EKS-BOT-00321
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00321
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20333.11.3E-9916272257
StatusUnreviewed
Ensembl ProteinENSBTAP00000001378
UniProt AccessionE1B902;
Protein NameMitogen-activated protein kinase kinase kinase kinase
Protein Synonyms/Alias
Gene NameMAP4K2
Gene Synonyms/Alias MAP4K2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000001037ENSBTAP00000001378ENSBTAT00000001378
OrganismBos taurus
Functional Description
Protein Length821
Protein Sequence
(FASTA)
MALLQNVSLQ DPRDRFELLQ RVGAGTYGDV YKARDTVTSE LAAVKIVKLD PGDDISSLQQ 60
EITILRECRH PNVVAYIGSY LRNDRLWICM EFCGGGSLQE IYHATGPLEE RQIAYVCREA 120
LKGLHHLHSQ GKIHRDIKGA NLLLTLQGDV KLADFGVSGE LTASVAKRRS FIGTPYWMAP 180
EVAAVERKGG YNELCDVWAL GITAIELGEL QPPLFHLHPM RALMLMSKSS FQPPKLRDKT 240
RWTQNFHHFL KLALTKNPKK RPTAERLLQH PFTTQHLPRA LLTQLLDKAN DPHLGTPSPE 300
DCDLETYDIF PDTIHSRGQH GPAERTPSEI QFHQVKFGAP RRKETDPLNE PWEEEWTLLG 360
KEELSGSLLQ SVQEALEERS LTIRPASELQ ELDSPDDTIG TIKRAPFLGS SPTEPPAEDL 420
HPSLPGTPPL PHPGPASPPL LPTAWATMKH REDPERSSCH GLPPTPKVHM GACFSKVFNG 480
CPLRIHAAIT WIHPVTRDQF LVVGAEEGIY TLNLHELHED TLEKLISHRC AWLYCVNNVL 540
LSLSGKSTHI WAHDLPGLFE QRRLQQQVPL SIPTNRLTQR IIPRRFALSN KIPDTKGCLQ 600
CRVVRNPHTG STFLLAALPS SLLLLQWYEP LQKFLLLKNF SSPLPSPAGM LEPLVLDGKE 660
LPQVCVGAEG PEGPGCRVLF HVLPLEAGLT PDILIPPAEG FPGSAQQVIQ VDRDTVLVCF 720
DRCVRIVNLL GEPTATLAPV LTFDFPIETV VCLQDSVLAF WSHGMQGRSL DTNEVTQEIT 780
DETRIFRVLG AHRDIILESI PTDKPGAHSN LYILTGHQSS Y 821
Nucleotide Sequence
(FASTA)
ATGGCGCTGC TGCAGAACGT GTCGCTGCAG GATCCACGGG ACCGCTTCGA GCTGCTGCAG 60
CGCGTGGGGG CCGGGACCTA TGGCGACGTC TACAAGGCCC GCGATACGGT CACGTCCGAA 120
CTGGCCGCGG TCAAAATAGT CAAGCTAGAC CCAGGGGACG ACATCAGCTC CCTTCAGCAG 180
GAAATCACCA TCCTGCGTGA GTGCCGCCAC CCCAATGTGG TGGCCTACAT TGGCAGCTAC 240
CTCAGGAATG ACCGCTTGTG GATCTGCATG GAGTTCTGCG GAGGGGGGTC CCTGCAGGAG 300
ATTTACCACG CCACCGGGCC CCTGGAGGAG CGGCAGATTG CCTATGTCTG TCGAGAGGCA 360
CTGAAGGGGC TCCACCACTT GCATTCTCAG GGGAAGATCC ACAGAGACAT CAAGGGAGCC 420
AACCTTCTCC TCACCCTCCA GGGAGATGTC AAGCTGGCTG ACTTCGGGGT GTCAGGCGAG 480
CTGACAGCGT CTGTGGCCAA GAGGAGGTCT TTCATTGGGA CTCCATACTG GATGGCCCCA 540
GAGGTGGCCG CCGTGGAGCG CAAAGGTGGC TACAATGAGC TGTGTGACGT CTGGGCCCTG 600
GGCATCACTG CCATCGAGCT GGGCGAGCTG CAGCCGCCTC TCTTCCACCT GCATCCCATG 660
AGGGCCTTGA TGCTTATGTC GAAGAGCAGC TTCCAGCCGC CAAAGCTGAG AGACAAGACT 720
CGCTGGACCC AGAATTTCCA TCACTTCCTC AAGCTTGCCT TGACCAAGAA TCCCAAGAAG 780
AGACCAACAG CGGAGAGGCT TCTGCAGCAC CCCTTCACGA CCCAGCACCT GCCTCGGGCT 840
CTCCTCACAC AGCTGTTGGA CAAGGCCAAT GATCCCCACC TGGGAACCCC CTCTCCAGAA 900
GACTGTGACC TGGAGACTTA TGACATATTT CCGGACACCA TTCACTCCCG GGGGCAGCAT 960
GGCCCAGCCG AGAGGACCCC CTCGGAGATC CAGTTTCACC AGGTGAAATT CGGCGCCCCA 1020
CGCAGGAAGG AAACAGACCC ACTGAATGAG CCGTGGGAAG AGGAGTGGAC GCTGCTGGGG 1080
AAGGAGGAGC TGAGTGGGAG CCTGCTGCAG TCAGTCCAGG AGGCCCTGGA GGAAAGGAGC 1140
CTGACCATCC GGCCGGCCTC GGAACTCCAG GAGCTGGACT CTCCAGATGA CACCATAGGA 1200
ACCATCAAGA GGGCCCCGTT CTTGGGGTCA TCTCCCACTG AGCCTCCAGC CGAGGACCTT 1260
CACCCCAGCC TCCCAGGAAC CCCACCCCTG CCGCACCCAG GCCCCGCCAG CCCTCCCCTG 1320
CTCCCCACCG CCTGGGCCAC CATGAAGCAC CGGGAAGATC CTGAGAGGTC ATCCTGCCAC 1380
GGGCTCCCCC CGACCCCCAA GGTGCACATG GGCGCCTGCT TCTCCAAGGT CTTCAATGGC 1440
TGCCCCCTGC GGATCCATGC CGCTATCACC TGGATTCACC CTGTCACCCG GGACCAGTTC 1500
CTGGTGGTGG GAGCCGAGGA GGGCATCTAT ACCCTCAACC TGCACGAACT GCATGAGGAT 1560
