| Tag | Content |
|---|
| EKPD ID | EKS-BOT-00017 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CAMK/PHK | 526.4 | 1.5E-158 | 24 | 291 | 268 |
|
| Status | Reviewed |
| Ensembl Protein | ENSBTAP00000004433 |
| UniProt Accession | Q2KJ16; A7E3T5; |
| Protein Name | Phosphorylase b kinase gamma catalytic chain, testis/liver isoform |
| Protein Synonyms/Alias | PHK-gamma-T; Phosphorylase kinase subunit gamma-2; Serine/threonine-protein kinase PHKG2; |
| Gene Name | PHKG2 |
| Gene Synonyms/Alias | PHKG2; |
| Ensembl Information | |
| Organism | Bos taurus |
| Functional Description | Catalytic subunit of the phosphorylase b kinase (PHK),which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase (PYGB, PYGL or PYGM). May regulate glycogeneolysis in the testis. In vitro, phosphorylates TNNI3, TNNT2, MAPT/TAU, GAP43 and NRGN/RC3. |
| Protein Length | 406 |
Protein Sequence
(FASTA) | | MTLDVGPEDE LPDWAAAKEF YQKYDPKDVI GRGVSSVVRR CVHRATGQEF AVKIMEVTAE 60 | | RLSPEQLEEV REATRRETHI LRQVAGHPHI ITLIDSYESS SFMFLVFDLM RKGELFDYLT 120 | | EKVALSEKET RSIMRSLLEA VSFLHNNNIV HRDLKPENIL LDDNMQIRLS DFGFSCHLEP 180 | | GEKLRELCGT PGYLAPEILK CSMDETHPGY GKEVDLWACG VILFTLLAGS PPFWHRRQIL 240 | | MLRMIMEGQY QFSSPEWDDR SDTVKDLISR LLQVDPVERL TAEQALQHPF FERCEGSQAW 300 | | NLTPRQRFRV AVWTVLAAGR VALSAHRIRP LTKSALLRDP YALRPVRRLI DNCAFRLYGH 360 | | WVKKGEQQNR AALFQHRPPG PFPMMGPEEE GDSATIAEDE AMLVLG 406 |
|
Nucleotide Sequence
(FASTA) | | ATGACATTGG ACGTGGGGCC AGAGGATGAG CTGCCCGACT GGGCTGCAGC CAAAGAATTT 60 | | TATCAGAAGT ACGATCCTAA AGACGTCATT GGCAGAGGAG TGAGCTCTGT GGTCCGCCGC 120 | | TGTGTTCATC GGGCTACTGG CCAGGAGTTT GCAGTGAAGA TCATGGAGGT GACAGCCGAG 180 | | CGGTTGAGTC CTGAGCAGCT GGAGGAGGTG CGAGAGGCCA CGCGGCGGGA GACACACATC 240 | | CTTCGCCAGG TCGCCGGCCA CCCCCACATC ATCACTCTCA TCGATTCCTA CGAGTCTTCT 300 | | AGCTTCATGT TCCTGGTGTT TGACCTGATG CGGAAGGGAG AGCTGTTTGA CTATCTCACA 360 | | GAGAAGGTGG CCCTCTCAGA AAAAGAAACC AGGTCCATCA TGAGGTCTCT GCTGGAAGCA 420 | | GTGAGTTTTC TCCACAACAA CAATATTGTA CACCGAGACC TGAAGCCCGA GAATATTCTC 480 | | CTAGATGACA ATATGCAGAT CCGACTTTCA GATTTTGGGT TCTCTTGCCA CCTGGAACCA 540 | | GGCGAGAAGC TTCGAGAGTT GTGTGGGACT CCAGGGTATC TAGCACCAGA GATCCTTAAG 600 | | TGCTCCATGG ATGAAACTCA CCCAGGCTAC GGCAAGGAGG TCGATCTCTG GGCCTGCGGG 660 | | GTGATCTTGT TCACACTCCT GGCGGGCTCC CCACCATTCT GGCACCGACG CCAGATCCTG 720 | | ATGTTACGTA TGATCATGGA GGGCCAGTAC CAGTTTAGTT CACCCGAGTG