EKS-BOT-00436

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00436

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	327.5	7.1E-98	4	254	251

Status

Unreviewed

Ensembl Protein

ENSBTAP00000038069

UniProt Accession

E1B793;

Protein Name

Protein Synonyms/Alias

Gene Name

STK36

Gene Synonyms/Alias

STK36;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000003819	ENSBTAP00000038069	ENSBTAT00000038254

Organism

Bos taurus

Functional Description

Protein Length

1317

Protein Sequence
(FASTA)

MEKYHVLEMI GEGSFGRVYK GRRKYSAQVV ALKFIPKLGR SEKELRNLQR EIEIMRGLRH 60

PNIVHMLDSF ETDKEVVVVT DYAEGELFQI LEDDGKLPED QVQAIAAQLV SALYYLHSHR 120

ILHRDMKPQN ILLAKGGGIK LCDFGFARAM STNTMVLTSI KGTPLYMSPE LVEERPYDHT 180

ADLWSVGCIL YELAVGTPPF YTTSIFQLVS LILKDPVRWP PTISPCFKNF LQGLLTKDPR 240

QRLSWPDLLH HPFIAGRVTI LTEPAGPDFG TPFTSRLPPE LQVLKDQQAH RLAPKGNRSH 300

ILRQACKRMA EEAKQKKHQN TEPPLEQEDR TSKVAPGTAP LPKLKDTPQE PGLLTGVVAS 360

EMKSSWAEWG AGEAPPAPRE NWITQDCEQV FPELRPEVKG QQSLDAVDLE NEEQDSDDEW 420

QYLLETTEPV PIQLKAPLTL LCNPDFCQRI QSQLHEAGEQ ILKGALEGAP CILPALRVLS 480

SLLSSCSDSV PLYSFCREAG LPGLLLSLLK HSQESNSIQQ QCWYGAFVQD LVAVIQAYFA 540

CTFNLERSQT GDSLQVFQEA ASLFLDLLGK LLAQPDDSEQ ALRRDILMCF TVLCEAMDGN 600

SWTVSKAFYS SLLTTHRAVL DGLLYGLTAP QLPFHSPPGA PQVSQPLREQ SEDLPGAISS 660

VLAAMCTAPV GLPGCWEAKE QIAQHLADQL TKDSNHLRSS LISALQHPIL CLPLLKVLYS 720

CCHVSERLCH LLGQEPLALE SLLNLAQGKV KVVDREESTE VTLYLLSLLV LRLQDLPCGM 780

EKLGSEIATV FTHSHVVSLV SAAACLLGQL GQQGVTFDLQ PGEWIAAATH ALSAPAEVRL 840

TPPGGCGFYD GLLILLLQLL TQVQQGKGNP IRDMASSEMW TVLWHRFFMA LRLPEEASTQ 900

EEEVSLSSPQ SPEPDWTLIS PQGMAALLSL AMATFTQEPQ LCLSHLSQRG SILMSTLKHL 960

LSPSFLHHLG QAPQGSEFLP VVVLSVCQLL CFPFALDVDA DLLEGVLADL TDSEVTAHLL 1020

QVCCHHLPLT QVELPISLLT RLALSDPAFL NQFVNTVVAS PRTTVSFLST ALLGDQPLLT 1080

SDLLSLLAHT ARLLSPSHLS FIHELLAGSD ESYRPLRSLL SHPETSVRAR TYGLLGHLLQ 1140

HSMALRGALQ SQAGLLNLLL LGLGDKDPAV RRGASFAVGN AAYQAGPLGP ALAAAVPGMT 1200

QLLEDPQAGI RRNAVSALGN LGPEGLGEEL LQCQVPQRLL EMACGDPQPN VKEAALVALR 1260

SLRQEPCIHQ VLVSLGASEK LALLSLGNQL LPHSSPRPAS AKHCRKLIHL LRPTHST 1317

Nucleotide Sequence
(FASTA)

