EKS-BOT-00020
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00020
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/Trio375.21.7E-11211001354255
StatusUnreviewed
Ensembl ProteinENSBTAP00000050032
UniProt AccessionF1MLS2;
Protein Name
Protein Synonyms/Alias
Gene NameTRIO
Gene Synonyms/Alias TRIO;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000005514ENSBTAP00000053254ENSBTAT00000061086
ENSBTAG00000005514ENSBTAP00000050032ENSBTAT00000053304
OrganismBos taurus
Functional Description
Protein Length1403
Protein Sequence
(FASTA)
MPNGIKPVDP LDSLSAVSTA YRGGGQPGTC KYWILDLDSL SVSSNDASPP ASVASLQPHM 60
VGAQSSPGPK RPGNTLRKWL TSPVRRLSSG KADGHVKKLA HKHKKSREVR KSADAGSQKD 120
SDDSAATPQD ETVEERGRNE GLSSGTLSKS SSSGMQSCGE EEGEEGADAV PLPPPMAIQQ 180
HSLLQPDSQD DKASSRLLVR PTSSETPSAA ELVSAIEELV KSKMALEDRP SSLLVDQGDS 240
SSPSFNPSDN SLLSSSSPID EMEERKSSSL KRRHYVLQEL VETERDYVRD LGCVVEGYMA 300
LMKEDGVPDD MKGKDKIVFG NIHQIYDWHR DFFLGELEKC LEDPEKLGSL FVKHERRLHM 360
YIVYCQNKPK SEHIVSEYID TFFEDLKQRL GHRLQLTDLL IKPVQRITKY QLLLKDFLKY 420
SKKASLDTSE LERAVEVMCV VPKRCNDMMN VGRLQGFDGK IVAQGKLLLQ DTFLVTDQDT 480
GLLPRCKERR VFLFEQIVIF SEPLDKKKGF SMPGFLFKNS IKVSCLCLEE NVENDPCKFA 540
LTSRTGDVVE TFILHSSSPS VRQTWIHEIN QILENQRNFL NALTSPIEYQ RNHSGGGGSG 600
GGGGSSGAPS GGGGGSNHSG GGGGPGGGGS GSSSRSRPSR IPQPVRHHSP VLVSSAASSQ 660
AEADKMSGTC TPGPPPPPPS RSPAPEASAG PPGRAPPSSE PDGPERDTEP IPKMKVLESP 720
RKSSGGVLPQ DGAAKEAPRS GPGPLPLGKA RPGAPSPLHS PLAAAAASPS PFGKEPLPPS 780
SPLQKGGSFW SSVPASPASR PGSFTFPGDS DSLQRQARRH AAPGKDADRM STCSSASEQS 840
VQSTQSNGSE SSSGSNISTM LVTHDYTAVK EDEINVYQGE VVQILASNQQ NMFLVFRAAT 900
DQCPAAEGWI PGFVLGHTSA VIMENPDGTL KKSTSWHTAL RLRKKSEKKD KDGKREGKLE 960
NGYRKSREGL SNKVSVKLLN PNYIYDVPPE FVIPLSEVTC EAGETVVLRC RVCGRPKASI 1020
TWKGPEHNTL NNDGHYSISY SDLGEAALKI VGVAAEDDGV YTCIAVNDMG SASSSASLRV 1080
LGPGSDGIVV TWKDNFDCFY SEVAELGRGR FSVVKKCDQK GTKRAVATKF VNKKLMKRDQ 1140
VTHELGILQN LQHPLLVGLL DTFETPTSYV LVLEMADQGR LLDCVVRWGN LTEGKIRAYL 1200
GEVLEAVRYL HNCRIVHLDL KPENILVDQS SAKPTIKLAD FGDAVQLNTT YHIHPLLGNP 1260
EFAAPEIILG NPVSLTSDTW SVGVLAYVLL SGVSPFLDDS VEETCLNICR LDFSFPEDYF 1320
QGVSQRAKDF VCFLLHEDPA KRPSAASALQ ERWLQAGHGH GKGAGVLDTS RLTSFIERRK 1380
HQNDVRPIRS MKNFLQSRLL PRV 1403
Nucleotide Sequence
(FASTA)
ATGCCGAACG GAATTAAGCC AGTAGATCCG CTGGACTCAC TTTCAGCCGT CAGCACAGCC 60
TACCGCGGCG GCGGGCAGCC TGGCACCTGC AAGTACTGGA TCCTGGACCT AGACTCACTG 120
TCCGTCTCCA GCAACGACGC CAGCCCGCCC GCCTCCGTGG CCTCCCTCCA GCCCCACATG 180
GTAGGGGCGC AGAGCTCGCC GGGCCCCAAG CGCCCGGGCA ACACGCTGCG TAAGTGGCTG 240
ACAAGCCCCG TGCGGCGGCT GAGCAGCGGC AAGGCGGATG GGCACGTGAA GAAGCTGGCG 300
CACAAGCACA AGAAGAGCCG CGAGGTCCGC AAGAGCGCCG ACGCCGGCTC GCAGAAGGAC 360
TCGGACGACA GCGCGGCCAC CCCGCAGGAC GAGACCGTGG AAGAGAGAGG CCGGAACGAG 420
GGCCTGAGCA GTGGCACGCT TTCCAAGTCC TCATCTTCGG GCATGCAGAG CTGCGGAGAG 480
GAAGAAGGGG AGGAGGGGGC CGACGCCGTG CCCCTGCCGC CACCCATGGC CATCCAGCAG 540
CACAGCCTGC TCCAGCCAGA CTCCCAGGAC GACAAGGCCT CTTCTCGGTT ATTAGTCCGC 600
CCCACCAGCT CCGAAACACC GAGCGCAGCC GAGCTTGTCA GTGCAATCGA GGAACTCGTG 660
AAAAGCAAGA TGGCTCTGGA GGATCGTCCC AGCTCGCTCC TCGTCGACCA GGGGGACAGC 720
AGCAGCCCCT CCTTCAACCC TTCAGACAAC TCCCTGCTGT CCTCCTCCTC ACCCATCGAT 780
GAGATGGAAG AGAGGAAGTC CAGCTCTTTA AAGAGACGCC ACTACGTTTT ACAAGAATTA 840
GTGGAGACAG AGCGTGACTA TGTGCGGGAC CTCGGCTGTG TGGTGGAGGG CTACATGGCA 900
CTTATGAAAG AAGATGGTGT TCCTGACGAC ATGAAAGGCA AAGACAAGAT TGTGTTTGGC 960
AACATCCATC AGATTTACGA CTGGCACAGA GACTTTTTTT TAGGAGAGTT GGAGAAGTGC 1020
CTTGAAGATC CGGAAAAACT AGGATCCCTT TTTGTTAAAC ATGAGAGAAG GTTGCACATG 1080
TACATAGTTT ATTGCCAAAA TAAACCAAAG TCTGAACACA TTGTCTCAGA ATACATTGAC 1140
ACCTTTTTTG AGGACTTAAA GCAGCGCCTG GGCCACAGGC TGCAGCTCAC GGACTTGCTG 1200
ATCAAACCCG TTCAGAGGAT CACGAAGTAC CAGCTGCTGC TGAAGGACTT CCTCAAGTAT 1260
TCCAAAAAGG CCAGCCTGGA TACATCAGAA CTAGAGAGAG CCGTGGAGGT CATGTGCGTC 1320
GTCCCGAAGC GCTGCAACGA CATGATGAAC GTCGGGAGGC TACAAGGCTT CGACGGTAAG 1380
ATCGTGGCCC AGGGCAAGCT GCTCCTGCAG GACACGTTCT TGGTCACGGA CCAGGACACG 1440
GGGCTGCTGC CTCGCTGCAA AGAGAGGCGG GTGTTCCTCT TCGAGCAGAT CGTCATTTTC 1500
AGTGAGCCGC TGGATAAAAA AAAGGGCTTC TCCATGCCAG GATTCCTGTT CAAGAACAGT 1560
ATCAAGGTGA GCTGCCTTTG CCTGGAGGAA AACGTGGAAA ATGATCCCTG TAAGTTCGCT 1620
CTGACATCGC GGACGGGTGA CGTGGTGGAG ACTTTCATCC TGCACTCATC CAGTCCAAGT 1680
GTCCGGCAGA CGTGGATCCA TGAAATCAAC CAGATTTTAG AAAACCAGCG CAATTTTTTA 1740
AACGCCTTGA CATCACCCAT CGAATATCAG AGGAACCACA GCGGGGGCGG CGGCAGCGGC 1800
GGGGGCGGGG GCAGCAGCGG GGCCCCCAGC GGCGGGGGCG GCGGCAGCAA CCACAGCGGC 1860
GGTGGGGGCG GCCCCGGTGG CGGCGGCAGC GGCAGCTCGA GCAGAAGTAG ACCCTCCCGG 1920
ATTCCCCAGC CCGTCAGACA CCACTCCCCC GTGCTGGTCT CCTCTGCAGC CTCGAGCCAG 1980
GCAGAGGCAG ACAAGATGTC AGGTACGTGC ACCCCGGGCC CGCCACCGCC TCCTCCCAGC 2040
CGCAGCCCCG CCCCGGAGGC CAGCGCCGGC CCGCCTGGCA GGGCGCCCCC CAGCAGCGAG 2100
CCCGACGGTC CCGAGCGAGA CACCGAGCCG ATCCCCAAGA TGAAGGTGCT GGAGAGCCCC 2160
CGGAAGTCGT CCGGGGGCGT GCTGCCACAG GACGGAGCCG CCAAGGAGGC ACCGCGGAGC 2220
GGCCCGGGCC CCCTTCCGCT GGGCAAGGCC AGGCCCGGGG CCCCCTCGCC CCTGCACTCA 2280
CCTCTGGCCG CCGCCGCCGC GTCCCCCTCT CCGTTCGGCA AGGAGCCCTT GCCCCCCAGC 2340
