESAI ETGSSSSTFI KREDETIEDI DMMDDIGIDS 1080
SDLVEDSFL 1089
Nucleotide Sequence
(FASTA)
ATGAGGACTT CCCTTCTGGG CTTCCTGATC TTAGGCTGTC TCCTCACAGG GCCCAGCCGA 60
ATCTTCTGCC AGCTTTCATT ACCCTCCATC CTGCCAAACG AAAATGAAAA GGTCGTGCAG 120
CTGAATTCAT CCTTTTCTCT GAGATGCTTT GGGGAGAGTG AAGTGAGCTG GCAGTACCCC 180
ATGTCTGAAG AAGAGAACCC CAATGTGGAA ATCAGAAACG AGGAGAACAA CAGTGGCCTT 240
TTTGTGGCCG TGCTGGAAGT GGTCAACGCG TCGGCGGCAC ACACGGGCTT GTACACTTGC 300
TATTACAACC ACACGCAGAC GGAGGAGACC GACGTCGAGG GCCGGCGTAT CTACATCTAT 360
GTGCCAGACC CGGATGTAGC CTTTGTGCCT CTGGGAATGA CAGATTATTT AGTCATCGTG 420
GAGAATGATG ATTCTGCCAT CATACCATGT CGCACGACTG ATCCCAAGAC TCCGGTCACC 480
TTGCGCAGCA ATGACAGGGT GGTGCACGCC TCCTATGACA GCAGACAGGG CTTCAATGGG 540
ACCTTCAGCG TTGGGCCCTA TATCTGTGAA GCCACCGTCA GGGGAAAGAA GTTCCAGACC 600
ATCCCATTTA ATATTTATTC TTTAAAAGCA ACGTCAGAAC TTGATCTAGA AATGGAAGCT 660
CTTAAAACTG TGTATAAGTC AGGGGAGACG ATTGTGGTCA CCTGCGCCGT CTTTAACAAC 720
GAGGTGGTCG ACCTTCAGTG GACTTACCCT GGAGAAGTGA AAGGCAAAGG CATCACCATG 780
CTGGAGGAAA TCAAGGTCCC GTCCATCAAA TTGGTGTATA CTCTGAGGGT CCCTGAGGCC 840
ACGGTGAAAG ATAGTGGAGA TTATGAGTGT GCTGCCCGCC AGGCCACCAA GGAGGTCAAA 900
GAGATGAAGA AAGTCACCAT TTCTGTCTAT GAGAAAGGGT TCATTGAAAT CAAACCCAAC 960
TTCAGCCCAT TGGAAGCTGT CGACCTGCAT GAAGTCAAAC ATTTCGTGGT GGATGTGCAG 1020
GCCTACCCCC CTCCCAGGAT ATCCTGGCTG AAGGACAACC TGACTCTGAT TGAAAATCTC 1080
ACGGAGATCA CCACGGACAT AGAAAAGATT CAGGAAATAA GGTATCGGAG CAAATTAAAG 1140
CTGATCCGTG CTAAGGAGGA AGACAGTGGC CATTACACGA TTGTCGTTCA AAATGAAGAT 1200
GACGTGAAGA GCTACACTTT CGAACTCTTA ACGCAAGTTC CCTCATCTAT TCTGGACTTG 1260
GTGGACGACC ACCACGGCTC CACGGGGGGA CAGACCGTGA GATGCACCGC TGAAGGGACA 1320
CCTCTTCCTG ATATCGAGTG GATGATTTGC AAGGATATTA AGAAGTGTAA TAATGAAACT 1380
TCATGGGTGA TTTTGGCCAG CAATATCTCA AACATCATCA CGGAGGTCCA CCCCCGAGAC 1440
AGGAACACTG TGGAGGGCCG AGTGACGTTC ACCAGAGTGG AGGAGACCAT CGCCGTTCGA 1500
TGTCTGGCCA AGAATCTCCT TGGGGCCCAG AGCCGCGAGC TCAAGCTGGT GGCCCCCACG 1560
CTGCGCTCTG AGCTCACTGT GGCCGCTGCC GTCCTCGTGC TGCTGGTGAT TGTGATCATC 1620
TCCCTTATCG TCCTGGTTGT CATTTGGAAA CAGAAACCGA GGTATGAAAT TCGCTGGAGG 1680
GTCATTGAAT CCATCAGCCC GGATGGACAT GAATATATTT ATGTGGACCC AATGCAGCTG 1740
CCTTATGACT CGAGATGGGA GTTTCCAAGA GATGGACTAG TGCTTGGTCG TATCCTGGGA 1800
TCTGGCGCGT TTGGGAAAGT GGTTGAAGGA ACTGCCTATG GATTAAGCCG CTCCCAGCCT 1860
GTCATGAAGG TAGCAGTGAA GATGCTGAAA CCCACAGCCA GATCCAGTGA GAAACAGGCT 1920
CTTATGTCGG AACTGAAGAT AATGACTCAC CTGGGGCCGC ATTTAAACAT TGTGAACTTG 1980
CTGGGAGCCT GTACCAAGTC AGGCCCTATT TACATCATCA CTGAGTACTG CTTCTATGGG 2040
GATTTGGTCA ACTATTTGCA TAAGAATCGG GATAGCTTCC TGAGCCGCCA CCCAGAGAAG 2100
CCAAAGAAAG AGCTGGACAT TTTTGGATTG AACCCTGCCG ACGACAGCAC ACGGAGTTAC 2160
GTCATTTTAT CTTTTGAAAA CAATGGTGAC TACATGGACA TGAAGCAAGC TGACGCCACC 2220
CAGTACGTCC CCATGCTGGA AAGGAAAGAG GCTGCCAAGT ACTCGGACGT CCAGAGGTCG 2280
CTGTATGATC GCCCGGCCTC GTCTAAGAAG AAGTCTGTGT TAGACTCAGA AGTCAAAAAC 2340
CTCCTTTCGG ATGATAACTC AGAAGGCCTT ACTTTGTTGG ATTTGTTGAG CTTTACCTAT 2400
CAAGTTGCGC GAGGAATGGA ATTTTTGGCT TCGAAAAATT GTGTCCACCG GGACCTGGCT 2460
GCTCGAAACG TCCTCCTGGC GCAAGGGAAA ATCGTGAAGA TCTGTGACTT CGGCCTGGCC 2520
AGAGATATCA TGCACGATTC GAACTACGTG TCAAAAGGCA GTACCTTTCT CCCCGTGAAG 2580
TGGATGGCCC CTGAGAGCAT CTTCGACAAC CTCTACACCA CACTGAGTGA CGTCTGGTCT 2640
TACGGCATTC TGCTCTGGGA GATCTTTTCC CTCGGCGGCA CACCCTACCC CGGCATGATG 2700
GTGGATTCTA CTTTCTACAA TAAGATTAAG AGTGGGTACC GGATGGCCAA GCCTGACCAC 2760
GCCACCAGTG AAGTCTACGA GATCATGGTG AAATGCTGGC ACAGTGAGCC GGAGAAGAGA 2820
CCCTCCTTCT ACCACCTGAG TGAGATTGTG GAGAATCTGC TGCCCGGACA GTATAAGAAG 2880
AGTTACGAAA AGATTCACCT GGACTTCCTG AAGAGCGACC ACCCCGCCGT GGCGCGCATG 2940
CGCGTGGACT CAGACAACGC CTACATTGGC GTTACCTACA AAAACGAGGA AGACAAGCTG 3000
AAGGACTGGG AGGGCAGCCT GGACGAGCAG AGGCTGAGTG CGGACAGCGG CTACATCATC 3060
