EKS-BOT-00338
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00338
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PEK401.81.8E-1205931076484
StatusUnreviewed
Ensembl ProteinENSBTAP00000000210
UniProt AccessionA5D791; F1MCN0;
Protein Name
Protein Synonyms/Alias EIF2AK3 protein;
Gene NameEIF2AK3
Gene Synonyms/Alias EIF2AK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000000184ENSBTAP00000000210ENSBTAT00000000210
OrganismBos taurus
Functional Description
Protein Length1115
Protein Sequence
(FASTA)
MERATGPGSL ARTLLLPLLL GLVAGTVTAR RTSDLLAPTA EAAFGLGAAA APTSATRVPA 60
TGAVIAAEVT VEDSEALPAA AGEQEAREPE PEPEEEPDIR PCGRSLVIIS TLDGRIAALD 120
PENHGKKQWD LDVGSGSLVS SSLSKPEVFG NKMIIPSLDG DLFQWDRDRE SMETVPFTVE 180
SLLESSYKFG DDVVLVGGKS LTTYGLSAYS GKVRYICSAL GCRQWDNDEM EQEEDILLLQ 240
RTQKTVRAVG PRSGNEKWNF SVGHFELRYI PDMETRAGFI ESTLKPSGNK EQSKIISDVE 300
EQEAVMMDTV IKVSVADWKV MAFNKKGGHL EWEYQFCTPI ASAWLVKDGK VIPISLFDDT 360
SYAPNDGVLE DEEDIVEAAR GATENSVYLG MYRGQLYLQS SVRISEKFPT SPKALESVSS 420
ENAIIPLPTI KWKPLIHSPS RTPVLVGSDE FDKCLSNDKF SHEEYSNGAL SILQYPYDNG 480
YYLPYYKRER NKRSTQITVR FLDNPNYKNI RKKDPVLLLH WWKEIVGTIV FCIVATTFIV 540
RRLFHPHPHR QRKESETQCQ TENKYDAVSG EANDSSWNDI KNSGYVSRYL TDFEPIQCMG 600
RGGFGVVFEA RNKVDDCNYA IKRIRLPNRE LAREKVMREV KALAKLEHPG IVRYFNAWLE 660
APPEKWQEKM DEIWLKDDST DWPLSSPSPV DAPSVKIRRM DPFSTKECIE IIAPSPHSSR 720
SFSVGISCSQ TSSSESQFSP LEFSGMDHGN VSKSADAVCQ LQDSCLTDCE GEDGTMDGND 780
EGHSFELCPS EASPYIRSRE RTSSSIVFED SGCDNASSKE EPRMNQPPVG NHYANKLSAL 840
RHSGSKSSEP TVSVSPSRPT TLSLDLTKSS VGKLQPSSPK VYLYIQMQLC RKENLKDWLN 900
SRCTIEARER SVCLHIFLQI AEAVEFLHSK GLMHRDLKPS NIFFTMDDVV KVGDFGLVTA 960
MDQDEEDQMV LTPMPGYARH TGQVGTKLYM SPEQIHGNSY SHKVDIFSLG LILFELLYPF 1020
GTQMERVRIL TDVRDLKFPP LFAQKYPREY AMVQDMLSPS PTERPEAASI IENAIFEDLE 1080
FPEKTLLRQR SRSMSSPGAK HSRHSSSPHS PLPSN 1115
Nucleotide Sequence
(FASTA)
ATGGAGCGCG CCACCGGCCC GGGGTCGCTG GCACGGACGC TGCTACTGCC GCTGCTGCTG 60
GGGCTCGTGG CTGGGACAGT GACCGCGCGG CGCACCTCTG ACCTCCTCGC ACCGACAGCG 120
GAGGCGGCGT TCGGCCTTGG GGCCGCGGCG GCTCCCACCT CGGCTACGCG GGTGCCGGCG 180
ACGGGAGCCG TGATTGCAGC CGAAGTGACG GTGGAGGACT CCGAGGCGCT GCCGGCGGCT 240
GCAGGCGAGC AGGAGGCGCG GGAGCCGGAG CCGGAGCCGG AAGAGGAGCC CGATATTCGG 300
CCGTGCGGCA GATCATTAGT GATCATCAGC ACTTTAGATG GCCGAATTGC TGCCTTGGAT 360
CCTGAGAATC ATGGGAAAAA GCAGTGGGAT TTGGACGTGG GGTCTGGTTC CTTGGTGTCA 420
TCCAGCCTTA GCAAACCAGA GGTATTTGGG AACAAGATGA TCATTCCTTC CCTGGATGGA 480
GACCTCTTCC AGTGGGACCG GGACCGTGAG AGCATGGAAA CAGTTCCGTT TACAGTTGAA 540
TCACTTCTCG AATCGTCTTA TAAGTTTGGA GATGATGTTG TCTTGGTTGG AGGAAAGTCT 600
CTCACTACAT ATGGACTCAG TGCATATAGT GGAAAGGTGA GGTACATTTG TTCAGCTCTG 660
GGTTGTCGCC AGTGGGATAA TGATGAAATG GAACAAGAAG AAGACATCTT GCTTCTGCAG 720
