EKS-BOT-00173
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00173
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC443.04.1E-133330598269
StatusUnreviewed
Ensembl ProteinENSBTAP00000053326
UniProt AccessionF1MQ96;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCI
Gene Synonyms/Alias PRKCI;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000001403ENSBTAP00000053326ENSBTAT00000061563
OrganismBos taurus
Functional Description
Protein Length672
Protein Sequence
(FASTA)
ARWEGRRREA CRARRWEEPC GSGCPGEATL GSAPRAGTTG RRGQPRLRGR LEVRSPLRRP 60
ARPPYPRPPA RRGNKEMPTQ RDSSTMSHPI AGGGIGDHSH QVRVKAYYRG DIMITHFEPS 120
ISFEGLCNEV RDMCSFDNEQ LFTMKWIDEE GDPCTVSSQL ELEEAFRLYE LNKDSELLIH 180
VFPCVPERPG MPCPGEDKSI YRRGARRWRK LYCANGHTFQ AKRFNRRAHC AICTDRIWGL 240
GRQGYKCINC KLLVHKKCHK LVTIECGRHS LPPEPMMPMD QSSMHSDHAQ TVIPYNPSSH 300
ESLDQVGEEK EAMNTRESGK ASSSLGLQDF DLLRVIGRGS YAKVLLVRLK KTDRIYAMKV 360
VKKELVNDDE DIDWVQTEKH VFEQASNHPF LVGLHSCFQT ESRLFFVIEY VNGGDLMFHM 420
QRQRKLPEEH ARFYSAEISL ALNYLHERGI IYRDLKLDNV LLDSEGHIKL TDYGMCKEGL 480
RPGDTTSTFC GTPNYIAPEI LRGEDYGFSV DWWALGVLMF EMMAGRSPFD IVGSSDNPDQ 540
NTEDYLFQVI LEKQIRIPRS LSVKAASVLK SFLNKDPKER LGCHPQTGFA DIQGHPFFRN 600
VDWDMMEQKQ VVPPFKPNIS GEFGLDNFDS QFTNEPVQLT PDDDDIVRKI DQSEFEGFEY 660
INPLLMSAEE CV 672
Nucleotide Sequence
(FASTA)
GCGAGGTGGG AGGGACGGAG GCGGGAGGCG TGCAGGGCCC GGCGGTGGGA GGAGCCGTGC 60
GGTTCCGGCT GCCCAGGCGA GGCGACACTT GGGTCCGCGC CGCGGGCGGG GACGACAGGT 120
AGGCGAGGGC AGCCGCGGCT CCGCGGGAGG CTCGAGGTGC GGAGTCCCCT GCGGCGCCCG 180
GCGCGCCCCC CGTACCCTCG GCCTCCGGCG AGGCGGGGGA ATAAGGAGAT GCCGACCCAG 240
AGAGACAGCA GCACCATGTC TCACCCGATC GCAGGCGGCG GCATTGGGGA CCACTCTCAC 300
CAGGTCCGGG TGAAAGCCTA CTACCGCGGG GATATCATGA TAACACATTT TGAACCTTCA 360
ATATCCTTCG AGGGTCTTTG TAATGAGGTT CGAGACATGT GTTCTTTTGA CAACGAACAA 420
CTTTTCACCA TGAAATGGAT AGATGAGGAA GGAGACCCGT GTACAGTATC ATCTCAGTTG 480
GAGTTAGAAG AAGCCTTTAG GCTTTATGAG CTAAACAAGG ATTCTGAACT GTTGATTCAT 540
GTATTCCCTT GTGTACCAGA ACGTCCTGGA ATGCCCTGTC CAGGGGAAGA TAAATCCATT 600
TACAGACGAG GTGCACGCCG CTGGAGAAAG CTTTATTGTG CAAATGGACA CACTTTTCAA 660
GCCAAGCGTT TCAACAGGCG TGCGCACTGT GCCATCTGCA CTGACCGAAT TTGGGGACTT 720
GGACGTCAAG GATATAAGTG TATCAACTGC AAGCTCCTGG TTCATAAGAA GTGCCACAAA 780
CTTGTCACAA TTGAATGTGG GCGGCATTCG TTGCCACCGG AACCAATGAT GCCCATGGAC 840
CAGTCATCCA TGCACTCAGA CCACGCACAG ACAGTAATTC CATATAATCC TTCAAGTCAT 900
GAGAGTTTGG ACCAAGTTGG TGAAGAAAAG GAGGCAATGA ACACCAGGGA AAGTGGCAAA 960
GCTTCTTCCA GTTTAGGTCT TCAGGACTTT GATTTGCTCC GAGTAATAGG AAGAGGAAGT 1020
TATGCTAAAG TACTGTTGGT ACGATTAAAA AAAACAGATC GTATTTATGC AATGAAAGTT 1080
GTGAAAAAAG AGCTTGTCAA TGATGATGAG GATATTGACT GGGTACAGAC AGAGAAACAT 1140
GTTTTTGAAC AGGCATCCAA TCATCCTTTT CTTGTTGGGC TGCATTCTTG CTTTCAGACA 1200
GAAAGCAGAT TGTTCTTTGT TATAGAGTAT GTTAATGGAG GAGATTTAAT GTTTCATATG 1260
CAACGACAAA GAAAACTTCC TGAAGAGCAT GCCAGATTTT ACTCTGCAGA AATCAGTCTA 1320
GCATTAAATT ATCTTCATGA ACGAGGGATA ATTTATAGAG ATTTGAAATT GGACAACGTG 1380
TTGCTGGACT CTGAAGGACA CATTAAACTC ACTGACTATG GCATGTGTAA GGAAGGATTA 1440
CGGCCAGGAG ATACAACTAG CACTTTCTGT GGTACTCCTA ATTACATCGC TCCTGAAATC 1500
TTAAGAGGAG AAGATTATGG TTTCAGTGTC GACTGGTGGG CTCTTGGAGT ACTCATGTTT 1560
GAGATGATGG CAGGAAGGTC TCCATTTGAT ATTGTTGGGA GCTCGGATAA CCCTGATCAA 1620
AACACAGAGG ATTATCTTTT TCAAGTTATT TTGGAAAAAC AAATTCGCAT ACCGCGTTCT 1680
TTATCTGTAA AAGCTGCAAG TGTCCTGAAG AGCTTCCTCA ACAAGGACCC AAAGGAACGA 1740
TTGGGTTGTC ATCCACAAAC AGGATTTGCT GATATTCAGG GACACCCATT CTTCCGAAAT 1800