CCCCTGCCCG ACATCGACCC TGTCCCTGAG GAGGAGGACC TGGGCAAGAG GAACAGACAC 3120
AGCTCGCAGA CCTCCGAAGA GAGCGCTATC GAGACAGGTT CGAGTAGCTC CACCTTCATC 3180
AAGAGAGAGG ACGAGACCAT CGAGGACATC GACATGATGG ATGACATTGG CATAGACTCC 3240
TCAGACCTGG TAGAGGACAG TTTCCTGTGA 3270
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 593   LVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  652
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++r+sfl+++ ek   +++eld+++
Q: 653   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSRHPEK---PKKELDIFG  709
         *********************************************999...9999*****
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         l +ad s+rs+++ls+e++++y+d+k++                +sdv++s +d++as+k
Q: 710   LnPADDSTRSYVILSFENNGDYMDMKQAdatqyvpmlerkeaakYSDVQRSLYDRPASSK  769
         *9*************************99*******************************
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
         kks+l++evk+ l++++se+l+l dllsf+yqva+Gmeflaskncvhrdlaarnvll++G
Q: 770   KKSVLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQG  829
         ************************************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillweif
Q: 830   KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF  889
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         slG+tpypg++vds+fy++ik+Gyrma+p++at+e+yeim+kcw++epekrpsf++l+e+
Q: 890   SLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWHSEPEKRPSFYHLSEI  949
         *********************************************************998
S: 344   l  344
         +
Q: 950   V  950
         6
Domain Sequence
(FASTA)
LVLGRILGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRDS FLSRHPEKPK KELDIFGLNP 120
ADDSTRSYVI LSFENNGDYM DMKQADATQY VPMLERKEAA KYSDVQRSLY DRPASSKKKS 180
VLDSEVKNLL SDDNSEGLTL LDLLSFTYQV ARGMEFLASK NCVHRDLAAR NVLLAQGKIV 240
KICDFGLARD IMHDSNYVSK GSTFLPVKWM APESIFDNLY TTLSDVWSYG ILLWEIFSLG 300
GTPYPGMMVD STFYNKIKSG YRMAKPDHAT SEVYEIMVKC WHSEPEKRPS FYHLSEIV 358
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0030325; P:adrenal gland development
GO:0055003; P:cardiac myofibril assembly
GO:0060326; P:cell chemotaxis
GO:0071230; P:cellular response to amino acid stimulus
GO:0007204; P:elevation of cytosolic calcium ion concentration
GO:0048701; P:embryonic cranial skeleton morphogenesis
GO:0048557; P:embryonic digestive tract morphogenesis
GO:0008210; P:estrogen metabolic process
GO:0030198; P:extracellular matrix organization
GO:0060325; P:face morphogenesis
GO:0001701; P:in utero embryonic development
GO:0033327; P:Leydig cell differentiation
GO:0030324; P:lung development
GO:0001553; P:luteinization
GO:0030539; P:male genitalia development
GO:0072277; P:metanephric glomerular capillary formation
GO:0010544; P:negative regulation of platelet activation
GO:0042475; P:odontogenesis of dentin-containing tooth
GO:0060021; P:palate development
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0070527; P:platelet aggregation
GO:0035790; P:platelet-derived growth factor receptor-alpha signaling pathway
GO:0030335; P:positive regulation of cell migration
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0045740; P:positive regulation of DNA replication
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863; P:positive regulation of phospholipase C activity
GO:0050920; P:regulation of chemotaxis
GO:2000739; P:regulation of mesenchymal stem cell differentiation
GO:0061298; P:retina vasculature development in camera-type eye
GO:0023019; P:signal transduction involved in regulation of gene expression
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
KEGG
aml:100464991;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013