| Tag | Content |
|---|
| EKPD ID | EPS-BOT-00072 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| PPP/PP2A | 419.5 | 1.7E-126 | 51 | 243 | 193 |
|
| Status | Reviewed |
| Ensembl Protein | ENSBTAP00000000596 |
| UniProt Accession | P67774; A6QLI7; P05323; P13197; |
| Protein Name | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform |
| Protein Synonyms/Alias | PP2A-alpha; |
| Gene Name | PPP2CA |
| Gene Synonyms/Alias | PPP2CA; |
| Ensembl Information | |
| Organism | Bos taurus |
| Functional Description | PP2A is the major phosphatase for microtubule-associatedproteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). |
| Protein Length | 309 |
Protein Sequence
(FASTA) | | MDEKVFTKEL DQWIEQLNEC KQLSESQVKS LCEKAKEILT KESNVQEVRC PVTVCGDVHG 60 | | QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER ITILRGNHES 120 | | RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI 180 | | RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA 240 | | HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV 300 | | TRRTPDYFL 309 |
|
Nucleotide Sequence
(FASTA) | | ATGGACGAGA AGGTGTTCAC CAAGGAGCTG GACCAGTGGA TCGAGCAGCT GAACGAGTGC 60 | | AAGCAGCTGT CTGAGTCCCA GGTTAAGAGC CTCTGCGAGA AGGCTAAAGA AATCCTGACA 120 | | AAAGAATCCA ATGTGCAAGA AGTTCGATGT CCAGTCACTG TCTGTGGAGA TGTGCATGGG 180 | | CAATTTCATG ATCTCATGGA ACTGTTTAGA ATTGGTGGCA AATCACCAGA TACAAATTAC 240 | | TTGTTTATGG GCGATTATGT TGACAGAGGA TATTATTCAG TGGAAACAGT TACTCTGCTT 300 | | GTAGCTCTTA AGGTTCGTTA CCGTGAACGT ATCACCATTC TTCGAGGAAA TCATGAGAGC 360 | | AGACAGATCA CACAAGTATA TGGTTTCTAC GATGAGTGTT TAAGGAAATA CGGAAATGCA 420 | | AATGTTTGGA AGTATTTTAC AGACCTTTTT GACTATCTTC CTCTCACTGC CTTGGTGGAT 480 | | GGGCAGATCT TCTGTCTACA TGGTGGCCTC TCACCATCCA TAGATACACT GGATCACATC 540 | | AGAGCACTTG ATCGCCTACA AGAAGTTCCT CATGAGGGTC CAATGTGTGA CTTGCTGTGG 600 | | TCAGATCCAG ATGACCGTGG AGGTTGGGGT ATATCTCCTC GAGGAGCTGG TTACACCTTT 660 | | GGGCAGGATA TTTCTGAGAC ATTTAATCAT GCCAATGGCC TCACGTTGGT GTCTAGAGCT 720 | | CATCAGCTGG TGATGGAGGG ATATAACTGG TGCCATGACC GAAATGTAGT AACGATTTTC 780 | | AGTGCTCCAA ACTATTGTTA TCGTTGTGGT AACCAAGCTG CAATCATGGA ACTTGATGAT 840 | | ACTCTAAAAT ACTCTTTCTT GCAGTTTGAC CCAGCACCTC GCAGAGGCGA GCCACATGTT 900 | | ACTCGTCGTA CCCCAGACTA CTTCCTGTAA 930 |
|
| Domain Profile | S: 1 pvtvcgdvhgqfhdllelfriggkspdtnylflgdyvdrgyysvetvtllvalkvryrer 60 | pvtvcgdvhgqfhdl+elfriggkspdtnylf+gdyvdrgyysvetvtllvalkvryrer | Q: 51 PVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRER 110 | 9*********************************************************** |
| S: 61 itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdgkifclhggl 120 | itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdg+ifclhggl | Q: 111 ITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGL 170 | ************************************************************ |
| S: 121 spsidtldeiraldrlqevphegplcdllwsdpddregwgisprgagytfgqdiseqfnh 180 | spsidtld+iraldrlqevphegp+cdllwsdpddr+gwgisprgagytfgqdise+fnh | Q: 171 SPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNH 230 | ************************************************************ |
| S: 181 angleliarahql 193 | angl+l++rahql | Q: 231 ANGLTLVSRAHQL 243 | ************8 |
|
Domain Sequence
(FASTA) | | PVTVCGDVHG QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER 60 | | ITILRGNHES RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL 120 | | SPSIDTLDHI RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH 180 | | ANGLTLVSRA HQL 193 |
|
| Keyword | Acetylation; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Hydrolase; Iron; Manganese; Meiosis; Metal-binding; Methylation; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |