EKS-BOT-00253

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00253

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	244.8	9.4E-73	1000	1252	253

Status

Unreviewed

Ensembl Protein

ENSBTAP00000001044

UniProt Accession

E1BJM5;

Protein Name

Protein Synonyms/Alias

Gene Name

PASK

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000000785	ENSBTAP00000001044	ENSBTAT00000001044

Organism

Bos taurus

Functional Description

Protein Length

1336

Protein Sequence
(FASTA)

MEDGGSMAST EDYQGPGGSP SLSVPPEGHA APAASEPGRS GSSAHRHLSR RTGLSKLCQS 60

RIALSEERWS SYCLTSLAAQ SICTSKLHCS ATPGQADRTG SLGSTSCCSL LRGLSPGWST 120

PLLPAPVCNP NKAVFTVDAK TAEILVANDR ACRLLGHSSH DLIGQKLTQF FLKPDPDVVQ 180

ALSEEHVEAD GHAAVAFGTV VDIVSRSGER IPVSVWMKRV KQECSLCCVV VLEPVERVSA 240

WVAFRSDGTV TSCDGLFAHL HGFASGEEVV GQRITDLIPS LQLPAPGEHV PTHLKIQRSV 300

GRARDGATFP VSLKLKSQPG SEEATDGEAA PGGGYSASIW VFSTISGLIT LLPDGTIYGI 360

NHSFALMLFG YGKAELLGKN ITFLIPGFYH HMDLAYDSSF PLRDLASCLD AGSQSGPGVS 420

TGDEPAGTAQ AAEGGTDSGR GNVTVVSTGR ECSLSDGVCQ ALVTDTLFSF SRIHRVRLID 480

TAQVSSCRSQ SPPERPRDVP EGGPPARSGS SSPEGQQRSV SEQEQPVTAE LLSWGLQPGS 540

RSELGDTKPS TSQEDSEAAI PGADRSGGDE THGPCQEVRE GRGGTSESGQ GPDAATAAPH 600

TEGHLAGQDP EGEQSVLPGS PRSAPSAPGT LQLLFSTPPL DEPWLGAQQD REELHTCLIK 660

EQLSASSLAG PWGVSYAELV LMGQPPPSAP ASLSDLRATD PRGGRSGSSS ACYALATDLP 720

GALEAVEVTE ASENSFSWNL KELVFRDWTD RTSSNCSCAT SELGGTPSPS LVGSDADVGA 780

LPRPRSDVLD DRELLLLTGT CVDLGGGRRF RESHLGLEET EPSQTCLVSS EHRDVNGLDS 840

PSCVLPVPGA GPEDECPLEA PGLSLQVTST PVRAEGPGPA PLRAADLQPE IQEGTYTGSC 900

CHRDGSQLSV QYEVRRVELQ GPAALFCCWL VKDLRHGRLD SALHTHLLLA SLPSSAHSTC 960

EPSAASLGEV LGTKPWFEEP PKAVELEGLA ACEGAYSLKY STLSPIGSGA FGFVWTAVDK 1020

EANKEVVVKF IKKEKVLEDC WIEDPKLGKV TLEIAILCKV EHANIIKVLD VFENQGFFQL 1080

VMEKHGSGLD LFAFIDRHPS LDEPLASYIF RQLVSAVVYL RSESILHRDI KDENIVIAED 1140

FSIKLIDFGS AAYLERGKLF YTFCGTIEYC APEVLMGNPY RGPELEMWSM GVTLYTLIFE 1200

ENPFCELEET MEAAINPPYL VSEDLMNLMS GLLQPVPEQR TTLEKLVTDR WVTQPVNLAD 1260

YTWEEVCRLN KSGSRALSTV GLELDGRSPS AAARAPEPHR PSCSRVGSRA PAGPAPCRAA 1320

DSLREARLSQ APSVRE 1336

Nucleotide Sequence
(FASTA)