CGCACCCAGA AAACTGTGAG AGCCGTTGGA CCTCGCAGTG GCAATGAGAA GTGGAATTTC 780
AGTGTTGGCC ACTTTGAACT TCGGTATATT CCAGACATGG AAACTAGAGC CGGATTTATT 840
GAAAGCACCT TAAAGCCCAG TGGAAACAAA GAACAGTCTA AAATTATTTC AGACGTGGAA 900
GAGCAGGAAG CTGTCATGAT GGATACAGTG ATAAAGGTCT CCGTTGCAGA TTGGAAAGTT 960
ATGGCGTTTA ATAAGAAGGG AGGACACCTG GAGTGGGAAT ACCAGTTTTG TACTCCCATT 1020
GCATCTGCCT GGTTGGTTAA GGATGGCAAA GTCATTCCCA TCAGTCTTTT TGATGATACA 1080
AGTTACGCGC CCAATGATGG AGTTTTAGAA GATGAAGAAG ATATTGTAGA AGCTGCCCGG 1140
GGAGCCACAG AAAACAGTGT TTACTTGGGA ATGTACAGAG GCCAGCTGTA TCTGCAATCA 1200
TCAGTCAGAA TTTCAGAAAA GTTTCCTACG AGTCCCAAGG CCTTGGAATC TGTCAGTAGT 1260
GAAAATGCTA TTATTCCTTT GCCAACCATC AAATGGAAAC CTCTAATTCA TTCTCCTTCT 1320
AGAACTCCTG TCTTGGTGGG CTCTGATGAA TTTGACAAAT GTCTTAGTAA TGATAAGTTT 1380
TCTCACGAAG AGTACAGTAA TGGTGCGCTT TCAATCTTGC AGTATCCTTA CGATAATGGT 1440
TATTATCTGC CATACTATAA GAGGGAAAGA AACAAACGGA GCACGCAGAT CACGGTCAGA 1500
TTTCTTGACA ACCCGAATTA CAAGAACATC CGCAAGAAGG ACCCTGTTCT TCTCTTACAC 1560
TGGTGGAAAG AAATAGTTGG AACCATCGTG TTTTGTATTG TAGCAACAAC TTTCATTGTA 1620
CGCAGACTCT TCCATCCTCA TCCTCACAGA CAAAGGAAGG AATCTGAAAC TCAGTGTCAA 1680
ACTGAAAATA AATATGATGC TGTCAGTGGA GAAGCTAATG ACAGTAGCTG GAATGACATA 1740
AAAAATTCTG GATACGTGTC ACGGTATCTA ACAGACTTTG AACCAATTCA GTGCATGGGC 1800
CGTGGGGGGT TTGGAGTTGT CTTTGAAGCT AGAAACAAGG TTGATGACTG CAATTATGCT 1860
ATCAAGAGAA TCCGTCTCCC CAACAGGGAA CTGGCTCGGG AGAAGGTAAT GCGAGAAGTG 1920
AAAGCCTTAG CCAAGCTTGA ACACCCAGGA ATTGTGAGAT ATTTCAATGC TTGGTTGGAA 1980
GCGCCACCAG AAAAGTGGCA AGAAAAAATG GATGAAATTT GGCTGAAAGA TGACAGCACA 2040
GACTGGCCGC TCAGCTCTCC TAGTCCCGTG GACGCGCCTT CTGTTAAAAT ACGCAGAATG 2100
GATCCTTTCT CTACAAAGGA ATGTATTGAA ATCATAGCTC CTTCGCCACA CAGCAGCAGG 2160
TCTTTTTCAG TTGGGATTTC TTGCAGCCAG ACCAGTTCAT CCGAGAGCCA GTTCTCTCCG 2220
CTGGAGTTTT CCGGGATGGA CCACGGAAAT GTGAGCAAGT CAGCAGATGC AGTATGCCAA 2280
CTCCAGGACA GCTGCCTTAC AGACTGCGAG GGGGAGGATG GTACCATGGA TGGTAATGAT 2340
GAAGGGCACT CCTTTGAACT TTGTCCTTCG GAAGCTTCTC CTTACATAAG GTCCAGGGAG 2400
CGAACCTCCT CGTCTATAGT ATTTGAAGAT TCTGGCTGTG ATAACGCGTC CAGCAAAGAG 2460
GAGCCCAGAA TGAACCAACC CCCTGTGGGC AACCATTATG CGAATAAACT GTCTGCACTC 2520
CGGCATTCCG GTAGCAAATC TTCGGAACCT ACTGTGTCTG TTTCTCCGTC AAGACCAACC 2580
ACTTTAAGTT TAGACCTCAC TAAAAGCTCG GTGGGGAAAC TCCAGCCCAG TTCGCCCAAG 2640
GTGTATCTGT ACATCCAGAT GCAGCTGTGC AGAAAGGAAA ACCTCAAAGA CTGGCTGAAC 2700
AGCCGCTGCA CCATTGAGGC GAGAGAGAGG AGCGTATGTT TGCACATCTT TCTGCAGATT 2760
GCAGAGGCGG TGGAGTTTCT GCACAGCAAA GGGCTCATGC ACAGGGACCT CAAGCCTTCC 2820
AACATATTCT TTACAATGGA TGATGTGGTC AAGGTTGGGG ATTTTGGACT GGTGACAGCA 2880
ATGGACCAAG ACGAGGAAGA TCAGATGGTT CTGACCCCAA TGCCGGGCTA CGCCAGGCAC 2940
ACGGGACAGG TGGGGACCAA GCTGTATATG AGCCCGGAAC AGATTCATGG CAACAGCTAC 3000
