EKS-BOT-00403
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00403
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR599.03.4E-180599957359
StatusUnreviewed
Ensembl ProteinENSBTAP00000053664
UniProt AccessionF1N759;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRB
Gene Synonyms/Alias PDGFRB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000002804ENSBTAP00000053664ENSBTAT00000061140
OrganismBos taurus
Functional Description
Protein Length1103
Protein Sequence
(FASTA)
MWLPSAMQAV VLKGRVLLLP LLFLLGPQAS WGLAIIPPGP ELVLNLSSTF VLTCSGPAPV 60
VWERMSQKPP QEMTETQDGT FSSVLTLVNV TGLDTGEYFC GYKRSHGLEA SERKRLYIFV 120
PDPSVGFLPV DPEELFIFLT EITETTIPCR VTDPRLVVML HEKKVDVPLP IAYDPQRGFS 180
GTFEDKTYIC KTTIGDREVD SDAYHVYSLQ VSSINVSVNA VQTVVRQGEN ITIMCIVTGN 240
EVVNFEWTYP RMESGRLVEP VTDFLFEMPH IRSILHIPSA ELGDSGTYIC NVSESVSDHR 300
DEKAINVTVV ENGYVRLLGE LDPVQFAELH RSRTLQVVFE AYPPPTVMWF KDNRTLGDSS 360
AGEIVLSTRN VSETRYVSEL TLVRVKVAEA GYYTMRAFHE DAEAQLSFQL QVNVPVRVLE 420
LSESHPANGE QTVRCRGRGM PQPHLTWSTC SDLKRCPREL PPTPLGNSSE EESQLETNVT 480
YWAEEQEFEV VSTLRLRHVD QPLSVRCTLH NLLGYDVQEV TVVPHSLPFK VVVISAILAL 540
VVLTIISLII LIMLWQKKPR YEIRWKVIES VSSDGHEYIY VDPMQLPYDS TWELPRDQLV 600
LGRTLGSGAF GQVVEATAHG LSHSQATMKV AVKMLKSTAR SSEKQALMSE LKIMSHLGPH 660
LNVVNLLGAC TKGGPIYIIT EYCRYGDLVD YLHRNKHTFL QRCSDKRRPP SAELYSNALP 720
VGLPLPSHVS LPGESDGGYM DMSKDESVDY VPMLDMKGDV KYADIESSNY MAPYDNYVPS 780
APERTCRVTL INESPVLSYT DLVGFSYQVA NGMEFLASKN CVHRDLAARN VLICEGKLVK 840
ICDFGLARDI MRDSNYISKG STFLPLKWMA PESIFNSLYT TLSDVWSFGI LLWEIFTLGG 900
TPYPELPMNE QFYNAIKRGY RMAQPAHASD EIYEIMQKCW EEKFEIRPPF SQLVLLLERL 960
LGEGYKKKYQ QVDEEFLRSD HPAILRSQAR LPGFNGLRSP LDSSSVLYTA VQPNEGDNDY 1020
IIPLPDPKPE VADEGPLEGS PSLASSTLNE VNTSSTISCD SPLEPQEEPE PEPQPASQVE 1080
PEPKWPPDSS CPGPRAEAED SFL 1103
Nucleotide Sequence
(FASTA)
ATGTGGCTTC CGAGCGCCAT GCAAGCTGTT GTCCTCAAAG GCCGGGTGCT ATTGCTGCCC 60
CTGCTGTTTC TGCTGGGACC ACAGGCCTCC TGGGGCCTGG CCATCATACC CCCGGGGCCA 120
GAACTTGTCC TCAACCTCTC CAGCACCTTT GTCCTGACCT GCTCGGGCCC AGCTCCAGTG 180
GTGTGGGAAC GGATGTCCCA GAAACCCCCC CAGGAAATGA CCGAGACCCA GGATGGCACA 240
TTCTCCAGCG TGCTGACACT GGTCAACGTC ACTGGACTAG ACACAGGAGA ATACTTCTGT 300
GGCTACAAAC GCTCCCATGG GCTGGAGGCC AGTGAGCGAA AACGGCTCTA CATCTTTGTA 360
CCAGATCCTT CTGTGGGCTT CCTCCCTGTC GACCCTGAGG AGCTATTCAT CTTTCTCACG 420
