EKS-BOT-00007
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00007
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph502.51.9E-151615874260
StatusUnreviewed
Ensembl ProteinENSBTAP00000037070
UniProt AccessionE1BIE4;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB4
Gene Synonyms/Alias EPHB4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000003446ENSBTAP00000037070ENSBTAT00000037233
OrganismBos taurus
Functional Description
Protein Length987
Protein Sequence
(FASTA)
MELRALLCWA SLAAALEETL LNTKLETADL KWVTFPQADG QWEELSGLDE EQHSVRTYEV 60
CDMQRAPGLA HWLRTGWVPR RGAVHVYATL RFTMLECLSL PRAGRSCKET FTVFYFESDA 120
DTATAHTPAW MENPYIKVDT VAAEHLTRKR PGAEATGKVN VKTLRLGPLT KAGFYLAFQD 180
QGACMALLSL HLFYKKCAQQ TVNLTYFPET VPRELVVPVA GSCVADAMPA PGPSPSLYCR 240
EDGQWAEQPV TGCSCNAGFE AAEGNTKCRA CAQGTFKPLS GEGSCQPCPA NSHSNAIGSS 300
ICQCRIGYFR ASTDPRSAPC TTPPSAPRSV VPRLNGSALR LEWSAPLESG GREDLTYALR 360
CRECRPGGSC TPCGGDLTFD PGPRDLVEPW VAIRGLRPDV TYTFEVTALN GVSSLASGPV 420
PFEAVNVTTD REVPPPVSDI RVTRSSPSSL SLAWAVPRAP SGAVLDYEVK YHEKGAEGPS 480
SVRFLKTSEN RAELRGLKRG ASYLVQVRAR SEAGYGPFGQ EHHSQTQLDE NEAWREQLAL 540
IAGTAVVGVV LVFVVIVIAV LCLRKQSNGR EAEYSDKHAQ YLIGHGTKVY IDPFTYEDPN 600
EAVREFAKEI DVSYVKIEEV IGAGEFGEVC RGRLKAPGKK ESCVAIKTLK GGYTERQRRE 660
FLSEASIMGQ FEHPNIIRLE GVVTNSVPVM ILTEFMENGA LDSFLRLNDG QFTVIQLVGM 720
LRGIASGMRY LAEMSYVHRD LAARNILVNS NLVCKVSDFG LSRFLEENSS DPTYTSSLGG 780
KIPIRWTAPE AIAFRKFTSA SDAWSYGIVM WEVMSFGERP YWDMSNQDVI NAIEQDYRLP 840
PPPDCPTSLH QLMLDCWQKD RNARPRFPQV VSALDKMIRN PASLKIVARE NGGASHPLLD 900
QRQPHYSAFG SVGEWLRAIK MGRYEESFAA AGFGSFELVS QISTEDLLRI GVTLAGHQKK 960
ILASVQHMKS QAKPGAPGGS GAPAPQY 987
Nucleotide Sequence
(FASTA)
ATGGAGCTCC GGGCTCTGCT CTGCTGGGCT TCGCTTGCAG CCGCCCTAGA AGAGACCCTA 60
CTGAACACGA AATTGGAAAC TGCCGATCTG AAGTGGGTGA CATTCCCTCA GGCGGACGGG 120
CAGTGGGAGG AGCTGAGCGG CCTGGACGAG GAGCAGCACA GCGTCCGGAC CTACGAGGTG 180
TGTGACATGC AGCGGGCCCC AGGCCTGGCC CACTGGCTGC GCACCGGCTG GGTCCCCCGC 240
CGCGGGGCCG TCCACGTGTA CGCCACGCTG CGCTTCACCA TGCTGGAGTG CCTCTCCCTG 300
CCGAGGGCCG GCCGCTCCTG CAAGGAGACC TTCACCGTCT TCTACTTCGA GAGCGACGCA 360
GACACGGCCA CGGCCCACAC GCCAGCCTGG ATGGAGAACC CCTACATCAA GGTGGACACG 420
GTGGCTGCTG AGCACCTCAC CCGGAAGCGC CCAGGGGCTG AGGCCACGGG GAAGGTGAAT 480
GTCAAGACGC TGCGTCTGGG CCCGCTCACC AAGGCCGGCT TCTACCTGGC CTTCCAGGAC 540
CAGGGCGCCT GCATGGCCCT GCTGTCCCTG CACCTCTTCT ATAAGAAGTG CGCCCAGCAG 600
ACTGTGAACC TCACCTACTT CCCGGAGACT GTGCCTCGGG AGCTGGTGGT GCCCGTGGCC 660
