EKS-BOT-00426

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00426

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/WEE	378.1	2.1E-113	85	355	271

Status

Unreviewed

Ensembl Protein

ENSBTAP00000047898

UniProt Accession

A7MBC3;

Protein Name

Protein Synonyms/Alias

WEE1 protein;

Gene Name

WEE1

Gene Synonyms/Alias

WEE1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000005278	ENSBTAP00000006114	ENSBTAT00000006114
ENSBTAG00000005278	ENSBTAP00000047898	ENSBTAT00000054711

Organism

Bos taurus

Functional Description

Protein Length

422

Protein Sequence
(FASTA)

MDTEKSGKRE FDVRQTPQVN INPFTPDSLL LHSSGQCRRR KRAYWNDSCG EDMEASDYEF 60

EDETRPAKRI TITESNMKSR YTTEFHELEK IGSGEFGSVF KCVKRLDGCV YAIKRSKKPL 120

AGSVDEQNAL REVYAHAVLG QHSHVVRYFS AWAEDDHMLI QNEYCNGGSL ADAISENYRS 180

MSYFTEAELK DLLLQVGRGL RYIHSMSLVH MDIKPSNIFI SRTSIPNAAS EEGDEDDWAS 240

NKVMFKIGDL GHVTRISSPQ VEEGDSRFLA NEVLQENYTH LPKADIFALA LTVVCAAGAE 300

PLPRNGDQWH EIRQGRLPRI PQVLSQEFTE LLKVMIHPDP ERRPSAMALV KHSVLLSASR 360

KSAEQLRIEL NAEKFKNSLL QKELKKAQMA KLQLRKEHSS LIGWLPGPPP RVIEHLDLLE 420

RK 422

Nucleotide Sequence
(FASTA)

ATGGATACAG AAAAATCAGG AAAAAGGGAA TTTGATGTTC GACAGACTCC TCAAGTGAAT 60

ATTAATCCTT TTACTCCAGA TTCTCTGTTA CTGCATTCCT CAGGACAGTG TCGGAGAAGA 120

AAGAGAGCAT ATTGGAATGA TTCCTGTGGT GAAGACATGG AAGCCAGTGA TTATGAGTTT 180

GAAGATGAAA CAAGACCTGC TAAAAGAATT ACAATTACTG AAAGCAATAT GAAGTCTCGA 240

TATACAACAG AATTTCATGA GCTAGAGAAG ATTGGTTCTG GAGAATTTGG TTCTGTGTTT 300

AAATGTGTGA AGAGGCTGGA TGGATGCGTT TATGCCATAA AACGATCAAA AAAGCCATTG 360

GCTGGCTCTG TTGATGAGCA GAATGCTTTG AGAGAAGTAT ATGCTCACGC AGTGCTTGGG 420

CAACATTCTC ATGTAGTTCG ATACTTCTCT GCCTGGGCAG AAGATGATCA TATGCTTATA 480

CAGAATGAAT ATTGTAACGG TGGCAGTTTA GCCGATGCCA TAAGTGAAAA CTACAGAAGT 540

ATGAGTTACT TTACAGAAGC AGAGTTGAAG GATCTCCTCT TACAAGTTGG CCGGGGCTTG 600

AGGTATATTC ATTCAATGTC TTTAGTTCAC ATGGATATAA AGCCTAGTAA TATTTTCATA 660

TCTCGAACTT CAATCCCAAA TGCTGCCTCT GAAGAAGGAG ATGAAGATGA CTGGGCATCC 720

AACAAAGTTA TGTTTAAAAT AGGTGACCTT GGACATGTAA CAAGGATCTC TAGTCCACAA 780

GTTGAAGAGG GTGATAGCCG TTTTCTTGCA AATGAAGTTT TACAGGAGAA CTATACTCAC 840

CTTCCAAAAG CAGATATTTT TGCCCTTGCC CTCACAGTGG TATGTGCTGC TGGTGCTGAG 900

CCTCTTCCCA GAAATGGAGA CCAATGGCAT GAAATTAGAC AGGGTAGATT ACCTCGGATT 960

CCACAAGTGC TTTCGCAAGA ATTTACAGAG TTGCTAAAAG TTATGATTCA TCCAGATCCA 1020

GAGAGAAGAC CTTCAGCAAT GGCACTGGTA AAGCATTCAG TATTACTATC TGCTTCAAGG 1080

AAGAGTGCAG AACAATTACG AATAGAATTG AATGCTGAAA AGTTCAAAAA TTCACTTCTG 1140

CAGAAAGAAC TCAAGAAAGC CCAGATGGCA AAGCTGCAGC TGAGGAAAGA GCACTCTTCA 1200

CTGATCGGAT GGCTACCAGG TCCACCACCC AGAGTAATAG AACATCTCGA CTTATTGGAA 1260

AGAAAATGA 1269

Domain Profile

S: 1     FeevekiGkGefgevfkvvkredgklyAikkskkplkglskekkalrEvtahavlgqhen  60

         F+e+ekiG+Gefg+vfk+vkr+dg++yAik+skkpl+g+++e++alrEv+ahavlgqh++

Q: 85    FHELEKIGSGEFGSVFKCVKRLDGCVYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSH  144

         99**********************************************************

S: 61    vvryisaWeeddslyiqtElCeggsLeaalqeceakkkaleeaelkkilldlllglrylH  120

         vvry+saW+edd+++iq+E+C+ggsL++a++e+++++++++eaelk++ll++ +glry+H

Q: 145   VVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRSMSYFTEAELKDLLLQVGRGLRYIH  204

         ************************************************************

S: 121   ssslvHlDikpenifi...................tkevtlklgDlGlvtelnsedkskv  161

         s+slvH+Dikp+nifi                   +++v++k+gDlG+vt++   ++++v

Q: 205   SMSLVHMDIKPSNIFIsrtsipnaaseegdeddwaSNKVMFKIGDLGHVTRI---SSPQV  261

         ****************************************************...9****

S: 162   eEGDsrylakEilqeeyskl.kaDiFslgltilevaanvelPsnGeaWhklRkgklpdei  220

         eEGDsr+la+E+lqe+y++l kaDiF+l+lt++++a++++lP+nG++Wh++R+g+lp +i

Q: 262   EEGDSRFLANEVLQENYTHLpKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLP-RI  320

         *********************************************************.**

S: 221   lkelsedlrellklmlepdperRptaeellkhevl  255

          ++ls++++ellk+m++pdperRp+a++l+kh+vl

Q: 321   PQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVL  355

         ********************************986

Domain Sequence
(FASTA)

FHELEKIGSG EFGSVFKCVK RLDGCVYAIK RSKKPLAGSV DEQNALREVY AHAVLGQHSH 60

VVRYFSAWAE DDHMLIQNEY CNGGSLADAI SENYRSMSYF TEAELKDLLL QVGRGLRYIH 120

SMSLVHMDIK PSNIFISRTS IPNAASEEGD EDDWASNKVM FKIGDLGHVT RISSPQVEEG 180

DSRFLANEVL QENYTHLPKA DIFALALTVV CAAGAEPLPR NGDQWHEIRQ GRLPRIPQVL 240

SQEFTELLKV MIHPDPERRP SAMALVKHSV L 271

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030010	; P:establishment of cell polarity
GO:0000226	; P:microtubule cytoskeleton organization
GO:0007067	; P:mitosis
GO:0048812	; P:neuron projection morphogenesis
GO:0018108	; P:peptidyl-tyrosine phosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017164	; Wee1-like_protein_kinase.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013