EKS-BOT-00037
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00037
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RAD53431.98.7E-130211477267
StatusUnreviewed
Ensembl ProteinENSBTAP00000006518
UniProt AccessionQ58DJ9;
Protein Name
Protein Synonyms/Alias Protein kinase CHK2 isoform a;
Gene NameCHEK2
Gene Synonyms/Alias CHEK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000004956ENSBTAP00000006518ENSBTAT00000006518
OrganismBos taurus
Functional Description
Protein Length534
Protein Sequence
(FASTA)
MSRETNVERQ QPRGSASPQS QGGFSQSQGP SSQPHSSSSQ SQGTSSQSSH SSSGTLSSLD 60
TVSTQELYSI PEDQEPEEPV PAPWARLWAL QDGFSNLDCI NDSYWFGRDR NCEYCFDEPL 120
LKSTDKYRTY SKKHFRIFRE MGPKNSYIAY IEDHSGNGTF VNRELVGKGR RLPLSNNSEI 180
ALSVWSNKVF VFFDLTVDDQ SVYPKELRDE YIMSKTLGSG ACGEVKLAFE RKTCKKVAIK 240
IISKRKFAIG SEREADPALD VETEIEILKK LNHPCIIKIK DFFDAEDYYI VLELMEGGEL 300
FDRVVGHKRL KEATCKLYFY QMLLAVQYLH ENGIIHRDLK PENVLLSSPK EDCLIKITDF 360
GQSKILGETS LMRTLCGTPT YLAPEVLNSF GTAGYNRAVD CWSLGVILFI CLSGYPPFSE 420
HKTQVSLKDQ ITSGKYNFIP EVWAEVSEKA LDLVKKLLIV DPKARFTTEE ALRHPWLQDE 480
DMKRKFNNLL SEEDKLMAVT QVPAQPSTSR KRLLEGEAES ADPTKRLAVC AAVS 534
Nucleotide Sequence
(FASTA)
ATGTCTCGGG AGACGAATGT GGAGCGTCAG CAGCCCCGCG GCAGCGCCTC CCCGCAGTCC 60
CAGGGTGGCT TCTCACAGTC CCAGGGTCCC TCCTCGCAGC CACACAGCTC CTCGTCACAG 120
TCCCAGGGCA CGTCCAGCCA GTCCTCCCAC TCCAGCTCTG GCACGCTGAG CTCCTTAGAC 180
ACAGTGTCCA CGCAGGAACT CTATTCTATT CCGGAGGACC AAGAACCCGA GGAGCCTGTC 240
CCTGCCCCTT GGGCTCGATT ATGGGCCCTT CAGGATGGAT TCTCCAATCT TGATTGTATT 300
AATGACAGCT ACTGGTTCGG GAGGGATAGA AACTGTGAAT ATTGCTTCGA TGAGCCCCTG 360
CTGAAAAGCA CCGATAAATA CCGGACATAC AGCAAGAAGC ACTTTCGGAT CTTCAGAGAA 420
ATGGGTCCTA AAAACTCTTA CATCGCATAC ATAGAAGATC ACAGTGGGAA TGGAACCTTT 480
GTAAATAGAG AGCTTGTAGG GAAAGGAAGA CGCCTTCCTT TGAGTAACAA TTCTGAAATT 540
GCACTTTCAG TATGGAGTAA TAAAGTTTTT GTATTTTTTG ATCTGACTGT AGATGATCAG 600
TCAGTGTATC CTAAGGAATT AAGAGACGAA TACATCATGT CAAAAACTCT CGGAAGCGGT 660
GCCTGTGGTG AGGTGAAGCT AGCTTTCGAG AGGAAGACAT GTAAGAAAGT GGCCATAAAG 720
ATCATTAGCA AGAGGAAGTT TGCTATCGGC TCTGAGAGAG AGGCAGATCC GGCACTTGAT 780
GTTGAAACAG AAATAGAAAT TTTGAAGAAA CTAAATCATC CTTGTATCAT CAAGATTAAA 840
GACTTTTTTG ATGCTGAAGA TTATTATATT GTTTTGGAAT TAATGGAAGG AGGAGAGCTG 900
TTCGACAGGG TGGTGGGGCA TAAGCGCCTG AAAGAAGCCA CATGCAAGCT CTATTTTTAC 960
CAGATGCTCC TGGCCGTGCA GTACCTTCAT GAAAATGGCA TTATACATCG GGATTTAAAG 1020
CCAGAGAATG TTCTCCTGTC ATCTCCAAAG GAGGACTGCC TTATAAAGAT TACTGATTTT 1080
GGGCAGTCCA AGATTTTGGG GGAGACCTCT CTGATGAGAA CCTTATGTGG TACCCCCACC 1140
TACCTGGCTC CGGAGGTTCT CAATTCCTTT GGAACCGCTG GGTATAACCG GGCTGTGGAC 1200
TGCTGGAGTT TAGGAGTTAT TCTTTTCATT TGCCTTAGTG GGTATCCACC TTTCTCTGAG 1260
CATAAGACTC AAGTGTCATT GAAGGATCAG ATCACCAGTG GAAAATACAA CTTCATTCCC 1320
GAAGTCTGGG CAGAGGTCTC AGAGAAGGCT CTGGATCTCG TCAAGAAGTT GTTGATAGTG 1380
GATCCAAAGG CGCGTTTTAC GACAGAAGAG GCTTTAAGAC ACCCGTGGCT TCAGGATGAG 1440
GACATGAAGA GAAAATTTAA CAACTTGCTT TCTGAAGAAG ATAAGTTGAT GGCTGTGACC 1500
CAGGTCCCTG CCCAGCCTTC CACAAGTCGA AAGCGGCTTC TTGAAGGGGA AGCAGAGAGT 1560
GCCGACCCCA CGAAGCGCCT GGCTGTGTGC GCGGCTGTCT CGTGA 1605
Domain Profile
S: 1     yilskelGkGafgkvklayekktgkkvavkilskrk.sirssreikkakeveeeveilkk  59
         yi+sk+lG+Ga+g+vkla+e+kt+kkva+ki+skrk +i+s+re++ a +ve+e+eilkk
