EKS-BOT-00166
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00166
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKG496.61.4E-149300558259
StatusUnreviewed
Ensembl ProteinENSBTAP00000003877
UniProt AccessionF1MDQ6;
Protein Name
Protein Synonyms/Alias
Gene NamePRKG2
Gene Synonyms/Alias PRKG2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000002978ENSBTAP00000003877ENSBTAT00000003877
OrganismBos taurus
Functional Description
Protein Length609
Protein Sequence
(FASTA)
SEKKLITDAL NKNQFLKRLD PQQIKDMVEC MYGRNYQQGS YIIKQGEPGN HIFVLAEGRL 60
EVSQGEKLLS SIPMWTTFGE LAILYNCTRT ASVKAITNVK TWALDREVFQ NIMRRTAQAR 120
DEQYRNFLRS VSLLKNLPED KLTKIIDCLE VEYYDKGDYI IREGEEGSTF FILAKGKVKV 180
TQSTEGHDQP QLIKTLQKGE YFGEKALISE DVRSANIIAE ENDVACLVID RETFNQTVGT 240
FEELQKYLEG YVANLNRDDE KRHAKRSMSS WKLSKALSLE MIQLKEKVAR FSSSSPFQNL 300
EIIATLGVGG FGRVELVKVK NENVAFAMKC IRKKHIVDTK QQEHVYSEKK ILEELCSPFI 360
VKLYRTFKDN KYVYMLLEAC LGGELWSILR DRGSFDEPTS KFCVACVTEA FDYLHRLGII 420
YRDLKPENLI LDAEGYLKLV DFGFAKKIGS GQKTWTFCGT PEYVAPEVIL NKGHDFSVDF 480
WSLGILVYEL LTGNPPFSGI DQMMTYNLIL KGIEKMDFPR KITRRPEDLI RRLCRQNPTE 540
RLGNLKNGIN DIKKHRWLNG FNWEGLKARN LPSPLQRELS GPTDHSYFDK YPPERGVPPD 600
ELSGWDKDF 609
Nucleotide Sequence
(FASTA)
AGTGAGAAGA AGCTCATTAC AGATGCCCTT AATAAAAATC AATTTCTGAA GAGACTGGAT 60
CCTCAGCAGA TCAAAGACAT GGTGGAATGC ATGTATGGGA GAAACTACCA GCAAGGGAGC 120
TACATTATTA AGCAAGGAGA ACCAGGAAAC CATATCTTTG TACTGGCAGA GGGTCGACTA 180
GAGGTGTCCC AAGGGGAGAA ATTGCTGTCA TCCATCCCTA TGTGGACCAC GTTTGGGGAG 240
CTAGCCATTT TATACAACTG TACAAGAACT GCCTCTGTGA AAGCTATTAC CAATGTTAAA 300
ACATGGGCAC TAGATCGAGA GGTATTCCAG AATATAATGA GAAGGACAGC TCAAGCTAGA 360
GATGAACAGT ACAGAAACTT CCTCAGAAGT GTATCCTTGC TGAAGAATTT ACCTGAAGAT 420
AAACTAACCA AGATCATTGA CTGCTTGGAA GTGGAATACT ATGACAAAGG AGATTACATT 480
ATTAGAGAGG GCGAGGAAGG AAGTACGTTT TTCATTTTAG CAAAAGGAAA GGTAAAAGTC 540
ACTCAAAGTA CTGAAGGCCA TGATCAACCA CAGCTAATAA AAACACTGCA GAAAGGAGAA 600
TATTTTGGAG AAAAAGCTCT TATCAGTGAA GATGTCAGAT CAGCTAACAT TATCGCCGAG 660
GAAAATGATG TCGCATGCCT GGTTATAGAT CGAGAAACAT TCAACCAAAC AGTGGGGACT 720
TTTGAAGAAC TCCAGAAATA TCTTGAAGGG TATGTGGCAA ACCTGAACCG GGATGATGAA 780
AAAAGACATG CGAAGAGATC CATGTCTAGC TGGAAGCTGT CCAAAGCACT CTCTTTGGAG 840
ATGATTCAAC TGAAGGAGAA AGTGGCCAGA TTTTCCTCAT CATCCCCCTT CCAGAACCTT 900
GAGATTATCG CAACACTGGG CGTTGGTGGG TTCGGAAGAG TTGAGCTTGT TAAGGTGAAA 960
AATGAGAACG TTGCTTTTGC TATGAAGTGT ATAAGGAAGA AGCACATCGT TGACACGAAG 1020
CAGCAGGAGC ATGTCTACTC AGAAAAGAAG ATCCTGGAAG AGCTATGCTC ACCCTTCATT 1080
GTGAAATTAT ATCGCACCTT CAAGGACAAT AAGTATGTAT ACATGCTTCT GGAGGCCTGC 1140
TTAGGTGGGG AGCTGTGGAG TATATTAAGA GACAGAGGCA GCTTTGATGA ACCCACCTCC 1200
AAGTTCTGTG TTGCCTGTGT GACAGAAGCA TTCGATTACC TGCATCGACT AGGTATTATC 1260
TACAGAGACC TGAAACCAGA AAACTTAATT CTAGATGCTG AGGGCTATCT TAAATTGGTT 1320
GACTTTGGAT TTGCTAAGAA AATAGGATCT GGACAGAAAA CATGGACGTT CTGTGGAACT 1380
CCAGAGTATG TAGCTCCTGA AGTCATTCTC AACAAAGGAC ATGACTTCAG TGTGGATTTT 1440
TGGTCCCTGG GAATTCTAGT ATATGAGCTC CTCACGGGCA ACCCTCCTTT TTCTGGGATT 1500
GACCAAATGA TGACCTACAA TCTGATTCTC AAAGGCATTG AAAAAATGGA TTTTCCCAGA 1560
AAGATAACAA GACGACCTGA GGATCTGATT CGGAGGCTTT GCAGGCAAAA TCCAACAGAA 1620
