EKS-BOT-00279

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00279

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	452.4	6.9E-136	204	491	288

Status

Unreviewed

Ensembl Protein

ENSBTAP00000002690

UniProt Accession

A7YWG6; F1N2N6;

Protein Name

Protein Synonyms/Alias

BMPR1B protein;

Gene Name

BMPR1B

Gene Synonyms/Alias

BMPR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000002081	ENSBTAP00000002690	ENSBTAT00000002690

Organism

Bos taurus

Functional Description

Protein Length

502

Protein Sequence
(FASTA)

MLLRSSGKLS VGTKKEDGES TAPTPRPKIL RCKCHHHCPE DSVNNICSTD GYCFTMIEED 60

DSGMPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKNRDFVD 120

GPIHHKALLI SVTVCSLLLV LIILFCYFRY KRQEARPRYS IGLEQDETYI PPGESLRDLI 180

EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS 240

WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDTKS 300

MLKLAYSSVS GLCHLHTEIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVKFISD 360

TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM YSFGLILWEV ARRCVSGGIV 420

EEYQLPYHDL VPSDPSYEDM REIVCIKKLR PSFPNRWSSD ECLRQMGKLM TECWAHNPAS 480

RLTALRVKKT LAKMSESQDI KL 502

Nucleotide Sequence
(FASTA)

ATGCTTTTGC GAAGTTCAGG AAAATTAAGT GTGGGCACCA AGAAAGAGGA TGGTGAGAGT 60

ACAGCCCCCA CCCCTCGTCC AAAGATCTTG CGATGCAAAT GCCACCACCA TTGTCCAGAA 120

GACTCGGTCA ACAATATTTG CAGCACAGAT GGATATTGTT TCACGATGAT AGAAGAAGAT 180

GACTCTGGGA TGCCCGTGGT CACTTCTGGA TGTCTAGGAC TAGAAGGCTC AGATTTTCAG 240

TGTCGGGACA CTCCCATTCC TCATCAGAGA CGATCCATTG AATGCTGCAC AGAACGGAAT 300

GAATGTAATA AAGATCTACA TCCCACACTT CCTCCGCTGA AAAACAGAGA TTTTGTTGAC 360

GGACCTATAC ACCACAAAGC TTTACTTATA TCTGTGACTG TGTGTAGTTT GCTCTTGGTC 420

CTCATCATTT TATTCTGTTA CTTCAGGTAT AAAAGACAAG AAGCCAGACC TCGCTACAGC 480

ATTGGGTTAG AACAGGATGA AACTTACATT CCTCCTGGAG AATCCCTGAG AGACTTAATT 540

GAGCAGTCGC AGAGCTCAGG GAGCGGATCA GGCCTCCCTC TGCTGGTCCA GAGGACGATA 600

GCAAAGCAAA TTCAGATGGT GAAACAGATT GGAAAAGGTC GCTATGGGGA AGTTTGGATG 660

GGAAAGTGGC GTGGCGAAAA GGTAGCTGTG AAAGTGTTCT TCACTACAGA GGAGGCCAGC 720

TGGTTCCGAG AGACAGAAAT ATATCAGACG GTGTTGATGA GGCATGAAAA CATCTTGGGC 780

TTCATTGCTG CAGATATCAA AGGGACGGGG TCCTGGACAC AACTGTACCT AATCACAGAT 840

TATCATGAAA ACGGTTCCCT CTATGATTAC CTGAAGTCCA CCACCCTAGA TACTAAGTCG 900

ATGTTGAAGT TAGCCTATTC CTCAGTCAGT GGCCTGTGTC ACTTACACAC TGAAATCTTT 960

AGTACTCAAG GCAAACCAGC AATTGCCCAT CGAGATCTGA AAAGTAAGAA CATCCTCGTG 1020

AAGAAAAATG GAACTTGCTG TATAGCTGAC CTGGGCTTGG CTGTTAAGTT TATTAGTGAC 1080

ACGAATGAAG TTGACATACC ACCCAACACT CGAGTTGGTA CCAAGCGCTA CATGCCTCCA 1140

GAAGTGCTGG ATGAGAGCTT GAACAGAAAC CACTTTCAGT CTTACATCAT GGCCGACATG 1200

TACAGCTTTG GACTCATCCT TTGGGAGGTC GCTAGGAGAT GTGTATCAGG AGGTATAGTG 1260

GAAGAATATC AGCTCCCCTA TCATGACCTG GTGCCCAGTG ACCCCTCTTA TGAGGACATG 1320

AGAGAGATCG TGTGTATCAA GAAGCTGCGG CCCTCCTTCC CCAACCGGTG GAGCAGCGAC 1380

GAGTGTCTCA GGCAGATGGG GAAACTCATG ACGGAATGCT GGGCTCACAA TCCTGCCTCA 1440

AGACTGACAG CCCTACGGGT TAAGAAGACA CTGGCCAAAA TGTCAGAGTC CCAGGACATT 1500

AAGCTCTGA 1509

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++++++igkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 204   IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  263

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+dyLk++tld++++l+la+s +sGl+hLH+ei+ t+

Q: 264   ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDTKSMLKLAYSSVSGLCHLHTEIFSTQ  323

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa+k+ ++++e+d+  n++vGtkRYm PE

Q: 324   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE  381

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+++ +aD+Ys+gL+lWEva+Rc + +++veey+lp+++ v+sdPs+e+m

Q: 382   VLDESLNRNHFQSYIMADMYSFGLILWEVARRCVS-GGIVEEYQLPYHDLVPSDPSYEDM  440

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +e+v+ kklrP++p++w+++e+l+++ kl++ecW+++p++Rltalrvkk+l

Q: 441   REIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTL  491

         *************************************************97

Domain Sequence
(FASTA)

IQMVKQIGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDYLKS TTLDTKSMLK LAYSSVSGLC HLHTEIFSTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVKFISDTNE VDIPPNTRVG TKRYMPPEVL 180

DESLNRNHFQ SYIMADMYSF GLILWEVARR CVSGGIVEEY QLPYHDLVPS DPSYEDMREI 240

VCIKKLRPSF PNRWSSDECL RQMGKLMTEC WAHNPASRLT ALRVKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0030509	; P:BMP signaling pathway
GO:0001502	; P:cartilage condensation
GO:0009953	; P:dorsal/ventral pattern formation
GO:0006954	; P:inflammatory response
GO:0035108	; P:limb morphogenesis
GO:0001550	; P:ovarian cumulus expansion
GO:0030501	; P:positive regulation of bone mineralization
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0060041	; P:retina development in camera-type eye
GO:0031290	; P:retinal ganglion cell axon guidance
GO:0023014	; P:signal transduction by phosphorylation

KEGG

bta:407128

;

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013