EKS-BOT-00110

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00110

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	474.8	5.6E-143	363	613	251

Status

Unreviewed

Ensembl Protein

ENSBTAP00000034966

UniProt Accession

A7Z039;

Protein Name

Protein Synonyms/Alias

ITK protein;

Gene Name

ITK

Gene Synonyms/Alias

ITK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000000306	ENSBTAP00000034966	ENSBTAT00000035086

Organism

Bos taurus

Functional Description

Protein Length

620

Protein Sequence
(FASTA)

MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKTSLAY FEDRHGKKRT LKGSIELSRI 60

KCVEIVKSDI IIPCHYKYPF QVVHDNYLLY VFAPDRESRQ RWVLALKEET RNNNSLVPKY 120

HPNFWLDGRW RCCAQMEKLA VGCAQYDPTK NASKKPLPPT PEDNRRSLRE LEETVVIALY 180

DYQTNDPQEL MLQRNEEYYL LDSSEIHWWR VQDRNGHEGY VPSSYLVEKS PNNLETYEWY 240

NKNISRDKAE KLLLDTGKEG AFMVRDSRTP GTYTVSVFTK AIVSENNPCI KHYHIKETND 300

NPKRYYVAEK YVFDSIPLLI NYHQHNGGGL VTRLRYPVCS WRQKAPVTAG LRYGKWVIDP 360

SELTFVQEIG SGQFGLVHLG YWLNKDKVAI KTIQEGAMSE EDFIEEAEVM MKLSHPKLVQ 420

LYGVCLEQAP ICLVFEFMEH GCLSDYLRSQ RGLFAAETLL GMCLDVCEGM AYLEEACVIH 480

RDLAARNCLV GENQVIKVSD FGMTRFVLDD QYTSSTGTKF PVKWASPEVF SFSRYSSKSD 540

VWSFGVLMWE VFSEGKIPYE NRSNSEVVED ITTGFRLYKP RLASQHIYQI MNHCWKEKPE 600

DRPPFSRLLS QLAEIAELGL 620

Nucleotide Sequence
(FASTA)

