EKS-BOT-00032

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00032

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	345.5	2.4E-103	874	1146	273

Status

Unreviewed

Ensembl Protein

ENSBTAP00000004101

UniProt Accession

F1N0D6;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK1

Gene Synonyms/Alias

JAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000003147	ENSBTAP00000004101	ENSBTAT00000004101

Organism

Bos taurus

Functional Description

Protein Length

1158

Protein Sequence
(FASTA)

LQYLNIKEDC SAMAFCAKMR SSKKAEMNLE APEPGVEVLF YLSDREPLRL GGGEYTAEEL 60

CIRAAQECCI SPLCHNLFAL YDENTKLWYA PNRTVTVDDK TSLRLHYRMR FYFTNWHGTN 120

DNEQSVWRHS PKKQKNGYEK KKVPDATPLL DASSLEYLFA QGQYDLVKCL APIRDPKTEQ 180

DGHDIENECL GMAVLAISHY AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI 240

NNVFKDFLKE FNNKTICDSS VSTHDLKVKY LATLETLTKH YGAEIFETSM LLISSENEMN 300

RFHPNDSGNV LCYEVMVTGN LGIQWRQKPH IVPVEKEKNK LKRKKLENKH KKDEEKNKIR 360

EEWNNFSYFP EITHIVIKES VVSINKQDNK KMELKLSSHE EALSFVSLVD GYFRLTADAH 420

HYLCTDVAPP LIVHNIQNGC HGPICTEYAI NKLRQEGSEE GMYVLRWSCT DFDNILMTVT 480

CFEKSEVLGI QKQFKNFQIE VQKGRYSLHG SDRSFPSLGD LMSHLKKQIL RTDNISFVLK 540

RCCQPKPREI SNLLVATKKA QEWQPVYTMS QLSFDRILKK DITQGEHLGR GTRTHIYSGT 600

LTDYKDDEGT SEEKRIKVIL KVLDPSHRDI SLAFFEAASM MRQVSHKHIV YLYGVCVRDV 660

ENIMVEEFVE GGPLDLFMHR KSDVLTTPWK FKVAKQLASA LSYLEDKDLV HGNVCTKNLL 720

LAREGIDSEC GPFIKLSDPG IPITVLSRQE CIERIPWIAP ECVEDSKNLS VAADKWSFGT 780

TLWEICYNGE IPLKDKTLIE KERFYESRCR PVTPSCKELA DLMTRCMNYD PNQRPFFRAI 840

MRDINKLEEQ NPDIVSEKKP TTEVDPTHFE KRFLKRIRDL GEGHFGKVEL CRYDPEGDNT 900

GEQVAVKSLK PESGGNHIAD LKKEIEILRN LYHENIVKYK GICTEDGGNG IKLIMEFLPS 960

GSLKEYLPKN KNKINLKQQL KYAVQICKGM DYLGSRQYVH RDLAARNVLV ESEHQVKIGD 1020

FGLTKAIETD KEYYTVKDDR DSPVFWYAPE CLIQCKFYIA SDVWSFGVTL HELLTYCDSD 1080

SSPMALFLKM IGPTHGQMTV TRLVNTLKEG KRLPCPPNCP DEVYQHMRKC WEFQPSNRTT 1140

FQNLIEGFEA LLRSMSNI 1158

Nucleotide Sequence
(FASTA)

