EKS-BOT-00429

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00429

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/Aur	470.8	8.8E-142	77	327	251

Status

Unreviewed

Ensembl Protein

ENSBTAP00000002250

UniProt Accession

Q08DN4;

Protein Name

Protein Synonyms/Alias

Aurora kinase B;

Gene Name

AURKB

Gene Synonyms/Alias

AURKB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000001717	ENSBTAP00000002250	ENSBTAT00000002250

Organism

Bos taurus

Functional Description

Protein Length

344

Protein Sequence
(FASTA)

MAQKENAYPW PYGRQTAQPG LNTLPQRVLR KEPVTPSALV LMSRSNAQPT AAPGQKVVEN 60

SSGTPNIPKR SFTIDDFEIG RPLGKGKFGN VYLAREKKSH FIVALKVLFK SQIEKEGVEH 120

QLRREIEIQA HLQHPNILRL YNYFYDRRRI YLILEYAPRG ELYKELQKSR TFDEQRTATI 180

MEELADALTY CHAKKVIHRD IKPENLLLGL RGELKIADFG WSVHAPSLRR KTMCGTLDYL 240

PPEMIEGRTH NEKVDLWCIG VLCYELLVGN PPFESASHNE TYRRIVKVDL KFPPSVPLGA 300

QDLIYKLLKH NPSERLPLAQ VSAHPWVRTH SRRVLPPSAP QSVP 344

Nucleotide Sequence
(FASTA)

ATGGCCCAGA AGGAGAACGC CTACCCCTGG CCCTATGGCC GGCAGACGGC TCAGCCTGGC 60

CTGAACACCC TGCCCCAGAG AGTTCTCCGG AAGGAGCCTG TCACTCCATC GGCACTTGTC 120

CTCATGAGTC GCTCCAATGC CCAGCCCACA GCTGCCCCTG GCCAGAAGGT GGTGGAGAAC 180

AGCAGTGGAA CCCCCAACAT CCCAAAGCGT TCCTTCACAA TCGATGACTT TGAGATTGGG 240

CGTCCTCTGG GCAAAGGCAA GTTTGGAAAT GTGTACTTGG CTCGGGAGAA GAAAAGCCAT 300

TTCATCGTGG CGCTCAAAGT CCTCTTCAAG TCTCAGATCG AGAAGGAGGG TGTGGAGCAC 360

CAGCTGCGTA GAGAGATCGA AATCCAAGCG CATCTGCAAC ATCCCAACAT CTTGCGTCTC 420

TACAACTATT TCTATGACCG GCGAAGGATC TACTTGATTC TGGAGTATGC CCCCCGGGGG 480

GAGCTCTACA AGGAGCTGCA GAAGAGCCGA ACTTTTGATG AGCAGCGAAC AGCCACGATC 540

ATGGAGGAGC TGGCAGATGC TCTGACATAC TGCCATGCGA AGAAGGTGAT TCACAGAGAC 600

ATCAAGCCTG AGAATCTGCT CTTGGGGCTC CGGGGAGAGC TGAAGATTGC TGACTTCGGC 660

TGGTCGGTGC ACGCCCCCTC CCTGAGGAGG AAGACAATGT GCGGCACTCT GGACTACCTG 720

CCCCCAGAGA TGATTGAGGG GCGCACGCAC AATGAAAAGG TGGACCTGTG GTGCATCGGT 780

GTGCTCTGCT ACGAGCTGCT GGTGGGAAAC CCACCCTTTG AGAGTGCTTC CCACAATGAG 840

ACGTACCGGC GCATCGTCAA GGTGGACCTA AAGTTCCCTC CTTCTGTGCC CTTGGGAGCC 900

CAGGACCTCA TCTACAAGCT GCTCAAGCAT AACCCCTCAG AACGCCTGCC GCTGGCCCAG 960

GTCTCGGCCC ACCCTTGGGT CCGAACCCAC TCTCGCAGGG TGCTGCCTCC CTCTGCCCCT 1020

CAGTCTGTCC CCTGA 1035

Domain Profile

S: 1     feiGrklGkGkfGnvylarekkskfivalkvlfkeqlekegvekqlrreieiqshlkhpn  60

         feiGr+lGkGkfGnvylarekks+fivalkvlfk+q+ekegve+qlrreieiq+hl+hpn

Q: 77    FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLQHPN  136

         9***********************************************************

S: 61    ilrlygyfhdekrvylileyaprGelykelqkskkldeqraakyieeladalsylhkkkv  120

         ilrly+yf+d++r+ylileyaprGelykelqks+++deqr+a+++eeladal+y+h kkv

Q: 137   ILRLYNYFYDRRRIYLILEYAPRGELYKELQKSRTFDEQRTATIMEELADALTYCHAKKV  196

         ************************************************************

S: 121   ihrdikpenlllgskgelkladfGwsvhapsskrktlcGtldylppemvegreydekvdl  180

         ihrdikpenlllg++gelk+adfGwsvhaps +rkt+cGtldylppem+egr+++ekvdl

Q: 197   IHRDIKPENLLLGLRGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRTHNEKVDL  256

         ************************************************************

S: 181   walGvlcyellvGkppfeseskdetykrikkvdlklpssvskgakdliskllkkepkerl  240

         w++GvlcyellvG+ppfes+s++ety+ri+kvdlk+p sv+ ga+dli kllk++p+erl

Q: 257   WCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPPSVPLGAQDLIYKLLKHNPSERL  316

         ************************************************************

S: 241   tladvlahpwi  251

         +la+v+ahpw+

Q: 317   PLAQVSAHPWV  327

         **********8

Domain Sequence
(FASTA)

FEIGRPLGKG KFGNVYLARE KKSHFIVALK VLFKSQIEKE GVEHQLRREI EIQAHLQHPN 60

ILRLYNYFYD RRRIYLILEY APRGELYKEL QKSRTFDEQR TATIMEELAD ALTYCHAKKV 120

IHRDIKPENL LLGLRGELKI ADFGWSVHAP SLRRKTMCGT LDYLPPEMIE GRTHNEKVDL 180

WCIGVLCYEL LVGNPPFESA SHNETYRRIV KVDLKFPPSV PLGAQDLIYK LLKHNPSERL 240

PLAQVSAHPW V 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0032133	; C:chromosome passenger complex
GO:0000780	; C:condensed nuclear chromosome, centromeric region
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0034644	; P:cellular response to UV
GO:0002903	; P:negative regulation of B cell apoptotic process
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0071777	; P:positive regulation of cell cycle cytokinesis
GO:0034501	; P:protein localization to kinetochore
GO:0051256	; P:spindle midzone assembly involved in mitosis

KEGG

bta:360192

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013