EKS-BOT-00008
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00008
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph490.58.7E-148614870257
StatusUnreviewed
Ensembl ProteinENSBTAP00000001080
UniProt AccessionE1BJ31;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA2
Gene Synonyms/Alias EPHA2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000000815ENSBTAP00000001080ENSBTAT00000001080
OrganismBos taurus
Functional Description
Protein Length975
Protein Sequence
(FASTA)
MGRRAPPACL ALLWGCALAA ASAAQGKEVV LLDFAAAKGE LGWLTHPYGK GWDLLQNIMN 60
DMPIYMYSVC NVVAGDQDNW LRTNWVYRGE AERIFIELKF TVRDCNSFPG GASSCKETFN 120
LYYAESDVDY GTNFQKRQFT KIDTIAPDEI TGSSDFEARH VKLNVEERSV GPLTRKGFYL 180
AFQDVGACVA LLSVRVYYKK CPELLKGLAR FPETIAGSDA PALATVAGNC VEHAVVPPGG 240
EEPRMHCAVD GEWLVPIGQC LCQAGYEKVE DACQACSPGF FKPEASESPC LECPAHTLPS 300
SEGATACECE DGYFRAPQDP LSLPCTRPPS APHYLTAVGM GAKVELRWTP PQDSGGREDL 360
TYSVSCEQCW PESGECGPCE ASVRYSEPPL GLTRTSVTVS DLEPHMNYTF TVEARNGVSG 420
LVSTRSFRTA SVSINQTEPP KVKLESRSTT SLSISWIIPP LQQSRVWKYE VTYRKKGDSN 480
SYNVRRTEGF SVTLDDLAPD TVYLVQVQAL TQEGQGAGSK VHEFQTLSTG GSGNMAVVGG 540
VAVGAVLLLV LAGIGFFIHR RRKSLRTRQS SEDVYFSKSE QLKPLKTYVD PHTYEDPNQA 600
VLKFTTEIHP SCVTRQKVIG AGEFGEVYKG TLKASGKKEV PVAIKTLKAG YTEKQRVDFL 660
SEASIMGQFS HHNIIRLEGV VSKYKPLMII TEYMENGALD KFLREKDGEF SVLQLVGMLR 720
GVAAGMKYLA NMSYVHRDLA ARNILVNSNL VCKVSDFGLS RVLEDDPEAT YTTSGGKIPI 780
RWTAPEAISY RKFTSASDVW SYGIVMWEVM TYGERPYWEL SNHEVMKAIN DGFRLPTPMD 840
CPSAIYQLMM QCWQQERTRR PKFADIVSIL DKLIRAPDSL KTLADFDPRV SIRLPSTSGS 900
EGVPFRTVSE WLESIKMQQY TEHFLVAGYT TIEKVVQMTN DDIKRIGVRL PGHQKRIAYS 960
LLGLKDQVNT VGVPI 975
Nucleotide Sequence
(FASTA)
ATGGGGCGTC GGGCGCCGCC CGCCTGCCTC GCGCTGCTGT GGGGCTGCGC GCTGGCCGCG 60
GCCTCCGCGG CGCAGGGCAA GGAAGTTGTC CTGTTGGATT TCGCTGCGGC TAAAGGGGAG 120
CTTGGCTGGC TCACACACCC GTATGGCAAA GGGTGGGACC TCCTGCAGAA CATCATGAAC 180
GACATGCCCA TCTACATGTA CTCCGTGTGC AACGTGGTGG CCGGCGACCA GGACAACTGG 240
CTCCGCACCA ACTGGGTCTA CCGGGGGGAG GCCGAGCGCA TCTTCATCGA GCTCAAGTTC 300
ACCGTGCGGG ACTGCAACAG CTTCCCCGGG GGCGCCAGCT CCTGCAAGGA GACCTTCAAC 360
CTCTATTACG CTGAGTCGGA CGTGGACTAC GGCACCAACT TCCAGAAGCG CCAGTTCACC 420
AAGATTGACA CCATCGCGCC CGATGAGATC ACGGGCAGCA GCGACTTTGA GGCGCGCCAC 480
GTGAAGCTGA ATGTGGAGGA GCGGTCCGTG GGGCCGCTCA CACGCAAGGG CTTCTACCTG 540
GCCTTCCAGG ACGTGGGCGC CTGCGTGGCA CTGCTGTCCG TCCGTGTCTA CTACAAGAAG 600
TGCCCCGAGC TGCTCAAGGG CCTGGCCCGC TTCCCCGAGA CCATCGCCGG CTCCGACGCG 660
CCCGCCCTGG CCACCGTCGC GGGCAACTGT GTGGAGCATG CTGTGGTGCC CCCCGGGGGT 720
GAGGAGCCCC GCATGCACTG TGCTGTGGAT GGCGAGTGGC TGGTGCCCAT CGGCCAGTGC 780
CTGTGCCAGG CGGGCTACGA GAAGGTGGAG GACGCCTGCC AGGCCTGCTC GCCGGGGTTC 840
TTCAAGCCCG AGGCGTCCGA GAGCCCGTGT CTGGAGTGCC CCGCACACAC CCTGCCGTCC 900
TCCGAGGGTG CCACCGCCTG CGAGTGTGAG GACGGCTACT TCCGGGCCCC GCAGGACCCA 960
CTGTCCCTGC CCTGCACGCG CCCCCCGTCT GCCCCACACT ACCTCACGGC CGTGGGCATG 1020
GGCGCCAAGG TGGAGCTGCG CTGGACGCCC CCCCAGGACA GCGGGGGCCG CGAGGACCTC 1080
