EKS-BOT-00372

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00372

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	424.4	1.5E-127	237	486	250

Status

Unreviewed

Ensembl Protein

ENSBTAP00000006659

UniProt Accession

Q08DU6;

Protein Name

Protein Synonyms/Alias

B lymphoid tyrosine kinase;

Gene Name

BLK

Gene Synonyms/Alias

BLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000005049	ENSBTAP00000006659	ENSBTAT00000006659

Organism

Bos taurus

Functional Description

Protein Length

501

Protein Sequence
(FASTA)

MGVVSSKRQV KEKGRSGWSP VKTSTQSKEP PPLPSLVVFN HLTPPPPDTT HPDQENHFVV 60

ALYDYKAMND RDLQMLKGEK LQILKETGDW WLAKSLITGR EGYVPSNFVA RVETLEVEKW 120

FFRSICRRDA ERQLLAPVNK AGAFLIRESE TSKGAFSLSV KDVTTQGEVI KHYKIRSLDE 180

GGYYISPRSA FPTLQALVQH YSKKGDGLCQ RLTHPCVSLA PQNPWGQDEW EIPRQSLKLV 240

RKLGSGQFGE VWMGYYKNNI KVAIKTLKEG TMSPEAFLGE ANLMKTLQHE RLVRLYAVVT 300

KEPIYIVTEY MARGCLLDFL KTDEGSRLSL SRLIDMSAQI AEGMAYIEQM NSIHRDLRAA 360

NILVSEALCC KIGDFGLARI IDNEYTAQEG AKFPIKWTAP EAIHFGVFTI KADVWSFGIL 420

LMEIVTYGRV PYPGMSNPEV IRNLERGYRM PRPDSCPPEL YNGIIAECWR SRPEERPTFE 480

FLQSVLEDFH TATEGQYELQ P 501

Nucleotide Sequence
(FASTA)