CTCCAGTATC TAAATATAAA AGAGGACTGC AGTGCCATGG CTTTCTGTGC TAAAATGAGG 60

AGCTCCAAGA AGGCGGAGAT GAATCTGGAG GCCCCTGAGC CGGGGGTGGA GGTGCTCTTC 120

TACCTGTCGG ATAGGGAGCC TCTCCGGCTG GGCGGTGGAG AGTACACGGC GGAGGAGCTG 180

TGCATCCGGG CGGCGCAGGA GTGCTGTATC TCTCCTCTGT GTCACAACCT CTTTGCCCTG 240

TATGACGAGA ACACCAAGCT CTGGTATGCT CCGAATCGCA CCGTCACCGT CGACGACAAA 300

ACGTCACTCC GGCTTCACTA CCGGATGAGG TTCTATTTCA CCAACTGGCA TGGGACCAAC 360

GACAATGAAC AATCAGTATG GCGACATTCT CCAAAGAAGC AGAAAAACGG CTATGAGAAA 420

AAAAAAGTTC CAGATGCAAC ACCTCTCCTT GACGCCAGCT CGCTGGAGTA TCTGTTTGCT 480

CAGGGACAGT ATGATTTGGT CAAATGCCTG GCTCCCATTC GAGACCCCAA GACGGAGCAG 540

GATGGGCACG ACATTGAGAA CGAGTGTCTT GGGATGGCCG TGCTGGCCAT CTCCCACTAC 600

GCCATGATGA AGAAGATGCA ATTGCCAGAA CTCCCCAAGG ACATCAGCTA CAAGCGATAT 660

ATTCCAGAAA CATTGAATAA GTCCATCAGA CAGAGGAACC TTCTCACCAG GATGCGGATA 720

AATAATGTTT TCAAAGATTT TCTAAAGGAG TTTAACAACA AGACCATTTG TGACAGCAGC 780

GTGTCCACGC ACGACCTGAA GGTGAAATAC CTGGCTACCT TGGAAACTTT GACAAAACAT 840

TATGGTGCTG AAATATTTGA GACTTCCATG CTACTGATTT CATCAGAAAA TGAGATGAAT 900

CGGTTCCATC CAAATGATAG TGGAAATGTT CTCTGCTATG AAGTGATGGT GACTGGAAAT 960

CTTGGAATCC AGTGGAGACA GAAACCACAT ATTGTTCCTG TTGAAAAGGA AAAAAACAAA 1020

CTGAAACGGA AAAAACTGGA AAATAAACAC AAGAAGGATG AGGAAAAAAA CAAAATCCGA 1080

GAAGAGTGGA ACAATTTTTC TTACTTCCCT GAGATCACTC ACATTGTAAT CAAGGAGTCT 1140

GTGGTCAGCA TTAATAAGCA GGACAACAAA AAAATGGAAC TGAAGCTCTC TTCCCACGAG 1200

GAGGCCTTGT CCTTCGTGTC CCTGGTCGAT GGCTACTTCC GGCTCACGGC AGACGCCCAT 1260

CACTACCTCT GCACTGACGT GGCTCCCCCA TTGATCGTCC ACAACATACA GAATGGCTGT 1320

CATGGTCCAA TCTGCACGGA GTATGCCATC AATAAGCTGC GGCAGGAGGG GAGCGAGGAG 1380

GGGATGTACG TGCTGCGGTG GAGCTGCACC GACTTTGACA ACATCCTTAT GACCGTCACC 1440

TGCTTCGAAA AGTCTGAGGT GCTGGGTATC CAGAAACAGT TCAAGAACTT TCAGATCGAG 1500

GTGCAGAAGG GCCGCTACAG CCTGCATGGC TCGGACCGCA GCTTCCCGAG CCTTGGGGAC 1560

CTCATGAGCC ACCTAAAGAA GCAGATCCTG CGCACGGACA ACATCAGCTT CGTGCTGAAG 1620

CGCTGCTGCC AGCCCAAGCC CCGAGAAATC TCCAATCTGC TGGTGGCCAC CAAGAAAGCC 1680

CAGGAGTGGC AGCCTGTCTA CACCATGAGC CAGCTGAGTT TCGATCGAAT CCTCAAGAAA 1740

GATATTACGC AAGGCGAGCA CCTTGGGAGA GGCACGCGGA CACACATCTA CTCTGGGACC 1800

CTCACGGATT ACAAGGATGA CGAAGGGACT TCTGAAGAGA AGAGAATAAA AGTCATCCTG 1860

AAGGTCTTAG ACCCCAGCCA CAGGGACATT TCTCTGGCCT TCTTTGAGGC AGCCAGCATG 1920

ATGAGGCAGG TCTCCCACAA ACACATCGTG TACCTCTATG GGGTTTGCGT CCGAGATGTG 1980

GAGAATATCA TGGTGGAAGA GTTTGTGGAG GGGGGACCCC TGGACCTCTT CATGCATCGG 2040

AAAAGTGACG TCCTCACCAC ACCCTGGAAG TTTAAAGTTG CCAAACAGCT GGCCAGCGCC 2100

CTGAGTTACT TGGAGGATAA AGACCTGGTC CACGGAAATG TGTGCACTAA AAACCTCCTT 2160

CTGGCCCGCG AGGGCATCGA CAGTGAGTGC GGCCCCTTCA TCAAGCTCAG TGACCCTGGC 2220

ATCCCCATCA CTGTGCTCTC CAGGCAAGAG TGCATAGAAC GAATCCCCTG GATTGCTCCC 2280

GAGTGTGTTG AAGACTCCAA GAATCTGAGT GTGGCTGCTG ACAAGTGGAG CTTTGGAACC 2340

ACACTCTGGG AAATCTGCTA CAATGGCGAG ATCCCCTTGA AAGACAAGAC GCTGATTGAG 2400

AAAGAGAGAT TCTATGAAAG CCGGTGCAGG CCAGTGACCC CATCTTGTAA GGAGCTAGCT 2460

GACTTGATGA CCCGCTGCAT GAACTACGAC CCCAACCAGA GACCCTTCTT CCGAGCCATC 2520

ATGAGAGACA TCAATAAGCT GGAGGAGCAG AATCCAGACA TTGTATCAGA AAAAAAGCCA 2580

