EKS-BOT-00177
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00177
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/SRPK881.41.9E-26580685606
StatusUnreviewed
Ensembl ProteinENSBTAP00000053405
UniProt AccessionF1MNS2;
Protein Name
Protein Synonyms/Alias
Gene NameSRPK2
Gene Synonyms/Alias SRPK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000002175ENSBTAP00000053405ENSBTAT00000061045
OrganismBos taurus
Functional Description
Protein Length687
Protein Sequence
(FASTA)
VNRNSPSSCF RPEPQQKAPL VPPPPPPPPP PPLPDPAPPE PEEEILGSDD EEQEDPADYC 60
KAIIGGYHPV KIGDLFNGRY HVIRKLGWGH FSTVWLCWDM QGKRFVAMKV VKSAQHYTET 120
ALDEIKLLKC VRESDPSDPN KDMVVQLIDD FKISGMNGIH VCMVFEVLGH HLLKWIIKSN 180
YQGLPVRCVK SIIRQVLQGL DYLHSKCKII HTDIKPENIL MCVDDAYVRR MAAEATEWQK 240
AGAPPPSGSA VSTAPQQKPI GKISKNKKKK MKKKQKRQAE LLEKRLQEIE ELEREAERKI 300
IEENVTSVVP SNEQDDEYHP EVKLKTAGLE EVAEGETANN NGEAEDQEEK EDTEKENTEK 360
DEDDVEQELA NIDPTWIESP KTNGHIENGP FLLEQQLDDE DDDEEDCPNP EECNLDEPNA 420
ESDYTYSSSY EQFNGELPNG RHKIPESQFP EFSTSLFSGP LEPVACGSAL SEGSPLTEHE 480
ESSPSHDRSR TVSASSTGDL PKTKTRAADL LVNPLDPRNA DKIRVKIADL GNACWVHKHF 540
TEDIQTRQYR SIEVLIGAGY STPADIWSTA CMAFELATGD YLFEPHSGED YSRDEDHIAH 600
IIELLGSIPR HFALSGKYSR EFFNRRGELR HITKLKPWSL FDVLVEKYGW PHEDAAQFTD 660
FLIPMLEMVP EKRASAGECL RHPWLNS 687
Nucleotide Sequence
(FASTA)
GTCAATAGGA ATTCTCCCTC CTCTTGTTTC AGGCCGGAGC CTCAGCAGAA AGCTCCCTTG 60
GTGCCTCCAC CGCCGCCTCC GCCACCACCG CCTCCTCTGC CGGACCCTGC CCCACCAGAG 120
CCAGAGGAGG AGATTCTGGG CTCAGACGAT GAGGAGCAGG AGGACCCCGC AGACTACTGC 180
AAAGCAATCA TAGGTGGCTA TCATCCAGTG AAAATTGGAG ACCTCTTCAA TGGCCGGTAC 240
CATGTTATTA GGAAGCTAGG ATGGGGCCAC TTCTCTACTG TCTGGCTGTG CTGGGATATG 300
CAGGGAAAAA GATTTGTTGC AATGAAAGTT GTAAAAAGTG CCCAGCATTA TACAGAGACA 360
GCCTTGGATG AAATAAAATT GCTCAAATGT GTTCGAGAAA GTGATCCCAG TGACCCAAAT 420
AAAGACATGG TAGTGCAGCT TATAGATGAC TTCAAGATTT CAGGCATGAA TGGAATACAT 480
GTCTGCATGG TCTTTGAAGT GCTTGGCCAC CATCTCCTCA AGTGGATCAT AAAGTCCAAC 540
TACCAAGGCC TCCCAGTACG TTGTGTGAAG AGCATCATTA GACAGGTCCT TCAAGGGTTA 600
GATTATCTCC ACAGTAAGTG CAAGATCATT CATACTGACA TAAAGCCGGA AAACATCTTG 660
ATGTGTGTGG ACGATGCATA TGTGAGAAGA ATGGCAGCCG AGGCCACTGA GTGGCAGAAA 720
GCGGGCGCTC CTCCTCCTTC AGGGTCTGCA GTGAGTACTG CTCCACAGCA AAAACCTATA 780
GGAAAAATAT CTAAAAACAA AAAGAAAAAA ATGAAAAAGA AGCAGAAAAG GCAGGCTGAG 840
TTACTGGAAA AGCGCTTGCA GGAAATAGAA GAATTGGAGC GAGAAGCTGA AAGAAAAATA 900
ATAGAGGAAA ACGTCACGTC AGTTGTACCT TCCAATGAGC AAGATGATGA ATACCACCCA 960
GAGGTGAAGC TAAAAACAGC AGGACTGGAG GAGGTGGCCG AGGGAGAGAC TGCAAATAAC 1020
AATGGTGAAG CTGAGGACCA GGAGGAGAAA GAAGACACTG AGAAAGAAAA CACTGAGAAA 1080
GATGAAGACG ATGTTGAACA GGAGCTCGCG AACATAGACC CTACCTGGAT AGAATCACCA 1140
AAAACTAACG GCCATATTGA GAACGGCCCC TTCTTACTGG AGCAACAGCT GGATGATGAA 1200
GACGACGATG AGGAAGATTG CCCAAATCCC GAGGAATGTA ACCTCGATGA GCCAAATGCA 1260
GAAAGCGATT ACACGTATAG CAGCTCCTAT GAACAATTCA ATGGTGAATT GCCAAATGGA 1320
CGACATAAAA TTCCCGAGTC ACAGTTTCCA GAATTTTCCA CATCATTGTT CTCTGGGCCT 1380
