EKS-BOT-00411
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00411
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Trk530.11.1E-159509780272
StatusUnreviewed
Ensembl ProteinENSBTAP00000003980
UniProt AccessionF1MC14;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameNTRK1
Gene Synonyms/Alias NTRK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000003060ENSBTAP00000003980ENSBTAT00000003980
OrganismBos taurus
Functional Description
Protein Length797
Protein Sequence
(FASTA)
MLRGGRGGQP GGHLRATGPG SLLAWLMLAS AGAASCPDVC CPHGPSGLRC TRPGALDNLL 60
HLPGAENLTE LYIENQQHLQ QLKRSDLRGL GELRKLTIVK SGLRSVAPNA FHYTPRLGRL 120
NLSFNALESL SWKTVQGLSL QELVLSGNPL HCSCALLWLQ RWEEEGRGGV REQKLQCPGQ 180
GPLALMSNAS CGEPTLKIQM SNASVDVGAD VLLQCQVEGQ GLEQAGWILT ELEGSATVME 240
SGSLPSLGLT LANVTSDLNR KNVTCWAEND VGRAEVSAQV NVSFPASVHL QAAVEQHHWC 300
IPFSVDGQPA PSLRWLFNGS VLNETSFIFT EFLDLAANET MRHGCLRLNQ PTHVNNGNYT 360
LLATNPLGQA AAWVMAAFMD NPFEFNPEDP IPVSFSPVDT NSTSGDPVEK DETPFGVSMA 420
VGLAVFACLF LSTTFLVLNK CGRRNKFGIN RPAVLAPEDG LAMSLHFMTL GGSSLSPTEG 480
KGSGLQGHII ENPQYFSDAC VHHIKRRDIV LKWELGEGAF GKVFLAECHN LLPEKDKMLV 540
AVKALKEVSE SARQDFQREA ELLTMLQHQH IVRFFGVCTE GRPLLMVFEY MRHGDLNRFL 600
RSHGPDAKLL AGGEDVAPGP LGLGQLLAVA SQVAAGMVYL AGLHFVHRDL ATRNCLVGQG 660
LVVKIGDFGM SRDIYSTDYY RVGGRTMLPI RWMPPESILY RKFTTESDVW SFGVVLWEIF 720
TYGKQPWYQL SNTEPQAIEC ITQGRELERP RACPPEVYAI MRGCWQREPQ QRHSIKDVHA 780
RLQALAQAPP VYLDVLG 797
Nucleotide Sequence
(FASTA)
ATGCTGCGAG GCGGACGGGG CGGGCAACCT GGCGGGCACC TCCGGGCTAC GGGGCCGGGA 60
AGCCTGCTGG CCTGGTTGAT GCTGGCATCT GCGGGCGCTG CATCCTGCCC CGATGTCTGC 120
TGCCCCCACG GCCCTTCGGG GCTACGCTGC ACCCGGCCGG GGGCCCTGGA TAACCTCCTC 180
CACCTGCCAG GCGCCGAGAA CCTGACAGAG CTCTACATCG AGAACCAGCA GCATCTGCAG 240
CAGCTGAAGC GCAGCGACCT GAGGGGCCTG GGGGAGCTGA GGAAACTCAC CATCGTGAAG 300
AGCGGTCTCC GTTCTGTGGC GCCAAATGCC TTCCATTACA CTCCGCGGCT CGGTCGACTG 360
AATCTCTCCT TCAACGCTCT GGAGTCTCTC TCCTGGAAAA CGGTCCAGGG CCTCTCCTTA 420
CAGGAACTAG TCCTGTCGGG GAACCCCCTG CACTGTTCCT GTGCCCTGCT CTGGCTGCAG 480
CGCTGGGAGG AGGAGGGGCG GGGAGGAGTG CGGGAACAGA AGCTGCAGTG TCCCGGGCAG 540
GGGCCCCTTG CCCTCATGTC CAATGCCAGC TGCGGTGAGC CCACGCTGAA GATCCAGATG 600
TCCAATGCTT CCGTGGATGT GGGGGCCGAC GTGTTGCTGC AGTGCCAGGT GGAGGGGCAG 660
GGCTTGGAGC AGGCTGGCTG GATCCTCACG GAGCTGGAGG GGTCAGCCAC AGTGATGGAA 720
TCTGGGAGTC TGCCGTCCTT GGGGCTGACC CTGGCCAATG TCACCAGTGA CCTCAATAGG 780
AAGAACGTGA CGTGCTGGGC GGAGAATGAT GTGGGCCGGG CTGAAGTCTC CGCCCAAGTC 840
AATGTCTCCT TCCCGGCCAG CGTGCATCTG CAAGCCGCCG TGGAGCAGCA CCACTGGTGC 900
ATCCCCTTCT CGGTGGACGG GCAGCCAGCG CCCTCTCTGC GCTGGCTCTT CAATGGCTCT 960