GGCAGCTGCG TGGCCGATGC CATGCCTGCC CCCGGCCCCA GCCCCAGCCT CTACTGCCGG 720
GAAGACGGCC AGTGGGCCGA GCAGCCGGTC ACGGGCTGCA GCTGCAATGC GGGGTTCGAG 780
GCCGCTGAGG GGAACACCAA GTGCCGAGCC TGTGCTCAGG GCACCTTCAA GCCCCTGTCC 840
GGGGAGGGGT CCTGCCAGCC GTGCCCAGCC AACAGCCACT CTAACGCCAT TGGCTCGTCC 900
ATCTGCCAGT GTCGCATCGG GTACTTCCGG GCCAGCACAG ACCCCCGAAG TGCGCCCTGT 960
ACCACACCCC CGTCAGCCCC GAGAAGCGTG GTTCCCCGCC TGAATGGCTC CGCCCTGCGC 1020
TTGGAGTGGA GTGCGCCCCT CGAGTCAGGC GGCCGGGAGG ACCTCACTTA CGCGCTCCGC 1080
TGCCGGGAGT GCCGGCCCGG TGGGTCCTGC ACGCCCTGCG GGGGAGACCT GACCTTCGAC 1140
CCCGGCCCCC GGGACCTGGT GGAGCCCTGG GTGGCGATTC GCGGTCTGCG TCCTGACGTC 1200
ACCTATACGT TTGAGGTCAC CGCCTTGAAT GGGGTGTCCT CCTTGGCCAG TGGGCCGGTC 1260
CCGTTTGAGG CTGTGAATGT CACCACGGAC CGCGAGGTGC CACCCCCCGT GTCTGACATC 1320
CGGGTGACTC GGTCATCACC CAGCAGCTTG AGCCTGGCAT GGGCCGTTCC CCGGGCGCCC 1380
AGCGGGGCAG TGCTGGACTA CGAGGTCAAG TACCACGAGA AGGGCGCTGA GGGCCCCAGC 1440
AGCGTGCGGT TCCTGAAGAC GTCAGAGAAC CGGGCAGAGC TGCGGGGACT GAAGCGGGGA 1500
GCCAGCTACC TGGTCCAGGT GCGGGCACGC TCCGAGGCCG GCTACGGGCC CTTTGGCCAG 1560
GAGCACCACA GCCAGACCCA GCTGGACGAG AATGAGGCCT GGAGGGAGCA GCTGGCCCTG 1620
ATTGCAGGCA CCGCGGTCGT GGGTGTGGTG CTAGTGTTCG TGGTCATCGT CATCGCAGTT 1680
CTCTGCCTCA GGAAGCAGAG CAACGGGAGA GAAGCTGAGT ACTCAGACAA ACACGCCCAG 1740
TATCTCATTG GGCACGGTAC TAAGGTCTAC ATTGACCCCT TCACTTACGA AGACCCTAAT 1800
GAGGCTGTCA GGGAGTTTGC AAAAGAGATC GATGTCTCCT ATGTCAAGAT TGAAGAGGTG 1860
ATTGGTGCAG GCGAGTTTGG TGAGGTGTGC CGGGGGCGCC TCAAGGCCCC TGGGAAGAAG 1920
GAGAGCTGCG TAGCCATCAA GACCCTGAAG GGCGGCTACA CGGAGCGGCA GCGGCGGGAG 1980
TTCCTGAGTG AGGCCTCCAT CATGGGCCAG TTCGAGCACC CCAATATCAT CCGCCTGGAG 2040
GGCGTGGTCA CCAACAGCGT GCCCGTCATG ATCCTCACCG AGTTCATGGA GAACGGTGCC 2100
CTGGACTCCT TCCTGCGGCT GAACGACGGC CAGTTCACCG TGATCCAGCT CGTGGGCATG 2160
CTACGGGGCA TCGCCTCGGG CATGCGCTAC CTTGCCGAGA TGAGCTACGT CCACCGAGAC 2220
CTGGCTGCCC GCAACATCCT GGTCAACAGC AACCTCGTCT GCAAGGTCTC AGACTTTGGC 2280
CTCTCCCGAT TCCTGGAGGA GAACTCCTCC GACCCCACCT ACACGAGCTC TCTGGGAGGA 2340
AAGATTCCCA TCCGCTGGAC AGCCCCCGAG GCCATTGCCT TCCGGAAGTT CACATCTGCC 2400
AGTGATGCCT GGAGCTACGG AATTGTCATG TGGGAGGTCA TGTCATTTGG GGAGCGGCCA 2460
TACTGGGATA TGAGCAATCA GGATGTGATC AACGCCATTG AACAGGACTA CCGGTTGCCC 2520
CCGCCCCCAG ACTGCCCCAC CTCCCTGCAT CAGCTCATGC TGGACTGTTG GCAGAAAGAC 2580
CGGAATGCGC GGCCCCGCTT CCCCCAGGTG GTCAGCGCCC TCGACAAGAT GATCCGGAAC 2640
CCTGCCAGCC TCAAAATCGT GGCCCGGGAG AACGGCGGGG CCTCGCACCC CCTCCTGGAT 2700