GGACGACCGT 780 | | TCAGACACTG TGAAAGACCT GATCTCCAGG CTGCTACAAG TGGATCCTGT GGAGCGCCTG 840 | | ACAGCTGAGC AGGCCCTACA GCACCCATTC TTTGAGCGCT GTGAAGGCAG CCAAGCCTGG 900 | | AACCTCACCC CTCGCCAGCG GTTTCGGGTG GCAGTGTGGA CCGTGCTGGC CGCTGGACGG 960 | | GTAGCCTTAA GCGCCCACCG TATCCGGCCA CTGACCAAGA GTGCGCTATT GAGGGACCCT 1020 | | TACGCGCTGC GGCCAGTGCG GCGCCTGATC GACAACTGTG CCTTCCGGCT CTACGGACAC 1080 | | TGGGTGAAGA AGGGTGAGCA GCAGAACCGG GCAGCCCTCT TCCAGCACCG GCCCCCGGGG 1140 | | CCTTTTCCCA TGATGGGCCC TGAAGAGGAA GGGGACTCGG CTACTATCGC TGAGGATGAG 1200 | | GCCATGCTAG TGCTGGGCTA G 1221 |
|
| Domain Profile | S: 1 yepkeilGrGvssvvrrciekatgqefavkiidvsaeklseeevkelreatlkeveilrq 60 | y+pk+++GrGvssvvrrc+++atgqefavki++v+ae+ls+e+++e+reat++e++ilrq | Q: 24 YDPKDVIGRGVSSVVRRCVHRATGQEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQ 83 | 9*********************************************************** |
| S: 61 vsGhpsiiklkdvyesssflflvfdlmkkGelfdyltekvtlseketrkimralleavey 120 | v+Ghp+ii+l+d+yesssf+flvfdlm+kGelfdyltekv+lseketr+imr+lleav++ | Q: 84 VAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSF 143 | ************************************************************ |
| S: 121 lhaknivhrdlkpenillddneniklsdfGfstqleeGeklrelcGtpgylapeilkcsm 180 | lh++nivhrdlkpenillddn++i+lsdfGfs++le+GeklrelcGtpgylapeilkcsm | Q: 144 LHNNNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSM 203 | ************************************************************ |
| S: 181 deeapGyskevdlwalGvilytllaGsppfwhrkqllmlrlimeGkyqftspewddisee 240 | de++pGy+kevdlwa+Gvil+tllaGsppfwhr+q+lmlr+imeG+yqf+spewdd+s++ | Q: 204 DETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSDT 263 | ************************************************************ |
| S: 241 vkdliskllvvdpekrltaeealahpff 268 | vkdlis+ll+vdp +rltae+al+hpff | Q: 264 VKDLISRLLQVDPVERLTAEQALQHPFF 291 | ***************************8 |
|
Domain Sequence
(FASTA) | | YDPKDVIGRG VSSVVRRCVH RATGQEFAVK IMEVTAERLS PEQLEEVREA TRRETHILRQ 60 | | VAGHPHIITL IDSYESSSFM FLVFDLMRKG ELFDYLTEKV ALSEKETRSI MRSLLEAVSF 120 | | LHNNNIVHRD LKPENILLDD NMQIRLSDFG FSCHLEPGEK LRELCGTPGY LAPEILKCSM 180 | | DETHPGYGKE VDLWACGVIL FTLLAGSPPF WHRRQILMLR MIMEGQYQFS SPEWDDRSDT 240 | | VKDLISRLLQ VDPVERLTAE QALQHPFF 268 |
|
| Keyword | ATP-binding; Calmodulin-binding; Carbohydrate metabolism; Complete proteome; Glycogen metabolism; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |