EKS-AIM-00374
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00374
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR601.65.1E-181585920336
StatusUnreviewed
Ensembl ProteinENSAMEP00000019453
UniProt AccessionG1MJB7;
Protein Name
Protein Synonyms/Alias
Gene NameKIT
Gene Synonyms/Alias KIT;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000018372ENSAMEP00000019453ENSAMET00000020222
ENSAMEG00000018372ENSAMEP00000019452ENSAMET00000020221
OrganismAiluropoda melanoleuca
Functional Description
Protein Length972
Protein Sequence
(FASTA)
ARSPRSFWFL FCFVLFCFVL IAGSSQPSVS PGELSLPSIH PAKSELIVSA GDEIRLLCTD 60
PGFVKWTFET PGQLSENTHN EWITEKAQAA NTGNYTCTNR DGLSRSIYVF VRDPAELFLV 120
DLRLYGKEDN DTLVRCPLTD PEVTNYSLRG CEGKPLPKDL TFVADPKAGI TIRNVKREYH 180
RLCLHCSADQ KGKSVLSAKF TLKVRAAIRA VPVVSVSKAS SLLREGEEFS VTCLVKDVSS 240
SVDSMWIKEN SQTNAQTQSN SWHQGDFNFV RQERLTISSA RVNDSGVFMC YANNTFGSAN 300
VTTTLEVVDK GFINIFPMMN TTIFVNDGEN VDLVVEYEAY PRPEHRHWVY MNRSFADKWE 360
DYPKSDNESN IRYVSELHLT RLKGNEGGTY TFQVSNSDVS SSVTFNVYVN TKPEILTHES 420
LVNGMLQCVV AGFPEPTVDW YFCPGTEQRC SAPVGPMDVQ MQNSSVAPSG KLVVQSSIDY 480
SAFKHNGTVE CRAYNNVGRS SAFFNFAFKE QIHPHTLFTP LLIGFVIAAG MMCIIVMILT 540
YKYLQKPMYE VQWKVVEEIN GNNYVYIDPT QLPYDHKWEF PRNRLSFGKT LGAGAFGKVV 600
EATAYGLIKS DAAMTVAVKM LKPSAHLTER EALMSELKVL SYLGNHMNIV NLLGACTVGG 660
PTLVITEYCC YGDLLNFLRR KRDSFICSKQ EDHAEVALYK NLLHSKESSC NDSTNEYMDM 720
KPGVSYVVPT KADKRRSARI GSYIERDVTP AIMEDDELAL DLEDLLSFSY QVAKGMAFLA 780
SKNCIHRDLA ARNILLTHGR ITKICDFGLA RDIKNDSNYV VKGNARLPVK WMAPESIFNC 840
VYTFESDVWS YGIFLWELFS LGSSPYPGMP VDSKFYKMIK EGFRMLSPEH APAEMYDIMK 900
TCWDADPLKR PTFKQMVQLI EKQISESTNH IYSNLANCSP RQERPAVDHS VRINSVGSSA 960
SSTQPLLVHE DV 972
Nucleotide Sequence
(FASTA)
GCTCGCTCAC CCAGGTCATT TTGGTTTTTG TTTTGTTTTG TTTTGTTTTG TTTTGTTTTG 60
ATAGCAGGCT CTTCTCAACC ATCTGTGAGT CCAGGGGAAC TGTCTCTACC ATCCATCCAT 120
CCAGCAAAAT CAGAGTTAAT AGTCAGCGCT GGCGACGAGA TTAGGCTGTT ATGCACCGAT 180
CCAGGATTTG TCAAGTGGAC TTTTGAGACC CCGGGTCAAT TGAGTGAGAA CACACACAAC 240
GAGTGGATCA CAGAGAAAGC GCAGGCCGCC AACACAGGCA ATTACACGTG CACCAACAGA 300
GACGGCTTAA GCAGGTCCAT TTATGTGTTT GTTAGAGATC CTGCAGAGCT TTTCCTCGTT 360
GACCTTCGCT TGTATGGGAA AGAAGACAAT GATACGCTGG TCCGCTGTCC TCTGACAGAC 420
CCAGAGGTGA CCAATTACTC CCTGAGGGGG TGCGAGGGGA AGCCTCTTCC CAAGGACCTG 480
ACGTTTGTCG CTGATCCCAA GGCTGGCATC ACGATCAGAA ACGTGAAGCG CGAGTATCAT 540
CGGCTCTGCT TGCACTGCTC TGCAGACCAG AAGGGCAAGT CCGTGCTGTC CGCGAAATTC 600
ACCCTGAAAG TGAGGGCAGC CATCAGAGCT GTACCGGTGG TGTCGGTGTC CAAAGCAAGC 660
TCTCTTCTTA GGGAAGGGGA AGAATTCTCT GTGACGTGCT TGGTAAAGGA TGTGTCTAGT 720
TCCGTGGACT CCATGTGGAT CAAGGAGAAC AGCCAGACTA ACGCGCAGAC GCAGAGTAAT 780
AGTTGGCATC AGGGTGACTT CAATTTTGTA CGTCAGGAAA GGCTGACGAT CAGCTCAGCA 840
AGAGTTAATG ATTCTGGAGT GTTCATGTGT TATGCCAATA ATACTTTCGG ATCGGCAAAT 900
GTCACAACAA CATTGGAAGT CGTAGATAAA GGATTCATCA ATATCTTCCC CATGATGAAT 960
ACTACGATAT TTGTGAATGA TGGAGAGAAC GTGGATCTGG TTGTTGAATA TGAGGCATAC 1020