AGCCCCCTGC AGAAGGGGGG CTCCTTCTGG AGCTCCGTGC CTGCCTCCCC TGCCAGCCGG 2400
CCCGGCTCCT TCACCTTCCC GGGGGACAGC GACTCCCTGC AGCGGCAGGC ACGGCGCCAC 2460
GCGGCCCCTG GCAAGGATGC GGACCGCATG AGCACGTGCT CCTCGGCCAG CGAGCAGTCC 2520
GTGCAGTCCA CCCAGAGCAA CGGGAGTGAA AGCAGCAGCG GTAGCAACAT CTCCACCATG 2580
TTGGTGACAC ACGACTACAC GGCAGTGAAG GAGGATGAGA TAAACGTCTA TCAAGGAGAG 2640
GTCGTTCAAA TTCTGGCCAG CAATCAACAG AACATGTTTC TGGTGTTCCG AGCCGCCACT 2700
GACCAGTGCC CCGCAGCCGA GGGCTGGATT CCGGGCTTCG TCCTGGGGCA CACCAGCGCA 2760
GTCATCATGG AGAACCCTGA CGGGACTCTC AAGAAGTCAA CATCTTGGCA CACAGCACTC 2820
CGCTTAAGGA AAAAATCTGA GAAAAAAGAT AAAGACGGCA AACGGGAAGG CAAGTTAGAG 2880
AACGGTTACC GGAAGTCTCG GGAAGGACTG AGCAACAAGG TATCTGTGAA GCTTCTCAAT 2940
CCCAACTACA TATATGACGT TCCCCCAGAA TTCGTCATTC CCTTGAGTGA GGTCACGTGT 3000
GAGGCAGGCG AGACCGTTGT TCTTCGATGT CGGGTTTGTG GCCGCCCCAA GGCCTCCATC 3060
ACCTGGAAGG GCCCTGAACA CAACACCTTG AACAACGACG GTCACTACAG CATCTCCTAC 3120
AGCGACTTGG GAGAGGCCGC TCTGAAGATC GTGGGTGTGG CCGCCGAGGA CGACGGCGTC 3180
TACACGTGCA TCGCGGTGAA CGACATGGGG TCAGCCTCGT CTTCAGCCAG CCTGAGGGTT 3240
CTAGGTCCAG GGAGTGATGG CATCGTGGTG ACCTGGAAGG ACAACTTTGA CTGCTTCTAC 3300
AGCGAGGTGG CCGAGCTCGG CAGGGGCAGA TTCTCTGTCG TGAAGAAATG TGATCAGAAA 3360
GGCACCAAAC GAGCCGTGGC CACTAAGTTT GTGAACAAGA AGCTGATGAA GCGTGACCAG 3420
GTCACCCACG AACTTGGGAT CCTGCAGAAC CTCCAGCACC CGCTGCTGGT GGGCCTCCTG 3480
GACACCTTCG AGACCCCCAC CAGCTACGTG CTGGTCCTGG AGATGGCCGA CCAGGGACGG 3540
CTCCTGGACT GCGTGGTGCG GTGGGGGAAC CTCACGGAGG GGAAGATCCG GGCGTACCTG 3600
GGGGAGGTTC TGGAAGCCGT GCGATACCTT CACAACTGCA GGATAGTGCA TCTGGACCTA 3660
AAGCCTGAGA ACATCCTCGT GGATCAGAGC TCAGCCAAGC CGACCATCAA GCTGGCTGAC 3720
TTCGGAGATG CCGTCCAACT CAACACGACC TACCACATCC ACCCATTGCT GGGGAACCCC 3780
GAGTTCGCAG CCCCCGAGAT CATCCTGGGG AACCCGGTCT CCCTGACCTC AGACACGTGG 3840
AGCGTGGGCG TGCTGGCCTA CGTGCTTCTC AGCGGCGTGT CCCCCTTCCT GGACGACAGC 3900
GTGGAAGAGA CCTGCCTCAA CATTTGCCGC CTGGACTTCA GCTTCCCAGA GGACTACTTC 3960
CAAGGAGTGA GCCAGAGGGC CAAGGACTTC GTGTGCTTCC TACTGCACGA GGACCCCGCC 4020
AAGCGCCCCT CGGCTGCGTC GGCCCTCCAG GAGCGGTGGC TGCAGGCGGG CCACGGCCAC 4080
GGCAAAGGCG CGGGCGTCCT CGACACGTCC AGACTGACCT CCTTCATTGA GCGGCGCAAA 4140
CACCAGAACG ACGTTCGACC TATCCGTAGC ATGAAAAACT TCTTACAGAG CAGGCTTCTG 4200
CCTCGAGTTT GA 4212
Domain Profile
S: 1     yevleeigRGrFsvvkkvrekatkravaakfvpkkakkkaqvlrEaeiLkrLqHpllvsl  60
         y++++e+gRGrFsvvkk+++k+tkrava+kfv+kk +k++qv++E+ iL++LqHpllv l
Q: 1100  YSEVAELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMKRDQVTHELGILQNLQHPLLVGL  1159
