EKS-BOT-00374

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00374

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	381.3	2.2E-114	233	482	250

Status

Unreviewed

Ensembl Protein

ENSBTAP00000002574

UniProt Accession

F1N1Q0;

Protein Name

Protein Synonyms/Alias

Gene Name

SRMS

Gene Synonyms/Alias

SRMS;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000001985	ENSBTAP00000002574	ENSBTAT00000002574

Organism

Bos taurus

Functional Description

Protein Length

494

Protein Sequence
(FASTA)

MEPFLRKRLA FLSFFWDKIW PAGAPRFPDP DADLELEPAA EEPSTAEPCS PPAPVQLFRA 60

LCDFTARRAE ELSVSRGDRL HALREEGGCI LARKLSGWPC TGLVPITYVA KVAPETLSDQ 120

PWYFSGISRT QAQQLLLSAP NAPGAFLVRP SESSHGDFSL SVRAQTKVCH YRISMAADGS 180

LYLQKDRLFP SLDELLAYYK ANWKLIQSPL LQPCTAQKSL EQDEWERPHS EFTLRRKLGE 240

GYFGEVWEGL WLGSMPVAVK VIRPGDVKLA DLAQEIQTLK SLRHERLIRL HAVCSAGEPV 300

YIVTELMRKG SLQAFLGSPE GQALSPPFLL TFACQVAEGM SYLEEQRIVH RDLAARNVLV 360

GDDLACKVAD FGLARLLKDD VYSPRSGSKI PVKWTAPEAA SYCVYSPKSD VWSFGVLLYE 420

VFTYGRCPYE GMSNHETLQQ IARGYRLPRP AACPAEVYAL MLGCWRRCPE ERPDFTTLRE 480

KLGATSRRRR PALT 494

Nucleotide Sequence
(FASTA)

