EKS-BOT-00107

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00107

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	490.6	8.6E-148	335	585	251

Status

Unreviewed

Ensembl Protein

ENSBTAP00000043974

UniProt Accession

F1MSH3;

Protein Name

Protein Synonyms/Alias

Gene Name

TEC

Gene Synonyms/Alias

TEC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000005062	ENSBTAP00000043974	ENSBTAT00000046704

Organism

Bos taurus

Functional Description

Protein Length

596

Protein Sequence
(FASTA)

LNYFDYNPHS KKYRKGFIDV SKIKCVEIVK NDDGVIPCQN KYPFQVVHDA NTLYIFAPSA 60

QSRDRWVKKL KEEIKNNNNI MIKYHPKFWA DGSYQCCRQT EKLAPGCEKY NLFESSIRKA 120

LPPTPAPEIK KRRPPPPIPP EEENGEEIVV AMYDFQATEA HDLRLERGQE YIILEKNDVH 180

WWKARDKYGS EGYIPSNYVT GKKSNNLDQY EWYCRNMNRS KAEQLLRSED KEGGFMVRDS 240

SQPGMYTVSL YTKFGGEGSS GFRHYHIKET MTSPKKYYLA EKHAFGSIPE IIEYHKHNAA 300

GLVTRLRYPV STKGKNAPTT AGFSYEKWEI NPSELTFMRE LGSGLFGVVR LGKWRAQYKV 360

AIKAIREGAM CEEDFIEEAK VMMKLTHPKL VQLYGVCTQQ KPIYIVTEFM ERGCLLNFLR 420

QRQGHFSRDM LLSMCQDVCE GMEYLERNSF IHRDLAARNC LVNEAGIVKV SDFGMARYVL 480

DDQYTSSSGA KFPVKWCPPE VFNYSRFSSK SDVWSFGVLM WEIFTEGRMP FEKNTNYEVV 540

TMVTRGHRLH QPKLASRYVY EVMLRCWQEK PEGRPSFEDL LRTIDELVEC GETFGR 596

Nucleotide Sequence
(FASTA)