AGACTGGGAA ATCTGAAGAA TGGAATCAAT GACATTAAGA AACACAGGTG GTTAAATGGT 1680
TTTAATTGGG AGGGACTGAA AGCACGAAAT CTTCCATCAC CTTTACAAAG AGAGCTCAGT 1740
GGACCCACAG ATCACAGCTA CTTTGACAAG TATCCTCCTG AAAGGGGGGT GCCTCCAGAT 1800
GAGCTGTCAG GCTGGGACAA AGACTTCTGA 1830
Domain Profile
S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60
         l++iatlgvggfgrvelvkvk+ e+ afa+k+++kkhivdtkqqehv+sek+ilee++s+
Q: 300   LEIIATLGVGGFGRVELVKVKN-ENVAFAMKCIRKKHIVDTKQQEHVYSEKKILEELCSP  358
         689******************9.999**********************************
S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120
         fivklyrtfkd+kyvy+lleaclggelw+ilrdrgsfd+ t+kf+vacv+ea++ylh+ +
Q: 359   FIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLG  418
         ************************************************************
S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180
         iiyrdlkpenl+ld+egylklvdfgfakk++sg+ktwtfcgtpeyvape+ilnkghd+sv
Q: 419   IIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSV  478
         ************************************************************
S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240
         d+w+lgilvyelltg+ppfsg+d+++tynlilkgi+k+++prkit+++edli++lcr+np
Q: 479   DFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNP  538
         ************************************************************
S: 241   aerlgylkggikdikkhkwf  260
         +erlg+lk+gi+dikkh+w+
Q: 539   TERLGNLKNGINDIKKHRWL  558
         *******************7
Domain Sequence
(FASTA)
LEIIATLGVG GFGRVELVKV KNENVAFAMK CIRKKHIVDT KQQEHVYSEK KILEELCSPF 60
IVKLYRTFKD NKYVYMLLEA CLGGELWSIL RDRGSFDEPT SKFCVACVTE AFDYLHRLGI 120
IYRDLKPENL ILDAEGYLKL VDFGFAKKIG SGQKTWTFCG TPEYVAPEVI LNKGHDFSVD 180
FWSLGILVYE LLTGNPPFSG IDQMMTYNLI LKGIEKMDFP RKITRRPEDL IRRLCRQNPT 240
ERLGNLKNGI NDIKKHRWL 259
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00158
EKS-ANC-00160
EKS-CAJ-00170
EKS-CAF-00173
EKS-CAP-00165
EKS-DAR-00456
EKS-EQC-00165
EKS-FEC-00155
EKS-GAM-00085
EKS-GAG-00142
EKS-GAA-00197
EKS-GOG-00165
EKS-HOS-00172
EKS-ICT-00161
EKS-LAC-00176
EKS-LOA-00165
EKS-MAM-00164
EKS-MEG-00131
EKS-MOD-00165
EKS-MUM-00171
EKS-MUP-00170
EKS-MYL-00174
EKS-NOL-00159
EKS-ORN-00207
EKS-ORA-00147
EKS-ORC-00153
EKS-ORL-00192
EKS-OTG-00172
EKS-PAT-00157
EKS-PEM-00088
EKS-POA-00162
EKS-PTV-00148
EKS-RAN-00162
EKS-SAH-00159
EKS-SUS-00145
EKS-TAG-00195
EKS-TAR-00214
EKS-VIP-00079
EKS-XET-00154
EKS-XIM-00202
Gene Ontology
GO:0005524; F:ATP binding
GO:0004692; F:cGMP-dependent protein kinase activity
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR002374; cGMP_dep_kinase.
IPR018490; cNMP-bd-like.
IPR018488; cNMP-bd_CS.
IPR000595; cNMP-bd_dom.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014710; RmlC-like_jellyroll.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00027; cNMP_binding; 2.
PF00069; Pkinase; 1.
SMARTs
SM00100; cNMP; 2.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00888; CNMP_BINDING_1; 2.
PS00889; CNMP_BINDING_2; 2.
PS50042; CNMP_BINDING_3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00104; CGMPKINASE.
Created Date20-Feb-2013