EKS-BOT-00488

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00488

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	430.0	2.5E-129	18	273	256

Status

Unreviewed

Ensembl Protein

ENSBTAP00000005539

UniProt Accession

F1MSR5;

Protein Name

Protein Synonyms/Alias

Gene Name

TBCK

Gene Synonyms/Alias

TBCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000004227	ENSBTAP00000005539	ENSBTAT00000005539

Organism

Bos taurus

Functional Description

Protein Length

893

Protein Sequence
(FASTA)

MFPLKDAEMG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTITH PRLCQYVDIS 60

RGKHERLVVV AEHCERSLED LLREGKPVSY SKVLCIAFEV LQGLQYMNKH GIVHRALSPH 120

NILLDQKGHV KLAKFGLYHM TAYGDDVDFP IGYPSYLAPE VIAQGIFKTS DHVPSEKPLP 180

SGPKSDVWSL GIILFELCVG RKLFQSLDIS ERLKFLLTLD CVDDTIIVLA EEHGCLDIIK 240

ELPETVIDLL KKCLTFHPSK RPTPDELMQD NVFSEVLPLY PPFIKPASLF SSSLRCADLT 300

LPEDISQLYE DINSDYLAER SIEEVYYLWC LAGGDLEKEL VNKEIIRSKP PICTLPNFLF 360

EDGESFGQGR DRSSLLDDTT VTLSLCQLRN RLKDVGGEAF YPLLEDDQSN LPHSNSNNEL 420

SAAATLPLII RERDTEYQLN RIILFDRLLK AYPYKKNQIW KEARVDIPPL MRGLTWAALL 480

GVEGAIHAKY DAIDKDTPIP TDRQIEVDIP RCHQYDELLS SPEGHAKFRR VLKAWVVSHP 540

DLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM 600

IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV 660

AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESINL FCWTPKSATY RQHAQPPKPT 720

SDSSGVRSST PYFPTECPDP PKTDLSRESI PLNDLKSEVS PRISAEDLID LCELTVTGHF 780

KTPTKKTKSS KPKLLVVDIR NSEDFVRGHI SGSINIPFST AFTAEGELTQ GPYTAMLQSF 840

KGKVIVIVGN VAKHTAEFAA HLVKMKYPRI CILDGGINKI KPTGLLTVPS PQI 893

Nucleotide Sequence
(FASTA)