CTTAATTATT TTGATTATAA TCCTCATAGT AAAAAGTACA GAAAGGGATT TATTGATGTG 60

TCAAAAATCA AGTGTGTGGA AATAGTGAAG AACGATGATG GTGTCATTCC CTGTCAAAAT 120

AAATATCCAT TTCAGGTTGT GCATGATGCT AACACACTTT ACATTTTTGC ACCTAGTGCA 180

CAAAGCAGGG ACCGGTGGGT AAAGAAGTTA AAAGAAGAAA TAAAGAACAA CAATAATATT 240

ATGATTAAAT ATCATCCTAA ATTTTGGGCA GACGGAAGTT ATCAGTGTTG CAGACAAACT 300

GAAAAACTAG CACCTGGATG TGAAAAATAT AATCTTTTTG AAAGTAGTAT AAGAAAAGCA 360

CTACCTCCAA CACCAGCGCC AGAAATAAAG AAACGAAGGC CTCCTCCACC AATTCCGCCT 420

GAAGAAGAAA ATGGTGAAGA AATAGTTGTA GCCATGTATG ATTTCCAAGC GACAGAAGCA 480

CATGATCTCA GGCTAGAGAG AGGCCAGGAG TATATCATAT TGGAAAAGAA TGACGTTCAT 540

TGGTGGAAAG CAAGAGATAA ATACGGGAGT GAAGGATATA TCCCAAGTAA TTATGTGACA 600

GGAAAGAAAT CAAACAACTT AGATCAATAT GAATGGTATT GCAGAAATAT GAATAGGAGC 660

AAAGCAGAGC AACTCCTTAG AAGTGAGGAT AAAGAAGGTG GTTTTATGGT AAGAGATTCC 720

AGTCAACCAG GCATGTACAC AGTTTCCCTT TATACAAAGT TTGGAGGCGA AGGTTCCTCA 780

GGTTTCAGGC ATTACCATAT AAAGGAAACA ATGACATCTC CAAAGAAGTA TTATCTGGCA 840

GAAAAACATG CTTTTGGTTC AATTCCTGAG ATTATTGAAT ATCATAAGCA CAATGCAGCA 900

GGACTTGTCA CAAGGCTGCG GTACCCAGTC AGCACAAAGG GGAAGAATGC ACCAACCACT 960

GCGGGGTTCA GCTACGAAAA ATGGGAGATT AACCCTTCAG AGCTGACCTT TATGAGGGAG 1020

TTGGGGAGTG GACTGTTCGG AGTGGTAAGG CTTGGCAAGT GGCGAGCTCA GTACAAAGTA 1080

GCCATCAAAG CTATTCGGGA AGGTGCCATG TGTGAGGAAG ACTTCATAGA AGAAGCTAAA 1140

GTGATGATGA AACTGACACA CCCGAAGTTA GTACAACTTT ATGGTGTATG CACACAGCAG 1200

AAACCCATTT ACATTGTTAC CGAGTTCATG GAGAGGGGAT GCCTTCTGAA TTTCCTCCGC 1260

CAGAGACAAG GCCATTTCAG TAGAGATATG CTGCTGAGCA TGTGTCAAGA TGTGTGTGAA 1320

GGGATGGAGT ACCTGGAGAG AAACAGCTTC ATCCACAGAG ACCTGGCTGC CAGAAATTGT 1380

CTAGTAAATG AGGCAGGAAT TGTGAAAGTG TCTGATTTTG GAATGGCTAG GTATGTCCTG 1440

GATGATCAGT ACACGAGTTC TTCTGGTGCT AAATTTCCTG TGAAGTGGTG TCCACCTGAG 1500

GTGTTTAATT ACAGCCGCTT TAGCAGCAAA TCAGATGTGT GGTCATTTGG TGTCTTAATG 1560

TGGGAAATAT TCACTGAAGG CAGAATGCCC TTTGAGAAAA ACACCAACTA TGAAGTGGTA 1620

ACCATGGTTA CTCGCGGCCA CCGACTCCAC CAGCCAAAGT TGGCCTCCAG ATATGTATAC 1680

GAGGTGATGC TGAGATGTTG GCAGGAGAAA CCAGAGGGAA GGCCTTCCTT CGAAGATCTG 1740

CTGCGCACGA TAGATGAACT AGTCGAATGT GGAGAAACTT TTGGAAGATG A 1791

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+++elgsg fgvv+lgkwra+++vaikai+egam+eedfieeakvmmkl+hpklvqly

Q: 335   LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLY  394

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvc++qkpiyivte++e+gclln+lr++++++++++ll+mc+dvcegmeyler+sfihrd

Q: 395   GVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDMLLSMCQDVCEGMEYLERNSFIHRD  454

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+e+ +vkvsdfg+aryvlddqy+ss+gakfpvkw+ppev++ys++ssksdvw

Q: 455   LAARNCLVNEAGIVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVW  514

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         +fgvlmwe+f+eg++p+ek++n+evv++v+rg+rl++pklas++vyevm +cw+ekpe+r

Q: 515   SFGVLMWEIFTEGRMPFEKNTNYEVVTMVTRGHRLHQPKLASRYVYEVMLRCWQEKPEGR  574

         ************************************************************

S: 241   ptfkellsale  251

         p+f++ll+++

Q: 575   PSFEDLLRTID  585

         ********995

Domain Sequence
(FASTA)

LTFMRELGSG LFGVVRLGKW RAQYKVAIKA IREGAMCEED FIEEAKVMMK LTHPKLVQLY 60

GVCTQQKPIY IVTEFMERGC LLNFLRQRQG HFSRDMLLSM CQDVCEGMEY LERNSFIHRD 120

LAARNCLVNE AGIVKVSDFG MARYVLDDQY TSSSGAKFPV KWCPPEVFNY SRFSSKSDVW 180

SFGVLMWEIF TEGRMPFEKN TNYEVVTMVT RGHRLHQPKL ASRYVYEVML RCWQEKPEGR 240

PSFEDLLRTI D 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543	; F:phospholipid binding
GO:0050853	; P:B cell receptor signaling pathway
GO:0007229	; P:integrin-mediated signaling pathway
GO:0035556	; P:intracellular signal transduction
GO:0010543	; P:regulation of platelet activation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00402	; TECBTKDOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013