TCTCATAAAG TGGACATCTT TTCTTTGGGC CTCATTCTGT TTGAATTACT ATACCCGTTC 3060
GGCACTCAAA TGGAAAGGGT CAGGATCCTA ACTGATGTAA GAGATCTCAA ATTTCCACCA 3120
CTATTTGCTC AAAAATATCC TCGTGAGTAT GCCATGGTGC AAGACATGCT GTCCCCATCC 3180
CCTACTGAAC GGCCAGAAGC GGCGAGCATC ATTGAAAACG CGATCTTCGA GGACTTGGAG 3240
TTTCCAGAAA AGACACTCCT CAGACAGAGG TCTCGCTCCA TGAGCTCGCC CGGAGCAAAA 3300
CATTCAAGAC ACTCCAGCAG CCCCCACAGC CCTTTGCCCA GCAATTAG 3348
Domain Profile
S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60
         fe i+++G+GgfgvV++a+nk+d+++yaikri+l++++ ++ekv+revkaLaklehp+iv
Q: 593   FEPIQCMGRGGFGVVFEARNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIV  652
         799*********************************************************
S: 61    rYfaawleekeesl..............................................  74
         rYf+awle ++e++                                              
Q: 653   RYFNAWLEAPPEKWqekmdeiwlkddstdwplsspspvdapsvkirrmdpfstkecieii  712
         ************************************************************
S: 75    ............................................................  74
                                                                     
Q: 713   apsphssrsfsvgiscsqtsssesqfsplefsgmdhgnvsksadavcqlqdscltdcege  772
         ************************************************************
S: 75    ..td.sseveaeaeleesesseesdtk.................................  98
           t+ ++++ +++el++se+s++ +++                                 
Q: 773   dgTMdGNDEGHSFELCPSEASPYIRSRertsssivfedsgcdnasskeeprmnqppvgnh  832
         **7779********************9*********************************
S: 99    .................................................llyiqmelcek  109
                                                          +lyiqm+lc+k
Q: 833   yanklsalrhsgsksseptvsvspsrpttlsldltkssvgklqpsspkvYLYIQMQLCRK  892
         ************************************************************
S: 110   etLkdwiderkllesrselvm.rlfkqllegleylHskgliHrdLkpsniFldsddqvKi  168
         e+Lkdw+++r+++e+r++ v+ ++f q++e++e+lHskgl+HrdLkpsniF+++dd vK+
Q: 893   ENLKDWLNSRCTIEARERSVClHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKV  952
         ************************************************************
S: 169   gDFgLatalaealkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGli  228
         gDFgL+ta++++++ +++ ++++++a+htgqvgtklymsPeq+++++Y++kvDifsLGli
Q: 953   GDFGLVTAMDQDEEDQMVLTPMPGYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLI  1012
         ************************************************************
S: 229   lfeLlypfstemervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasellk  288
         lfeLlypf t+merv++lt++rd+k+p  f++k+p e+ ++q++ls +p+eRp+a  +++
