EKS-BOT-00331

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00331

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	314.2	7.2E-94	27	293	267

Status

Unreviewed

Ensembl Protein

ENSBTAP00000053721

UniProt Accession

F1MDE3;

Protein Name

Protein Synonyms/Alias

Gene Name

MYO3B

Gene Synonyms/Alias

MYO3B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000003626	ENSBTAP00000053721	ENSBTAT00000061222

Organism

Bos taurus

Functional Description

Protein Length

1125

Protein Sequence
(FASTA)

RRHLYGLFHY NATMLGLESL PDPTDTWEII ETIGKGTYGK VYKVTNKRDG SLAAVKILDP 60

ISDMDEEIEA EYNILQFLPN HPNVVKFYGM FYKADHCVGG QLWLVLELCN GGSVTELVKS 120

LLRCNQRLDE AVISYILYGA LLGLQHLHNN RIIHRDVKGN NILLTTEGGV KLVDFGVSAQ 180

LTSTRLRRNT SVGTPFWMAP EVIACEQQYD SSYDARCDVW SLGITAIELG DGDPPLFDMH 240

PVKTLFKIPR NPPPTLLHPE KWCEEFNHFI SQCLIKDFEK RPSVTHLLDH PFIKGVHGKL 300

LFLQKQLAKV LQDQKHLNPV VKTRHERMHT KRPYHVEDAE KYCLEDDLVN MEVLDEDTII 360

HQLQKRYVDL LIYTYVGDIL IALNPFQNLS IYSPQFSRLY HGVKRASNPP HIFASADAAY 420

QCMVTFSKDQ CIVISGESGS GKTESAHLIV QHLTFLGKAD NQTLREKILQ VNSLVEAFGN 480

ACTAINDNSS RFGKYLEMMF TPTGAVMGAR ISEYLLEKSR VIKQAVGEKN FHIFYYIYAG 540

LYHQKKLSEF RLPEEKPPRY LADETGRVMH DITSKESYRR QFEAIQHCFR IIGFTDKEVH 600

SVYSILSGIL NIGNIEFAAI SSQHQTDKSE VPNAEALENA ASVLCISPEE LQEALTSHCV 660

VTRGETIIRA NTVDRASDVR DAMSKGLYGR LFSWIVNRIN TLLQPDKNIC TADDGMNVGI 720

LDIFGFENFQ RNSFEQLCIN IANEQIQYYF NQHVFALEQM EYQNEGIDAT PVEYEDNRPL 780

LDMFLQKPLG LLALLDEESR FPQATDQTLV DKFEDNLRCK YFWRPKGMEL CFGIQHYAGK 840

VLYDASGVLE KNRDTLPADV VVILRASENQ LLQQLFSIPL TKTGNLAQTR ARITAASRSL 900

PPHFSSGRLK VDTLEVIRHP EETTNMKGQT MASYFRYSLM DLLSKMVVGQ PHFVRCIKPN 960

DDREALKFST DKVRAQLRST GILETVSIRQ QGYSHRILFE EFVKRYYYLA FRAHQTPLAS 1020

KESCIAILEK SRLDHWLLGK TKVFLKYYHV EQLNLLLREV IGRVVVLQAY AKGWLGARRY 1080

RRVREKREKG AVAIQSAWRG YDARRKFKKI SNRRSEPAVH IHAGN 1125

Nucleotide Sequence
(FASTA)