TTAGAACCTG TGGCTTGTGG CTCTGCACTT TCTGAGGGAT CCCCCCTTAC TGAACATGAG 1440
GAAAGCAGTC CATCCCATGA CAGAAGCAGG ACAGTTTCAG CCTCCAGCAC TGGGGATTTG 1500
CCAAAAACGA AAACCCGGGC AGCCGACCTG CTGGTGAATC CCCTGGACCC CCGGAATGCC 1560
GATAAGATTA GAGTTAAAAT TGCAGACCTT GGAAATGCTT GTTGGGTGCA TAAACACTTC 1620
ACAGAAGACA TCCAGACGCG TCAGTATAGA TCCATAGAGG TTTTAATAGG AGCAGGTTAC 1680
AGTACGCCTG CTGACATTTG GAGTACGGCA TGTATGGCAT TTGAGCTGGC AACGGGAGAT 1740
TATTTGTTTG AACCACATTC TGGGGAAGAC TATTCCAGAG ATGAAGACCA CATAGCCCAC 1800
ATCATAGAGC TGCTAGGCAG TATCCCAAGG CACTTTGCTC TATCTGGAAA ATATTCTCGG 1860
GAATTCTTCA ATCGCAGAGG AGAGCTGCGG CACATCACCA AACTGAAGCC CTGGAGCCTC 1920
TTTGATGTAC TTGTGGAGAA GTATGGCTGG CCCCATGAAG ATGCTGCACA GTTTACAGAT 1980
TTCCTGATCC CGATGCTAGA AATGGTTCCA GAAAAACGAG CTTCAGCAGG CGAATGCCTT 2040
CGGCATCCTT GGTTGAATTC TTAG 2064
Domain Profile
S: 1     yhvirkLGWGhfstvWLawdlqekrfvalkvvksaehytetaldeikllksvresdpsdp  60
         yhvirkLGWGhfstvWL+wd+q+krfva+kvvksa+hytetaldeikllk+vresdpsdp
Q: 80    YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDP  139
         9***********************************************************
S: 61    krekvvqllddfkisGvnGvhvclvfevLGenLlkliiksnyrGlpleqvkkiirqvLeg  120
         ++++vvql+ddfkisG+nG+hvc+vfevLG++Llk+iiksny+Glp+++vk+iirqvL+g
Q: 140   NKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQG  199
         ************************************************************
S: 121   LdylhekCkiihtdikPenvLlavddeyirrlaaeatewqkagakppsgsavstapqkka  180
         Ldylh+kCkiihtdikPen+L++vdd+y+rr+aaeatewqkaga+ppsgsavstapq+k+
Q: 200   LDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKP  259
         ************************************************************
S: 181   ieklsknkkkklkkkqkrqaellekrlqeleele..........................  214
         i+k+sknkkkk+kkkqkrqaellekrlqe+eele                          
Q: 260   IGKISKNKKKKMKKKQKRQAELLEKRLQEIEELEreaerkiieenvtsvvpsneqddeyh  319
         ************************************************************
S: 215   .................aaeanseaedqelkedaekgeleeieadveeevanedea....  253
                          +a++n+eaedqe+ked+ek+++e++e+dve+e+an+d++    
Q: 320   pevklktagleevaegeTANNNGEAEDQEEKEDTEKENTEKDEDDVEQELANIDPTwies  379
         ****************9999************************************8888
S: 254   ...................seeee....................essltsssdaesksge  274
                            +   e                    es++t+ss++e+++ge
Q: 380   pktnghiengpflleqqldD---EdddeedcpnpeecnldepnaESDYTYSSSYEQFNGE  436
         88888888888877776651...144556778888888888888****************
S: 275   l............seastellsesleqlacgsvls.........................  297
         l            +e+st+l+s++le++acgs ls                         
Q: 437   LpngrhkipesqfPEFSTSLFSGPLEPVACGSALSegsplteheesspshdrsrtvsass  496
         **********9999**********************************************
S: 298   ...............vnplepknadkikvkiadLGnaCwvhkhftediqtrqyrslevli  342