ATGGAAAAGT ACCACGTATT GGAGATGATT GGAGAAGGCT CTTTTGGGAG GGTGTACAAG 60

GGTCGAAGAA AATACAGTGC TCAGGTGGTG GCCCTGAAGT TCATTCCAAA ACTGGGACGC 120

TCAGAGAAGG AGCTGAGGAA TCTGCAACGG GAGATTGAAA TCATGCGGGG TTTGCGGCAC 180

CCCAACATTG TGCATATGCT TGATAGCTTT GAGACTGACA AAGAGGTGGT GGTGGTGACA 240

GACTATGCTG AAGGAGAGCT CTTTCAGATC CTCGAAGATG ACGGAAAACT TCCAGAAGAC 300

CAGGTTCAGG CCATTGCTGC CCAGTTGGTG TCAGCCCTGT ACTACCTGCA TTCCCACCGT 360

ATCCTCCACC GAGACATGAA GCCTCAGAAC ATCCTTCTTG CCAAGGGTGG TGGTATCAAG 420

CTCTGTGACT TTGGGTTTGC CCGGGCTATG AGCACTAACA CAATGGTGCT AACATCCATC 480

AAAGGCACAC CACTCTACAT GTCCCCAGAG CTGGTGGAGG AACGACCTTA CGACCACACT 540

GCGGACCTCT GGTCGGTGGG CTGCATATTG TATGAGCTGG CAGTAGGCAC CCCTCCCTTC 600

TATACCACGA GCATCTTTCA GCTGGTCAGC CTTATTCTCA AGGACCCTGT GCGCTGGCCC 660

CCCACCATTA GTCCTTGCTT CAAGAACTTC CTTCAGGGAC TGCTCACCAA GGACCCCCGG 720

CAGCGTCTGT CCTGGCCAGA CCTCTTACAT CACCCCTTTA TTGCTGGTCG AGTCACCATA 780

CTAACCGAGC CAGCAGGCCC AGATTTTGGT ACCCCATTCA CCAGTCGCTT ACCCCCAGAA 840

CTTCAGGTCC TAAAGGACCA ACAGGCTCAT CGGCTGGCCC CCAAGGGCAA TCGATCTCAC 900

ATATTGCGGC AAGCCTGTAA ACGCATGGCT GAGGAGGCCA AGCAGAAGAA ACACCAGAAC 960

ACAGAACCTC CCCTTGAGCA AGAGGATAGG ACCAGCAAGG TGGCTCCTGG CACAGCCCCT 1020

CTGCCCAAAC TCAAGGACAC TCCTCAGGAA CCAGGCCTCT TAACTGGGGT TGTAGCATCA 1080

GAAATGAAGA GCAGCTGGGC TGAGTGGGGT GCTGGAGAGG CGCCCCCTGC ACCTCGGGAA 1140

AACTGGATCA CTCAGGACTG TGAGCAAGTG TTCCCAGAGC TGAGGCCAGA GGTGAAGGGC 1200

CAGCAGAGCC TTGATGCAGT GGATCTGGAA AATGAGGAGC AAGACAGCGA TGATGAGTGG 1260

CAATACCTGC TAGAGACTAC CGAGCCTGTG CCCATCCAGC TGAAGGCCCC TCTCACCCTG 1320

CTGTGCAATC CTGACTTTTG CCAGCGCATC CAGAGTCAGC TGCATGAGGC TGGAGAGCAG 1380

ATCCTAAAAG GCGCCCTGGA GGGTGCTCCC TGCATCCTTC CTGCACTCCG GGTACTGAGC 1440

AGTCTCCTGT CCAGCTGCAG TGACTCTGTT CCCTTGTATT CCTTCTGCCG TGAGGCTGGG 1500

CTCCCCGGGC TGCTGCTTAG TCTCCTCAAA CACAGCCAGG AGAGCAACAG TATCCAGCAG 1560

CAATGTTGGT ATGGGGCCTT CGTACAGGAC CTGGTGGCTG TGATTCAGGC CTACTTTGCC 1620

TGCACCTTCA ATCTGGAGAG GAGCCAGACA GGTGACAGCC TACAGGTATT TCAGGAGGCC 1680

GCCAGCCTCT TTCTGGACCT GTTGGGGAAA CTGCTGGCCC AACCAGATGA CTCCGAGCAG 1740

GCTTTGCGGA GGGACATCCT TATGTGCTTT ACTGTTCTGT GTGAAGCCAT GGACGGGAAT 1800

AGCTGGACCG TCTCCAAAGC CTTCTACTCC AGCCTGCTGA CTACACATCG GGCTGTGTTG 1860

GACGGGCTCC TTTATGGCTT GACAGCTCCA CAGCTCCCTT TCCATAGCCC CCCAGGAGCC 1920