GTTGATTGGG ATATGATGGA GCAAAAGCAG GTGGTACCTC CGTTTAAACC AAATATTTCT 1860
GGGGAATTTG GTTTGGACAA CTTTGATTCT CAGTTTACTA ATGAACCTGT CCAGCTCACT 1920
CCTGATGATG ATGACATTGT GAGGAAGATC GATCAGTCTG AATTTGAAGG TTTTGAGTAC 1980
ATTAATCCTC TCTTGATGTC TGCAGAAGAA TGTGTCTGA 2019
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f+ll+v+G+Gs++kvll++lkktd++ya+kv+kk++v++d+d++++++ek+v+++as++p
Q: 330   FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP  389
         89**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         flv l+scfqte+rlffv+eyvnGGdlmfh+q++rkl+ee+arfy+aei+lal++lhe+g
Q: 390   FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERG  449
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnvlld+eGhikl+d+G+cke++  g+ttstfcGtP+yiaPeil++e+yg+s
Q: 450   IIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFS  509
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfe.........gededelfesilekevlyPkslskeaveil  231
         vdwwalGvl++em+ag+sPf+         +++ed+lf++ilek++++P+sls++a+++l
Q: 510   VDWWALGVLMFEMMAGRSPFDivgssdnpdQNTEDYLFQVILEKQIRIPRSLSVKAASVL  569
         *****************************99*****************************
S: 232   kglltkdpekrlGvk.eegeedikehaff  259
         k++l+kdp++rlG++ ++g +di+ h+ff
Q: 570   KSFLNKDPKERLGCHpQTGFADIQGHPFF  598
         **************989***********9
Domain Sequence
(FASTA)
FDLLRVIGRG SYAKVLLVRL KKTDRIYAMK VVKKELVNDD EDIDWVQTEK HVFEQASNHP 60
FLVGLHSCFQ TESRLFFVIE YVNGGDLMFH MQRQRKLPEE HARFYSAEIS LALNYLHERG 120
IIYRDLKLDN VLLDSEGHIK LTDYGMCKEG LRPGDTTSTF CGTPNYIAPE ILRGEDYGFS 180
VDWWALGVLM FEMMAGRSPF DIVGSSDNPD QNTEDYLFQV ILEKQIRIPR SLSVKAASVL 240
KSFLNKDPKE RLGCHPQTGF ADIQGHPFF 269
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00167
EKS-ANC-00167
EKS-CAE-00132
EKS-CAJ-00178
EKS-CAF-00180
EKS-CAP-00175
EKS-CII-00115
EKS-CIS-00206
EKS-DAR-00465
EKS-DRM-00085
EKS-EQC-00170
EKS-ERE-00041
EKS-FEC-00163
EKS-GAM-00090
EKS-GAA-00207
EKS-GOG-00172
EKS-HOS-00179
EKS-LAC-00184
EKS-LOA-00171
EKS-MOD-00170
EKS-MUM-00178
EKS-MUP-00177
EKS-MYL-00182
EKS-NOL-00166
EKS-ORN-00218
EKS-ORA-00151
EKS-ORC-00159
EKS-ORL-00204
EKS-OTG-00182
EKS-PAT-00164
EKS-PES-00152
EKS-POA-00167
EKS-RAN-00169
EKS-SAH-00164
EKS-SUS-00149
EKS-TAG-00201
EKS-TAR-00224
EKS-TAS-00058
EKS-TEN-00216
EKS-TUT-00155
EKS-XET-00165
EKS-XIM-00212
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0005829; C:cytosol
GO:0005634; C:nucleus
GO:0043220; C:Schmidt-Lanterman incisure
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0005543; F:phospholipid binding
GO:0004697; F:protein kinase C activity
GO:0007015; P:actin filament organization
GO:0045216; P:cell-cell junction organization
GO:0035089; P:establishment of apical/basal cell polarity
GO:0042462; P:eye photoreceptor cell development
GO:0035556; P:intracellular signal transduction
GO:0034351; P:negative regulation of glial cell apoptotic process
GO:0043524; P:negative regulation of neuron apoptotic process
GO:2000353; P:positive regulation of endothelial cell apoptotic process
GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane
GO:0060252; P:positive regulation of glial cell proliferation
GO:0046326; P:positive regulation of glucose import
GO:0010976; P:positive regulation of neuron projection development
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR000270; OPR_PB1.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF00564; PB1; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 1.
SM00666; PB1; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013