ATGAACAACT TTATCCTCCT GGAAGAGCAG CTCATCAAGA AATCCCAACA AAAGAGAAGA 60

ACTTCTCCTT CAAACTTTAA AGTCCGATTC TTTGTTTTAA CCAAAACCAG CCTGGCATAC 120

TTTGAAGATC GTCATGGGAA AAAGCGCACT TTGAAGGGCT CCATCGAACT CTCCCGAATC 180

AAATGTGTCG AGATTGTGAA AAGTGACATT ATCATCCCAT GTCACTATAA ATATCCATTT 240

CAGGTTGTTC ACGACAACTA CCTCCTGTAT GTGTTTGCTC CAGACCGGGA GAGCCGGCAG 300

CGCTGGGTGC TGGCCCTCAA AGAAGAAACC AGGAATAACA ACAGTTTGGT GCCCAAGTAT 360

CACCCTAATT TCTGGTTGGA TGGGAGATGG CGGTGCTGTG CTCAGATGGA GAAGCTTGCA 420

GTGGGCTGTG CCCAGTACGA TCCCACCAAA AATGCTTCAA AGAAGCCTCT TCCTCCTACT 480

CCTGAAGACA ATAGGCGGTC ACTTCGGGAA CTTGAAGAAA CTGTGGTCAT TGCCCTGTAT 540

GACTACCAAA CGAATGATCC ACAGGAACTC ATGCTACAGC GCAATGAGGA GTACTACCTG 600

CTCGACAGCT CTGAGATTCA CTGGTGGAGG GTTCAGGACA GGAACGGGCA TGAAGGATAT 660

GTTCCAAGCA GTTATCTGGT GGAAAAGTCT CCAAATAACC TGGAAACCTA TGAGTGGTAC 720

AATAAGAACA TCAGCCGAGA CAAAGCTGAA AAACTTCTTT TGGACACAGG CAAAGAAGGA 780

GCCTTTATGG TGCGAGATTC CAGGACTCCA GGGACATACA CAGTGTCCGT TTTCACCAAG 840

GCCATCGTAA GTGAGAACAA CCCCTGTATA AAGCATTATC ACATCAAAGA AACAAATGAC 900

AACCCCAAGC GATATTACGT GGCTGAAAAG TATGTGTTTG ATTCCATCCC TCTCCTCATC 960

AATTATCACC AGCACAACGG AGGAGGCCTG GTCACTAGAC TCCGGTATCC AGTTTGCTCC 1020

TGGAGGCAGA AAGCCCCCGT CACCGCAGGG CTGAGATACG GGAAATGGGT GATTGATCCC 1080

TCGGAGCTCA CTTTTGTGCA GGAGATTGGC AGTGGGCAGT TTGGGTTGGT GCACCTTGGC 1140

TACTGGCTCA ACAAGGACAA GGTGGCCATC AAAACCATTC AAGAAGGGGC TATGTCAGAA 1200

GAGGACTTCA TTGAGGAGGC TGAAGTCATG ATGAAACTCT CTCACCCCAA ACTAGTCCAG 1260

CTCTATGGAG TATGCCTGGA ACAGGCCCCC ATCTGCCTGG TGTTTGAATT CATGGAACAC 1320

GGCTGCCTGT CAGATTACCT GCGTAGCCAG AGGGGGCTCT TTGCTGCGGA GACCCTGCTG 1380

GGCATGTGTC TGGACGTATG TGAGGGCATG GCCTACCTGG AAGAGGCGTG TGTCATCCAC 1440

AGAGACTTGG CTGCCCGGAA TTGTTTAGTT GGGGAAAACC AAGTTATCAA GGTGTCCGAC 1500

TTTGGGATGA CAAGGTTCGT CCTTGATGAC CAATACACCA GTTCCACAGG CACCAAATTC 1560

CCAGTGAAGT GGGCATCTCC GGAAGTCTTC TCCTTCAGTC GCTACAGCAG CAAGTCAGAT 1620

GTGTGGTCAT TTGGTGTGCT GATGTGGGAA GTCTTCAGTG AAGGCAAAAT CCCATACGAA 1680

AACCGAAGCA ACTCAGAGGT GGTAGAAGAC ATCACCACTG GATTTCGGTT ATACAAGCCC 1740

CGACTGGCCT CCCAGCATAT CTACCAGATC ATGAATCATT GCTGGAAAGA GAAACCAGAA 1800

GACCGGCCAC CTTTCTCCAG ACTCTTGAGT CAACTGGCTG AAATTGCAGA ATTGGGGCTT 1860

TAA 1863

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+++e+gsgqfg+v+lg+w +k++vaik+i+egamseedfieea+vmmklshpklvqly

Q: 363   LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLY  422

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvcl+q+pi++v+e++e+gcl++ylr++++ +++e+ll mc dvcegm+yle++++ihrd

Q: 423   GVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRD  482

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+e++v+kvsdfg++r+vlddqy+ss+g+kfpvkw++pev+s+s+yssksdvw

Q: 483   LAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVW  542

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         +fgvlmwevfsegk+pye++snsevve++++g+rly+p+las+++y++m++cwkekpe+r

Q: 543   SFGVLMWEVFSEGKIPYENRSNSEVVEDITTGFRLYKPRLASQHIYQIMNHCWKEKPEDR  602

         ************************************************************

S: 241   ptfkellsale  251

         p f++lls+l+

Q: 603   PPFSRLLSQLA  613

         ********996

Domain Sequence
(FASTA)

LTFVQEIGSG QFGLVHLGYW LNKDKVAIKT IQEGAMSEED FIEEAEVMMK LSHPKLVQLY 60

GVCLEQAPIC LVFEFMEHGC LSDYLRSQRG LFAAETLLGM CLDVCEGMAY LEEACVIHRD 120

LAARNCLVGE NQVIKVSDFG MTRFVLDDQY TSSTGTKFPV KWASPEVFSF SRYSSKSDVW 180

SFGVLMWEVF SEGKIPYENR SNSEVVEDIT TGFRLYKPRL ASQHIYQIMN HCWKEKPEDR 240

PPFSRLLSQL A 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543	; F:phospholipid binding
GO:0007202	; P:activation of phospholipase C activity
GO:0002250	; P:adaptive immune response
GO:0032609	; P:interferon-gamma production
GO:0032633	; P:interleukin-4 production
GO:0035556	; P:intracellular signal transduction
GO:0001865	; P:NK T cell differentiation
GO:0050852	; P:T cell receptor signaling pathway

KEGG

bta:522311

;

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013