CCCAGACCTG AGCACCGGCA CTGGGTCTAC ATGAACAGAT CCTTCGCTGA TAAATGGGAA 1080
GATTATCCCA AGTCTGACAA TGAGAGTAAT ATCAGATATG TGAGTGAACT TCATCTAACC 1140
AGATTAAAAG GGAATGAAGG AGGCACTTAC ACGTTTCAAG TGTCCAATTC CGATGTCAGT 1200
TCTTCCGTGA CATTTAATGT TTATGTGAAC ACAAAACCAG AAATCCTGAC TCATGAAAGT 1260
CTCGTGAACG GTATGCTCCA GTGTGTGGTA GCAGGATTCC CAGAGCCCAC AGTAGATTGG 1320
TATTTTTGTC CAGGAACCGA GCAGAGATGT TCCGCTCCTG TTGGGCCAAT GGACGTGCAG 1380
ATGCAAAACT CATCTGTAGC ACCGTCTGGA AAACTCGTGG TTCAGAGCTC CATTGATTAC 1440
AGTGCATTCA AGCACAACGG CACAGTCGAG TGTAGGGCTT ACAACAATGT GGGCAGGAGT 1500
TCTGCCTTTT TTAACTTTGC ATTTAAAGAA CAAATCCATC CCCACACCCT GTTCACACCT 1560
TTGCTGATTG GTTTTGTGAT CGCAGCTGGT ATGATGTGCA TTATCGTGAT GATTCTTACC 1620
TACAAATATT TGCAGAAACC CATGTATGAA GTGCAGTGGA AGGTGGTTGA GGAGATAAAT 1680
GGAAACAATT ACGTTTACAT AGACCCAACA CAGCTTCCTT ACGATCATAA ATGGGAGTTT 1740
CCCAGAAACA GGCTGAGTTT TGGGAAGACT TTGGGTGCCG GTGCCTTCGG GAAAGTGGTT 1800
GAGGCCACTG CGTATGGCCT CATTAAGTCG GATGCGGCCA TGACTGTTGC CGTCAAGATG 1860
CTCAAACCAA GTGCCCATTT AACCGAACGA GAAGCCCTAA TGTCTGAGCT CAAGGTCTTG 1920
AGTTACCTCG GGAACCACAT GAATATTGTG AATCTTCTTG GAGCCTGCAC CGTTGGAGGG 1980
CCCACCCTGG TCATTACCGA ATATTGTTGC TATGGTGATC TTCTGAATTT TTTGCGAAGA 2040
AAACGTGATT CATTTATTTG CTCGAAGCAG GAAGATCACG CCGAAGTGGC ACTTTACAAG 2100
AACCTCCTTC ATTCAAAGGA GTCTTCCTGC AATGATAGTA CTAATGAATA CATGGACATG 2160
AAACCCGGAG TTTCTTATGT TGTGCCAACC AAGGCAGACA AAAGGAGATC GGCGAGAATA 2220
GGCTCATACA TAGAAAGAGA TGTGACTCCC GCCATCATGG AAGATGACGA GTTGGCTCTA 2280
GACCTGGAGG ACTTGCTGAG CTTTTCTTAC CAGGTGGCCA AGGGCATGGC CTTCCTCGCC 2340
TCAAAGAATT GTATTCACAG AGACTTGGCT GCTAGAAATA TCCTCCTTAC TCATGGTCGA 2400
ATCACAAAGA TTTGTGATTT TGGTCTAGCC AGAGACATCA AGAATGATTC TAATTATGTG 2460
GTCAAAGGAA ACGCTCGGCT ACCTGTGAAG TGGATGGCAC CTGAAAGCAT TTTCAACTGT 2520
GTGTACACAT TTGAAAGTGA TGTCTGGTCC TATGGGATTT TTCTGTGGGA GCTGTTCTCT 2580
CTAGGAAGCA GCCCCTACCC CGGGATGCCA GTCGATTCTA AGTTCTACAA GATGATCAAG 2640
GAGGGGTTCC GAATGCTCAG CCCTGAGCAT GCACCTGCCG AAATGTACGA CATCATGAAG 2700
ACTTGCTGGG ATGCTGATCC CCTGAAAAGG CCAACGTTCA AGCAGATGGT GCAGCTCATT 2760
GAGAAGCAGA TTTCAGAGAG CACCAATCAT ATTTACTCCA ACCTGGCGAA CTGCAGCCCC 2820
CGCCAGGAGC GCCCTGCCGT GGACCACTCC GTGCGGATCA ACTCTGTGGG CAGCAGCGCG 2880
TCTTCCACTC AGCCCCTGCT GGTGCACGAA GACGTCTGA 2919
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveatayGl+ksda+++vavkmlk++a+ +e+ealmselk+ls+lG
Q: 585   LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLG  644
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGact+gGp++viteyccyGdlln+lrrkr+sf+   ++k+++++e + +k+
Q: 645   NHMNIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDSFI---CSKQEDHAEVALYKN  701
         ******************************************...999999*99999999
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
         l     l+sk+s++ +s++ey+d+k++vs+v ++kadk++s+++ s++er+v++a++e+d
Q: 702   L-----LHSKESSCNDSTNEYMDMKPGVSYVVPTKADKRRSARIGSYIERDVTPAIMEDD  756
         9.....9*****************************************************