GTGCTCAACG AGACCTCCTT CATCTTCACC GAGTTCCTGG ACCTGGCAGC CAATGAGACG 1020
ATGCGCCACG GCTGCCTGCG CCTCAACCAG CCCACCCATG TCAACAACGG CAACTACACG 1080
CTGCTGGCAA CCAACCCTTT GGGCCAGGCC GCCGCTTGGG TCATGGCCGC TTTCATGGAC 1140
AACCCTTTCG AATTCAACCC TGAGGACCCC ATTCCTGTCT CCTTCTCGCC AGTGGACACC 1200
AACAGCACTT CCGGAGACCC AGTGGAGAAG GATGAGACTC CTTTTGGGGT CTCAATGGCT 1260
GTGGGCCTGG CCGTTTTTGC CTGCCTCTTC CTTTCTACAA CATTTCTTGT GCTCAACAAA 1320
TGTGGACGCA GGAACAAGTT TGGGATCAAC CGCCCTGCTG TGCTGGCTCC GGAGGATGGA 1380
TTGGCCATGT CCTTGCATTT CATGACTCTG GGTGGCAGCT CCTTGTCTCC CACTGAGGGC 1440
AAAGGCTCTG GGCTCCAAGG CCACATCATT GAGAACCCAC AGTACTTCAG TGATGCCTGT 1500
GTTCATCACA TCAAACGCCG AGATATCGTG CTCAAGTGGG AGCTGGGTGA GGGTGCCTTT 1560
GGGAAGGTCT TCCTTGCCGA GTGCCACAAC CTGCTGCCTG AGAAGGACAA GATGCTAGTG 1620
GCTGTCAAGG CGCTGAAGGA GGTGTCTGAG AGCGCCCGGC AGGACTTCCA GCGAGAGGCC 1680
GAGCTGCTCA CCATGCTCCA GCACCAGCAC ATCGTGCGCT TCTTCGGCGT CTGCACTGAG 1740
GGCCGCCCAC TGCTCATGGT CTTTGAATAC ATGCGGCACG GTGACCTCAA CCGCTTCCTC 1800
CGGTCCCACG GGCCTGATGC CAAGCTGCTG GCTGGTGGGG AGGACGTGGC TCCGGGACCC 1860
CTGGGCCTGG GGCAGCTGCT GGCCGTGGCT AGCCAGGTCG CTGCGGGAAT GGTGTACCTG 1920
GCAGGTCTGC ACTTCGTGCA TCGGGACCTG GCCACACGCA ACTGCCTGGT GGGTCAGGGA 1980
CTAGTGGTTA AGATCGGCGA TTTCGGCATG AGCCGGGATA TCTACAGCAC CGACTACTAT 2040
CGCGTGGGAG GCCGCACCAT GCTGCCCATT CGCTGGATGC CGCCCGAGAG CATCCTCTAC 2100
CGCAAGTTCA CCACCGAGAG CGACGTGTGG AGCTTCGGCG TGGTGCTCTG GGAGATCTTC 2160
ACCTACGGCA AGCAACCCTG GTACCAGCTC TCCAACACCG AGCCCCAGGC GATCGAGTGC 2220
ATCACGCAGG GACGTGAGCT GGAGCGGCCG CGTGCTTGCC CACCGGAGGT CTACGCCATT 2280
ATGCGGGGCT GCTGGCAGCG GGAGCCCCAA CAACGCCACA GCATCAAGGA TGTGCATGCC 2340
CGGCTGCAAG CCCTGGCCCA GGCGCCTCCT GTCTACTTGG ATGTCCTGGG CTAG 2394
Domain Profile
S: 1     ivlkrelgegafgkvflaecynllpekdkllvavkalkdaseaarkdfkreaelltnlqh  60
         ivlk+elgegafgkvflaec+nllpekdk+lvavkalk+ se+ar+df+reaellt+lqh
Q: 509   IVLKWELGEGAFGKVFLAECHNLLPEKDKMLVAVKALKEVSESARQDFQREAELLTMLQH  568
         89**********************************************************
S: 61    ehivklyGvctegdplllvfeymkhGdlnkflrahgpdakllvegep..kgelglsqlla  118
         +hiv+++Gvcteg+pll+vfeym+hGdln+flr+hgpdakll++ge+  +g+lgl+qlla
Q: 569   QHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDvaPGPLGLGQLLA  628
         ***********************************************999**********
S: 119   iakqiaaGlvylasqhfvhrdlatrnclvgedllvkigdfgmsrdvystdyyrvggrtml  178
         +a+q+aaG+vyla +hfvhrdlatrnclvg++l+vkigdfgmsrd+ystdyyrvggrtml
Q: 629   VASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTML  688
         ************************************************************