ACCTACAGCG TCTCCTGTGA GCAGTGCTGG CCCGAGTCGG GCGAGTGCGG GCCCTGCGAG 1140
GCCAGTGTGC GCTACTCGGA GCCGCCGCTG GGGCTGACCC GCACCAGCGT GACCGTCAGT 1200
GACCTGGAGC CCCACATGAA CTACACTTTC ACCGTAGAGG CCCGCAACGG CGTCTCGGGC 1260
CTGGTGAGCA CCCGCAGCTT CCGCACCGCC AGCGTCAGCA TCAACCAGAC CGAGCCCCCC 1320
AAGGTGAAGC TGGAGAGCCG CAGCACCACC TCACTGAGCA TCTCCTGGAT CATCCCTCCG 1380
CTGCAGCAGA GCCGCGTATG GAAGTATGAG GTCACCTACC GCAAGAAGGG CGACTCTAAC 1440
AGCTACAACG TGCGGCGCAC GGAAGGCTTC TCTGTGACGC TGGACGACCT GGCCCCAGAC 1500
ACCGTCTACC TGGTGCAGGT GCAGGCGCTG ACGCAGGAGG GCCAGGGCGC GGGCAGCAAG 1560
GTGCACGAAT TCCAGACGCT GTCCACGGGA GGGTCTGGCA ACATGGCAGT GGTCGGCGGT 1620
GTGGCTGTCG GTGCGGTCTT GCTCCTGGTG CTGGCAGGAA TCGGCTTCTT CATCCACCGC 1680
AGGAGGAAGA GCCTGCGGAC ACGCCAGTCC TCGGAGGACG TTTACTTCTC CAAATCAGAA 1740
CAACTGAAAC CCCTGAAGAC CTATGTGGAC CCCCACACCT ACGAGGACCC CAACCAGGCT 1800
GTGCTCAAGT TCACCACAGA GATCCATCCG TCTTGCGTCA CGCGGCAGAA GGTGATCGGA 1860
GCCGGAGAGT TTGGGGAGGT GTACAAGGGC ACCCTGAAGG CGTCGGGGAA GAAGGAGGTA 1920
CCTGTGGCCA TCAAGACGCT GAAAGCCGGC TACACGGAGA AGCAGCGAGT AGACTTTCTC 1980
AGCGAGGCCA GCATCATGGG CCAGTTCAGC CACCACAACA TTATCCGCCT GGAGGGCGTC 2040
GTCTCCAAGT ACAAACCTCT GATGATCATC ACCGAATACA TGGAGAACGG GGCCCTGGAC 2100
AAGTTCCTGC GGGAGAAGGA CGGCGAGTTC AGCGTGCTGC AGCTGGTGGG CATGCTGCGG 2160
GGCGTCGCGG CCGGCATGAA GTACCTGGCC AACATGAGCT ATGTCCACCG CGACCTGGCC 2220
GCCCGCAATA TCCTCGTCAA CAGCAACCTG GTCTGCAAGG TGTCTGACTT CGGCCTGTCC 2280
CGTGTGCTGG AGGACGACCC CGAGGCCACC TACACCACCA GTGGTGGCAA GATCCCAATC 2340
CGCTGGACGG CTCCTGAGGC CATTTCCTAC CGGAAGTTCA CCTCGGCCAG CGATGTGTGG 2400
AGCTATGGCA TCGTCATGTG GGAGGTGATG ACGTATGGGG AGCGGCCCTA CTGGGAGCTG 2460
TCGAACCATG AGGTGATGAA GGCCATCAAT GACGGCTTCC GGCTGCCCAC GCCCATGGAC 2520
TGCCCCTCCG CCATCTACCA GCTCATGATG CAGTGCTGGC AGCAGGAACG CACCCGCCGC 2580
CCCAAGTTCG CCGACATCGT CAGCATCCTG GACAAGCTCA TCCGTGCCCC CGACTCCCTC 2640
AAGACCCTGG CTGATTTTGA CCCCCGGGTG TCCATCCGGC TGCCCAGCAC CAGCGGCTCA 2700
GAGGGTGTGC CCTTCCGCAC GGTGTCCGAG TGGCTGGAGT CCATCAAGAT GCAGCAGTAC 2760
ACGGAGCACT TCCTGGTGGC TGGCTACACC ACCATCGAGA AGGTGGTGCA GATGACCAAC 2820
GACGACATCA AGAGGATTGG GGTGCGGCTG CCCGGCCACC AGAAGCGCAT CGCCTACAGC 2880
CTGCTGGGTC TCAAGGACCA GGTGAACACG GTGGGGGTCC CCATCTGA 2928
Domain Profile
S: 2     kiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhpn  61
         + +kviGaGefGev++G+lk++gk+e++vaiktlkag+tekqr+dflseasi+Gqf+h+n
Q: 614   TRQKVIGAGEFGEVYKGTLKASGKKEVPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHN  673
         6789********************************************************
S: 62    iirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmg  121
         iirleGvv+k kp+mi+teymengald+flr+kdg+f+v+qlvgmlrG+a+gmkyl++m+
Q: 674   IIRLEGVVSKYKPLMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGVAAGMKYLANMS  733
         ************************************************************
S: 122   yvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrkf  181