                        vnpl+p+nadki+vkiadLGnaCwvhkhftediqtrqyrs+evli
Q: 497   tgdlpktktraadllVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLI  556
         ************************************************************
S: 343   GagygtpadiWstaClafeLatGdyLfephsgedysrdedhiakiiellGkiPrklilkG  402
         Gagy+tpadiWstaC+afeLatGdyLfephsgedysrdedhia+iiellG+iPr+++l+G
Q: 557   GAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSG  616
         ************************************************************
S: 403   kysreffnkkgeLrhitkLkpwsLlevLvekyewskeeaaefsdfLlPmleldpekrasa  462
         kysreffn++geLrhitkLkpwsL++vLveky+w++e+aa+f+dfL+Pmle++pekrasa
Q: 617   KYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASA  676
         ************************************************************
S: 463   aeclkhpwL  471
         +ecl+hpwL
Q: 677   GECLRHPWL  685
         ********8
Domain Sequence
(FASTA)
YHVIRKLGWG HFSTVWLCWD MQGKRFVAMK VVKSAQHYTE TALDEIKLLK CVRESDPSDP 60
NKDMVVQLID DFKISGMNGI HVCMVFEVLG HHLLKWIIKS NYQGLPVRCV KSIIRQVLQG 120
LDYLHSKCKI IHTDIKPENI LMCVDDAYVR RMAAEATEWQ KAGAPPPSGS AVSTAPQQKP 180
IGKISKNKKK KMKKKQKRQA ELLEKRLQEI EELEREAERK IIEENVTSVV PSNEQDDEYH 240
PEVKLKTAGL EEVAEGETAN NNGEAEDQEE KEDTEKENTE KDEDDVEQEL ANIDPTWIES 300
PKTNGHIENG PFLLEQQLDD EDDDEEDCPN PEECNLDEPN AESDYTYSSS YEQFNGELPN 360
GRHKIPESQF PEFSTSLFSG PLEPVACGSA LSEGSPLTEH EESSPSHDRS RTVSASSTGD 420
LPKTKTRAAD LLVNPLDPRN ADKIRVKIAD LGNACWVHKH FTEDIQTRQY RSIEVLIGAG 480
YSTPADIWST ACMAFELATG DYLFEPHSGE DYSRDEDHIA HIIELLGSIP RHFALSGKYS 540
REFFNRRGEL RHITKLKPWS LFDVLVEKYG WPHEDAAQFT DFLIPMLEMV PEKRASAGEC 600
LRHPWL 606
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00169
EKS-ANC-00170
EKS-CAJ-00181
EKS-CAF-00184
EKS-CAP-00204
EKS-EQC-00175
EKS-FEC-00167
EKS-GAM-00096
EKS-GAG-00153
EKS-GAA-00219
EKS-GOG-00176
EKS-HOS-00183
EKS-ICT-00173
EKS-LAC-00189
EKS-LOA-00176
EKS-MAM-00176
EKS-MEG-00139
EKS-MOD-00177
EKS-MUM-00182
EKS-MUP-00180
EKS-MYL-00185
EKS-NOL-00170
EKS-ORN-00224
EKS-ORA-00156
EKS-ORC-00164
EKS-ORL-00209
EKS-OTG-00183
EKS-PAT-00167
EKS-PEM-00094
EKS-POA-00173
EKS-RAN-00173
EKS-SAH-00169
EKS-SUS-00156
EKS-TAG-00207
EKS-TAR-00230
EKS-TEN-00228
EKS-XET-00210
EKS-XIM-00219
EKS-SAC-00082
EKS-SCP-00104
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005730; C:nucleolus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0001525; P:angiogenesis
GO:0007243; P:intracellular protein kinase cascade
GO:0045071; P:negative regulation of viral genome replication
GO:0035063; P:nuclear speck organization
GO:0045787; P:positive regulation of cell cycle
GO:0008284; P:positive regulation of cell proliferation
GO:0010628; P:positive regulation of gene expression
GO:0043525; P:positive regulation of neuron apoptotic process
GO:0045070; P:positive regulation of viral genome replication
GO:0000245; P:spliceosomal complex assembly
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013