ATGGAGGACG GGGGTTCGAT GGCCTCCACA GAGGACTACC AGGGCCCGGG CGGGAGCCCC 60

TCCCTGTCAG TGCCCCCGGA GGGCCACGCC GCGCCTGCCG CCTCGGAGCC CGGCAGGTCT 120

GGGTCCTCAG CCCACAGACA CTTGAGCAGG AGGACCGGGC TGTCGAAGCT CTGCCAGAGC 180

CGTATTGCAC TGTCGGAGGA GAGGTGGAGC TCCTACTGCC TGACGTCACT GGCCGCCCAA 240

AGCATCTGCA CAAGCAAGTT GCACTGCTCG GCCACGCCTG GGCAGGCGGA CCGCACGGGG 300

TCCCTGGGCA GCACGTCCTG CTGCTCCCTG CTGCGGGGCT TGTCCCCAGG GTGGTCCACG 360

CCGCTGCTCC CGGCCCCCGT GTGCAACCCC AACAAGGCCG TGTTCACCGT GGATGCCAAG 420

ACCGCAGAGA TCCTGGTGGC CAACGACAGG GCCTGCCGGC TCCTGGGCCA CAGCAGCCAT 480

GACCTCATCG GCCAGAAGCT CACGCAGTTC TTCCTGAAGC CGGACCCCGA CGTGGTGCAG 540

GCCCTCAGCG AGGAGCACGT GGAGGCTGAC GGGCACGCCG CCGTCGCGTT CGGCACTGTG 600

GTGGACATTG TGAGCCGCAG CGGGGAGAGG ATCCCGGTCT CCGTGTGGAT GAAGCGGGTG 660

AAGCAGGAGT GCAGCCTCTG CTGCGTGGTC GTGCTGGAGC CCGTGGAGCG GGTCTCGGCC 720

TGGGTGGCGT TCCGGAGCGA CGGCACCGTG ACATCCTGCG ACGGGCTCTT CGCACACCTG 780

CATGGCTTCG CGTCTGGGGA GGAGGTGGTT GGGCAGCGCA TCACAGACCT CATCCCTTCC 840

CTGCAGCTCC CCGCTCCTGG CGAGCACGTC CCCACGCACC TCAAGATTCA GAGATCCGTC 900

GGAAGAGCCA GGGATGGAGC CACCTTCCCT GTGAGCCTGA AGCTGAAGTC CCAGCCGGGC 960

AGCGAGGAGG CTACAGATGG CGAGGCGGCC CCTGGCGGGG GCTACTCAGC ATCCATCTGG 1020

GTGTTCTCCA CCATCAGTGG GCTCATCACG CTCCTGCCGG ACGGGACCAT CTACGGCATC 1080

AACCACAGCT TTGCCCTCAT GCTGTTTGGT TACGGAAAGG CTGAGCTCCT GGGCAAGAAC 1140

ATCACCTTCC TGATTCCCGG TTTCTACCAC CACATGGACC TTGCCTACGA CAGCTCCTTC 1200

CCTCTGCGGG ACCTGGCCAG CTGCCTGGAC GCTGGCAGCC AGAGTGGGCC TGGGGTCAGC 1260

ACGGGGGACG AGCCTGCGGG CACAGCCCAG GCAGCCGAAG GCGGGACTGA CTCAGGGAGG 1320

GGAAATGTGA CTGTGGTGTC GACGGGACGT GAGTGCTCCC TGTCAGATGG TGTGTGTCAG 1380

GCCTTAGTCA CTGATACCCT TTTCTCTTTT TCCAGAATCC ATCGTGTGAG GCTTATTGAC 1440

ACCGCACAGG TTTCAAGTTG TCGAAGCCAG TCACCGCCCG AGCGCCCGCG AGACGTGCCC 1500

GAGGGAGGCC CACCCGCCCG CAGCGGCTCG TCGTCACCCG AGGGCCAGCA GCGCTCTGTC 1560

TCAGAGCAAG AGCAGCCGGT GACAGCAGAG CTCCTCAGCT GGGGCCTTCA GCCGGGGAGT 1620

CGATCTGAGC TGGGGGACAC GAAGCCATCT ACTTCCCAGG AAGACTCCGA AGCTGCCATC 1680

CCCGGGGCAG ACAGGAGTGG TGGGGACGAG ACGCATGGCC CATGTCAGGA GGTGCGGGAG 1740

GGGCGGGGTG GCACCAGCGA GTCAGGCCAG GGCCCTGACG CTGCCACGGC CGCGCCCCAC 1800

ACCGAGGGTC ATCTGGCCGG GCAGGACCCC GAGGGGGAGC AGAGCGTGCT GCCGGGAAGC 1860

CCGCGCTCGG CCCCCAGCGC CCCAGGGACG CTGCAGCTCT TGTTCTCGAC GCCACCTTTG 1920

GACGAGCCCT GGCTGGGGGC ACAGCAGGAC AGGGAGGAGC TGCACACGTG CCTGATAAAG 1980