         yvhrdlaarnilvnsnlvckvsdfGlsrvledd+ea+yttsggkipirwtapeai+yrkf
Q: 734   YVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKF  793
         ************************************************************
S: 182   tsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldcw  241
         tsasdvwsyGiv+wev++yGerpyw++sn++v+kai++g+rlp+pmdcp+a+yqlm++cw
Q: 794   TSASDVWSYGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCW  853
         ************************************************************
S: 242   qkdraerpkfeqivsil  258
         q++r++rpkf++ivsil
Q: 854   QQERTRRPKFADIVSIL  870
         **************985
Domain Sequence
(FASTA)
TRQKVIGAGE FGEVYKGTLK ASGKKEVPVA IKTLKAGYTE KQRVDFLSEA SIMGQFSHHN 60
IIRLEGVVSK YKPLMIITEY MENGALDKFL REKDGEFSVL QLVGMLRGVA AGMKYLANMS 120
YVHRDLAARN ILVNSNLVCK VSDFGLSRVL EDDPEATYTT SGGKIPIRWT APEAISYRKF 180
TSASDVWSYG IVMWEVMTYG ERPYWELSNH EVMKAINDGF RLPTPMDCPS AIYQLMMQCW 240
QQERTRRPKF ADIVSIL 257
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00009
EKS-ANC-00009
EKS-CAJ-00009
EKS-CAF-00010
EKS-CAP-00007
EKS-DAR-00015
EKS-EQC-00010
EKS-FEC-00007
EKS-GAM-00004
EKS-GAA-00015
EKS-GOG-00009
EKS-HOS-00011
EKS-ICT-00009
EKS-LAC-00010
EKS-LOA-00010
EKS-MAM-00009
EKS-MAE-00001
EKS-MEG-00012
EKS-MUM-00010
EKS-MUP-00010
EKS-MYL-00011
EKS-NOL-00009
EKS-OCP-00002
EKS-ORN-00018
EKS-ORA-00008
EKS-ORC-00009
EKS-ORL-00015
EKS-OTG-00010
EKS-PAT-00012
EKS-PES-00008
EKS-POA-00010
EKS-RAN-00009
EKS-SAH-00008
EKS-SUS-00007
EKS-TAR-00014
EKS-TEN-00014
EKS-XIM-00015
Gene Ontology
GO:0005925; C:focal adhesion
GO:0005887; C:integral to plasma membrane
GO:0031256; C:leading edge membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
GO:0032863; P:activation of Rac GTPase activity
GO:0006915; P:apoptotic process
GO:0048320; P:axial mesoderm formation
GO:0046849; P:bone remodeling
GO:0060444; P:branching involved in mammary gland duct morphogenesis
GO:0060326; P:cell chemotaxis
GO:0030216; P:keratinocyte differentiation
GO:0070309; P:lens fiber cell morphogenesis
GO:0033598; P:mammary gland epithelial cell proliferation
GO:0051898; P:negative regulation of protein kinase B signaling cascade
GO:0021915; P:neural tube development
GO:0030182; P:neuron differentiation
GO:0060035; P:notochord cell development
GO:0014028; P:notochord formation
GO:0001649; P:osteoblast differentiation
GO:0030316; P:osteoclast differentiation
GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane
GO:0043491; P:protein kinase B signaling cascade
GO:0045765; P:regulation of angiogenesis
GO:0043535; P:regulation of blood vessel endothelial cell migration
GO:0033628; P:regulation of cell adhesion mediated by integrin
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0010591; P:regulation of lamellipodium assembly
GO:0070848; P:response to growth factor stimulus
GO:0001501; P:skeletal system development
GO:0001570; P:vasculogenesis
KEGG
bta:512798;
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013