ACACTGGAGA AGCTGATTTC GCACCGCTGC GCCTGGCTCT ACTGCGTGAA CAACGTGCTC 1620
CTGTCCCTCT CAGGGAAATC CACGCACATC TGGGCCCATG ACCTCCCAGG CCTGTTTGAA 1680
CAGCGGCGGC TACAGCAGCA GGTCCCCCTC TCCATCCCCA CCAACCGCCT CACCCAGCGC 1740
ATCATCCCCA GGCGCTTTGC CCTGTCCAAC AAGATTCCTG ACACCAAAGG CTGCCTGCAG 1800
TGTCGTGTGG TGCGGAACCC CCACACGGGC AGCACCTTCC TGCTGGCCGC GCTCCCCTCC 1860
AGCCTGCTCC TGCTGCAGTG GTACGAGCCG TTGCAGAAGT TCCTGCTGCT GAAGAACTTC 1920
TCCAGCCCCT TGCCCAGCCC AGCAGGGATG CTGGAGCCGC TGGTACTGGA CGGGAAGGAG 1980
CTCCCGCAGG TGTGTGTGGG GGCCGAGGGC CCTGAGGGGC CCGGCTGCCG CGTCCTGTTC 2040
CACGTCCTAC CACTGGAGGC TGGCCTGACG CCGGACATCC TCATCCCACC CGCAGAGGGG 2100
TTCCCGGGCT CGGCCCAGCA GGTGATCCAG GTGGACAGGG ACACAGTCCT GGTCTGCTTT 2160
GACCGCTGCG TGAGGATTGT CAACCTGCTG GGCGAGCCCA CGGCCACGCT GGCGCCCGTG 2220
CTGACCTTTG ACTTCCCCAT TGAGACTGTG GTGTGCCTGC AGGACAGCGT GCTGGCCTTC 2280
TGGAGCCATG GGATGCAGGG CCGCAGCCTG GACACCAATG AGGTGACCCA GGAGATCACA 2340
GATGAGACGA GGATCTTCCG AGTGCTCGGC GCCCACAGAG ACATCATCCT TGAGAGCATT 2400
CCCACCGACA AGCCCGGGGC TCACAGCAAC CTCTACATTC TCACAGGCCA CCAGAGCAGT 2460
TACTGA 2466
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60
         +ell+++g G++g+vy+ar++ t+el+a+k+++l+  +++++lq+ei++l++++hpn+v+
Q: 16    FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNVVA  75
         899*********************************************************
S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120
         y++s+l++++lw++me++ gGsl+++++   + +l+E+qiay++re+lk+L++lHs+++i
Q: 76    YIGSYLRNDRLWICMEFCGGGSLQEIYH--ATGPLEERQIAYVCREALKGLHHLHSQGKI  133
         ****************************..9*****************************
S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179
         Hrdik++n+Llt +g+VkL+dfgv+ +l+++++kr++++gtpywmAPEv a+e + gY+e
Q: 134   HRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVErKGGYNE  193
         ****************************************************98889***
S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237
          +D+w+lGItaiel e +pP+++l+p++al++++k++  ppkl++k++++++f++f++ +
Q: 194   LCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSfqPPKLRDKTRWTQNFHHFLKLA  253
         **********************************99988*********************
S: 238   lqknpekRpsasellkhkF  256
         l+knp+kRp+a++ll+h+F
Q: 254   LTKNPKKRPTAERLLQHPF  272
         ******************9
Domain Sequence
(FASTA)
FELLQRVGAG TYGDVYKARD TVTSELAAVK IVKLDPGDDI SSLQQEITIL RECRHPNVVA 60
YIGSYLRNDR LWICMEFCGG GSLQEIYHAT GPLEERQIAY VCREALKGLH HLHSQGKIHR 120
DIKGANLLLT LQGDVKLADF GVSGELTASV AKRRSFIGTP YWMAPEVAAV ERKGGYNELC 180
DVWALGITAI ELGELQPPLF HLHPMRALML MSKSSFQPPK LRDKTRWTQN FHHFLKLALT 240
KNPKKRPTAE RLLQHPF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00310
EKS-CAJ-00329
EKS-CAF-00324
EKS-CAP-00353
EKS-CII-00179
EKS-CIS-00081
EKS-DAR-00674
EKS-DIO-00040
EKS-EQC-00329
EKS-FEC-00324
EKS-GAA-00396
EKS-GOG-00316
EKS-HOS-00329
EKS-ICT-00315
EKS-MUM-00354
EKS-MYL-00331
EKS-ORN-00418
EKS-OTG-00342
EKS-PAT-00304
EKS-POA-00311
EKS-PTV-00073
EKS-RAN-00352
EKS-SUS-00279
EKS-XET-00387
EKS-XIM-00410
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
GO:0007257; P:activation of JUN kinase activity
GO:0046330; P:positive regulation of JNK cascade
GO:0006903; P:vesicle targeting
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR021160; MAPKKKK.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013