GAAATAACTG AGACCACAAT TCCATGCCGA GTGACGGATC CGAGGCTGGT GGTGATGCTG 480
CACGAGAAGA AGGTGGATGT CCCCCTGCCC ATAGCCTATG ACCCTCAGCG TGGCTTCTCT 540
GGTACCTTTG AGGACAAGAC CTACATCTGC AAAACCACCA TCGGGGACAG GGAGGTGGAT 600
TCCGATGCCT ACCATGTCTA CAGCCTCCAG GTGTCATCCA TCAATGTCTC AGTGAATGCA 660
GTGCAGACTG TGGTCCGCCA AGGGGAGAAT ATCACCATCA TGTGCATTGT GACAGGGAAT 720
GAGGTGGTCA ACTTCGAGTG GACATACCCA CGCATGGAGA GTGGGCGCCT GGTGGAGCCA 780
GTGACTGACT TCCTCTTTGA AATGCCCCAC ATACGTTCTA TCCTGCACAT CCCCAGTGCT 840
GAGCTAGGAG ACTCAGGGAC CTACATCTGC AATGTATCAG AAAGCGTGAG CGACCATCGT 900
GATGAAAAGG CTATCAATGT CACCGTGGTC GAGAACGGCT ATGTGCGCCT GCTGGGAGAG 960
CTGGACCCTG TACAATTCGC CGAGCTCCAC CGCAGCCGGA CACTGCAGGT GGTGTTTGAG 1020
GCCTACCCGC CACCCACTGT CATGTGGTTC AAAGACAACC GAACCCTGGG TGACTCCAGT 1080
GCCGGCGAGA TCGTGCTGTC CACACGCAAT GTGTCTGAGA CTCGGTATGT GTCAGAGCTG 1140
ACACTGGTGC GGGTGAAGGT GGCTGAGGCT GGCTACTACA CCATGCGGGC CTTCCATGAG 1200
GATGCTGAAG CCCAGCTCTC CTTCCAGCTG CAGGTCAATG TGCCTGTCCG TGTGCTGGAG 1260
CTGAGCGAGA GCCACCCTGC CAATGGGGAG CAGACAGTTC GTTGTCGCGG CCGGGGCATG 1320
CCCCAGCCAC ACCTCACCTG GTCTACCTGC AGTGATCTCA AAAGGTGTCC GCGGGAGCTG 1380
CCGCCCACGC CGCTGGGGAA CAGTTCCGAG GAGGAGAGCC AGCTAGAGAC GAATGTGACG 1440
TACTGGGCGG AGGAGCAGGA GTTCGAGGTG GTGAGCACAC TGCGCCTGCG CCATGTGGAT 1500
CAGCCGCTGT CCGTGCGCTG CACGCTGCAC AACCTGCTGG GCTACGACGT GCAGGAGGTC 1560
ACCGTGGTGC CACATTCCCT GCCCTTCAAG GTGGTGGTGA TCTCGGCCAT CCTGGCCTTG 1620
GTGGTCCTCA CGATCATCTC CCTCATTATC CTCATCATGC TCTGGCAGAA GAAGCCACGC 1680
TATGAAATCC GATGGAAAGT GATCGAATCT GTGAGCTCTG ATGGCCATGA GTACATCTAT 1740
GTGGACCCTA TGCAGCTGCC CTACGACTCC ACCTGGGAGC TGCCACGGGA CCAGCTTGTG 1800
CTTGGACGCA CCCTGGGCTC CGGGGCCTTT GGGCAGGTGG TGGAGGCCAC GGCTCACGGC 1860
CTGAGCCATT CTCAGGCTAC CATGAAAGTG GCTGTGAAGA TGCTGAAATC CACAGCCCGC 1920
AGCAGTGAGA AGCAAGCCCT CATGTCGGAG CTGAAGATCA TGAGTCACCT TGGGCCCCAC 1980
CTGAACGTGG TCAACCTGCT GGGCGCCTGC ACTAAAGGAG GACCCATCTA CATCATTACC 2040
GAGTACTGCC GTTATGGCGA CCTGGTGGAC TACCTGCACC GCAACAAGCA CACCTTCCTG 2100
CAGCGCTGCT CGGACAAGCG CCGCCCACCC AGCGCCGAGC TCTACAGCAA CGCCCTGCCT 2160
GTTGGGCTCC CTCTGCCTAG CCACGTGTCA CTGCCTGGGG AGAGCGATGG TGGCTACATG 2220
GACATGAGCA AGGACGAGTC GGTGGACTAT GTGCCCATGC TGGACATGAA AGGAGATGTC 2280
AAATACGCAG ACATCGAGTC CTCGAACTAC ATGGCTCCTT ATGATAACTA CGTCCCCTCT 2340
GCTCCTGAGA GGACTTGCCG GGTGACTTTG ATCAACGAGT CCCCAGTGCT TAGCTACACG 2400