ATGGAGCCCT TCCTCAGGAA GAGGCTGGCC TTCCTGTCCT TTTTCTGGGA CAAGATCTGG 60

CCGGCCGGGG CACCGCGGTT CCCAGACCCC GACGCTGACC TGGAGCTGGA GCCCGCCGCA 120

GAGGAGCCCA GTACCGCGGA GCCTTGCAGC CCCCCGGCGC CCGTGCAGCT CTTCAGGGCG 180

CTGTGCGACT TCACGGCGCG GCGCGCGGAG GAGCTGAGCG TCAGCCGCGG GGACAGGCTC 240

CACGCCCTCA GGGAGGAGGG CGGCTGCATT CTGGCCCGCA AGCTCTCGGG CTGGCCCTGC 300

ACTGGCCTGG TGCCCATCAC CTACGTGGCC AAGGTGGCCC CTGAGACGCT CTCAGACCAG 360

CCCTGGTACT TCAGTGGCAT CAGCCGAACC CAGGCCCAGC AGCTGCTCCT GTCTGCCCCC 420

AACGCGCCGG GAGCCTTCCT CGTCCGGCCC AGTGAGAGCA GCCATGGGGA CTTCTCACTG 480

TCAGTCCGGG CCCAGACCAA AGTCTGCCAC TACCGCATCT CCATGGCAGC CGACGGCAGC 540

CTCTACCTGC AGAAGGACCG GCTCTTCCCC AGTCTGGATG AGCTGCTGGC ATATTACAAG 600

GCCAACTGGA AGCTGATCCA GAGCCCACTG CTGCAGCCCT GCACAGCCCA GAAGTCCCTT 660

GAGCAGGATG AGTGGGAGCG GCCCCACTCG GAGTTCACCC TGCGGAGGAA GCTGGGCGAA 720

GGCTACTTCG GGGAGGTGTG GGAAGGCCTG TGGCTGGGCT CCATGCCCGT GGCAGTCAAG 780

GTCATCAGAC CAGGCGACGT GAAGCTCGCC GACCTGGCCC AGGAGATACA AACGCTCAAG 840

AGCCTGCGGC ATGAGCGCCT CATCCGGCTT CATGCGGTGT GCTCAGCGGG CGAGCCCGTG 900

TACATCGTCA CGGAGCTCAT GCGCAAGGGC AGCCTGCAGG CCTTCCTTGG CAGCCCTGAA 960

GGCCAGGCCC TGAGCCCGCC CTTCCTGCTG ACCTTTGCCT GTCAGGTGGC CGAGGGCATG 1020

AGCTACCTGG AGGAGCAGCG CATCGTGCAT AGGGACCTGG CTGCCAGGAA CGTGCTCGTG 1080

GGCGACGACC TGGCCTGCAA GGTGGCCGAC TTTGGCCTGG CCCGGCTGCT CAAGGATGAC 1140

GTCTACTCCC CGCGCAGCGG CTCCAAGATC CCCGTCAAGT GGACAGCGCC TGAGGCAGCC 1200

AGCTACTGCG TGTACTCACC CAAGTCCGAC GTCTGGTCCT TCGGGGTCCT GCTCTACGAG 1260

GTCTTCACAT ATGGCCGGTG TCCCTACGAA GGGATGAGCA ACCACGAGAC TCTACAGCAG 1320

ATCGCACGGG GGTACCGGCT CCCGCGCCCG GCCGCCTGCC CAGCTGAGGT CTACGCGCTC 1380

ATGCTGGGGT GCTGGAGGCG CTGCCCGGAA GAGCGGCCAG ACTTCACCAC ACTGCGGGAG 1440

AAGCTGGGTG CCACGAGCAG GCGCCGCCGC CCCGCCCTCA CATGA 1485

Domain Profile

S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61

         +l +klGeG+fGevw+g+w gs++vavk++++g+++ +++ +e+q+lk+lrhe+l++l+a

Q: 233   TLRRKLGEGYFGEVWEGLWLGSMPVAVKVIRPGDVKLADLAQEIQTLKSLRHERLIRLHA  292

         689*********************************************************

S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121

         v+s++eP+yivtelm+kGsl++fl + eg++l+ p l+ +a+qvaeGm+ylee++++hrd

Q: 293   VCSAGEPVYIVTELMRKGSLQAFLGSPEGQALSPPFLLTFACQVAEGMSYLEEQRIVHRD  352

         ************************************************************

S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181

         laarnvlvg++l++kvadfGlarl++dd y++++g+k+P+kWtaPea+++ +++ ksdvW

Q: 353   LAARNVLVGDDLACKVADFGLARLLKDDVYSPRSGSKIPVKWTAPEAASYCVYSPKSDVW  412

         ************************************************************

S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241

         sfG+ll+e++t+G++Py+Gm+n+e+l+q+ rgyrlprp++cp+e+y l+l cw++ peer

Q: 413   SFGVLLYEVFTYGRCPYEGMSNHETLQQIARGYRLPRPAACPAEVYALMLGCWRRCPEER  472

         ************************************************************

S: 242   Ptfetlqevl  251

         P f tl+e+l

Q: 473   PDFTTLREKL  482

         ******9876

Domain Sequence
(FASTA)

TLRRKLGEGY FGEVWEGLWL GSMPVAVKVI RPGDVKLADL AQEIQTLKSL RHERLIRLHA 60

VCSAGEPVYI VTELMRKGSL QAFLGSPEGQ ALSPPFLLTF ACQVAEGMSY LEEQRIVHRD 120

LAARNVLVGD DLACKVADFG LARLLKDDVY SPRSGSKIPV KWTAPEAASY CVYSPKSDVW 180

SFGVLLYEVF TYGRCPYEGM SNHETLQQIA RGYRLPRPAA CPAEVYALML GCWRRCPEER 240

PDFTTLREKL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

bta:521816

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR011511	; SH3_2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF07653	; SH3_2; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013