EPS-BOT-00023

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-BOT-00023

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	229.3	7.1E-68	93	349	257

Status

Reviewed

Ensembl Protein

ENSBTAP00000050151

UniProt Accession

A5PJZ2;

Protein Name

Protein phosphatase 1L

Protein Synonyms/Alias

Protein phosphatase 1-like; Protein phosphatase 2C isoform epsilon; PP2C-epsilon;

Gene Name

PPM1L

Gene Synonyms/Alias

PPM1L; PP2CE;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000001274	ENSBTAP00000050151	ENSBTAT00000053250

Organism

Bos taurus

Functional Description

Acts as a suppressor of the SAPK signaling pathways byassociating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6 (By similarity).

Protein Length

360

Protein Sequence
(FASTA)

MIEDTMTLLS LLGRIMRYFL LRPETLFLLC ISLALWSYFF HTDEVKTIVK SSRDAVKMVK 60

GKVAEIMQND RLGGLDVLEA EFSKTWEFKS HNVAVYSIQG RRDHMEDRFE VLMDLANKTH 120

PSIFGIFDGH GGETAAEYVK SRLPEALKQH LQDYEKDKEN SVLSYQTILE QQILSIDREM 180

LEKLTVSYDE AGTTCLIALL SDKDLTVANV GDSRGVLCDK DGNAIPLSHD HKPYQLKERK 240

RIKRAGGFIS FNGSWRVQGI LAMSRSLGDY PLKNLNVVIP DPDILTFDLD KLQPEFMILA 300

SDGLWDAFSN EEAVRFIKDR LDEPHFGAKS IVLQSFYRGC PDNITVMVVK FRNSSKTEEQ 360

Nucleotide Sequence
(FASTA)

ATGATAGAGG ATACAATGAC TTTGCTATCT CTCCTGGGTC GCATCATGCG CTACTTCTTG 60

CTGAGACCCG AGACGCTGTT CCTGCTGTGC ATCAGCCTGG CGCTGTGGAG TTACTTCTTC 120

CACACGGACG AGGTGAAGAC TATCGTCAAA TCCAGCCGGG ACGCCGTGAA GATGGTGAAG 180

GGCAAGGTGG CCGAGATCAT GCAGAACGAT CGACTAGGGG GGCTCGACGT GCTGGAGGCT 240

GAGTTCTCCA AGACCTGGGA GTTCAAGAGC CACAATGTGG CGGTGTATTC CATCCAGGGT 300

CGGAGAGACC ACATGGAGGA CCGTTTCGAA GTTCTTATGG ACCTAGCCAA CAAGACGCAC 360

CCCTCTATCT TCGGGATCTT CGACGGGCAC GGGGGCGAGA CAGCAGCTGA ATATGTAAAA 420

TCTCGACTCC CAGAGGCCCT TAAGCAGCAT CTTCAAGACT ACGAGAAAGA CAAAGAAAAT 480

AGTGTATTGT CTTACCAGAC CATCCTTGAA CAGCAGATTC TATCAATTGA CCGAGAAATG 540

CTAGAAAAAT TGACTGTATC CTATGATGAA GCAGGTACAA CGTGTTTGAT TGCTCTGCTA 600

TCAGATAAAG ACCTCACTGT GGCCAACGTG GGTGACTCGC GTGGGGTCCT ATGTGACAAG 660

GATGGGAACG CCATTCCTTT GTCTCATGAT CACAAACCCT ACCAGCTGAA GGAGAGGAAG 720

AGGATAAAGA GAGCCGGTGG TTTTATCAGT TTCAATGGCT CCTGGAGGGT CCAGGGGATC 780

CTGGCCATGT CTCGATCGCT GGGGGATTAT CCACTGAAAA ACCTCAATGT GGTCATCCCA 840

GACCCAGATA TCCTGACCTT TGACCTGGAC AAGCTCCAGC CCGAGTTCAT GATCTTGGCA 900

TCAGATGGCC TCTGGGATGC TTTCAGCAAT GAGGAAGCTG TTCGATTCAT CAAGGACCGC 960

TTGGATGAAC CTCACTTTGG GGCCAAGAGC ATCGTTTTAC AGTCCTTTTA CAGAGGCTGC 1020

CCTGACAATA TAACAGTCAT GGTGGTGAAG TTCAGGAATA GCAGCAAAAC AGAAGAGCAG 1080

TGA 1083

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheila  62

         v v+s++grr++med++++  ++++++      ++fg++DGhgg+++a++++++l e+l+

Q: 93    VAVYSIQGRRDHMEDRFEVLMDLANKTHP----SIFGIFDGHGGETAAEYVKSRLPEALK  148

         6789**************98888887665....69*************************

S: 63    eele....sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdskly  118

         + l+    ++e++    +++l++  ls+d+e+  le+ + + d+ G+t+++al++d++l+

Q: 149   QHLQdyekDKENSVLSYQTILEQQILSIDREM--LEKLTVSYDEAGTTCLIALLSDKDLT  206

         ****654333333344459*************..999999********************

S: 119   vanvGdSravLcr.ngkavelssdHkpsredEleRieeaggsvilkdga.RvlGvLavsR  176

         vanvGdSr vLc+ +g+a++ls dHkp + +E++Ri++agg +  + g  Rv+G La+sR

Q: 207   VANVGDSRGVLCDkDGNAIPLSHDHKPYQLKERKRIKRAGGFISFN-GSwRVQGILAMSR  265

         *************566************************999977.667**********

S: 177   alGdlylk..pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdvlekke  233

         +lGd+ lk   +v+p+P++  ++l++ +  f+iLasDGlwd +sneeav++++d+l+

Q: 266   SLGDYPLKnlNVVIPDPDILTFDLDKLQPeFMILASDGLWDAFSNEEAVRFIKDRLD---  322

         ********8889************765544***************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

         ++   ak++v ++  rg+ dn++++vv

Q: 323   EPHFGAKSIVLQSFYRGCPDNITVMVV  349

         999********************9997

Domain Sequence
(FASTA)

VAVYSIQGRR DHMEDRFEVL MDLANKTHPS IFGIFDGHGG ETAAEYVKSR LPEALKQHLQ 60

DYEKDKENSV LSYQTILEQQ ILSIDREMLE KLTVSYDEAG TTCLIALLSD KDLTVANVGD 120

SRGVLCDKDG NAIPLSHDHK PYQLKERKRI KRAGGFISFN GSWRVQGILA MSRSLGDYPL 180

KNLNVVIPDP DILTFDLDKL QPEFMILASD GLWDAFSNEE AVRFIKDRLD EPHFGAKSIV 240

LQSFYRGCPD NITVMVV 257

Keyword

Complete proteome; Hydrolase; Magnesium; Manganese; Membrane; Metal-binding; Protein phosphatase; Reference proteome; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0000165	; P:MAPK cascade
GO:0006470	; P:protein dephosphorylation
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

bta:541235

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013