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
         + +l+ledllsfsyqvakGm+flasknc+hrdlaarn+llt+G+++kicdfGlardi++d
Q: 757   ELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKND  816
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvvkGnarlpvkwmapesif+++yt++sdvwsyGi+lwe+fslGs+pypg++vdskfy
Q: 817   SNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFY  876
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         k+ikeG+rm +p++a++e+y+im++cw+a+p krp+fkq+v+l+
Q: 877   KMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQMVQLI  920
         *****************************************996
Domain Sequence
(FASTA)
LSFGKTLGAG AFGKVVEATA YGLIKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG 60
NHMNIVNLLG ACTVGGPTLV ITEYCCYGDL LNFLRRKRDS FICSKQEDHA EVALYKNLLH 120
SKESSCNDST NEYMDMKPGV SYVVPTKADK RRSARIGSYI ERDVTPAIME DDELALDLED 180
LLSFSYQVAK GMAFLASKNC IHRDLAARNI LLTHGRITKI CDFGLARDIK NDSNYVVKGN 240
ARLPVKWMAP ESIFNCVYTF ESDVWSYGIF LWELFSLGSS PYPGMPVDSK FYKMIKEGFR 300
MLSPEHAPAE MYDIMKTCWD ADPLKRPTFK QMVQLI 336
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-DAR-00787
EKS-EQC-00394
EKS-FEC-00386
EKS-GAG-00341
EKS-GAA-00515
EKS-GOG-00394
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MEG-00335
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-NOL-00368
EKS-ORN-00514
EKS-ORA-00347
EKS-ORC-00378
EKS-ORL-00472
EKS-OTG-00405
EKS-PAT-00381
EKS-PES-00357
EKS-POA-00394
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-SUS-00353
EKS-TAG-00473
EKS-TAR-00510
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0005737; C:cytoplasm
GO:0009897; C:external side of plasma membrane
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005020; F:stem cell factor receptor activity
GO:0031532; P:actin cytoskeleton reorganization
GO:0000187; P:activation of MAPK activity
GO:0097067; P:cellular response to thyroid hormone stimulus
GO:0048066; P:developmental pigmentation
GO:0038093; P:Fc receptor signaling pathway
GO:0035234; P:germ cell programmed cell death
GO:0006687; P:glycosphingolipid metabolic process
GO:0007243; P:intracellular protein kinase cascade
GO:0002320; P:lymphoid progenitor cell differentiation
GO:0008584; P:male gonad development
GO:0002551; P:mast cell chemotaxis
GO:0032762; P:mast cell cytokine production
GO:0043303; P:mast cell degranulation
GO:0002573; P:myeloid leukocyte differentiation
GO:0002318; P:myeloid progenitor cell differentiation
GO:0043069; P:negative regulation of programmed cell death
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0008284; P:positive regulation of cell proliferation
GO:0010628; P:positive regulation of gene expression
GO:0043410; P:positive regulation of MAPK cascade
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0048070; P:regulation of developmental pigmentation
GO:0009314; P:response to radiation
GO:0007286; P:spermatid development
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013