S: 179   pirwlppesilyrkfttesdvwslGvvlweiltyGkqpfyqlsnte..viecitqGrvle  236
         pirw+ppesilyrkfttesdvws+Gvvlwei+tyGkqp+yqlsnte  +iecitqGr+le
Q: 689   PIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEpqAIECITQGRELE  748
         *********************************************8768***********
S: 237   rpracpkevydlmlgcwqrepqkrlnikeiya  268
         rpracp+evy++m+gcwqrepq+r++ik+++a
Q: 749   RPRACPPEVYAIMRGCWQREPQQRHSIKDVHA  780
         ******************************97
Domain Sequence
(FASTA)
IVLKWELGEG AFGKVFLAEC HNLLPEKDKM LVAVKALKEV SESARQDFQR EAELLTMLQH 60
QHIVRFFGVC TEGRPLLMVF EYMRHGDLNR FLRSHGPDAK LLAGGEDVAP GPLGLGQLLA 120
VASQVAAGMV YLAGLHFVHR DLATRNCLVG QGLVVKIGDF GMSRDIYSTD YYRVGGRTML 180
PIRWMPPESI LYRKFTTESD VWSFGVVLWE IFTYGKQPWY QLSNTEPQAI ECITQGRELE 240
RPRACPPEVY AIMRGCWQRE PQQRHSIKDV HA 272
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00382
EKS-ANC-00399
EKS-CAJ-00416
EKS-CAF-00411
EKS-CAP-00439
EKS-DAR-00800
EKS-DIO-00067
EKS-EQC-00404
EKS-FEC-00394
EKS-GAM-00238
EKS-GAG-00348
EKS-GAA-00500
EKS-GOG-00403
EKS-HOS-00418
EKS-ICT-00391
EKS-LAC-00427
EKS-LOA-00421
EKS-MAM-00410
EKS-MEG-00341
EKS-MOD-00400
EKS-MUM-00444
EKS-MUP-00404
EKS-NOL-00373
EKS-OCP-00087
EKS-ORN-00525
EKS-ORC-00386
EKS-OTG-00414
EKS-PAT-00389
EKS-PES-00364
EKS-POA-00402
EKS-RAN-00426
EKS-SAH-00381
EKS-SUS-00364
EKS-TEN-00519
EKS-TUT-00123
EKS-XET-00523
EKS-XIM-00515
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0010465; F:nerve growth factor receptor activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0060385; P:axonogenesis involved in innervation
GO:0030183; P:B cell differentiation
GO:0042490; P:mechanoreceptor differentiation
GO:0008285; P:negative regulation of cell proliferation
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0045766; P:positive regulation of angiogenesis
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0010976; P:positive regulation of neuron projection development
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0032320; P:positive regulation of Ras GTPase activity
GO:0046579; P:positive regulation of Ras protein signal transduction
GO:0046777; P:protein autophosphorylation
GO:0048485; P:sympathetic nervous system development
KEGG
InterPros
IPR000483; Cys-rich_flank_reg_C.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR020461; Tyr_kinase_neurotrophic_rcpt_1.
IPR020777; Tyr_kinase_NGF_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00082; LRRCT; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR01939; NTKRECEPTOR.
PR01940; NTKRECEPTOR1.
PR00109; TYRKINASE.
Created Date20-Feb-2013