EKS-BOT-00367

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00367

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	447.4	1.4E-134	275	524	250

Status

Unreviewed

Ensembl Protein

ENSBTAP00000001995

UniProt Accession

A7MB57;

Protein Name

Protein Synonyms/Alias

YES1 protein;

Gene Name

YES1

Gene Synonyms/Alias

YES1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000001523	ENSBTAP00000001995	ENSBTAT00000001995

Organism

Bos taurus

Functional Description

Protein Length

541

Protein Sequence
(FASTA)

MGCIKSKENK SPSIKYRPEN TPEPVSTGVG HYGGEHAVVA PTSSTKSTSA NFSSLSMTPF 60

GGSSAVTPFG GASSSFSVVP SSYPAGLTGG VTIFVALYDY EARTTEDLSF KKGERFQIIN 120

NTEGDWWEAR SIATGKNGYI PSNYVAPADS IQAEEWYFGK MGRKDAERLL LNPGNQRGIF 180

LVRESETTKG AYSLSIRDWD EVRGDNVKHY KIRKLDNGGY YITTRAQFDT LQKLVKHYTE 240

HADGLCHKLT TVCPTVKPQT QGLAKDAWEI PRESLRLEVK LGQGCFGEVW MGTWNGTTKV 300

AIKTLKPGTM MPEAFLQEAQ IMKKLRHDKL VPLYAVVSEE PIYIVTEFMS KGSLLDFLKE 360

GDGKYLKLPQ LVDMAAQIAD GMAYIERMNY IHRDLRAANI LVGENLVCKI ADFGLARLIE 420

DNEYTARQGA KFPIKWTAPE AALYGRFTIK SDVWSFGILQ TELVTKGRVP YPGMVNREVL 480

EQVERGYRMP CPQGCPESLH ELMNLCWKKD PDERPTFEYI QSFLEDYFTA TEPQYQPGEN 540

L 541

Nucleotide Sequence
(FASTA)

ATGGGCTGCA TTAAAAGTAA AGAGAACAAA AGTCCATCCA TTAAATATAG ACCAGAAAAC 60

ACGCCAGAGC CGGTCAGCAC AGGAGTAGGC CATTATGGAG GAGAACACGC TGTGGTGGCA 120

CCAACATCCT CCACGAAGAG CACATCTGCC AATTTCAGCA GCCTCTCCAT GACGCCATTC 180

GGAGGGTCCT CGGCGGTGAC ACCTTTTGGA GGAGCATCTT CCTCGTTTTC AGTGGTGCCA 240

AGTTCATATC CTGCTGGTTT AACAGGTGGT GTTACTATAT TTGTGGCCTT ATATGATTAT 300

GAAGCTAGAA CTACAGAAGA CCTTTCATTT AAGAAAGGTG AAAGATTTCA AATAATTAAC 360

AACACGGAAG GAGACTGGTG GGAGGCGAGA TCAATCGCTA CAGGAAAGAA CGGCTACATC 420

CCAAGCAATT ACGTAGCCCC GGCGGATTCC ATTCAGGCTG AAGAATGGTA TTTTGGCAAA 480

ATGGGGAGAA AAGATGCGGA AAGATTACTT CTGAATCCTG GGAATCAGCG AGGTATTTTC 540

TTAGTAAGAG AGAGTGAAAC TACTAAAGGT GCTTACTCCC TCTCTATTCG GGACTGGGAT 600

GAGGTGAGGG GTGACAATGT GAAGCACTAC AAAATTAGGA AACTTGACAA TGGTGGATAC 660

TACATCACAA CCAGAGCACA GTTTGACACT CTGCAGAAAC TGGTAAAACA CTACACAGAA 720

CATGCCGATG GTTTATGCCA TAAGTTAACA ACTGTGTGTC CAACTGTGAA ACCCCAGACT 780

CAAGGTCTAG CAAAAGATGC TTGGGAAATC CCGCGAGAAT CTTTGCGACT AGAGGTTAAA 840

CTAGGACAAG GATGTTTTGG TGAAGTTTGG ATGGGAACGT GGAATGGAAC CACAAAAGTA 900

GCGATCAAAA CACTGAAGCC AGGTACAATG ATGCCAGAAG CTTTTCTTCA AGAGGCTCAG 960

ATAATGAAAA AACTAAGACA TGATAAACTT GTTCCACTAT ATGCTGTTGT TTCTGAAGAG 1020

CCGATTTACA TTGTCACTGA GTTTATGTCA AAAGGGAGCT TATTGGATTT CCTGAAGGAG 1080

GGAGATGGAA AGTATCTGAA GCTCCCACAG CTGGTTGACA TGGCTGCTCA GATTGCTGAT 1140

GGTATGGCCT ATATTGAAAG AATGAACTAT ATTCATCGAG ATCTTCGGGC TGCTAATATT 1200

CTCGTAGGCG AAAACCTTGT GTGCAAAATA GCAGATTTTG GCTTAGCAAG GTTAATTGAA 1260

GACAATGAAT ATACGGCAAG ACAAGGTGCA AAATTTCCAA TCAAGTGGAC AGCTCCTGAG 1320

GCTGCACTGT ATGGTCGATT TACAATCAAG TCTGATGTAT GGTCATTTGG AATTCTACAG 1380

ACAGAACTGG TAACAAAGGG CAGAGTGCCA TATCCAGGTA TGGTGAACCG TGAGGTGCTG 1440

GAGCAGGTGG AGCGAGGGTA CAGGATGCCA TGCCCGCAGG GCTGCCCAGA GTCCCTCCAC 1500

GAATTGATGA ATCTGTGTTG GAAGAAGGAC CCTGATGAGA GACCAACATT TGAGTATATC 1560

CAGTCCTTCC TGGAAGACTA TTTCACTGCT ACAGAGCCAC AGTACCAGCC AGGAGAAAAT 1620

TTATAA 1626

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g++kva+ktlk+gt++peafl+eaqi+kklrh+klv ly

Q: 275   LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY  334

         68999*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflke +gk+lklp+lvd+aaq+a+Gmay+e++n+ihr

Q: 335   AVVSE-EPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHR  393

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvge+lv+k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 394   DLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  453

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGil te+vtkG+vPypGm n+evleqvergyr+p+p+ cpe+l+el++ cwkkdp+e

Q: 454   WSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDE  513

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe++q++l

Q: 514   RPTFEYIQSFL  524

         *******9986

Domain Sequence
(FASTA)

LRLEVKLGQG CFGEVWMGTW NGTTKVAIKT LKPGTMMPEA FLQEAQIMKK LRHDKLVPLY 60

AVVSEEPIYI VTEFMSKGSL LDFLKEGDGK YLKLPQLVDM AAQIADGMAY IERMNYIHRD 120

LRAANILVGE NLVCKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILQTELV TKGRVPYPGM VNREVLEQVE RGYRMPCPQG CPESLHELMN LCWKKDPDER 240

PTFEYIQSFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0015758	; P:glucose transport

KEGG

bta:507632

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013