GATCTTGTGG GCTTCAGCTA CCAGGTGGCC AATGGCATGG AGTTCCTGGC GTCCAAGAAT 2460
TGTGTCCACC GAGACCTGGC AGCCAGGAAC GTGCTCATCT GTGAGGGCAA GCTGGTCAAG 2520
ATCTGCGACT TTGGCCTGGC TCGTGACATC ATGCGGGACT CGAACTACAT CTCCAAGGGC 2580
AGCACCTTCC TGCCTCTGAA GTGGATGGCC CCCGAGAGCA TCTTCAACAG CCTCTACACT 2640
ACCCTGAGCG ACGTGTGGTC CTTTGGCATC TTGCTCTGGG AGATCTTCAC GCTGGGTGGC 2700
ACCCCATACC CAGAGCTGCC CATGAACGAG CAGTTCTACA ACGCCATCAA GAGGGGCTAC 2760
CGCATGGCCC AGCCTGCCCA CGCCTCTGAC GAGATCTACG AGATCATGCA GAAGTGCTGG 2820
GAAGAGAAGT TCGAGATCCG GCCCCCCTTC TCCCAGCTGG TGCTGCTTCT CGAGAGACTG 2880
CTGGGTGAGG GCTACAAAAA GAAGTACCAG CAGGTGGATG AGGAGTTTCT GAGGAGCGAC 2940
CACCCAGCCA TCCTTCGGTC CCAAGCCCGC TTGCCTGGCT TCAATGGCCT CCGATCTCCT 3000
CTGGACTCCA GCTCCGTCCT CTATACTGCT GTGCAGCCCA ACGAGGGGGA CAATGACTAC 3060
ATCATCCCCC TGCCTGACCC CAAACCTGAG GTTGCTGATG AGGGCCCACT GGAGGGTTCC 3120
CCCAGCCTTG CCAGCTCCAC CCTGAATGAA GTCAACACCT CCTCCACCAT CTCCTGTGAC 3180
AGCCCTCTGG AACCCCAAGA GGAGCCAGAG CCAGAGCCGC AGCCCGCCTC CCAGGTGGAG 3240
CCAGAGCCCA AGTGGCCGCC GGATTCCAGC TGCCCCGGGC CTCGGGCCGA GGCGGAGGAC 3300
AGCTTCCTGT AG 3312
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafG+vveata+Gls+s+a++kvavkmlkstarssek+almselki+shlG
Q: 599   LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG  658
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+n+vnllGactkgGpiy+iteyc+yGdl++yl+r++++fl++ ++k++++++el+s+a
Q: 659   PHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQRCSDKRRPPSAELYSNA  718
         ************************************************************
S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklasekk  164
         l+++  l s++sl  es++ y+d++kd                ++d++ss++++++++++
Q: 719   LPVGLPLPSHVSLPGESDGGYMDMSKDesvdyvpmldmkgdvkYADIESSNYMAPYDNYV  778
         ************************************************************
S: 165   ksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGk  224
          sa er+++ +l++e s vl+++dl+ fsyqva+Gmeflaskncvhrdlaarnvl++eGk
Q: 779   PSAPERTCRVTLINE-SPVLSYTDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGK  837
         *************99.9*******************************************
S: 225   vvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifs  284
         +vkicdfGlardim+dsny++kG+++lp+kwmapesif+slyt+ sdvws+Gillweif+
Q: 838   LVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFT  897
