EKS-BOT-00109
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00109
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec476.41.9E-143271521251
StatusUnreviewed
Ensembl ProteinENSBTAP00000006670
UniProt AccessionF1MQA9;
Protein Name
Protein Synonyms/Alias
Gene NameTXK
Gene Synonyms/Alias TXK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000005055ENSBTAP00000006670ENSBTAT00000006670
OrganismBos taurus
Functional Description
Protein Length527
Protein Sequence
(FASTA)
MICFSDNTIQ SIFCCCCCCS VQKRQVRTQI SLSKDEELSE KYTQRRRPWF SDLPSKKQSN 60
RGHGQPSKRK PLPPLPPSEV SEEKIHVKAL YDFLPREPYD LALKRAEEYL ILEKYDPHWW 120
KARDRLGNEG LIPSNYVTEN KPTNLEIYEW YHRNITRNQA ERLLRQESKE GAFIVRDSRH 180
LGSYTISVFI RGCRDMEATI KHYQIKRNDS GQWYVAERHL FQSIPELIWY HQHNAAGLMS 240
RLRYPVGLMG SCLPATAGFS YEKWEIDPSE LAFVKQIGSG QFGVVYLGQW RAHVQVAIKA 300
INEGFMSEED FIEEAKVMMK LSHSKLVQLY GVCIQQKPLY IVTEFMEHGC LLNYLRERKG 360
KLSKEILLSV CQDICEGMEY LERNCFIHRD LAARNCLVSS TCIVKISDFG MTRYVLDDEY 420
VSSSGAKFPV KWSPPEVFHF NRYSSKSDVW SFGVLMWEVF SEGKMPFENR SNLQVVEAIS 480
KGFRLYRPYL APMCIYEVMY SCWHEKPKGR PTFAELLQVL TEIAETW 527
Nucleotide Sequence
(FASTA)
ATGATCTGCT TTTCAGATAA CACCATCCAG TCGATTTTCT GCTGCTGCTG TTGCTGTTCC 60
GTGCAGAAGC GGCAAGTGAG GACACAAATA AGCCTTAGCA AAGATGAAGA ACTTTCAGAA 120
AAATACACAC AGCGTCGCAG ACCGTGGTTC AGTGACTTGC CAAGTAAGAA GCAATCCAAC 180
AGGGGCCATG GGCAACCATC AAAACGCAAG CCACTGCCTC CCCTCCCACC CTCTGAGGTT 240
TCTGAAGAGA AGATCCATGT TAAGGCACTG TACGATTTCC TGCCCAGAGA GCCCTATGAT 300
CTAGCTTTAA AGAGAGCAGA GGAATACCTT ATCTTGGAGA AGTATGATCC TCACTGGTGG 360
AAGGCAAGAG ACCGCTTGGG GAATGAAGGC TTAATTCCAA GCAACTATGT GACCGAAAAC 420
AAACCAACTA ATTTAGAAAT ATATGAGTGG TACCATAGGA ATATTACTAG AAATCAGGCA 480
GAACGTCTTT TGAGACAAGA GTCTAAAGAA GGTGCATTTA TTGTCAGAGA TTCAAGACAT 540
TTGGGATCCT ACACCATTTC TGTGTTTATA AGAGGTTGTA GAGATATGGA GGCTACCATC 600
AAGCATTATC AAATTAAAAG GAATGACTCA GGACAGTGGT ATGTGGCTGA AAGACACCTG 660
TTTCAATCAA TCCCCGAGTT GATCTGGTAT CACCAGCACA ATGCAGCCGG ACTCATGTCC 720
CGTCTCCGTT ACCCAGTTGG TCTGATGGGC AGTTGTTTGC CGGCCACAGC TGGTTTTAGT 780
TATGAAAAGT GGGAGATAGA TCCATCTGAA TTGGCTTTTG TGAAGCAGAT TGGAAGTGGT 840
CAGTTTGGGG TGGTCTATTT AGGCCAATGG CGAGCACATG TCCAGGTAGC TATCAAGGCC 900
ATCAACGAAG GCTTCATGTC TGAAGAGGAT TTCATTGAAG AGGCTAAAGT GATGATGAAG 960
TTATCTCATT CGAAGCTGGT TCAGCTTTAT GGAGTGTGTA TACAGCAGAA GCCCCTTTAC 1020
ATTGTGACAG AGTTTATGGA ACATGGCTGC CTGCTTAACT ATCTGAGAGA GAGAAAAGGA 1080
AAGCTCAGCA AGGAGATACT ACTGAGTGTG TGCCAAGATA TCTGTGAAGG AATGGAGTAT 1140
CTGGAGAGAA ACTGCTTTAT CCATAGAGAT TTAGCAGCAA GGAATTGTTT GGTCAGTTCT 1200
ACATGTATAG TAAAAATTTC GGACTTTGGA ATGACAAGGT ACGTTTTGGA TGATGAATAT 1260
GTCAGTTCTT CTGGAGCCAA GTTCCCAGTC AAGTGGTCCC CTCCTGAAGT TTTTCATTTC 1320