ATGTTTCCCT TGAAGGATGC CGAAATGGGT GCCTTTACCT TCTTTGCCTC TGCTCTGCCC 60

CATGATGTCT GTGGAAGCAA TGGGCTTCCT CTCACACCAA ATTCCATCAA GATTTTAGGG 120

CGCTTTCAAA TCCTCAAGAC CATCACTCAC CCCAGACTGT GCCAGTATGT GGATATTTCT 180

AGGGGAAAGC ACGAGAGATT GGTGGTGGTA GCTGAACACT GTGAACGGAG TCTAGAAGAC 240

TTGCTCCGTG AAGGGAAACC CGTGAGCTAT TCAAAGGTTT TGTGCATAGC ATTTGAGGTA 300

CTTCAGGGCT TGCAGTATAT GAATAAACAT GGTATAGTAC ACCGGGCACT GTCTCCTCAT 360

AATATCCTTT TGGATCAAAA GGGACATGTT AAATTGGCTA AATTTGGACT TTATCACATG 420

ACAGCATATG GTGACGATGT TGATTTCCCA ATTGGGTATC CATCATACTT GGCACCTGAG 480

GTAATTGCGC AAGGAATTTT CAAAACCAGT GATCATGTGC CAAGTGAAAA ACCATTGCCT 540

TCTGGCCCCA AATCAGATGT CTGGTCTCTT GGAATCATTT TGTTTGAGCT CTGTGTGGGA 600

AGAAAATTAT TTCAGAGTTT GGATATTTCT GAAAGACTAA AATTTTTGCT TACACTGGAC 660

TGTGTAGATG ACACTATAAT AGTTCTGGCT GAGGAGCATG GCTGTCTGGA CATTATAAAG 720

GAGCTTCCTG AAACTGTGAT AGATCTTTTA AAGAAGTGCC TCACCTTCCA CCCTTCCAAG 780

AGGCCAACCC CAGATGAATT AATGCAGGAC AATGTGTTCA GTGAAGTGTT ACCCTTATAC 840

CCTCCCTTTA TCAAACCTGC CAGCCTGTTT TCTTCTTCTC TGAGATGTGC TGATTTGACT 900

CTGCCAGAGG ATATCAGTCA GTTGTATGAA GATATAAACA GTGATTACCT GGCAGAAAGA 960

TCTATTGAAG AAGTGTATTA CCTTTGGTGT TTAGCTGGAG GTGACTTGGA AAAAGAGCTT 1020

GTGAACAAGG AAATCATTCG ATCCAAACCA CCTATCTGCA CACTCCCCAA TTTTCTCTTT 1080

GAAGATGGTG AAAGCTTTGG ACAAGGTCGA GATAGAAGTT CACTATTAGA TGACACCACT 1140

GTGACACTGT CATTATGCCA GCTAAGAAAT AGATTAAAAG ATGTTGGTGG AGAAGCATTT 1200

TACCCTCTAC TTGAAGATGA TCAGTCTAAT TTACCTCATT CAAACAGCAA TAATGAGCTC 1260

TCTGCAGCTG CCACTCTCCC TTTAATCATC CGAGAGAGGG ACACAGAGTA CCAACTAAAC 1320

AGAATCATTC TCTTTGACAG GCTGCTAAAG GCTTATCCAT ATAAAAAAAA TCAAATCTGG 1380

AAAGAGGCAA GAGTCGACAT TCCTCCTCTT ATGAGAGGTT TAACCTGGGC TGCTCTTCTG 1440

GGAGTTGAGG GGGCTATTCA TGCCAAGTAT GATGCAATTG ATAAAGACAC TCCAATTCCT 1500

ACAGATAGAC AGATTGAAGT GGATATTCCT CGTTGTCATC AGTATGATGA GCTGTTATCC 1560

TCACCAGAAG GTCATGCAAA ATTTCGGCGT GTCTTAAAAG CCTGGGTCGT GTCCCATCCT 1620

GATCTTGTGT ATTGGCAAGG TCTTGACTCA CTTTGTGCTC CATTTCTATA TTTAAATTTC 1680

AATAATGAAG CTCTGGCTTA TGCCTGTATG TCTGCTTTTA TCCCCAAATA CCTGTACAAC 1740

TTCTTCTTGA AAGACAACTC ACATGTAATA CAAGAGTATC TGACTGTGTT CTCTCAGATG 1800

ATTGCATTTC ATGATCCAGA GCTAAGCAAT CATCTCAATG AGATTGGATT TATTCCAGAT 1860

CTCTATGCCA TCCCTTGGTT TCTCACCATG TTTACTCATG TATTTCCACT GCACAAAATT 1920

TTCCACCTCT GGGATACCTT ACTGCTTGGG AATTCCTCCT TCCCATTCTG TATCGGAGTA 1980

GCAATTCTTC AGCAGCTGCG TGACCGACTT TTGGCTAATG GCTTTAATGA GTGCATTCTT 2040

CTCTTCTCGG ACTTACCAGA AATTGACATT GAACGCTGTG TGCGAGAATC AATCAACCTG 2100

TTTTGTTGGA CTCCTAAAAG TGCTACTTAT AGGCAGCATG CTCAACCTCC AAAGCCAACA 2160

TCTGATAGCA GTGGAGTCAG AAGTTCAACA CCTTATTTCC CCACTGAGTG TCCAGATCCT 2220

CCAAAAACAG ATCTGTCAAG AGAATCCATT CCGTTAAATG ACCTAAAGTC GGAAGTATCA 2280

CCCCGGATTT CAGCAGAGGA CCTGATTGAC TTGTGTGAGC TGACAGTGAC TGGCCACTTC 2340

AAAACACCCA CCAAGAAGAC AAAGTCCAGT AAACCAAAGC TCTTGGTAGT CGACATCCGG 2400

AATAGTGAAG ATTTTGTTCG GGGTCACATT TCAGGCAGCA TCAACATTCC ATTCAGCACT 2460

GCATTTACTG CTGAAGGGGA GCTTACCCAG GGACCTTACA CGGCCATGCT CCAGAGCTTC 2520

AAAGGGAAGG TCATTGTCAT CGTGGGGAAT GTGGCAAAGC ACACAGCAGA GTTTGCAGCT 2580

CATCTTGTGA AGATGAAATA TCCAAGAATC TGTATTCTAG ATGGTGGCAT TAATAAAATC 2640

AAGCCCACAG GCCTCCTCAC CGTTCCTTCT CCTCAAATAT GA 2682

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk+++h+rLcqY+disrgkher++vvaeh+e+s

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVVVAEHCERS  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         LeDll+e+kpvs s+vl+ia+evl+gl+y+nkh+ivhral+p++illd+kg+ vkLak+G

Q: 78    LEDLLREGKPVSYSKVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDQKGH-VKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+tayG+dvdfpigy+sylaPe+i+q+         ++k+l++++ksDvWsLg+il+e

Q: 137   LYHMTAYGDDVDFPIGYPSYLAPEVIAQGifktsdhvpSEKPLPSGPKSDVWSLGIILFE  196

         ************************************************************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l++g+kLf++ld+serlk+ll+l++vd+t+i+laee++cldiik+l+e++++llkkCLt+

Q: 197   LCVGRKLFQSLDISERLKFLLTLDCVDDTIIVLAEEHGCLDIIKELPETVIDLLKKCLTF  256

         ************************************************************

S: 232   lpskRpspdellkekvf  248

         +pskRp+pdel++++vf

Q: 257   HPSKRPTPDELMQDNVF  273

         **************997

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKT ITHPRLCQYV DISRGKHERL VVVAEHCERS 60

LEDLLREGKP VSYSKVLCIA FEVLQGLQYM NKHGIVHRAL SPHNILLDQK GHVKLAKFGL 120

YHMTAYGDDV DFPIGYPSYL APEVIAQGIF KTSDHVPSEK PLPSGPKSDV WSLGIILFEL 180

CVGRKLFQSL DISERLKFLL TLDCVDDTII VLAEEHGCLD IIKELPETVI DLLKKCLTFH 240

PSKRPTPDEL MQDNVF 256

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

bta:528650

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013