         ************************************************************
S: 285   lGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         lG+tpyp+l+++++fy++ik+Gyrmaqpa+a++eiyeimqkcwe+++e rp+f+qlv ll
Q: 898   LGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLL  957
         ********************************************************9986
Domain Sequence
(FASTA)
LVLGRTLGSG AFGQVVEATA HGLSHSQATM KVAVKMLKST ARSSEKQALM SELKIMSHLG 60
PHLNVVNLLG ACTKGGPIYI ITEYCRYGDL VDYLHRNKHT FLQRCSDKRR PPSAELYSNA 120
LPVGLPLPSH VSLPGESDGG YMDMSKDESV DYVPMLDMKG DVKYADIESS NYMAPYDNYV 180
PSAPERTCRV TLINESPVLS YTDLVGFSYQ VANGMEFLAS KNCVHRDLAA RNVLICEGKL 240
VKICDFGLAR DIMRDSNYIS KGSTFLPLKW MAPESIFNSL YTTLSDVWSF GILLWEIFTL 300
GGTPYPELPM NEQFYNAIKR GYRMAQPAHA SDEIYEIMQK CWEEKFEIRP PFSQLVLLL 359
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00377
EKS-ANC-00390
EKS-CAJ-00406
EKS-CAF-00403
EKS-CAP-00431
EKS-DAR-00792
EKS-EQC-00395
EKS-FEC-00387
EKS-GAG-00340
EKS-GAA-00491
EKS-GOG-00395
EKS-HOS-00408
EKS-ICT-00382
EKS-LAC-00418
EKS-LOA-00411
EKS-MAM-00401
EKS-MEG-00334
EKS-MOD-00394
EKS-MUM-00434
EKS-MUP-00396
EKS-MYL-00398
EKS-NOL-00367
EKS-OCP-00083
EKS-ORN-00513
EKS-ORA-00353
EKS-ORC-00377
EKS-ORL-00471
EKS-OTG-00404
EKS-PES-00358
EKS-POA-00393
EKS-RAN-00417
EKS-SAH-00371
EKS-SUS-00358
EKS-TAG-00472
EKS-TAR-00509
EKS-TEN-00510
EKS-XET-00513
EKS-XIM-00505
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005019; F:platelet-derived growth factor beta-receptor activity
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0030325; P:adrenal gland development
GO:0060326; P:cell chemotaxis
GO:0001701; P:in utero embryonic development
GO:0001822; P:kidney development
GO:0006807; P:nitrogen compound metabolic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0046488; P:phosphatidylinositol metabolic process
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863; P:positive regulation of phospholipase C activity
GO:0032516; P:positive regulation of phosphoprotein phosphatase activity
GO:0046777; P:protein autophosphorylation
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0048705; P:skeletal system morphogenesis
GO:0048745; P:smooth muscle tissue development
GO:0001894; P:tissue homeostasis
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
KEGG
bta:527165;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013