         8999********************************************************
S: 61    hdayetprslvlilElcsdeeLLdrlaekeslsEsevkaylrqllealqYLHnsrvlHLD  120
         +d++etp+s+vl+lE++++++LLd+++++++l+E +++ayl ++lea++YLHn+r++HLD
Q: 1160  LDTFETPTSYVLVLEMADQGRLLDCVVRWGNLTEGKIRAYLGEVLEAVRYLHNCRIVHLD  1219
         ************************************************************
S: 121   ikpenllv.laaaeeavkivDlgnAqeltpeepqekllgtpEfvaPEiiegepvseatDi  179
         +kpen+lv ++ a++++k++D+g+A++l+++++++ llg+pEf+aPEii g+pvs ++D+
Q: 1220  LKPENILVdQSSAKPTIKLADFGDAVQLNTTYHIHPLLGNPEFAAPEIILGNPVSLTSDT  1279
         ********999*************************************************
S: 180   WavGvlayvlLsgvsPfldeskretllnilkgrvsfseelfaglseeAkeFlkkvLqedp  239
         W+vGvlayvlLsgvsPfld+s +et+lni+++++sf+e++f+g+s+ Ak+F++++L edp
Q: 1280  WSVGVLAYVLLSGVSPFLDDSVEETCLNICRLDFSFPEDYFQGVSQRAKDFVCFLLHEDP  1339
         ************************************************************
S: 240   rkRPsaaecLqhpWl  254
         +kRPsaa++Lq+ Wl
Q: 1340  AKRPSAASALQERWL  1354
         **************8
Domain Sequence
(FASTA)
YSEVAELGRG RFSVVKKCDQ KGTKRAVATK FVNKKLMKRD QVTHELGILQ NLQHPLLVGL 60
LDTFETPTSY VLVLEMADQG RLLDCVVRWG NLTEGKIRAY LGEVLEAVRY LHNCRIVHLD 120
LKPENILVDQ SSAKPTIKLA DFGDAVQLNT TYHIHPLLGN PEFAAPEIIL GNPVSLTSDT 180
WSVGVLAYVL LSGVSPFLDD SVEETCLNIC RLDFSFPEDY FQGVSQRAKD FVCFLLHEDP 240
AKRPSAASAL QERWL 255
KeywordComplete proteome; Reference proteome; Repeat; SH3 domain.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Oryctolagus cuniculus"; ?>Petromyzon marinus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>
EKS-ANC-00016
EKS-HOS-00021
EKS-ICT-00019
EKS-MAM-00020
EKS-ORC-00020
EKS-PEM-00011
EKS-SAH-00019
EKS-SUS-00020
EKS-TEN-00032
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005089; F:Rho guanyl-nucleotide exchange factor activity
GO:0035023; P:regulation of Rho protein signal transduction
KEGG
InterPros
IPR001251; CRAL-TRIO_dom.
IPR000219; DH-domain.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR001452; SH3_domain.
IPR018159; Spectrin/alpha-actinin.
IPR002017; Spectrin_repeat.
Pfam
PF07679; I-set; 1.
PF00069; Pkinase; 1.
PF00621; RhoGEF; 2.
PF00018; SH3_1; 1.
PF00435; Spectrin; 3.
SMARTs
SM00408; IGc2; 1.
SM00233; PH; 2.
SM00325; RhoGEF; 2.
SM00220; S_TKc; 1.
SM00516; SEC14; 1.
SM00326; SH3; 2.
SM00150; SPEC; 6.
Prosites
PS50191; CRAL_TRIO; 1.
PS50010; DH_2; 2.
PS50835; IG_LIKE; 1.
PS50003; PH_DOMAIN; 2.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50002; SH3; 1.
Prints
Created Date20-Feb-2013