EKS-BOT-00385

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00385

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	260.9	1.3E-77	201	445	245

Status

Unreviewed

Ensembl Protein

ENSBTAP00000000927

UniProt Accession

G5E505;

Protein Name

Protein Synonyms/Alias

Integrin-linked protein kinase;

Gene Name

ILK

Gene Synonyms/Alias

ILK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000000696	ENSBTAP00000000927	ENSBTAT00000000927

Organism

Bos taurus

Functional Description

Protein Length

452

Protein Sequence
(FASTA)

MDDIFTQCRE GNAVAVRLWL DNTENDLNQG DDHGFSPLHW ACREGRSAVV EMLIMRGARI 60

NVMNRGDDTP LHLAASHGHR DIVQKLLQYK ADINAVNEHG NVPLHYACFW GQDQVAEDLV 120

ANGALVSICN KYGEMPVDKA KPPLRELLRE RAEKMGQNLN RIPYKDTFWK GTTRTRPRNG 180

TLNKHSGIDF KQLNFLVMEN ENHSGELWKG RWQGNDIVVK MLKVRDWSTR KSRDFNEECP 240

RLRIFSHPNV LPVLGACQSP PAPHPTLITH WMPYGSLYNV LHEGTNFVVD QSQAVKFALD 300

MARGMAFLHT LEPLIPRHAL NSRSVMIDED MTARISMADV KFSFQCPGRM YAPAWVAPEA 360

LQKKPEDTNR RSADMWSFAV LLWELVTREV PFADLSNMEI GMKVALEGLR PTIPPGISPH 420

VCKLMKICMN EDPAKRPKFD MIVPILEKMQ DK 452

Nucleotide Sequence
(FASTA)

ATGGACGACA TTTTCACTCA GTGCCGGGAG GGCAACGCGG TTGCGGTCCG CCTGTGGCTG 60

GACAACACGG AGAACGACCT CAACCAGGGG GACGATCATG GCTTCTCCCC CTTGCACTGG 120

GCCTGCCGAG AAGGCCGATC TGCTGTGGTT GAGATGCTGA TCATGCGGGG GGCACGAATC 180

AATGTGATGA ACCGTGGGGA TGATACCCCT CTGCACCTGG CAGCCAGTCA TGGGCACCGT 240

GATATTGTAC AGAAGCTGCT GCAGTACAAA GCTGACATCA ATGCGGTGAA TGAGCATGGG 300

AATGTGCCCC TGCACTATGC CTGTTTCTGG GGCCAAGATC AGGTGGCAGA GGACCTCGTG 360

GCAAATGGGG CCCTTGTCAG CATCTGTAAC AAGTATGGAG AGATGCCTGT GGACAAAGCT 420

AAGCCACCCC TGAGAGAGCT GCTCCGAGAG CGGGCAGAGA AGATGGGCCA GAATCTGAAC 480

CGTATACCAT ACAAGGACAC ATTCTGGAAG GGGACTACCC GCACTCGGCC CCGAAATGGG 540

ACTCTGAACA AACACTCCGG CATTGACTTC AAACAGCTCA ACTTCCTGGT GATGGAGAAC 600

GAGAATCACT CTGGAGAGCT ATGGAAGGGC CGCTGGCAGG GCAATGACAT TGTCGTGAAG 660

ATGCTAAAGG TTCGAGACTG GAGTACAAGG AAGAGCAGAG ACTTCAATGA GGAGTGTCCC 720

CGGCTCAGGA TTTTCTCACA TCCCAATGTG CTCCCAGTGC TTGGTGCCTG TCAGTCTCCA 780

CCTGCTCCTC ACCCCACCCT CATCACACAC TGGATGCCAT ACGGATCCCT GTACAATGTG 840

CTACATGAAG GCACCAATTT TGTTGTGGAC CAGAGCCAGG CTGTGAAGTT TGCATTGGAC 900

ATGGCAAGGG GCATGGCCTT CCTACACACA CTAGAGCCCC TCATCCCACG ACATGCACTC 960

AACAGCCGTA GTGTAATGAT TGATGAGGAC ATGACTGCTC GAATCAGTAT GGCCGACGTC 1020

AAGTTCTCCT TCCAGTGCCC CGGGCGCATG TATGCACCTG CCTGGGTGGC TCCTGAAGCT 1080

CTGCAAAAGA AGCCTGAAGA CACAAACAGA CGCTCAGCAG ATATGTGGAG TTTTGCAGTG 1140

CTTCTATGGG AACTGGTGAC ACGGGAGGTA CCCTTTGCTG ACCTCTCCAA CATGGAAATT 1200

GGAATGAAGG TGGCACTGGA AGGCCTTCGG CCTACCATCC CACCAGGCAT TTCCCCCCAC 1260

GTATGTAAAC TCATGAAGAT CTGCATGAAT GAAGACCCTG CTAAGCGACC CAAGTTTGAC 1320

ATGATCGTGC CTATCCTGGA GAAGATGCAG GACAAGTAG 1359

Domain Profile

S: 9     sgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiellGvclee  68

         ++++g+++k++w++++++vK l++++++++k++++++e+ +l+ +shpn++ +lG+c+++

Q: 201   ENHSGELWKGRWQGNDIVVKMLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSP  260

         7899********************************************************

S: 69    pn..lllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkkiihrd  126

         p+   +l+++++++gsL+nvlhe ++ ++d++++v++al++ArGma+Lh+ +p  i ++

Q: 261   PAphPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPL-IPRHA  319

         99745**********************************************997.*****

S: 127   LksknvLlseekktlkicdFGtarelskstkmsaa.gtlawmaPEvlkeekvs...eksD  182

         L+s++v++ +e++t++i++ +++++   s+++  + +++aw+aPE+l++++ +   +++D

Q: 320   LNSRSVMI-DEDMTARISM-ADVKF---SFQCPGRmYAPAWVAPEALQKKPEDtnrRSAD  374

         ********.**********.88888...78999998**************99988899**

S: 183   vwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedpe  242

         +wS++v+LWel+trevP++dls+++i +kval+glr++ip+ ++++++kLmk c+nedp+

Q: 375   MWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPA  434

         ************************************************************

S: 243   kRpsfseivks  253

         kRp+f++iv +

Q: 435   KRPKFDMIVPI  445

         ********986

Domain Sequence
(FASTA)

ENHSGELWKG RWQGNDIVVK MLKVRDWSTR KSRDFNEECP RLRIFSHPNV LPVLGACQSP 60

PAPHPTLITH WMPYGSLYNV LHEGTNFVVD QSQAVKFALD MARGMAFLHT LEPLIPRHAL 120

NSRSVMIDED MTARISMADV KFSFQCPGRM YAPAWVAPEA LQKKPEDTNR RSADMWSFAV 180

LLWELVTREV PFADLSNMEI GMKVALEGLR PTIPPGISPH VCKLMKICMN EDPAKRPKFD 240

MIVPI 245

Keyword

ANK repeat; Complete proteome; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0001658	; P:branching involved in ureteric bud morphogenesis
GO:0045197	; P:establishment or maintenance of epithelial cell apical/basal polarity
GO:0030513	; P:positive regulation of BMP signaling pathway
GO:0090263	; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0008284	; P:positive regulation of cell proliferation
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0042327	; P:positive regulation of phosphorylation
GO:0045893	; P:positive regulation of transcription, DNA-dependent

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR016253	; Integrin-linked_kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF12796	; Ank_2; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00248

; ANK; 3.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 3.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013