AGGAGACATC TGTATGGATT GTTTCATTAC AACGCCACGA TGCTTGGACT TGAATCGCTT 60

CCAGATCCCA CAGATACCTG GGAAATTATA GAGACCATAG GTAAAGGCAC CTATGGCAAG 120

GTCTACAAGG TGACTAATAA GAGAGATGGG AGCCTGGCCG CAGTAAAAAT TCTAGATCCA 180

ATCAGTGATA TGGATGAAGA GATTGAGGCA GAATACAACA TTTTGCAGTT TCTCCCGAAT 240

CATCCCAATG TTGTAAAGTT TTACGGAATG TTTTACAAAG CGGATCACTG TGTGGGAGGA 300

CAGCTGTGGC TGGTCCTGGA GCTGTGTAAT GGGGGCTCAG TCACCGAGCT TGTCAAAAGT 360

CTACTTAGGT GCAACCAGCG GTTGGACGAA GCAGTGATCT CATACATCTT ATATGGGGCC 420

CTCTTGGGCC TTCAGCATTT GCACAATAAC CGAATCATCC ACCGTGATGT CAAGGGGAAT 480

AACATTCTTC TGACAACAGA AGGAGGAGTT AAGCTCGTTG ACTTTGGTGT CTCAGCTCAA 540

CTCACCAGTA CACGTCTACG GAGAAACACA TCTGTTGGCA CCCCATTCTG GATGGCCCCT 600

GAGGTCATTG CTTGTGAGCA GCAGTATGAC TCTTCCTATG ACGCTCGCTG TGACGTCTGG 660

TCCTTGGGGA TCACAGCTAT TGAACTGGGG GACGGAGATC CTCCCCTCTT TGACATGCAT 720

CCTGTGAAAA CGCTCTTTAA GATTCCAAGA AATCCTCCAC CTACTTTACT TCATCCGGAA 780

AAATGGTGTG AAGAATTCAA CCACTTCATT TCACAGTGTC TCATTAAAGA TTTTGAAAAG 840

CGACCTTCGG TCACGCATCT CCTCGACCAC CCATTTATTA AAGGAGTCCA CGGAAAGCTT 900

TTGTTTCTGC AGAAGCAGCT GGCTAAGGTC CTCCAAGACC AGAAGCATCT AAATCCTGTT 960

GTTAAAACCA GGCATGAAAG GATGCACACC AAAAGACCCT ATCATGTGGA AGATGCTGAA 1020

AAATACTGCC TTGAGGATGA CTTGGTCAAT ATGGAGGTCC TGGATGAGGA TACAATTATT 1080

CATCAGCTGC AGAAGCGTTA TGTGGACTTA CTTATTTACA CATATGTTGG AGATATCTTA 1140

ATTGCCTTAA ACCCCTTCCA GAATCTAAGC ATATACTCTC CACAGTTTTC CAGACTGTAT 1200

CATGGAGTGA AACGTGCCTC AAATCCCCCC CACATATTTG CATCAGCAGA TGCTGCTTAT 1260

CAATGCATGG TTACTTTCAG CAAAGATCAG TGCATTGTCA TCAGCGGAGA AAGTGGCTCT 1320

GGGAAGACGG AAAGTGCCCA CCTGATCGTT CAGCATTTGA CTTTCTTGGG AAAGGCAGAT 1380

AATCAGACCT TGAGAGAAAA AATTCTGCAA GTCAACTCTC TGGTGGAAGC CTTTGGAAAT 1440

GCATGCACTG CCATCAATGA CAATTCCAGC CGTTTTGGAA AATATCTGGA AATGATGTTT 1500

ACACCAACTG GAGCTGTGAT GGGAGCAAGA ATCTCTGAAT ATCTCCTTGA AAAATCCAGA 1560

GTTATAAAAC AGGCAGTAGG AGAGAAAAAT TTTCACATAT TTTACTATAT TTATGCTGGT 1620

CTTTATCACC AGAAGAAACT TTCTGAGTTC CGACTTCCTG AGGAAAAGCC TCCTAGGTAC 1680

CTAGCTGATG AAACTGGAAG GGTGATGCAT GACATAACTT CCAAGGAGTC TTACAGAAGA 1740

CAGTTTGAAG CAATTCAGCA TTGCTTCAGG ATTATAGGAT TCACTGACAA GGAGGTGCAC 1800

TCAGTGTACA GTATATTATC TGGGATTTTG AATATTGGAA ACATTGAGTT TGCAGCTATT 1860

TCCTCTCAGC ATCAAACTGA CAAAAGTGAG GTGCCCAATG CAGAAGCCTT GGAAAATGCT 1920

GCCTCGGTTC TCTGCATCAG CCCTGAAGAG CTCCAGGAGG CTCTCACCTC ACACTGTGTG 1980

GTCACTCGGG GTGAGACCAT CATCCGCGCC AACACTGTGG ACAGGGCCTC GGACGTCAGA 2040

GACGCCATGT CCAAAGGCCT GTACGGGAGG CTTTTCAGCT GGATTGTAAA TCGCATCAAC 2100

ACGCTCCTGC AGCCAGACAA AAACATATGT ACTGCAGACG ATGGTATGAA TGTGGGGATC 2160

TTGGACATTT TTGGATTCGA AAACTTTCAG AGAAATTCAT TTGAGCAGCT CTGCATAAAC 2220

ATCGCCAATG AGCAAATTCA GTACTATTTC AATCAGCATG TTTTTGCTCT CGAGCAGATG 2280

GAGTATCAGA ACGAGGGCAT TGACGCTACC CCCGTGGAGT ACGAGGACAA TCGCCCCCTC 2340

CTGGATATGT TCCTCCAGAA ACCCCTGGGA CTGCTTGCGC TTCTGGATGA GGAAAGCCGG 2400

TTTCCTCAGG CAACGGACCA GACCCTAGTT GATAAATTTG AAGATAATCT TCGATGCAAA 2460

TACTTCTGGA GGCCCAAAGG AATGGAGCTG TGCTTTGGCA TTCAGCACTA TGCTGGAAAG 2520

GTATTATATG ATGCTTCTGG GGTTCTTGAG AAAAACAGAG ACACTCTCCC TGCTGATGTG 2580

GTGGTCATAC TGAGGGCATC AGAAAACCAG CTTCTCCAGC AACTCTTCTC AATCCCTTTG 2640