Q: 211   YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKfAIGSEREADPALDVETEIEILKK  270
         89*********************************999**********************
S: 60    lshPnivklkdvfeeeeskylvlelvegGelldkvvakkllkedlskllfkqlltavkyl  119
         l+hP+i+k+kd+f++e++ y+vlel+egGel+d+vv +k+lke+++kl+f+q+l av+yl
Q: 271   LNHPCIIKIKDFFDAEDY-YIVLELMEGGELFDRVVGHKRLKEATCKLYFYQMLLAVQYL  329
         *****************9.*****************************************
S: 120   hekgiihrDlkPeniLlsekeedvlvkitDfGlakvlgevslmktlCGtpsyvaPevlvk  179
         he+giihrDlkPen+Lls+ +ed+l+kitDfG++k+lge+slm+tlCGtp+y+aPevl +
Q: 330   HENGIIHRDLKPENVLLSSPKEDCLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLNS  389
         ************************************************************
S: 180   kgraeytskvDiWslGvvlfvilsGypPfseeltqvslkeqilkgkyafieekwkkisee  239
          g+a+y+++vD+WslGv+lf++lsGypPfse++tqvslk+qi++gky+fi+e+w+++se+
Q: 390   FGTAGYNRAVDCWSLGVILFICLSGYPPFSEHKTQVSLKDQITSGKYNFIPEVWAEVSEK  449
         ************************************************************
S: 240   akdlikklLvvdPeerlsieealnhpWl  267
         a+dl+kklL+vdP++r+++eeal+hpWl
Q: 450   ALDLVKKLLIVDPKARFTTEEALRHPWL  477
         ***************************8
Domain Sequence
(FASTA)
YIMSKTLGSG ACGEVKLAFE RKTCKKVAIK IISKRKFAIG SEREADPALD VETEIEILKK 60
LNHPCIIKIK DFFDAEDYYI VLELMEGGEL FDRVVGHKRL KEATCKLYFY QMLLAVQYLH 120
ENGIIHRDLK PENVLLSSPK EDCLIKITDF GQSKILGETS LMRTLCGTPT YLAPEVLNSF 180
GTAGYNRAVD CWSLGVILFI CLSGYPPFSE HKTQVSLKDQ ITSGKYNFIP EVWAEVSEKA 240
LDLVKKLLIV DPKARFTTEE ALRHPWL 267
KeywordComplete proteome; Kinase; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00032
EKS-CAE-00032
EKS-CAJ-00036
EKS-CAF-00037
EKS-CAP-00037
EKS-CII-00014
EKS-CIS-00038
EKS-DAR-00048
EKS-DRM-00013
EKS-EQC-00034
EKS-FEC-00034
EKS-GAG-00030
EKS-GOG-00035
EKS-HOS-00037
EKS-ICT-00032
EKS-LAC-00038
EKS-LOA-00036
EKS-MAM-00036
EKS-MEG-00032
EKS-MOD-00036
EKS-MUM-00038
EKS-MUP-00038
EKS-MYL-00038
EKS-NOL-00035
EKS-ORN-00053
EKS-ORA-00032
EKS-ORC-00035
EKS-ORL-00049
EKS-OTG-00038
EKS-PAT-00034
EKS-PES-00033
EKS-POA-00034
EKS-RAN-00038
EKS-SAH-00035
EKS-TAG-00034
EKS-TAR-00053
EKS-TEN-00057
EKS-XET-00037
EKS-XIM-00051
EKS-SCP-00036
Gene Ontology
GO:0000781; C:chromosome, telomeric region
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0044257; P:cellular protein catabolic process
GO:0006975; P:DNA damage induced protein phosphorylation
GO:0006302; P:double-strand break repair
GO:0000086; P:G2/M transition of mitotic cell cycle
GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage response
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0046777; P:protein autophosphorylation
GO:0042176; P:regulation of protein catabolic process
GO:0010332; P:response to gamma radiation
GO:0072428; P:signal transduction involved in intra-S DNA damage checkpoint
GO:0090307; P:spindle assembly involved in mitosis
KEGG
bta:518897;
InterPros
IPR000253; FHA_dom.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR008984; SMAD_FHA_domain.
Pfam
PF00498; FHA; 1.
PF00069; Pkinase; 1.
SMARTs
SM00240; FHA; 1.
SM00220; S_TKc; 1.
Prosites
PS50006; FHA_DOMAIN; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013