GAGCAGCTGT CCGCCTCGAG CCTGGCGGGG CCGTGGGGCG TCTCCTACGC TGAGCTGGTC 2040

CTGATGGGGC AGCCCCCGCC CTCTGCCCCT GCCTCCTTGT CAGACCTGAG AGCCACAGAC 2100

CCACGGGGTG GCCGCTCGGG CAGCTCCTCG GCCTGCTACG CCCTGGCCAC CGACCTGCCC 2160

GGCGCCCTTG AGGCTGTGGA GGTCACAGAA GCTAGCGAGA ATTCGTTTTC CTGGAACCTC 2220

AAGGAGCTTG TTTTCAGGGA CTGGACAGAC CGAACTTCTT CCAACTGTTC GTGTGCCACG 2280

TCTGAACTCG GGGGCACACC CTCGCCTTCG CTGGTGGGCT CGGACGCGGA CGTGGGTGCC 2340

CTGCCCAGGC CGCGGTCAGA TGTGCTGGAC GACCGGGAGC TGCTGCTGCT GACTGGCACC 2400

TGTGTTGATC TGGGTGGGGG CCGGCGCTTC CGTGAGAGCC ACCTGGGCCT GGAGGAGACA 2460

GAGCCGTCCC AGACCTGTCT GGTGTCCTCC GAGCACCGGG ATGTGAACGG CCTCGACAGC 2520

CCGAGCTGCG TCCTCCCCGT GCCGGGAGCC GGCCCTGAGG ACGAGTGCCC GTTGGAGGCG 2580

CCTGGGCTGA GCCTCCAGGT CACCTCCACG CCCGTGAGAG CCGAGGGCCC CGGCCCTGCA 2640

CCCCTCAGGG CGGCTGACCT GCAGCCGGAG ATCCAGGAGG GCACGTACAC AGGGAGCTGC 2700

TGCCACCGCG ACGGCTCGCA GCTGAGTGTG CAGTACGAGG TGCGGCGCGT GGAGCTCCAG 2760

GGCCCGGCCG CCCTCTTCTG CTGCTGGCTC GTGAAGGACC TGCGGCACGG CCGCCTGGAC 2820

TCGGCCCTGC ACACCCACCT GCTGCTGGCC AGCCTGCCGA GCTCTGCCCA CTCCACCTGC 2880

GAGCCGTCTG CGGCCAGCCT GGGGGAGGTG CTTGGAACCA AGCCCTGGTT TGAGGAGCCC 2940

CCCAAGGCCG TGGAGCTGGA GGGGCTGGCG GCCTGCGAGG GGGCGTACTC CCTTAAGTAC 3000

AGCACGCTCA GCCCGATCGG CAGCGGGGCC TTTGGCTTCG TGTGGACGGC GGTGGACAAG 3060

GAGGCGAATA AGGAGGTGGT GGTGAAGTTC ATAAAGAAGG AGAAGGTTTT GGAGGACTGT 3120

TGGATTGAGG ACCCCAAGCT TGGGAAGGTC ACTTTAGAGA TCGCCATCCT GTGCAAGGTG 3180

GAGCACGCCA ACATCATCAA GGTGCTGGAC GTGTTTGAGA ACCAAGGCTT CTTTCAGCTG 3240

GTAATGGAGA AGCACGGCTC CGGCCTGGAC CTGTTTGCAT TCATTGACCG CCATCCCAGC 3300

CTCGATGAGC CCCTGGCGAG CTACATCTTT CGACAGCTGG TGTCGGCCGT GGTGTACCTG 3360

CGCTCCGAGA GCATCCTCCA CCGGGACATC AAGGACGAGA ACATTGTCAT TGCCGAGGAC 3420

TTCTCCATCA AGCTCATCGA CTTTGGCTCG GCCGCCTACC TGGAGCGGGG CAAGCTCTTC 3480

TACACCTTCT GTGGGACGAT CGAGTACTGC GCGCCCGAGG TCCTCATGGG GAACCCGTAC 3540

CGGGGGCCGG AGCTGGAGAT GTGGTCCATG GGGGTCACGC TGTACACGCT GATCTTCGAG 3600

GAGAACCCCT TCTGTGAGCT GGAGGAGACC ATGGAGGCCG CAATAAACCC CCCGTATCTG 3660

GTCTCGGAAG ACCTCATGAA CCTCATGTCT GGGCTGTTGC AGCCTGTGCC CGAGCAGCGT 3720

ACCACCTTGG AGAAGCTGGT GACAGACCGC TGGGTGACAC AGCCCGTGAA CCTGGCGGAC 3780

TACACCTGGG AGGAGGTGTG TCGGCTAAAC AAGTCAGGGA GCAGAGCTCT GTCCACCGTT 3840

GGTCTGGAGC TGGACGGCAG GAGCCCCAGT GCCGCGGCTC GGGCCCCAGA GCCCCACCGG 3900

CCCTCGTGCA GCAGGGTGGG ATCCAGAGCG CCGGCTGGCC CAGCTCCCTG CCGCGCTGCA 3960