ACTAAAACAG GTAACTTGGC CCAGACAAGA GCCAGGATAA CAGCAGCCTC AAGATCTTTG 2700

CCTCCGCATT TCAGTTCTGG GAGACTCAAG GTGGACACTC TGGAGGTGAT ACGGCATCCG 2760

GAAGAAACCA CCAACATGAA GGGGCAAACC ATGGCTTCTT ACTTTCGGTA TTCTCTGATG 2820

GATCTGCTCT CTAAAATGGT GGTGGGACAG CCCCACTTTG TACGCTGCAT CAAGCCCAAT 2880

GATGACCGAG AGGCCCTGAA GTTCTCCACA GACAAAGTGC GGGCCCAGCT CCGCTCCACG 2940

GGCATCCTAG AGACAGTCAG CATCCGCCAG CAGGGGTATT CTCACCGCAT CCTCTTCGAG 3000

GAGTTTGTGA AAAGGTATTA TTACTTGGCA TTCAGAGCAC ATCAAACACC TCTTGCTAGC 3060

AAAGAGAGTT GCATCGCTAT CTTGGAGAAG TCCAGATTAG ATCACTGGCT GCTGGGAAAA 3120

ACAAAGGTTT TTCTCAAGTA TTATCATGTT GAGCAGTTAA ATTTGCTGCT GCGGGAAGTC 3180

ATAGGCAGAG TGGTTGTGCT GCAGGCCTAT GCCAAGGGGT GGCTGGGAGC CAGGAGATAC 3240

AGAAGAGTCA GAGAGAAGAG AGAGAAGGGG GCTGTTGCCA TCCAGTCAGC CTGGAGAGGA 3300

TATGATGCTC GGAGGAAATT TAAGAAAATA AGCAACAGAA GGAGTGAGCC TGCTGTTCAT 3360

ATTCACGCAG GTAATTAA 3378

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkkl.khpniv  59

         +e++e+igkG++gkvy+ ++k+ g+l+a+k+++  + ++ ee++ e+++l+ l +hpn+v

Q: 27    WEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPIS-DMDEEIEAEYNILQFLpNHPNVV  85

         799******************************998.99************98356****

S: 60    eylesflk.....eeelwlvmeylagGslsdlvk..eelkselkEeqiayilrevlkaLe  112

         +++++f+k       +lwlv+e+++gGs+++lvk    ++++l+E  i+yil ++l +L+

Q: 86    KFYGMFYKadhcvGGQLWLVLELCNGGSVTELVKslLRCNQRLDEAVISYILYGALLGLQ  145

         *******99888889*******************766899********************

S: 113   ylHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaq  172

         +lH++++iHrd+k++niLlt+eg VkL+dfgv+aql++tr +r+t vgtp+wmAPEvia+

Q: 146   HLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIAC  205

         ************************************************************

S: 173   e...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfske  229

         e   +++Yd+++D+wslGItaiel +g+pP++d++p+k l+ki++n+pp+l +++k+++e

Q: 206   EqqyDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPEKWCEE  265

         9888899*****************************************************

S: 230   fkefvekclqknpekRpsasellkhkFl  257

         f++f+++cl k++ekRps+++ll+h+F+

Q: 266   FNHFISQCLIKDFEKRPSVTHLLDHPFI  293

         ***************************7

Domain Sequence
(FASTA)

WEIIETIGKG TYGKVYKVTN KRDGSLAAVK ILDPISDMDE EIEAEYNILQ FLPNHPNVVK 60

FYGMFYKADH CVGGQLWLVL ELCNGGSVTE LVKSLLRCNQ RLDEAVISYI LYGALLGLQH 120

LHNNRIIHRD VKGNNILLTT EGGVKLVDFG VSAQLTSTRL RRNTSVGTPF WMAPEVIACE 180

QQYDSSYDAR CDVWSLGITA IELGDGDPPL FDMHPVKTLF KIPRNPPPTL LHPEKWCEEF 240

NHFISQCLIK DFEKRPSVTH LLDHPFI 267

Keyword

ATP-binding; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016459	; C:myosin complex
GO:0005524	; F:ATP binding
GO:0003774	; F:motor activity
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000048	; IQ_motif_EF-hand-BS.
IPR011009	; Kinase-like_dom.
IPR001609	; Myosin_head_motor_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00612	; IQ; 1.
PF00063	; Myosin_head; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00015	; IQ; 2.
SM00242	; MYSc; 1.
SM00220	; S_TKc; 1.

Prosites

PS50096	; IQ; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00193

; MYOSINHEAVY.

Created Date

20-Feb-2013