ACAACTGAAG TGGATCCCAC ACATTTTGAA AAGCGGTTCT TAAAGAGGAT CCGTGACTTG 2640

GGAGAGGGCC ACTTTGGGAA GGTCGAGCTC TGCAGGTATG ACCCTGAGGG GGACAATACA 2700

GGGGAGCAAG TGGCTGTCAA ATCCCTGAAG CCCGAGAGTG GAGGGAACCA CATCGCTGAT 2760

CTGAAGAAGG AGATTGAAAT CTTAAGAAAT CTTTATCATG AGAACATTGT GAAGTATAAA 2820

GGCATCTGCA CAGAAGATGG TGGAAATGGT ATTAAGCTCA TCATGGAGTT TCTGCCTTCA 2880

GGGAGCCTTA AGGAATATCT TCCAAAGAAT AAGAACAAAA TTAACCTCAA ACAGCAATTA 2940

AAATACGCCG TTCAGATTTG TAAGGGGATG GACTATCTGG GTTCTCGGCA GTACGTTCAC 3000

CGGGACTTAG CAGCAAGAAA CGTCCTCGTG GAGAGTGAGC ACCAGGTGAA AATCGGGGAC 3060

TTCGGTCTCA CCAAAGCCAT CGAAACCGAT AAGGAGTACT ACACAGTCAA GGACGACCGG 3120

GACAGCCCTG TGTTTTGGTA TGCTCCAGAA TGTTTAATTC AGTGTAAGTT CTATATCGCC 3180

TCTGATGTCT GGTCTTTCGG AGTGACTCTG CATGAGCTGC TTACTTACTG TGATTCAGAT 3240

TCCAGTCCCA TGGCCTTGTT CCTGAAAATG ATAGGCCCAA CTCATGGTCA GATGACGGTA 3300

ACAAGACTCG TGAATACATT AAAAGAAGGA AAACGCTTGC CATGTCCACC GAACTGTCCA 3360

GATGAGGTTT ATCAACATAT GCGAAAGTGT TGGGAATTTC AACCGTCTAA TCGGACAACC 3420

TTTCAGAACC TTATTGAAGG ATTTGAAGCA CTTCTAAGAA GCATGAGTAA CATTTAA 3477

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv+++r+d+egd+t+e+va+k Lk esg ++++d+k+e+eil++l+h

Q: 874   LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKpESGGNHIADLKKEIEILRNLYH  933

         6899********************************************************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         e+ivk+kg+c+++g n  +l+me+++sGsL++yL+k+k++++l+++l++a q++k+m+YL

Q: 934   ENIVKYKGICTEDGGNgiKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYL  993

         ************************************************************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         +++++vhrd+aarnvLve+e++      vk++d+gl+ka+++d eYy+v+++rds+++w+

Q: 994   GSRQYVHRDLAARNVLVESEHQ------VKIGDFGLTKAIETDkEYYTVKDDRDSPVFWY  1047

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224

         apecl+++k +++asdvWsFgvtl+ellt c++++sp    l++++++       r++++

Q: 1048  APECLIQCK-FYIASDVWSFGVTLHELLTyCDSDSSPmalfLKMIGPThgqmtvtRLVNT  1106

         *********.*******************************9****999***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         l+e++rlp+p+ cp+e+++ m++c++ +ps+r++F++++e

Q: 1107  LKEGKRLPCPPnCPDEVYQHMRKCWEFQPSNRTTFQNLIE  1146

         *************************************987

Domain Sequence
(FASTA)

LKRIRDLGEG HFGKVELCRY DPEGDNTGEQ VAVKSLKPES GGNHIADLKK EIEILRNLYH 60

ENIVKYKGIC TEDGGNGIKL IMEFLPSGSL KEYLPKNKNK INLKQQLKYA VQICKGMDYL 120

GSRQYVHRDL AARNVLVESE HQVKIGDFGL TKAIETDKEY YTVKDDRDSP VFWYAPECLI 180

QCKFYIASDV WSFGVTLHEL LTYCDSDSSP MALFLKMIGP THGQMTVTRL VNTLKEGKRL 240

PCPPNCPDEV YQHMRKCWEF QPSNRTTFQN LIE 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0019221	; P:cytokine-mediated signaling pathway
GO:0007167	; P:enzyme linked receptor protein signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0046677	; P:response to antibiotic

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776	; Tyr_kinase_non-rcpt_Jak1.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01824	; JANUSKINASE1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013