CAGCGGCAGC CTCACTACTC AGCTTTTGGC TCCGTGGGGG AGTGGCTTCG AGCCATTAAG 2760
ATGGGAAGAT ACGAAGAAAG CTTTGCAGCT GCTGGGTTTG GCTCCTTTGA GCTGGTCAGC 2820
CAGATCTCCA CTGAGGACCT GCTCCGAATC GGAGTCACTC TGGCGGGACA CCAGAAGAAA 2880
ATCCTGGCCA GTGTCCAGCA CATGAAATCC CAGGCCAAGC CTGGAGCCCC AGGCGGGTCG 2940
GGAGCACCGG CCCCCCAGTA CTGA 2964
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGevc+Grlk+pgk+e++vaiktlk+g+te+qrr+flseasi+Gqf+hp
Q: 615   VKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHP  674
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvt+s pvmi+te+mengaldsflr +dgqftviqlvgmlrGiasgm+yl++m
Q: 675   NIIRLEGVVTNSVPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEM  734
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr+le++s +++yt+s ggkipirwtapeaia+
Q: 735   SYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSsDPTYTSSlGGKIPIRWTAPEAIAF  794
         *******************************99988*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasd+wsyGiv+wev+s+Gerpywdmsnqdvi+aie++yrlppp dcp++l+qlml
Q: 795   RKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLML  854
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqkdr++rp+f q+vs+l
Q: 855   DCWQKDRNARPRFPQVVSAL  874
         *****************975
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVCRGRL KAPGKKESCV AIKTLKGGYT ERQRREFLSE ASIMGQFEHP 60
NIIRLEGVVT NSVPVMILTE FMENGALDSF LRLNDGQFTV IQLVGMLRGI ASGMRYLAEM 120
SYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEENSSDPTY TSSLGGKIPI RWTAPEAIAF 180
RKFTSASDAW SYGIVMWEVM SFGERPYWDM SNQDVINAIE QDYRLPPPPD CPTSLHQLML 240
DCWQKDRNAR PRFPQVVSAL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00008
EKS-CAJ-00008
EKS-CAF-00009
EKS-CAP-00006
EKS-DAR-00013
EKS-EQC-00009
EKS-FEC-00006
EKS-GAA-00011
EKS-GOG-00008
EKS-HOS-00009
EKS-ICT-00008
EKS-LAC-00014
EKS-LOA-00009
EKS-MAM-00007
EKS-MOD-00008
EKS-MUM-00009
EKS-MUP-00009
EKS-MYL-00010
EKS-NOL-00008
EKS-ORN-00012
EKS-ORA-00007
EKS-ORC-00008
EKS-ORL-00012
EKS-OTG-00009
EKS-PAT-00009
EKS-POA-00006
EKS-PRC-00003
EKS-RAN-00008
EKS-SAH-00007
EKS-SUS-00006
EKS-TEN-00011
EKS-TUT-00005
EKS-XIM-00010
Gene Ontology
GO:0009986; C:cell surface
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
GO:0007155; P:cell adhesion
GO:0002042; P:cell migration involved in sprouting angiogenesis
GO:0046777; P:protein autophosphorylation
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013