GACTCGCTTA GGGAGGCACG GCTTTCTCAG GCGCCTTCCG TTCGGGAGTA A 4011

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl......seeslekikrEieilkk  54

         y++l+ +G+g+fg V +a++ke +++v+vK+ikk+k+      ++ +l k++ Ei+il k

Q: 1000  YSTLSPIGSGAFGFVWTAVDKEANKEVVVKFIKKEKVledcwiEDPKLGKVTLEIAILCK  1059

         88999*******************************99999998899*************

S: 55    lkhpniikllevietkkklylvle.yasggeLfdyieekgrlkekearklfkqlvsavkY  113

         ++h niik+l+v+e++ +++lv+e + sg +Lf  i ++ +l+e  a+ +f+qlvsav Y

Q: 1060  VEHANIIKVLDVFENQGFFQLVMEkHGSGLDLFAFIDRHPSLDEPLASYIFRQLVSAVVY  1119

         ************************888899******************************

S: 114   lhskgivHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkk  173

         l+s++i HrD+K eN+++ ++ +ik++DFG a+++++gkl+ tfcG+++Y+aPe+l+g++

Q: 1120  LRSESILHRDIKDENIVIAEDFSIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNP  1179

         ************************************************************

S: 174   YegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklL  233

         Y+gp++++Ws+Gv+Ly+l++++ Pf e       e++++  ++ p+ +s++l++L++ lL

Q: 1180  YRGPELEMWSMGVTLYTLIFEENPFCEL------EETMEAAINPPYLVSEDLMNLMSGLL  1233

         *************************998......7888999999****************

S: 234   vvdpekRatieeilkhewl  252

         +  pe+R+t+e++++++w+

Q: 1234  QPVPEQRTTLEKLVTDRWV  1252

         ******************6

Domain Sequence
(FASTA)

YSTLSPIGSG AFGFVWTAVD KEANKEVVVK FIKKEKVLED CWIEDPKLGK VTLEIAILCK 60

VEHANIIKVL DVFENQGFFQ LVMEKHGSGL DLFAFIDRHP SLDEPLASYI FRQLVSAVVY 120

LRSESILHRD IKDENIVIAE DFSIKLIDFG SAAYLERGKL FYTFCGTIEY CAPEVLMGNP 180

YRGPELEMWS MGVTLYTLIF EENPFCELEE TMEAAINPPY LVSEDLMNLM SGLLQPVPEQ 240

RTTLEKLVTD RWV 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0035091	; F:phosphatidylinositol binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004871	; F:signal transducer activity
GO:0045719	; P:negative regulation of glycogen biosynthetic process
GO:0046777	; P:protein autophosphorylation
GO:2000505	; P:regulation of energy homeostasis
GO:0070092	; P:regulation of glucagon secretion
GO:0043576	; P:regulation of respiratory gaseous exchange

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000014	; PAS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00091	; PAS; 2.
SM00220	; S_TKc; 1.

Prosites

PS50112	; PAS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013