CCCCAGGTGA GCCAGCCGCT TCGGGAGCAG AGTGAGGATC TGCCTGGAGC CATTTCTTCA 1980

GTGCTGGCGG CCATGTGCAC GGCTCCCGTG GGGCTGCCAG GCTGCTGGGA AGCCAAGGAG 2040

CAGATCGCTC AGCATCTGGC TGATCAGCTC ACCAAAGACA GCAACCACCT GAGGTCATCC 2100

CTCATCTCTG CCCTGCAGCA TCCCATCTTG TGCCTACCCC TTCTCAAGGT TCTCTACTCC 2160

TGCTGCCATG TTAGTGAGCG CTTATGCCAT CTTCTTGGGC AAGAACCCCT GGCCTTGGAG 2220

TCACTGTTGA ACTTGGCCCA GGGCAAGGTA AAGGTAGTAG ATAGGGAAGA GTCTACTGAA 2280

GTGACTCTCT ACCTCCTCTC CCTTCTTGTC CTGCGCCTCC AAGATCTGCC TTGTGGAATG 2340

GAGAAGCTAG GCAGTGAGAT TGCTACCGTC TTTACGCATT CGCACGTCGT CTCTCTTGTG 2400

AGTGCGGCGG CCTGTCTGTT GGGGCAGCTT GGTCAGCAAG GGGTGACTTT TGACCTGCAG 2460

CCTGGGGAGT GGATCGCTGC AGCCACACAT GCCCTGTCTG CCCCTGCAGA GGTCCGGCTG 2520

ACTCCACCTG GTGGCTGTGG ATTCTATGAT GGCCTCCTCA TCCTTCTGCT GCAGCTCCTT 2580

ACCCAGGTAC AGCAGGGGAA GGGTAATCCG ATAAGGGACA TGGCCAGCTC AGAAATGTGG 2640

ACCGTCCTGT GGCACCGCTT CTTCATGGCT CTGAGGCTCC CCGAGGAGGC ATCTACACAG 2700

GAAGAGGAGG TGTCGCTGTC CAGCCCACAA AGCCCAGAGC CAGACTGGAC GCTGATCTCA 2760

CCCCAAGGCA TGGCAGCCCT GTTGAGCTTG GCCATGGCCA CCTTTACCCA GGAGCCCCAG 2820

TTATGCCTGA GTCACCTGTC TCAGCGTGGA AGTATCCTCA TGTCCACCCT GAAGCATCTG 2880

CTTTCGCCCA GCTTCCTGCA TCACCTGGGC CAGGCGCCAC AAGGGTCTGA GTTTCTCCCC 2940

GTCGTGGTGC TCTCTGTCTG CCAGCTCCTC TGCTTCCCTT TTGCCCTGGA TGTGGATGCT 3000

GACCTCCTTG AAGGTGTCTT GGCTGACCTC ACAGACTCAG AAGTCACCGC CCACCTACTG 3060

CAGGTCTGCT GCCACCATCT CCCACTGACA CAAGTCGAGC TGCCCATCAG TCTCCTCACA 3120

CGCCTGGCTC TCTCGGATCC CGCTTTTCTC AACCAGTTTG TGAACACAGT GGTTGCCTCC 3180

CCTAGAACCA CTGTCTCATT CCTGTCCACT GCCCTCCTGG GTGACCAGCC TCTGCTGACA 3240

TCTGACCTTC TCTCCCTCCT GGCCCACACT GCCCGGTTAC TGTCTCCTAG CCATTTGTCT 3300

TTTATCCATG AACTCCTGGC TGGCTCCGAT GAATCCTATC GGCCCCTGCG CAGCCTCCTG 3360

AGCCACCCAG AGACTTCTGT GCGAGCCCGT ACTTACGGGC TCCTGGGACA CTTGCTCCAA 3420

CACAGCATGG CCCTGCGTGG GGCCCTGCAG AGCCAGGCAG GACTGCTCAA CCTTCTGCTG 3480

CTGGGGCTCG GAGACAAGGA CCCTGCTGTG CGCCGTGGAG CCAGCTTCGC TGTAGGCAAC 3540

GCAGCCTACC AAGCTGGTCC CCTGGGACCT GCCCTGGCAG CCGCAGTACC TGGTATGACC 3600

CAGTTGCTTG AAGATCCTCA GGCTGGTATC CGGCGCAATG CCGTATCAGC TCTGGGCAAC 3660

CTGGGGCCTG AGGGTCTGGG GGAGGAGCTG CTACAGTGCC AAGTGCCCCA GCGGCTCCTG 3720

GAGATGGCGT GTGGAGACCC CCAGCCAAAT GTGAAGGAAG CCGCCCTCGT TGCTCTCCGC 3780