AACAGATACA GCAGCAAATC TGACGTCTGG TCATTCGGAG TTTTGATGTG GGAAGTTTTC 1380
TCAGAAGGAA AAATGCCTTT TGAAAATAGG TCAAATTTGC AAGTCGTGGA AGCTATTTCT 1440
AAAGGCTTCA GGCTGTACCG ACCTTACCTG GCACCAATGT GCATATATGA AGTCATGTAT 1500
AGCTGCTGGC ATGAGAAACC TAAAGGCCGC CCGACGTTTG CTGAGCTGCT ACAGGTTCTT 1560
ACAGAGATTG CAGAAACCTG GTGA 1584
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         l+++k++gsgqfgvv lg+wra+++vaikai+eg mseedfieeakvmmklsh+klvqly
Q: 271   LAFVKQIGSGQFGVVYLGQWRAHVQVAIKAINEGFMSEEDFIEEAKVMMKLSHSKLVQLY  330
         68**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc++qkp+yivte++e+gcllnylre+k+kl+ke+ll++c+d+cegmeyler++fihrd
Q: 331   GVCIQQKPLYIVTEFMEHGCLLNYLRERKGKLSKEILLSVCQDICEGMEYLERNCFIHRD  390
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+++++vk+sdfg++ryvldd+yvss+gakfpvkwsppev+++++yssksdvw
Q: 391   LAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSSGAKFPVKWSPPEVFHFNRYSSKSDVW  450
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevfsegk+p+e++sn +vve++s+g+rlyrp la++ +yevm+scw+ekp++r
Q: 451   SFGVLMWEVFSEGKMPFENRSNLQVVEAISKGFRLYRPYLAPMCIYEVMYSCWHEKPKGR  510
         ************************************************************
S: 241   ptfkellsale  251
         ptf+ell+ l+
Q: 511   PTFAELLQVLT  521
         *******9986
Domain Sequence
(FASTA)
LAFVKQIGSG QFGVVYLGQW RAHVQVAIKA INEGFMSEED FIEEAKVMMK LSHSKLVQLY 60
GVCIQQKPLY IVTEFMEHGC LLNYLRERKG KLSKEILLSV CQDICEGMEY LERNCFIHRD 120
LAARNCLVSS TCIVKISDFG MTRYVLDDEY VSSSGAKFPV KWSPPEVFHF NRYSSKSDVW 180
SFGVLMWEVF SEGKMPFENR SNLQVVEAIS KGFRLYRPYL APMCIYEVMY SCWHEKPKGR 240
PTFAELLQVL T 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>
EKS-AIM-00100
EKS-CAJ-00110
EKS-CAF-00110
EKS-CAP-00106
EKS-EQC-00106
EKS-ERE-00053
EKS-FEC-00104
EKS-GAG-00089
EKS-GOG-00109
EKS-HOS-00111
EKS-LAC-00111
EKS-LOA-00104
EKS-MAM-00104
EKS-MEG-00084
EKS-MIM-00047
EKS-MOD-00108
EKS-MUM-00110
EKS-MUP-00112
EKS-MYL-00122
EKS-NOL-00101
EKS-ORC-00100
EKS-OTG-00110
EKS-PAT-00099
EKS-PES-00091
EKS-POA-00101
EKS-RAN-00106
EKS-SAH-00103
EKS-SUS-00096
EKS-TUT-00096
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0001012; F:RNA polymerase II regulatory region DNA binding
GO:0007202; P:activation of phospholipase C activity
GO:0002250; P:adaptive immune response
GO:0032609; P:interferon-gamma production
GO:0032633; P:interleukin-4 production
GO:0001865; P:NK T cell differentiation
GO:0032729; P:positive regulation of interferon-gamma production
GO:0060335; P:positive regulation of interferon-gamma-mediated signaling pathway
GO:0046777; P:protein autophosphorylation
GO:0006357; P:regulation of transcription from RNA polymerase II promoter
GO:0050852; P:T cell receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013