ATGGGAGTGG TGAGCAGCAA AAGGCAGGTC AAGGAGAAGG GTAGGAGTGG ATGGAGCCCT 60

GTGAAGACCA GCACTCAGAG CAAAGAGCCC CCACCACTGC CATCCCTGGT TGTGTTTAAC 120

CACCTGACTC CCCCACCTCC TGACACCACG CACCCAGATC AAGAGAATCA CTTCGTGGTG 180

GCCCTGTATG ACTATAAGGC CATGAACGAC CGGGACCTGC AGATGCTGAA GGGGGAGAAG 240

CTGCAGATCC TGAAGGAAAC TGGAGACTGG TGGTTGGCCA AGTCTCTCAT CACAGGAAGA 300

GAAGGCTACG TGCCCAGCAA CTTTGTGGCC CGGGTAGAGA CCCTGGAAGT GGAAAAGTGG 360

TTCTTTAGAT CAATTTGCCG GAGAGATGCC GAGAGGCAGC TTCTGGCTCC AGTCAATAAG 420

GCTGGCGCCT TTCTTATTAG AGAGAGTGAA ACCAGCAAAG GTGCCTTTTC TCTGTCTGTG 480

AAGGATGTGA CCACGCAGGG GGAGGTGATC AAACACTATA AGATCCGCTC CCTGGACGAA 540

GGCGGCTATT ACATCTCCCC CCGGAGCGCC TTCCCCACTC TGCAGGCTCT GGTGCAGCAC 600

TATTCTAAGA AAGGGGACGG GTTGTGCCAA AGGCTGACCC ACCCCTGTGT GAGCCTGGCT 660

CCCCAGAACC CCTGGGGCCA GGATGAATGG GAAATCCCCC GGCAGTCTCT CAAGCTGGTC 720

AGGAAGCTTG GATCCGGGCA GTTTGGTGAA GTCTGGATGG GTTATTATAA AAACAACATC 780

AAGGTGGCCA TCAAGACCTT GAAGGAGGGA ACCATGTCTC CGGAGGCCTT CCTGGGCGAG 840

GCCAACCTGA TGAAAACTCT CCAGCATGAG AGGCTGGTCC GTCTCTACGC TGTGGTCACC 900

AAGGAGCCCA TCTACATCGT GACCGAATAT ATGGCCAGAG GCTGCCTGCT GGATTTCCTG 960

AAGACGGATG AAGGTAGCCG ATTGTCCCTC TCAAGGCTGA TTGACATGTC GGCCCAGATT 1020

GCAGAAGGAA TGGCGTACAT CGAGCAGATG AATTCAATCC ACCGGGACCT GAGAGCGGCC 1080

AACATCCTGG TGTCTGAGGC CTTGTGCTGC AAAATTGGTG ACTTTGGCTT GGCCCGGATC 1140

ATCGACAATG AATACACCGC CCAGGAGGGG GCCAAGTTCC CCATTAAGTG GACCGCCCCA 1200

GAGGCCATCC ATTTTGGGGT GTTCACCATC AAAGCGGACG TGTGGTCATT TGGAATCCTC 1260

CTGATGGAAA TTGTCACTTA TGGGCGTGTG CCCTACCCAG GGATGAGCAA CCCCGAGGTC 1320

ATCCGCAACC TGGAGCGCGG CTACCGCATG CCCCGCCCAG ACTCGTGCCC GCCTGAGCTG 1380

TACAACGGCA TCATCGCCGA GTGCTGGCGC AGCCGGCCGG AGGAGCGGCC CACCTTCGAG 1440

TTCCTGCAGT CGGTGCTCGA GGACTTCCAC ACGGCCACCG AGGGCCAGTA CGAGCTGCAG 1500

CCCTAG 1506

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lklv+klG+GqfGevw+g++k+++kva+ktlkegt+speafl ea+++k+l+he+lv+ly

Q: 237   LKLVRKLGSGQFGEVWMGYYKNNIKVAIKTLKEGTMSPEAFLGEANLMKTLQHERLVRLY  296

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePiyivte+ma+G+lldflk++eg++l+l++l+d++aq+aeGmay+e++n ihr

Q: 297   AVVTK-EPIYIVTEYMARGCLLDFLKTDEGSRLSLSRLIDMSAQIAEGMAYIEQMNSIHR  355

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+e l++k++dfGlar+i d+eyta+egak+PikWtaPeai++g+ftik+dv

Q: 356   DLRAANILVSEALCCKIGDFGLARII-DNEYTAQEGAKFPIKWTAPEAIHFGVFTIKADV  414

         *************************9.89*******************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelye.lllecwkkdpe  239

         WsfGill+eivt+G+vPypGm+n ev++++ergyr+prp++cp ely+ +++ecw+++pe

Q: 415   WSFGILLMEIVTYGRVPYPGMSNPEVIRNLERGYRMPRPDSCPPELYNgIIAECWRSRPE  474

         ************************************************************

S: 240   erPtfetlqevl  251

         erPtfe+lq+vl

Q: 475   ERPTFEFLQSVL  486

         ********9986

Domain Sequence
(FASTA)

LKLVRKLGSG QFGEVWMGYY KNNIKVAIKT LKEGTMSPEA FLGEANLMKT LQHERLVRLY 60

AVVTKEPIYI VTEYMARGCL LDFLKTDEGS RLSLSRLIDM SAQIAEGMAY IEQMNSIHRD 120

LRAANILVSE ALCCKIGDFG LARIIDNEYT AQEGAKFPIK WTAPEAIHFG VFTIKADVWS 180

FGILLMEIVT YGRVPYPGMS NPEVIRNLER GYRMPRPDSC PPELYNGIIA ECWRSRPEER 240

PTFEFLQSVL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0050853	; P:B cell receptor signaling pathway
GO:0032024	; P:positive regulation of insulin secretion

KEGG

bta:532587

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013