AGCCTCCGAC AGGAGCCCTG CATCCATCAG GTGCTGGTGT CCCTGGGCGC CAGTGAGAAA 3840

TTAGCCTTGC TCTCTCTGGG GAATCAGTTA CTGCCACACA GCAGTCCCAG GCCTGCCTCT 3900

GCCAAACACT GCAGGAAACT CATCCACCTC CTGAGGCCAA CACACAGCAC ATGA 3954

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkkl.kkslenlekeikilkelkhen  59

         y++ e+iG+Gsf+ vykgr rk ++qvvA+k++ k ++ +k+l+nl++ei+i++ l+h+n

Q: 4     YHVLEMIGEGSFGRVYKGR-RKYSAQVVALKFIPKLGRsEKELRNLQREIEIMRGLRHPN  62

         8999***************.******************9*********************

S: 60    ivalldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskki  119

         iv++ld++et+kev++v++y++ g+L ++l+++++L+ed+v+++++ql+sal++Lhs++i

Q: 63    IVHMLDSFETDKEVVVVTDYAE-GELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRI  121

         **********************.*************************************

S: 120   vhrDlkPqniLlsyadakkelkkvtlkladFglarvlkeesma.atlkGsplYmaPEvvk  178

         +hrD+kPqniLl+        k +++kl+dFg+ar++++++m  +++kG+plYm+PE+v+

Q: 122   LHRDMKPQNILLA--------KGGGIKLCDFGFARAMSTNTMVlTSIKGTPLYMSPELVE  173

         *************........89********************9****************

S: 179   eqqydakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvleppipkeisselkdl  238

         e+ yd++aDlWS+G+ilyel+vG+pPf+++si++Lv+ i k++v   ++p +is+++k++

Q: 174   ERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPV---RWPPTISPCFKNF  230

         ********************************************...*************

S: 239   lqsLLqrdpkkRisfeelfahpfl  262

         lq+LL++dp++R+s+ +l++hpf+

Q: 231   LQGLLTKDPRQRLSWPDLLHHPFI  254

         **********************96

Domain Sequence
(FASTA)

YHVLEMIGEG SFGRVYKGRR KYSAQVVALK FIPKLGRSEK ELRNLQREIE IMRGLRHPNI 60

VHMLDSFETD KEVVVVTDYA EGELFQILED DGKLPEDQVQ AIAAQLVSAL YYLHSHRILH 120

RDMKPQNILL AKGGGIKLCD FGFARAMSTN TMVLTSIKGT PLYMSPELVE ERPYDHTADL 180

WSVGCILYEL AVGTPPFYTT SIFQLVSLIL KDPVRWPPTI SPCFKNFLQG LLTKDPRQRL 240

SWPDLLHHPF I 251

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0042384	; P:cilium assembly
GO:0007228	; P:positive regulation of hh target transcription factor activity
GO:0045880	; P:positive regulation of smoothened signaling pathway
GO:0009791	; P:post-embryonic development

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013