Q: 1013  LFELLYPFGTQMERVRILTDVRDLKFPPLFAQKYPREYAMVQDMLSPSPTERPEAASIIE  1072
         ***********************************************************9
S: 289   sell  292
         ++++
Q: 1073  NAIF  1076
         9875
Domain Sequence
(FASTA)
FEPIQCMGRG GFGVVFEARN KVDDCNYAIK RIRLPNRELA REKVMREVKA LAKLEHPGIV 60
RYFNAWLEAP PEKWQEKMDE IWLKDDSTDW PLSSPSPVDA PSVKIRRMDP FSTKECIEII 120
APSPHSSRSF SVGISCSQTS SSESQFSPLE FSGMDHGNVS KSADAVCQLQ DSCLTDCEGE 180
DGTMDGNDEG HSFELCPSEA SPYIRSRERT SSSIVFEDSG CDNASSKEEP RMNQPPVGNH 240
YANKLSALRH SGSKSSEPTV SVSPSRPTTL SLDLTKSSVG KLQPSSPKVY LYIQMQLCRK 300
ENLKDWLNSR CTIEARERSV CLHIFLQIAE AVEFLHSKGL MHRDLKPSNI FFTMDDVVKV 360
GDFGLVTAMD QDEEDQMVLT PMPGYARHTG QVGTKLYMSP EQIHGNSYSH KVDIFSLGLI 420
LFELLYPFGT QMERVRILTD VRDLKFPPLF AQKYPREYAM VQDMLSPSPT ERPEAASIIE 480
NAIF 484
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00317
EKS-ANC-00330
EKS-CAE-00275
EKS-CAJ-00347
EKS-CAF-00346
EKS-CAP-00372
EKS-CII-00189
EKS-CIS-00091
EKS-DAR-00702
EKS-DRM-00166
EKS-EQC-00330
EKS-FEC-00329
EKS-GAG-00285
EKS-GAA-00421
EKS-GOG-00335
EKS-HOS-00345
EKS-ICT-00322
EKS-LAC-00353
EKS-LOA-00350
EKS-MAM-00344
EKS-MEG-00279
EKS-MOD-00334
EKS-MUM-00373
EKS-MUP-00333
EKS-MYL-00337
EKS-NOL-00309
EKS-ORN-00442
EKS-ORA-00297
EKS-ORC-00317
EKS-ORL-00409
EKS-OTG-00343
EKS-PAT-00321
EKS-PES-00298
EKS-PEM-00179
EKS-POA-00331
EKS-PTV-00079
EKS-RAN-00353
EKS-SAH-00317
EKS-SUS-00302
EKS-TAG-00414
EKS-TAR-00445
EKS-TEN-00441
EKS-VIP-00041
EKS-XET-00434
EKS-XIM-00430
Gene Ontology
GO:0005789; C:endoplasmic reticulum membrane
GO:0005524; F:ATP binding
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0030282; P:bone mineralization
GO:0019722; P:calcium-mediated signaling
GO:0002063; P:chondrocyte development
GO:0031018; P:endocrine pancreas development
GO:0007029; P:endoplasmic reticulum organization
GO:0030968; P:endoplasmic reticulum unfolded protein response
GO:0006983; P:ER overload response
GO:0045444; P:fat cell differentiation
GO:0030073; P:insulin secretion
GO:0048009; P:insulin-like growth factor receptor signaling pathway
GO:0007595; P:lactation
GO:0031642; P:negative regulation of myelination
GO:0017148; P:negative regulation of translation
GO:0001503; P:ossification
GO:0032092; P:positive regulation of protein binding
GO:0009967; P:positive regulation of signal transduction
GO:0046777; P:protein autophosphorylation
GO:0051260; P:protein homooligomerization
GO:0019217; P:regulation of fatty acid metabolic process
GO:0032933; P:SREBP signaling pathway
GO:0006412; P:translation
GO:0006926; P:virus-infected cell apoptotic process
KEGG
bta:535820;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR011047; Quinonprotein_ADH-like.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013